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具有范数结构多目标优化问题的近似方法及应用

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重庆师范大学学报（自然科学版） 2023年第2期40卷 28-33页

作者：谭豫琳杨春蓉赵克全重庆师范大学数学科学学院重庆401331

[目的]研究了一类特殊的具有范数结构的多目标优化问题,并应用于解决实际问题。[方法]针对这类多目标优化问题的求解,基于标量化思想,在适当假设条件下提出了一种近似方法。[结果]可以通过调整几类参数的取值范围获得多目标优化问题的Pa... 详细信息

[目的]研究了一类特殊的具有范数结构的多目标优化问题,并应用于解决实际问题。[方法]针对这类多目标优化问题的求解,基于标量化思想,在适当假设条件下提出了一种近似方法。[结果]可以通过调整几类参数的取值范围获得多目标优化问题的Pareto解。[结论]利用具有范数结构的多目标优化模型和本文提出的近似求解方法于绩效管理中基础工作量的设置和电厂发电机的分配问题。

关键词：多目标优化问题范数结构标量化思想近似方法

Multi-omics revealed the mechanism of feed efficiency in sheep by the combined action of the host and rumen microbiota

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Animal Nutrition 2024年第3期18卷 367-379页

作者： Guangchen Zhou Junda Li Xuhui Liang Bohua Yang Ximeng He Hongyu tang Hongran Guo Gongwei Liu Wenyuan Cui yulin Chen Yuxin Yang Key Laboratory of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China

This study was conducted to investigate potential regulatory mechanisms of feed efficiency(FE)in sheep by linking rumen microbiota with its host by the multi-omics *** hundred and ninety-eight hybrid female sheep(initial body weight=30.88±4.57 kg;4-month-old)were selected as candidate *** test sheep was fed in an individual pen for 60 days,and the residual feed intake(RFI)was *** ten candidate sheep with the highest RFI were divided into the Low-FE group,and the ten with the lowest RFI were divided into the High-FE group,all selected for sample *** RFI,average daily gain and average daily feed intake were highly significantly different between the two experimental groups(P<0.05).Compared with Low-FE group,the insulin-like growth factor-1 and very low-density lipoprotein in serum and the propionate in rumen significantly increased in High-FE group(P<0.01),but the acetate:propionate ratio in rumen significantly decreased in High-FE group(P¼0.034).Metagenomics revealed Selenomonas ruminantium,Selenomonas *** Faecalibacterium prausnitzii were key bacteria,and increased abundance of the genes encoding the enzymes for cellulose degradation and production of propionate in High-FE *** results of proteomics and section showed the rumen papilla length and expression of carbonic anhydrase and Na^(+)/K^(+)-ATPase were significantly higher in High-FE group(P<0.05).On the other hand,the acetyl-CoA content significantly increased in the liver of High-FE group(P¼0.002).The relative expression levels of insulin-like growth factor-1 and apolipoprotein A4 genes were significantly up-regulated in the liver of High-FE group(P<0.05),but relative expression level of monoacylglycerol O-acyltransferase 3 gene was significantly down-regulated(P¼0.037).These findings provide the mechanism by which the collaborative interaction between rumen microbiota fermentation and host uptake and metabolism of fermentation products impacts feed efficiency tr

关键词： Residual feed intake Sheep Microbial composition Rumen proteome Liver transcriptome Metabolite

泛癌Siglec-9表达的预后意义及其与肿瘤微环境关系的可视化分析

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武汉大学学报（医学版） 2022年第6期43卷 940-946页

作者：王汉宇谭玉林邱美琪廖斐武汉大学人民医院消化内科湖北武汉430060

目的:探讨Siglec⁃9在泛癌中的表达、预后价值、免疫功能及肿瘤进展中扮演的角色。方法:本研究从多个数据库收集转录组、预后及免疫相关信息,可视化分析Siglec⁃9与预后、肿瘤突变负荷(TMB)、微卫星不稳定性(MSI)及肿瘤微环境(TME)的相关... 详细信息

目的:探讨Siglec⁃9在泛癌中的表达、预后价值、免疫功能及肿瘤进展中扮演的角色。方法:本研究从多个数据库收集转录组、预后及免疫相关信息,可视化分析Siglec⁃9与预后、肿瘤突变负荷(TMB)、微卫星不稳定性(MSI)及肿瘤微环境(TME)的相关性,并进行免疫基因共表达和基因富集分析。结果:Siglec⁃9在大多数肿瘤和癌旁正常组织间有显著的差异表达,并与多种癌症的预后相关。此外,Siglec⁃9还与多种肿瘤的TMB、MSI、TME评分及肿瘤浸润免疫细胞(TIIC)显著相关。基因共表达分析表明Siglec⁃9与多种常见的免疫基因相关,进一步的基因富集分析揭示了Siglec⁃9参与多种免疫相关通路。结论:Siglec⁃9可影响多种癌症的TMB、MSI、TME和TIIC,可作为潜在的癌症预后指标。

