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面向高耗能企业铝加工过程的节能减碳潜力评价及画像研究

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综合智慧能源 2024年第8期46卷 1-11页

作者：罗玉伶彭道刚赵慧荣渠博岗上海电力大学自动化工程学院上海200090

为引导高耗能企业实施可持续发展战略,促进碳减排和能源效率提升,以高耗能企业中铝加工过程为例,考虑能效、碳排放和环境多维指标,建立节能减碳评价指标体系,以确保评估的全面性和准确性。运用层次分析法对铝加工过程中的各加工工段的... 详细信息

为引导高耗能企业实施可持续发展战略,促进碳减排和能源效率提升,以高耗能企业中铝加工过程为例,考虑能效、碳排放和环境多维指标,建立节能减碳评价指标体系,以确保评估的全面性和准确性。运用层次分析法对铝加工过程中的各加工工段的效能、碳排放水平和环境影响进行评估。在评估过程中,结合具体企业案例,对其各加工工段的节能减碳潜力情况进行详细分析,并对节能减碳评价指标体系进行了敏感性分析,确保建立的节能减碳潜力评价指标体系的普适性。结果表明:铝加工企业可以从熔铸工段开始,提升其节能减碳能力。通过用户画像分析,提出优化生产过程等建议,减少能源消耗和环境污染,实现可持续发展目标。

关键词：高耗能企业铝加工过程节能减碳潜力层次分析法用户画像

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斛参增免合剂抑菌剂效力研究与抑菌剂筛选

亚太传统医药 2024年第5期20卷 14-17页

作者：罗玉玲杨仁惠杨元凤张敬杰贵州中医药大学第二附属医院贵州贵阳550003 贵州中医药大学贵州贵阳550025

目的:建立斛参增免合剂的抑菌效力检测方法,筛选适用于斛参增免合剂的抑菌剂。方法:依据《中华人民共和国药典》2020年版4部(通则1121),以金黄色葡萄球菌、铜绿假单胞菌、大肠埃希菌、白色念珠菌和黑曲霉菌为试验菌株,确定菌落计数方法... 详细信息

目的:建立斛参增免合剂的抑菌效力检测方法,筛选适用于斛参增免合剂的抑菌剂。方法:依据《中华人民共和国药典》2020年版4部(通则1121),以金黄色葡萄球菌、铜绿假单胞菌、大肠埃希菌、白色念珠菌和黑曲霉菌为试验菌株,确定菌落计数方法,建立样品的抑菌效力测定方法;并对添加不同浓度(0.10%、0.15%、0.20%、0.25%、0.30%)苯甲酸钠和山梨酸钾的斛参增免合剂进行抑菌效力测定。结果:添加苯甲酸钠、山梨酸钾浓度分别为0.20%、0.25%、0.30%的斛参增免合剂对5株试验菌的抑菌效力均达到《中华人民共和国药典》2020年版抑菌效力检查法的规定,但添加苯甲酸钠、山梨酸钾浓度分别为0.10%和0.15%的斛参增免合剂的抑菌效力达不到药典要求;0.20%山梨酸钾对大肠埃希菌的抑制作用较同浓度的苯甲酸钠弱。结论:0.20%苯甲酸钠可作为斛参增免合剂抑菌剂的最低添加量。

关键词：斛参增免合剂抑菌效力抑菌剂筛选苯甲酸钠山梨酸钾

Blueberry anthocyanins extract attenuates oxidative stress and angiogenesis on an in vitro high glucose-induced retinopathy model through the miR-33/GLCCI1 axis

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BIOCELL 2024年第8期48卷 1275-1284页

作者： WENBIN luo yuling ZOU HONGXI WU ZHONGYI YANG ZHIPENG YOU Department of Ophthalmology The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang330000China Department of Ophthalmology in Ocular Fundus Diseases Affiliated Eye Hospital of Nanchang UniversityNanchang330000China Department of Ophthalmic Treatment of Refractive Errors Affiliated Eye Hospital of Nanchang UniversityNanchang330000China

Background:Diabetes retinopathy(DR)is a complication of diabetes that affects patients’*** studies have found blueberry anthocyanins extract(BAE)can inhibit the progression of DR,but its mechanism is not completely ***:To study the role of BAE in diabetes retinopathy,we treated human retinal endothelial cells(HRCECs)with 30 mM high glucose to simulate the microenvironment of diabetes retinopathy and used BAE to intervene the in vitro high glucose-induced retinopathy *** cell viability and apoptosis rates were examined by Cell Counting Kit 8(CCK-8)assay and flow cytometry *** binding sites between miR-33 and glucocorticoid-induced transcript 1(GLCCI1)were assessed by luciferase reporter *** neovascularization and oxidative stress contribute to diabetic *** tubule formation assay was applied to detect the retinal *** oxidative stress in the HRCECs was manifested by the reactive oxygen species(ROS)level,the malondialdehyde(MDA)level,and the superoxide dismutase(SOD)***:Compared with HRCECs cells cultured under normal conditions,high glucose(HG)can induce oxidative stress in HRCRCs,specifically manifested in the increase of ROS and MDA levels,and the decrease of SOD *** relieved the tubule formation in n the *** also relieved the ROS and MDA levels and increased the SOD *** reporter assay revealed that GLCCI1 is a target molecule downstream of *** HRCEC,BAE significantly inhibited the expression of miR-33 induced by ***-33 mimic inhibited the BAE’s effects on oxidative stress and angiogenesis in an in vitro high glucose-induced retinopathy ***:BAE alleviated the oxidative stress and microangiogenesis of HRCEC by regulating the miR-33/GLCCI1 axis.

