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Chinese Chemical Letters 2024年第2期35卷 118-130页

作者： Zihan liu Han liu Jialing Cheng Hongliang Wang Yanfang Yang Jun Ye yuling liu State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences & Peking Union Medical CollegeBeijing 100050China Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation Institute of Materia MedicaChinese Academy of Medical Sciences & Peking Union Medical CollegeBeijing 100050China

Ulcerative colitis(UC)is a common progressive inflammatory disease whose incidence has increased rapidly in recent years,and can develop into colorectal cancer in severe *** are currently no adequate or effective treatments for UC due to the fact that some patients have found suboptimal results after repeated administration,while others have experienced adverse *** the rapid development of nanotechnology,developing innovative colon-targeting platforms is essential to improving efficacy,reducing side effects,and improving patient *** this review,we summarize the pathophysiological characteristics of UC and the most recent status of numerous nanodrug delivery systems based on different targeting mechanisms in treating ***,intravenous,and rectal drug delivery nanoparticles targeting the colon are discussed,which can provide ideas for the design of colon-targeting nanoparticles for the treatment of colon diseases,especially for the treatment of *** but not least,we provide a glimpse into the future of colon-targeted delivery systems,as well as future advancements in the field.

关键词： Ulcerative colitis Physiological characteristics Colon-specific drug delivery Mechanisms of action Targeted therapy of UC

Unlocking the potential of amorphous calcium carbonate: A star ascending in the realm of biomedical application

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Acta Pharmaceutica Sinica B 2024年第2期14卷 602-622页

作者： Han liu Zhiyang Wen Zihan liu Yanfang Yang Hongliang Wang Xuejun Xia Jun Ye yuling liu State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

Calcium-based biomaterials have been intensively studied in the field of drug delivery owing to their excellent biocompatibility and ***-based materials can also deliver contrast agents,which can enhance real-time imaging and exert a Ca^(2+)-interfering therapeutic *** on these characteristics,amorphous calcium carbonate(ACC),as a brunch of calcium-based biomaterials,has the potential to become a widely used *** functional ACC can be either discovered in natural organisms or obtained by chemical synthesis However,the standalone presence of ACC is unstable in *** are required to be used as stabilizers or core-shell structures formed by permeable layers or lipids with modified molecules constructed to maintain the stability of ACC until the ACC carrier reaches its *** has high chemical instability and can produce biocompatible products when exposed to an acidic condition in vivo,such as Ca^(2+) with an immune-regulating ability and CO_(2) with an imaging-enhancing *** to these characteristics,ACC has been studied for selfsacrificing templates of carrier construction,targeted delivery of oncology drugs,immunomodulation,tumor imaging,tissue engineering,and calcium *** in this paper has been placed on the origin,structural features,and multiple applications of ***,ACC faces many challenges in clinical translation,and long-term basic research is required to overcome these *** hope that this study will contribute to future innovative research on ACC.

关键词： Amorphous calcium carbonate Drugdelivery system Nanoparticle Acid sensitivity Water instability,Tumortherapy Tissue engineering Calcium supplement

Detecting compromised email accounts via login behavior characterization

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Cybersecurity 2024年第1期7卷 16-36页

作者： Jianjun Zhao Can Yang Di Wu Yaqin Cao yuling liu Xiang Cui Qixu liu Institute of Information Engineering Chinese Academy of SciencesBeijing100085China School of Cyber Security University of Chinese Academy of SciencesBeijing100049China China Cybersecurity Review Technology and Certification Center Beijing100013China Zhongguancun Laboratory Beijing100089China

The illegal use of compromised email accounts by adversaries can have severe consequences for enterprises and *** compromised email accounts is more challenging than in the social network field,where email accounts have only a few interaction events(sending and receiving).To address the issue of insufficient features,we propose a novel approach to detecting compromised accounts by combining time zone differences and alternate logins to identify abnormal *** on this approach,we propose a compromised email account detection framework that relies on widely available and less sensitive login logs and does not require *** framework characterizes login behaviors to identify logins that do not belong to the account owner and outputs a list of account-subnet pairs ranked by their likelihood of having abnormal login *** approach reduces the number of account-subnet pairs that need to be investigated and provides a reference for investigation *** evaluation demonstrates that our method can detect most email accounts that have been accessed by disclosed malicious IP addresses and outperforms similar ***,our framework has the capability to uncover undisclosed malicious IP addresses.

