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Immune-awakening Saccharomyces-inspired nanocarrier for oral target delivery to lymph and tumors

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Acta Pharmaceutica Sinica B 2022年第12期12卷 4501-4518页

作者： yuling mao Xiudan Wang Caishun Chen Qinfu Zhao Yanfeng Liu Jinghai Zhang Siling Wang Department of Pharmaceutics School of PharmacyShenyang Pharmaceutical UniversityShenyang 110016China Department of Biomedical Engineering School of Medical DevicesShenyang Pharmaceutical UniversityShenyang 110016China School of Life Science and Bio-pharmaceutics Shenyang Pharmaceutical UniversityShenyang 110016China

Utilization of the intestinal lymphatic pathway will allow extraordinary gains in lymph and tumors cascade-targeted delivery of oral drugs and awakening the innate/adaptive immunity of the body and the lesion microenvironment,in addition to improving oral bioavailability relative to other means of delivery of oral ***,inspired by the specific invasion route of intestinal microorganisms,we pioneered an immune-awakening Saccharomyces-inspired mesoporous silicon nanoparticle(yMSN)for the ingenious cascade-targeted delivery of therapeutic cancer vaccines and antitumor drugs to lymph and tumors via the intestinal lymphatic ***,yMSN high-loaded tumor-specific antigens(OVA,11.9%)and anti-tumor drugs(Len,28.6%)with high stability,namely Len/OVA/yMSN,efficiently co-delivered OVA and Len to their desired target ***,yMSN concomitantly awakened the innate antitumor immunity of dendritic cells and macrophages,strengthening vaccine-induced adaptive immune responses and reversing macrophage-associated immunosuppression in the tumor ***,Len/OVA/yMSN treatment resulted in excellent synergistic antitumor efficacy and long-term antitumor memory in OVA-Hepa1-6-bearing *** high-performance nanocarrier provides a novel approach for lesion-targeting delivery of oral drugs accompanied with awakening of the innate/adaptive immunity of the lesion environment,and also represents a novel path for the oral delivery of diverse therapeutic agents targeting other lymph-mediated diseases.

关键词： Oral delivery Saccharomyces-inspired Immune-awakening nanoparticles Intestinal lymphatic pathway Vaccine delivery Cascade-targeted delivery Awakening the innate/adaptive immunity Co-delivery

MSNCs and MgO-MSNCs as drug delivery systems to control the adsorption kinetics and release rate of indometacin

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Asian Journal of Pharmaceutical Sciences 2019年第3期14卷 275-286页

作者： Xin Zheng Shuang Feng Xiudan Wang Zhenning Shi yuling mao Qinfu Zhao Siling Wang Department of Pharmaceutics School of PharmacyShenyang Pharmaceutical UniversityShenyang110016China School of Pharmaceutical Engineering Shenyang Pharmaceutical UniversityShenyang110016China

Mesoporous silica cocoon materials(MSNCs) and MgO doped mesoporous silica cocoons(MgO-MSNCs) with the cocoon-like hierarchical morphology and different alkalinities were synthesized as carriers for acidic drugs. Indomethacin(IMC) was selected as a model drug and loaded into carriers. All materials and the drug-loaded samples were characterized by nitrogen adsorption, FTIR spectroscopy, transmission electron microscopy(TEM), powder X-Ray diffraction(XRD) and differential scanning calorimetry(DSC). The effect of the Mg/Si molar ratio on the kinetics and equilibrium of IMC adsorption on MgO-MSNCs was thoroughly examined, and it was found that the increase in the Mg/Si molar ratio resulted in an increasing IMC adsorption rate due to the increased affinity between alkaline MgO-MSNCs and weak acid IMC. The adsorption kinetics fitted a pseudo second-order model well. The Freundlich isotherm showed a better fit, indicating that the coverage of IMC on the surface of MgO-MSNCs was heterogeneous. The maximum adsorption capacity of adsorbent was calculated by the Langmuir isotherm equation. The Temkin equation provided further support that the IMC adsorption on MgO-MSNCs was dominated by a chemisorption process. MgO-MSNCs also have the advantage of allowing an adjustment of the drug release rate of weak acid drug. The cytotoxicity assay indicated good biocompatibility of MgO-MSNCs. Our research on MgO-MSNCs carriers demonstrated their potential therapeutic benefit for safe and effective management of IMC adsorption and in vitro release.