关键词： Blueberry anthocyanins extract Diabetic retinopathy Oxidative stress Retinal neovascularization miR-33 CLCCI1

药材粒度对冷浸法提取水冬瓜伤科止痛酊中黄芩苷和总固体物收率的影响

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贵州科学 2024年第1期42卷 1-4页

作者：杨元凤罗玉玲代欣陈永敏周训蓉贵州中医药大学第二附属医院药学部贵州贵阳550003 贵州中医药大学中药制剂研发中心贵州贵阳550003 贵州中医药大学制剂研究中心贵州贵阳550003

目的:考察不同药材粒度(最粗粉、粗粉、中粉、细粉)对冷浸法提取水冬瓜伤科止痛酊中黄芩苷和总固体物收率的影响。方法:采用高效液相色谱法测定黄芩苷,采用干燥失重法测定总固体物收率。以黄芩苷含量和总固体物收率为指标,优选制备水冬... 详细信息

目的:考察不同药材粒度(最粗粉、粗粉、中粉、细粉)对冷浸法提取水冬瓜伤科止痛酊中黄芩苷和总固体物收率的影响。方法:采用高效液相色谱法测定黄芩苷,采用干燥失重法测定总固体物收率。以黄芩苷含量和总固体物收率为指标,优选制备水冬瓜伤科止痛酊最适宜的药材粒度。结果:最粗粉制得的酊剂中黄芩苷含量和总固体物收率均最高,分别是416.1μg/mL、18.08%。结论:药材粉碎粒度对黄芩苷含量和总固体物收率均有影响。

关键词：水冬瓜伤科止痛酊不同粉碎粒度黄芩苷总固体物收率

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芪锦颗粒提取纯化工艺研究

贵州科学 2024年第4期42卷 38-44页

作者：杨仁惠徐献梅杨元凤罗玉玲张方文陈永敏贵州中医药大学第二附属医院贵州贵阳550003 贵州中医药大学第二附属医院制剂研发中心贵州贵阳550003

目的:优选芪锦颗粒的提取纯化工艺。方法:以出膏率、莫诺苷含量为评价指标,通过单因素试验和L_(9)(3^(4))正交试验,综合评价制定芪锦颗粒提取工艺,参照处方中各有效成分的理化性质,拟定出以乙醇为溶剂进行澄清工艺研究,确定最佳的提取... 详细信息

目的:优选芪锦颗粒的提取纯化工艺。方法:以出膏率、莫诺苷含量为评价指标,通过单因素试验和L_(9)(3^(4))正交试验,综合评价制定芪锦颗粒提取工艺,参照处方中各有效成分的理化性质,拟定出以乙醇为溶剂进行澄清工艺研究,确定最佳的提取纯化工艺条件。结果:最佳提取纯化条件为饮片8倍量的水,煎煮提取3次,每次0.5 h,合并提取液浓缩至相对密度为1.23~1.28的浓缩液,缓慢加入95%的乙醇,边加边搅拌,使其醇浓度达80%为止,静止过夜,过滤,滤液回收乙醇后备用。醇沉后出膏率为19.5%,莫诺苷提取率为93.50%。最大限度地保留了制剂有效成分。结论:该提取方法可行,纯化条件下有效成分保留率高、除杂效果好,适用于芪锦颗粒提取纯化工艺研究。

关键词：芪锦颗粒工艺研究正交试验

Study on Quality Standard of Lujing Yiqi Shengxue Pills

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Agricultural Biotechnology 2022年第3期11卷 93-98,153页

作者： Lida CHEN Xianmei XU Yuchuan LI Yuanfeng YANG yuling luo The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine Guizhou 550025China

[Objectives]This study was conducted to establish the quality standard for Lujing Yiqi Shengxue Pills to provide a basis for its quality control.[Methods]According to the quality requirements in the 2020 edition of Chinese Pharmacopoeia,the quality of Lujing Yiqi Shengxue Pills was evaluated from the aspects of properties,identification,inspection and content *** Astragali,Radix Angelicae Sinensis,Macrocephalae Rhizoma stir-fried with bran and Radix Paeoniae Alba in the preparation were identified and studied by thin layer chromatography(TLC).A high performance liquid chromatography(HPLC)method was established to determine the content of paeoniflorin in the preparation.[Results]The thin layer spots of Radix Astragali,Radix Angelicae Sinensis,Macrocephalae Rhizoma and Radix Paeoniae Alba were clear and round,and the negative preparations had no *** properties,moisture,weight difference,loading difference,dissolution time limit and microbial limit all met the *** regression formula for the quantitative analysis of paeoniflorin in the concentration range of 4.86-194.40μg/ml was:Y=12.0241X+0.8797,R^(2)=0.9999;and the average recovery was 98.9%,and the RSD was 1.7%.[Conclusions]The method has good repeatability,and is stable,feasible,simple and convenient in operation and suitable for quality control of Lujing Yiqi Shengxue Pills.

关键词： Lujing Yiqi Shengxue pills Quality evaluation Thin layer chromatography Paeoniflorin Content determination