关键词： Compromised account detection Mixture model Login log analysis Attribution and forensic

Simple and versatile in situ thermo-sensitive hydrogel for rectal administration of SZ-A to alleviate inflammation and repair mucosal barrier in ulcerative colitis

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Chinese Chemical Letters 2024年第6期35卷 462-468页

作者： Yu Yan Jiawei Song Dongdong liu Zihan liu Jialing Cheng Zhiyang Chen Yanfang Yang Weizhe Jiang Hongliang Wang Jun Ye yuling liu State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China College of Pharmacy Guangxi Medical UniversityNanning 530021China Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

Ulcerative colitis(UC)is a chronic inflammatory bowel disease characterized by persistent inflammation of the colon and disrupted intestinal *** mori(Sangzhi)alkaloids(SZ-A),derived from twigs of mulberry,were approved by the National Medical Products Administration in 2020 for treating type 2 diabetes *** evidence has confirmed that SZ-A also alleviates non-alcoholic fatty liver disease and ameliorates inflammation,indicating its potential to address inflammation in ***,the treatment of UC faces challenges due to low drug delivery efficiency and short retention *** overcome these challenges,an injectable and adherent in-situ thermo-sensitive hydrogel containing SZ-A was developed for rectal drug delivery,utilizing the thermo-sensitive polymers Poloxamer 407and *** thermo-sensitive hydrogel system was designed with a moderate gelation temperature of 32±0.5℃,a short gelation time of 64 s,a p H range of 7-10,high moisturizing capability exceeding 90%,and moderate mechanical strength of 4-5 *** a rat model with UC,the in situ thermo-sensitive hydrogel significantly extended the retention time at the colonic site and enabled sustained release after rectal *** of UC were markedly reduced following rectal administration of SZ-A thermosensitive ***,the release of inflammatory factors,such as interleukin-1β(IL-1β),IL-6,IL-18,tumor necrosis factor-α(TNF-α),and transforming growth factor-β1(TGF-β1),significantly decreased in the SZ-A thermo-sensitive hydrogel *** integrity of the colonic mucosal barrier was significantly enhanced following the application of SZ-A thermo-sensitive *** conclusion,rectal administration of SZ-A in situ thermo-sensitive hydrogel effectively alleviated UC symptoms,inhibited the secretion of inflammatory factors,and promoted the repair of the colonic mucosal *** approach holds promise as a potential treatment for UC.

关键词： Ulcerative colitis SZ-A Thermo-sensitive hydrogel Rectal administration Alleviation of inflammation Mucosal barrier repair

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简短关联可编辑环签名及其区块链修正应用

北京航空航天大学学报 2024年第6期50卷 1911-1920页

作者：王杰昌刘玉岭张平刘牧华李杰郑州大学体育学院郑州450000 中国科学院信息工程研究所北京100190 河南科技大学数学与统计学院洛阳471023

关联可编辑环签名(LRRS)可提升区块链的匿名性,防止双花攻击,修正区块链数据,但其签名大小随环成员的增多而增大。针对该问题,结合已有LRRS和简短关联环签名方案,利用动态累加器对环成员的公钥进行累加计算,依据原知识证明签名(SPK)构... 详细信息

关联可编辑环签名(LRRS)可提升区块链的匿名性,防止双花攻击,修正区块链数据,但其签名大小随环成员的增多而增大。针对该问题,结合已有LRRS和简短关联环签名方案,利用动态累加器对环成员的公钥进行累加计算,依据原知识证明签名(SPK)构造出新的SPK,提出简短LRRS(SLRRS)方案,基于该签名又提出新的区块链修正协议。在随机谕言机模型下,证明所提签名具有不可伪造性、匿名性、关联性。性能评估表明:随着环成员的增多,已有签名的大小在增大,而所提签名不变;同时此类签名所消耗的时间均在增多,而所提签名的时间增速较缓且最少。

