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炼油厂加氢柴油外观雾浊的原因分析

炼油与化工 2017年第2期28卷 14-16页

作者：范跃超花卉聂春梅金煜林方新湘克拉玛依石化有限责任公司炼油化工研究院新疆克拉玛依834000

克拉玛依石化公司生产的加氢柴油出现了外观浑浊"发雾"的问题,针对该问题开展了针对性的试验与分析。结果表明,油品中微量水是影响油品外观的主要原因,当温度低于25℃时,油品中微量水含量低于70 mg/kg时,外观符合要求。

关键词：加氢柴油浑浊微量水粒度微生物

罗哌卡因通过JAK-PI3K-AKT通路抑制宫颈癌细胞增殖的研究

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今日药学 2024年第1期34卷 18-22页

作者：陈月月郭小花刘文兴金宇林陈茜广州医科大学附属妇女儿童医疗中心麻醉科广东省儿童健康与疾病临床医学研究中心广东广州510623

目的探讨罗哌卡因对宫颈癌细胞的影响,为宫颈癌手术麻醉剂的选择提供实验依据。方法以不同浓度罗哌卡因作用于宫颈癌细胞Hela,应用MTT法检测细胞增殖能力,流式细胞术检测细胞凋亡情况,Transwell小室法测定细胞侵袭力变化。建立人宫颈... 详细信息

目的探讨罗哌卡因对宫颈癌细胞的影响,为宫颈癌手术麻醉剂的选择提供实验依据。方法以不同浓度罗哌卡因作用于宫颈癌细胞Hela,应用MTT法检测细胞增殖能力,流式细胞术检测细胞凋亡情况,Transwell小室法测定细胞侵袭力变化。建立人宫颈癌Hela细胞裸鼠异种移植模型,观察罗哌卡因处理对肿瘤细胞生长的影响。Western-blot蛋白印迹法检测STAT3磷酸化水平和JAK、PI3K、AKT蛋白表达水平,抑制剂及罗哌卡因处理后STAT3磷酸化水平。结果罗哌卡因可显著抑制宫颈癌细胞Hela的生长及迁徙能力,促进其凋亡,抑制STAT3磷酸化及JAK-PI3K-AKT通路;动物实验结果显示,罗哌卡因可抑制宫颈癌细胞生长。结论罗哌卡因可通过抑制JAK-PI3K-AKT通路对宫颈癌细胞产生抑制作用。

关键词：罗哌卡因宫颈癌凋亡 AKT信号通路麻醉

原子高激发态的激光增强电离光谱(LEIS)

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吉林大学自然科学学报 1991年第2期 69-71页

作者：晏于模丁大军孙昕任玉林邴贵德金钦汉张在宣吉林大学中国计量学院

研究了可谐染料激光激励火焰中的Rb,K原子从基态跃迁到高激发态下的激光增强电离光谱(LEIS),检测到Rb原子从基态5s^2S_(1/2)跃迁到高激发态np^2P_(1/2,3/2)~0(n=13～20),K原子从基态4s^2S_(1/2)跃迁到高激发态np^2P_(1/2,3/2)~0(n=19～... 详细信息

关键词：原子高激发态电离光谱 LEIS 基态

Patterns of gas hydrate accumulation in mass transport deposits related to canyon activity: Example from Shenhu drilling area in the South China Sea

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Acta Oceanologica Sinica 2019年第5期38卷 118-128页

作者： Chao Fu Shengli Li Xinghe Yu jinqiang Liang Zenggui Kuang yulin He Lina jin School of Energy Resources China University of Geosciences Guangzhou Marine Geological Survey China Geological Survey