关键词： Siglec⁃9 泛癌预后肿瘤微环境免疫浸润可视化分析

Widely targeted metabolomics analysis of the effects of probiotic fermentation on the phytochemicals of kiwifruit juice and prediction of key metabolic pathways

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Food Science and Human Wellness 2024年

作者： Tian Lan Qinyu Zhao Jiaqi Wang Xiangyu Sun yulin Fang Tingting Ma College of Food Science and Engineering， Northwest A&F University College of Enology， Northwest A&F University

Metabolomics can be used to identify the changes and metabolic pathways of nutrients and flavor substances in foods at specific processing or fermentation stages. This study revealed the accumulation and degradation of phytochemicals during the fermentation of kiwifruit juice (KJ) by lactic acid bacteria (LAB) through widely targeted metabolomics and explored the impact of different fermentation strategies on the nutritional quality and functional characteristics of KJ. LAB utilized the original sugars， acids， amino acids， and nucleotides of the matrix to produce numerous bioactive compounds， including phenols， organic acids， free fatty acids， and vitamins， while achieving bacterial proliferation and reduced anti-nutritional factors such as alkaloids， thus improving the nutritional and functional properties of KJ. Moreover， compared with monoculture fermentation， mixed fermentation promoted the production of more biologically active phenols and alkaloids， among which vanillic acid and luteolin-8-C-arabinoside were the characteristic metabolites of mixed and mono- fermentation. Subsequently， the metabolic pathways of key metabolites were predicted， including the glycolytic Embden–Meyerhof–Parnas pathway， pentose phosphoketolase pathway， organic acid metabolic and arginine deiminase pathways for improving the acid resistance of LAB， and the phenolic-acid–based phenylalanine and tyrosine metabolic pathway.

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LED驱动电源综述

智能计算机与应用 2020年第12期10卷 226-228,F0003页

作者：谭钰霖马奎贵州大学大数据与信息工程学院贵阳550025 半导体功率器件可靠性教育部工程研究中心贵阳550025

在全球关注气候变化和可持续资源利用的推动下,研究人员正致力于通过使用LED来优化照明系统的能源消耗,LED的能效大约是传统光源的3倍。现代固态和有机发光二极管提供了均匀、可控和高功率照明的途径,可用于如显示器、指示器和背光等。... 详细信息

在全球关注气候变化和可持续资源利用的推动下,研究人员正致力于通过使用LED来优化照明系统的能源消耗,LED的能效大约是传统光源的3倍。现代固态和有机发光二极管提供了均匀、可控和高功率照明的途径,可用于如显示器、指示器和背光等。最先进的基于LED的设计,提供便携性、寿命、节能、遥控和自动控制功能,对家庭、办公室和公共照明应用非常有吸引力。LED在照明领域正扮演着越来越重要的角色,而其中LED驱动电源的品质会直接影响着LED产品的性能。本文结合国内外文献,总结LED驱动特性的分类,分析目前LED驱动电源的现状,并对未来LED驱动电源的发展进行展望。

关键词： LED OLED 驱动电源智能照明

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心源性胸腔积液6例临床病理解剖与误诊分析

湘南学院学报（医学版） 2009年第4期11卷 10-13页

作者：谢明谭玉林湘南学院附属医院湘南学院基础医学课部湖南郴州423000

目的探讨胸腔积液死亡的误诊原因,提出预防误诊的对策。方法收集我院病理科胸腔积液死亡6例尸体解剖的临床资料进行回顾性分析。结果胸腔积液死亡6例尸体解剖结果:风湿性心脏病3例,误诊为胃炎2例、慢性胆囊炎1例;慢性肺源性心脏病2例,... 详细信息

目的探讨胸腔积液死亡的误诊原因,提出预防误诊的对策。方法收集我院病理科胸腔积液死亡6例尸体解剖的临床资料进行回顾性分析。结果胸腔积液死亡6例尸体解剖结果:风湿性心脏病3例,误诊为胃炎2例、慢性胆囊炎1例;慢性肺源性心脏病2例,胸部食管下端周围静脉丛血栓机化管腔闭塞伴间质性肺炎1例,均误诊为上呼吸道感染。结论本病临床早期诊断困难,症状隐蔽,需要全面检查确诊。为提高对本病的认识,对可疑患者选用全面检查手段,可降低误诊率和死亡率。