关键词：知识证明签名动态累加器简短关联可编辑环签名时间更新变色龙哈希区块链修正

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考虑分布式电源的配电网灾中-灾后两阶段协同韧性恢复决策

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电力系统自动化 2024年第2期48卷 48-59页

作者：刘玉玲张峰张刚丁磊电网智能化调度与控制教育部重点实验室(山东大学) 山东省济南市250061 烟台哈尔滨工程大学研究院山东省烟台市264006

频繁的极端自然灾害极易引发配电网大规模故障,基于分布式电源的负荷恢复是提高配电网韧性水平的重要手段。然而,现有研究一般将灾中和灾后阶段进行独立决策,忽略了二者决策的连续性和耦合性,延缓了恢复进程。为此,文中提出一种基于灾中... 详细信息

频繁的极端自然灾害极易引发配电网大规模故障,基于分布式电源的负荷恢复是提高配电网韧性水平的重要手段。然而,现有研究一般将灾中和灾后阶段进行独立决策,忽略了二者决策的连续性和耦合性,延缓了恢复进程。为此,文中提出一种基于灾中-灾后两阶段协同决策的配电网快速恢复方法,充分考虑灾中-灾后过程中的相互作用,综合分布式电源调度、网络拓扑改变、维修人员调度等在内的恢复措施,保障灾中-灾后阶段连续决策的最优性。首先,考虑灾后供能路径对灾中网络拓扑的需求关系,建立灾中阶段以分布式电源为核心的拓扑调整模型与负荷元胞恢复模型,实现部分重要负荷的供电;其次,考虑灾中决策对灾后恢复的影响,建立灾后阶段故障维修人员调度和负荷快速恢复的联合决策模型,实现所有负荷的有序恢复;然后,以灾中-灾后全阶段失负荷量最小为目标,实现灾中-灾后恢复的协同决策;最后,基于IEEE 123节点配电系统验证了所提模型的有效性。

关键词：分布式电源配电网韧性灾中-灾后协同维修人员调度供能路径负荷恢复

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基于洛伦茨曲线的降雨时间分布均匀度变化

科技创新与生产力 2024年第2期45卷 119-121,125页

作者：刘玉玲松山区气象局内蒙古赤峰024005

本文提出了基于洛伦茨曲线的降雨时间分布均匀度变化方法,为新疆农耕提供降雨分布数据。该方法以洛伦茨曲线原理为基础,依据降雨时间分布均匀度基尼系数和洛伦茨不对称系数指标,建立了降雨时间分布均匀度评价模型。以新疆作为研究对象,... 详细信息

本文提出了基于洛伦茨曲线的降雨时间分布均匀度变化方法,为新疆农耕提供降雨分布数据。该方法以洛伦茨曲线原理为基础,依据降雨时间分布均匀度基尼系数和洛伦茨不对称系数指标,建立了降雨时间分布均匀度评价模型。以新疆作为研究对象,研究结果表明:新疆在2006年、2016年和2018年的降雨时间分布基尼系数较大,其降雨时间分布不够均匀。

关键词：降雨时间分布均匀度洛伦茨曲线基尼系数洛伦茨不对称系数

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支架式教学模式在初中英语阅读教学中的应用

英语教师 2024年第3期24卷 110-113,117页

作者：刘玉玲甘肃省白银市第十一中学甘肃白银730900

阐述初中英语阅读教学中教学支架的主要类型,以及支架式教学模式在初中英语阅读教学中的核心应用原则。结合教学实例,从搭建支架、创设情境、独立探索、协作学习、效果评价等五个方面探究支架式教学模式在初中英语阅读教学中的应用策略... 详细信息

阐述初中英语阅读教学中教学支架的主要类型,以及支架式教学模式在初中英语阅读教学中的核心应用原则。结合教学实例,从搭建支架、创设情境、独立探索、协作学习、效果评价等五个方面探究支架式教学模式在初中英语阅读教学中的应用策略。认为在初中英语阅读教学中合理、有效地应用支架式教学模式有助于构建高效英语阅读课堂,提升学生的英语阅读学习效率、语篇研读能力与语篇分析理解能力。