关键词： MSNCs MgO-MSNCs Indometacin Adsorption Release rate

Author correction to“Immune-awakening Saccharomyces-inspired nanocarrier for oral target delivery to lymph and tumors”[Acta Pharmaceutica Sinica B 12(2022)4501-4518]

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1478-1482页

作者： yuling mao Xiudan Wang Caishun Chen Qinfu Zhao Yanfeng Liu Jinghai Zhang Siling Wang Department of Pharmaceutics School of PharmacyShenyang Pharmaceutical University103 Wenhua RoadShenyang110016China Department of Biomedical Engineering School of Medical DevicesShenyang Pharmaceutical University103 Wenhua RoadShenyang110016China School of Life Science and Bio-pharmaceutics Shenyang Pharmaceutical University103 Wenhua RoadShenyang110016China

The authors regret that there is an error in the article Fig.9D1 due to the mistake of copying and pasting in the process of assembling figures and negligence in the proofreading,and also a mislabled error in the supp... 详细信息

关键词： correction supporting proof

A bioactive nanocomposite integrated specific TAMs target and synergistic TAMs repolarization for effective cancer immunotherapy

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Bioactive Materials 2024年第8期38卷 472-485页

作者： Wei Gu Wen Guo Zhishuang Ren Yimeng Zhang Meiqi Han Qinfu Zhao Yikun Gao yuling mao Siling Wang Department of Pharmaceutics School of PharmacyShenyang Pharmaceutical University103 Wenhua RoadShenyangLiaoning Province110016China School of Life Sciences and Biopharmaceuticals Shenyang Pharmaceutical University103 Wenhua RoadShenyangLiaoning Province110016China

Reactive oxygen species(ROS)generated from photosensitizers exhibit great potential for repolarizing immunosuppressive tumor-associated macrophages(TAMs)toward the anti-tumor M1 phenotype,representing a promising cancer immunotherapy ***,their effectiveness in eliminating solid tumors is generally limited by the instability and inadequate TAMs-specific targeting of ***,a novel core-shell integrated nano platform is proposed to achieve a coordinated strategy of repolarizing TAMs for potentiating cancer *** mesoporous silica nanoparticles(CMSN)are fabricated to encapsulate photosensitizer-Indocyanine Green(ICG)to improve their *** ginseng-derived exosome(GsE)was coated on the surface of ICG/CMSN for targeting TAMs,as well as repolarizing TAMs concurrently,named ICG/CMSN@*** expected,with the synergism of ICG and GsE,ICG/CMSN@GsE exhibited better stability,mild generation of ROS,favorable specificity toward M2-like macrophages,enhancing drug retention in tumors and superior TAMs repolarization potency,then exerted a potent antitumor *** vivo,experiment results also confirm the synergistic suppression of tumor growth accompanied by the increased presence of anti-tumor M1-like macrophages and maximal tumor *** together,by integrating the superiorities of TAMs targeting specificity and synergistic TAMs repolarization effect into a single nanoplatform,ICG/CMSN@GsE can readily serve as a safe and high-performance nanoplatform for enhanced cancer immunotherapy.

关键词： Ginseng-derived exosome Colloidal mesoporous silica nanoparticles Tumor-associated macrophages TAMs-specific targeting delivery Repolarizing TAMs

Intracellular PEDF contributes to triglyceride degradation

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Intracellular PEDF contributes to triglyceride degradation

木质林产品进口对中国林产工业污染排放的影响

第11届全国脂质与脂蛋白学术会议

作者： Zhiyu Dai Cen Li Weiwei Qi Juling Lu yuling mao Xia Yang Guoquan Gao Department of Biochemistry Zhongshan Medical SchoolSun Yat-sen University

Baekgroup/Aims:Pigment epithelium-derived factor(PEDF) is well known as a secreted glycoprotein with anti-angiogenic activity,but its role in liver lipid regulation is largely *** present study is to demonstrate that cytoplasmic PEDF associates with adipose triglyceride lipase(ATGL) and G/G switch gene 2(G0S2) to regulate triglyceride (TG) degradation. Methods:The expression pattern of hepatic PEDF mRNA and protein,TG and FFA level were investigated in progressing obesity mice induced by high fat ***

关键词： ATGL G0S2 Triglyceride hepatocyte lipid droplet

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林业经济问题 2021年第6期41卷 635-644页

作者：毛玉铃万璐张羽婷北京林业大学经济管理学院北京100083

基于2003-2015年木质林产品及行业层面的面板数据,采用污染排放模型对木质林产品进口作用于林产工业污染排放的影响进行实证检验,再以全要素生产率为中介变量构建中介效应模型作进一步检验。结果表明:木质林产品进口对林产工业行业污染... 详细信息

基于2003-2015年木质林产品及行业层面的面板数据,采用污染排放模型对木质林产品进口作用于林产工业污染排放的影响进行实证检验,再以全要素生产率为中介变量构建中介效应模型作进一步检验。结果表明:木质林产品进口对林产工业行业污染排放有显著减排作用;木质林产品进口能提升全要素生产率,从而促进林产工业污染减排;此外,从不同要素密集度产品角度出发,实证结果表明资本技术密集型和劳动密集型木质林产品进口通过提升全要素生产率对污染减排产生不同的正向影响。因此,应该适当扩大林产工业木质林产品进口规模,进一步拓宽木质林产品进口渠道,并加速吸收转化进口产品所蕴含先进技术。