Since 2017, a plenty of gas hydrates have been drilled in a new area of Shenhu, and good heterogeneity has been found throughout the spatial distribution of the reservoir. After distinguishing different sedimentary sequence types and matching their formation with slope deposition settings, this study proposes three mass transport deposit(MTD) patterns related to canyon activity that occurred contemporaneously or epigenetically with it: well preserved MTDs, MTDs eroded by canyon migration, and MTDs dislocated by contemporaneous faults. Based on seismic reflection characteristics, this study proposed methods of quantitatively analyzing sedimentary factors,such as measuring the turbidities flow rate in the canyon, and results are interpreted with respect to canyon activity. Combining the above parameters and their relationship with gas hydrate accumulation, fine-grained seals overlapping coarse MTDs reservoirs are found to be indispensable to gas hydrate accumulation, as they prevent the release of free gas. Based on grain size data of hydrate samples from drilling wells, multi-layered gas hydrate reservoirs capped by fine-grained sediments and overlapping mud show favorable hydrate-bearing prospects. The release of gas hydrates, however, is mostly caused by the lack of mud sealing in relation to canyon activity, such as turbidities flow erosion and contemporaneous fault breaking. Canyon migration with respect to MTDs may be the actual cause of erosion of overlapping syn-sedimentary layers, and high bottom flows may contribute to an increase in the release of free gas. It is believed that contemporaneous faults caused by unstable canyon walls may break the muddy over layers and decrease the accumulation pressure of gas hydrate ***, according to the sedimentary characteristics of MTDs and the hydrate accumulation process, three responding accumulation or releasing patterns are proposed, which respond to the different types of MTDs distinguished above: a well-pr

关键词： South China Sea gas hydrate sedimentary characteristics MTDs hydrate responding pattern

NiCo_(2)S_(4)/N microspheres grown on N,S co-doped reduced graphene oxide as an efficient bifunctional electrocatalyst for overall water splitting in alkaline and neutral pH

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Nano Research 2022年第2期15卷 950-958页

作者： Haoquan Li Long Chen Pengfei jin Yafei Li Jianxiang Pang Juan Hou Shanglong Peng Gang Wang yulin Shi Key Laboratory for Green Process of Chemical Engineering of Xinjiang Bingtuan School of Chemistry and Chemical EngineeringShihezi UniversityShihezi 832003China National&Local Joint Engineering Laboratory for Optical Conversion Materials and Technology School of Physical Science and TechnologyLanzhou UniversityLanzhou 730000China

It is of vital importance to design efficient and low-cost bifunctional catalysts for the electrochemical water splitting under alkaline and neutral pH *** this work,we report an efficient and stable NiCo_(2)S_(4)/N,S co-doped reduced graphene oxide(NCS/NS-rGO)electrocatalyst for water splitting,in which NCS microspheres are composed of one-dimentional(1D)nanorods grown homogeneously on the surface of NS-rGOs).The synergetic effect,abundant active sites,and hybridization of NCS/NS-rGO endow their outstanding electrocatalytic performance for hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)in both alkaline and neutral ***,NCS/NS-rGO employed as both anode and cathode in a two-electrode alkaline and neutral system electrolyzers deliver 10 mA/cm^(2) with the low cell voltage of 1.58 V in alkaline and 1.91 V in neutral *** results illustrate the rational design of carbon-supported nickel-cobalt based bifunctional materials for practical water splitting over a wide pH range.

关键词： wide pH range bifunctional electrocatalyst overall water splitting NiCo_(2)S_(4)/N Sco-doped reduced graphene oxide(NCS/NS-rGO)

Semi-crosslinked polyacrylamides as high-resolution and dynamic self-coating sieving matrices for protein capillary electrophoresis

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Chinese Science Bulletin 2008年第19期53卷 2953-2957页

作者： ZHOU jin XU JianDong XIE Yao QU Feng DENG yulin GENG LiNa School of Life Science and Technology Beijing Institute of Technology Beijing 100081 China

This paper describes non-gel capillary sieving electrophoresis employing semi-crosslinked polyacrylamide as a high performance and low viscous replaceable separation matrix for separation of non-denatured protein separation. Arising from the fine sieving and dynamic coating ability of this polymer, a mixture of basic proteins lysozyme, cytochrome C, ribonuclease A, and trypsin was resolved with excellent reproducibility. Mixing different semi-crosslinked polyacrylamides together further improves the separation. The separtion mechanism was analyzed. With network structure developed to an intermediate state between crosslinked gel and linear polymer solutions, these semi-crosslinked polyacrylamide polymers demonstrate a promise as a new class of size sieving separation medium, not only in capillary electrophoresis, but also in microfluidic chip separation schemes.