关键词：支架式教学模式初中英语阅读教学

基于毒理基因组学的工业废气颗粒物毒性分析方法及应用

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环境科学研究 2024年第4期37卷 719-727页

作者：何剑吴兴刚王珊珊郑兴刘玉玲西安理工大学市政与环境工程系陕西西安710048

为了解决现有颗粒物毒性检测方法存在的成本高、周期长、过程复杂等问题,引入毒理基因组学分析方法,提出工业废气颗粒物样品预处理方法,基于酶标仪开展毒性测试,利用基因热图分析、应激模式反应和毒性终点深入探究颗粒物的毒性作用机制... 详细信息

为了解决现有颗粒物毒性检测方法存在的成本高、周期长、过程复杂等问题,引入毒理基因组学分析方法,提出工业废气颗粒物样品预处理方法,基于酶标仪开展毒性测试,利用基因热图分析、应激模式反应和毒性终点深入探究颗粒物的毒性作用机制,验证了方法的可行性,并将该方法应用于某烧结机头电除尘器内4个电场(1号、2号、3号、4号)中颗粒物的毒性变化规律分析.结果表明:①对于有机组分,其主要诱导大肠杆菌细胞发生氧化应激反应和潜在的蛋白应激反应,颗粒物有机组分毒性呈4号电场>3号电场>1号电场>2号电场的特征,4号电场的颗粒物毒性终点最小,为3.01×10^(−10) mg/mL.②对于无机组分,4个电场(1号、2号、3号、4号)主要诱导大肠杆菌细胞分别发生普遍应激、DNA应激、氧化应激和蛋白应激,颗粒物无机组分毒性大小呈4号电场>2号电场>1号电场>3号电场的特征,4号电场的颗粒物毒性终点最小,为8.44×10^(−6) mg/mL.研究显示,基于毒理基因组学的工业废气颗粒物毒性分析方法不仅具有准确性,还能更加全面地阐述潜在的毒性模式,实现了工业废气颗粒物毒性的快捷可靠分析,可为后续相关研究提供理论支撑.

关键词：工业废气颗粒物毒理基因组学毒性分析毒性机制

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添加富镉稻草对土壤镉含量及活性动态变化的影响机制

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农业资源与环境学报 2024年第3期41卷 636-644页

作者：付鑫曾煜晖罗必昊刘玉玲叶长城罗斯湖南农业大学环境与生态学院长沙410128 广电计量检测(湖南)有限公司长沙410000

为探究稻草还田在腐解过程中对土壤镉(Cd)含量和活性的影响机制,本研究以土壤和稻草为研究对象,通过不添加稻草(T0)和添加稻草(T1)处理进行土培试验,探究稻草及土壤中的Cd含量变化;从稻草中提取溶解性有机质(DOM),并在黑暗和光照条件下... 详细信息

为探究稻草还田在腐解过程中对土壤镉(Cd)含量和活性的影响机制,本研究以土壤和稻草为研究对象,通过不添加稻草(T0)和添加稻草(T1)处理进行土培试验,探究稻草及土壤中的Cd含量变化;从稻草中提取溶解性有机质(DOM),并在黑暗和光照条件下分别设置不同浓度的DOM处理(CK、C1和C2),进一步揭示稻草对土壤Cd活性的影响及机制。结果表明,在土培试验中,土壤pH先升高后下降,Eh先下降后上升,稻草腐解90 d后,有机质含量增加,稻草Cd含量减少27.93%,土壤总Cd含量升高15.79%,土壤有效Cd含量先下降后缓慢上升,较初始值降低9.15%。对稻草腐解过程中提取的DOM进行表征发现,其亲水性较强、分子量较大,且含有羧基、羟基等官能团。在光照条件下,稻草DOM可以使土壤pH升高,并降低土壤有效Cd含量,且DOM浓度越高,下降得越多,C1和C2处理分别比CK处理低0.13 mg·kg^(-1)和0.29 mg·kg^(-1)。研究表明,富镉稻草还田在短时间内可降低土壤Cd活性,并且稻草的主要腐解产物DOM在光照条件下可抑制Cd在土壤环境中的迁移。

关键词：土壤稻草镉溶解性有机质光照

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