关键词：木质林产品进口林产工业污染排放全要素生产率

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融资约束对中国纸制品出口产品质量影响研究

林业经济问题 2020年第3期40卷 295-301页

作者：袁璐瑶万璐毛玉铃北京林业大学经济管理学院北京100083

基于2002—2016年中国纸制品出口数量和出口价格数据以及中国与30个主要纸制品贸易伙伴的面板数据,测度分析中国2002—2016年纸制品出口产品的质量和质量变化特征,并探讨融资约束对中国纸制品出口产品质量的影响。实证结果表明:银行信... 详细信息

基于2002—2016年中国纸制品出口数量和出口价格数据以及中国与30个主要纸制品贸易伙伴的面板数据,测度分析中国2002—2016年纸制品出口产品的质量和质量变化特征,并探讨融资约束对中国纸制品出口产品质量的影响。实证结果表明:银行信贷约束和内源现金流约束对纸制品出口产品质量有显著的抑制作用;商业信贷约束和内源实收资本变化对纸制品出口产品质量作用不显著;人均收入、劳动力成本以及研发投入对中国纸制品出口产品质量上升有显著的促进作用;外商直接投资对中国纸制品出口产品质量的影响不显著。因此,完善金融市场体系,完善企业信用评价体系,企业提高经营能力和创新能力,能够缓解融资约束从而提高纸制品出口产品质量。

关键词：融资约束纸制品出口产品质量

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中国木家具出口产品质量影响因素

林业经济问题 2021年第3期41卷 289-295页

作者：袁璐瑶万璐毛玉铃北京林业大学经济管理学院北京100083

基于质量内生决定理论,采用回归反推法利用中国木家具出口数量和价格数据测度中国2002—2016年木家具出口产品质量,并在此基础上结合中国与15个木家具主要出口贸易伙伴的面板数据,利用固定效应等方法考察中国木家具出口产品质量的影响... 详细信息

基于质量内生决定理论,采用回归反推法利用中国木家具出口数量和价格数据测度中国2002—2016年木家具出口产品质量,并在此基础上结合中国与15个木家具主要出口贸易伙伴的面板数据,利用固定效应等方法考察中国木家具出口产品质量的影响因素。结果表明:贸易伙伴居民收入、木家具行业研发投入密度、木家具行业人均工资对中国木家具出口产品质量提升起促进作用;签订自由贸易协议对木家具出口产品质量提升起抑制作用。为此,企业应加大研发投入、提高员工素质,行业协会应发挥引导作用,形成高质量发展的良好态势,政府应给予政策和财政上的支持,共同促进木家具行业转型升级。

关键词：木家具出口产品质量影响因素

子宫内膜异位症患者新鲜胚胎移植临床妊娠率预测模型的建立与验证

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南方医科大学学报 2024年第7期44卷 1407-1415页

作者：潘甚豪李炎坤伍哲维毛玉玲王春艳广州医科大学附属第三医院妇产科//生殖医学中心//广东省产科重大疾病重点实验室//广东省妇产疾病临床医学研究中心//粤港澳母胎医学高校联合实验室广东广州510150 广州医科大学临床医学系广东广州511436

目的构建并验证子宫内膜异位症(EMs)患者辅助生殖治疗(ART)中新鲜胚胎移植的临床妊娠率预测模型。方法选取2017年5月~2023年11月在本院生殖医学中心进行ART治疗的464例子宫内膜异位症不孕患者,并将其分为建模人群(60%)和验证人群(40%)... 详细信息

目的构建并验证子宫内膜异位症(EMs)患者辅助生殖治疗(ART)中新鲜胚胎移植的临床妊娠率预测模型。方法选取2017年5月~2023年11月在本院生殖医学中心进行ART治疗的464例子宫内膜异位症不孕患者,并将其分为建模人群(60%)和验证人群(40%)。采用单因素分析、多因素Logistic回归分析、LASSO回归分析EMs患者新鲜胚胎移植妊娠率的相关因素,并建立预测EMs患者新鲜胚胎移植临床妊娠率的列线图模型。采用ROC的曲线下面积(AUC)、校准曲线和决策曲线分别在建模人群和验证人群对预测模型进行验证。为提高模型性能,本研究采用Stacking集成学习方法集成GBM、XGBOOST、MLP 3种机器学习方法,利用它们各自优势相互补充以提高模型预测性能。结果女性年龄、Gn启动用量、ART次数、移植胚胎数是影响新鲜胚胎移植临床妊娠率的独立因素(P<0.05)。通过LASSO模型筛选纳入变量:女性年龄、FSH、Gn时间、Gn启动用量、ART次数、获卵数、移植胚胎数、HCG日内膜厚度、HCG日P。训练集中,模型准确性为0.642(95%CI:0.605-0.679),测试集中,模型准确性为0.652(95%CI:0.600-0.704)。集成学习方法可以提高模型的性能:训练集中,模型准确性为0.725(95%CI:0.680-0.770),测试集中,模型准确性为0.718(95%CI:0.675-0.761)。结论本研究所建立预测模型有助于预测子宫内膜异位症患者新鲜胚胎移植的临床妊娠率,为子宫内膜异位症ART治疗提供指导意见。

关键词：子宫内膜异位症不孕临床妊娠率预测模型列线图