关键词：毛细管筛子电泳聚丙烯酰胺蛋白质分离

Hierarchical Classification of Factors Associated With Noninvasive Prenatal Testing Failures and Its Impact on Pregnancy Outcomes

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Maternal-Fetal Medicine 2024年第4期6卷 215-224页

作者： Jieqiong Xie Yu Jiang yulin Zhou Dandan jin Xingxiu Lu Yunsheng Ge Department of Prenatal Diagnosis Center Women and Children's HospitalSchool of MedicineXiamen UniversityXiamenFujian 361001China United Diagnostic and Research Center for Clinical Genetics Women and Children's HospitalSchool of Medicine and School of Public HealthXiamen UniversityXiamenFujian 361001China.

Objective To conduct a hierarchical classification analysis of the nonreportable results of noninvasive prenatal testing in an attempt to reduce failure rates and provide pregnant women with accurate information to alleviate their *** In this study,30,039 singleton pregnancies who underwent noninvasive prenatal testing in a single center from May 2019 to April 2022 were collected,and 811 samples with initial noninvasive prenatal testing failure were retrospectively *** was based on the reasons for initial test failure;tracking the noninvasive prenatal testing results and prenatal diagnosis results(if any)of the“z-scores in the gray area”group and analyzing the possible influencing factors of the“low fetal fraction”group in the pre-experimental and experimental period by using one-way analysis of variance,Mann-Whitney U test,andχ2 test;and tracking the pregnancy outcomes of the test failures samples to analyze the risk of perinatal complications and adverse pregnancy outcomes of the different types of test *** None of the samples'initial inconclusive results because of z-scores in the gray area were found to have chromosomal ***,pregnancy complications(P=0.018)and a high likelihood of adverse pregnancy outcomes(P=0.048)may still *** gestational age(P<0.001),body mass index(P<0.001),library concentration(P<0.001),and fetal gender(P<0.001)were considered to be the associated factors for the initial low fetal fraction *** may be associated with pregnancy complications(P<0.001)and a high likelihood of adverse pregnancy outcomes(P=0.034).The body mass index(P=0.015)and time between draws(P=0.001)were associated with the second test’s *** incidence of low fetal fraction samples was more frequent with blood collection tubes of the G type than with the K type(P<0.001).Conclusion Initial inconclusive results because of z-scores in the gray area did not imply an increased risk of aneuploidy,but v

关键词： Noninvasive prenatal testing Initial failure rate Low fetal fraction Positive predictive values Z-score

Puerarin mediated miR-30b-5p targeting fibroblast activation protein against oral submucous fibrosis

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BIOCELL 2024年第4期48卷 591-599页

作者： SAIFEI XIE HUI XIE jinCAI GUO jin TAN yulin YU MINYI ZHANG SHANG WEN Department of Periodontal Mucosa Hunan University of Chinese MedicineChangshaChina Department of Periodontal Mucosa Changsha Stomatology HospitalChangshaChina Department of Pharmacy Changsha Stomatology HospitalChangshaChina Department of Stomatology The First Hospital of Hunan University of Chinese MedicineChangshaChina