关键词：胸腔积液误诊心源性疾病消化道疾病

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乡村振兴涉农品牌的视觉传达设计研究

西部皮革 2022年第8期44卷 54-56页

作者：谭玉琳于亚伟云南师范大学

在新时代的背景下，立足云南地区乡村振兴战略，分析云南农特产品的自然资源优势，探索涉农品牌视觉传达设计的设计思路和创意表现方法。将符合大众审美元素融入现代视觉传达设计之中，以凸显云南高原特色农产品视觉传达设计语汇，提升... 详细信息

在新时代的背景下，立足云南地区乡村振兴战略，分析云南农特产品的自然资源优势，探索涉农品牌视觉传达设计的设计思路和创意表现方法。将符合大众审美元素融入现代视觉传达设计之中，以凸显云南高原特色农产品视觉传达设计语汇，提升其商业价值。

关键词：乡村振兴涉农产品品牌设计视觉传达设计

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探析新兴媒体在民族民间艺术的传播发展

鞋类工艺与设计 2022年第6期2卷 102-104页

作者：谭玉琳于亚伟云南师范大学云南昆明650500

融媒体多样性的开发和利用将为民间艺术的传播与推广提供全新的科学技术手段和传播方法途径,新媒体带来一系列传播方式的革命,改善了传统民间艺术因为传播手段有限、传播范围有限、本土文化气息浓厚造成的传播壁垒。民间艺术也需要在多... 详细信息

融媒体多样性的开发和利用将为民间艺术的传播与推广提供全新的科学技术手段和传播方法途径,新媒体带来一系列传播方式的革命,改善了传统民间艺术因为传播手段有限、传播范围有限、本土文化气息浓厚造成的传播壁垒。民间艺术也需要在多元文化融合的当代社会背景下重新审视自身的传承与创新问题,艺术与媒体相互结合的趋势,结合大众所接受生活习惯,从发挥新媒体传播优势、重视新媒体传播手段多样、利用新媒体内容分发的传播优势入手,积极推动文化产品在形式、个性化定制、推广等方面的革命,扩大民间艺术自身影响力。

关键词：融媒体民间艺术传播路径现状分析

Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases

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Signal Transduction and Targeted Therapy 2024年第1期9卷 105-149页

作者： Yumin Wang Jing Hu Shuang Wu Joshua S.Fleishman yulin Li Yinshi Xu Wailong Zou Jinhua Wang Yukuan Feng Jichao Chen Hongquan Wang Department of Respiratory and Critical Care Medicine Aerospace Center HospitalPeking University Aerospace School of Clinical MedicineBeijing 100049PR China Department of Pathogen Biology School of Basic Medical SciencesTianjin Medical UniversityTianjin 300060PR China Department of Neurology Zhongnan Hospital of Wuhan UniversityWuhan 430000PR China Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNY 11439USA Department of Outpatient Aerospace Center HospitalPeking University Aerospace School of Clinical MedicineBeijing 100049PR China Beijing Key Laboratory of Drug Target and Screening Research Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050PR China Department of Pancreatic Cancer Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin 300060PR China

Ferroptosis,a unique modality of cell death with mechanistic and morphological differences from other cell death modes,plays a pivotal role in regulating tumorigenesis and offers a new opportunity for modulating anticancer drug *** epigenetic modifications and posttranslational modifications(PTMs)promote anticancer drug resistance,cancer progression,and *** studies indicate that epigenetic modifications can transcriptionally and translationally determine cancer cell vulnerability to ferroptosis and that ferroptosis functions as a driver in nervous system diseases(NSDs),cardiovascular diseases(CVDs),liver diseases,lung diseases,and kidney *** this review,we first summarize the core molecular mechanisms of ***,the roles of epigenetic processes,including histone PTMs,DNA methylation,and noncoding RNA regulation and PTMs,such as phosphorylation,ubiquitination,SUMOylation,acetylation,methylation,and ADP-ribosylation,are concisely *** roles of epigenetic modifications and PTMs in ferroptosis regulation in the genesis of diseases,including cancers,NSD,CVDs,liver diseases,lung diseases,and kidney diseases,as well as the application of epigenetic and PTM modulators in the therapy of these diseases,are then discussed in *** the mechanisms of ferroptosis regulation mediated by epigenetic modifications and PTMs in cancer and other diseases will facilitate the development of promising combination therapeutic regimens containing epigenetic or PTM-targeting agents and ferroptosis inducers that can be used to overcome chemotherapeutic resistance in cancer and could be used to prevent other *** addition,these mechanisms highlight potential therapeutic approaches to overcome chemoresistance in cancer or halt the genesis of other diseases.

关键词： diseases epigenetic overcome