Background:Puerarin(Pue)has been reported to be a natural active ingredient with multiple antiﬁbrotic *** work aimed at exploring the function of Pue in oral submucousﬁbrosis(OSF)***:Human oral mucosaﬁbroblasts(hOMF)were induced with transforming growth factor beta1(TGF-β1)and intervened with *** ofﬁbrosis-related markers were analyzed by Western blot and IF *** viability was characterized by the CCK-8 *** of miR-30 family members were quantiﬁed by *** correlation betweenﬁbroblast activation protein(FAP)and miR-30 family expression was evaluated by the Pearson correlation coefﬁ*** prediction and dual-luciferase reporter assay were employed to verify the regulation between FAP and *** speciﬁc mechanism of Pue on OSF was explored through the promotion or inhibition of ***:After induction by TGF-β1,hOMF showed upregulated Collagen I,Collagen III,and FAP expressions,while miR-30 family expression was downregulated with miR-30b-5p being the most signiﬁ*** intervention inhibited the excessive proliferation of TGF-β1-induced hOMF,downregulated FAP,collagen type 3(COL3A1),collagen type 1(COL1A1),matrix metalloproteinase 1(MMP1),and matrix metalloproteinase 3(MMP3)expressions,and restored miR-30 family *** prediction and dual-luciferase reporter assay revealed that miR-30b-5p selectively inhibited FAP ***,miR-30b-5p mimic suppressed the excessive proliferation of TGF-β1-induced hOMF and declinedﬁbrosis *** intervention signiﬁcantly reversed the promotion of TGF-β1-induced OSF by miR-30b-5p ***:Pue mediated miR-30b-5p targeting FAP against OSF,which provided a theoretical basis for the pathogenesis research and Pue application in OSF.

关键词： Puerarin miR-30b-5p FAP Oral submucous fibrosis

Comparison of Ex‑PRESS implantation versus trabeculectomy combined with phacoemulsification in primary open‑angle glaucoma:a retrospective in vivo confocal microscopy study

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Eye and Vision 2024年第2期10卷 1-11页

作者： Yuqiao Zhang Beiting He yulin Zhang jin Zeng Yanlei Chen Yongyi Niu Honghua Yu Yongjie Qin Hongyang Zhang Department of Ophthalmology Guangdong Eye InstituteGuangdong Academy of Medical SciencesGuangdong Provincial People’s HospitalNo.106 Zhongshan Er RoadGuangzhou 510080China Shantou University Medical College ShantouChina The Second School of Clinical Medicine Southern Medical UniversityGuangzhouChina Department of Ophthalmology School of MedicineSouth China University of TechnologyGuangzhouChina

Background:To compare the efficacy of Ex-PRESS implantation versus trabeculectomy combined with ***:A retrospective 12-month study on patients with coincident primary open-angle glaucoma(POAG)and *** patients underwent combined phacoemulsification and Ex-PRESS implant(Phaco-ExPRESS,n=35)or phacotrabeculectomy(Phaco-Trab,n=35).The morphological structures of the filtering bleb were examined by slitlamp,anterior segment optical coherence tomography(AS-OCT)and in vivo confocal microscopy(IVCM).Complete success was defined as postoperative intraocular pressure(IOP)<18 mmHg without the use of anti-glaucoma *** success was defined as postoperative IOP<18 mmHg with or without anti-glaucoma *** data were collected preoperatively and postoperatively at 2 weeks,1 month,3 months,6 months,and 12 ***:No significant difference in the variables such as age,IOP and perimetry was found between the groups of Phaco-ExPRESS and *** the one-year postoperative visit for filtering blebs,Phaco-ExPRESS increased the mean area of epithelial microcysts significantly from 0.10±0.05 to 0.20±0.09μm^(2)perμm^(2),while Phaco-Trab decreased the mean area significantly from 0.08±0.04 to 0.04±0.06μm^(2)perμm^(2).Notably,the hyperreflective dots detected by IVCM decreased by 84.9%in Phaco-ExPRESS but increased by 36.3%in *** hyperreflective dots were further identified as neutrophil-and monocyte-like *** number of these cells were negatively correlated with the microcysts area(r=−0.7,P<0.01)but positively associated with the grade of connective tissue(r=0.5,P<0.01).By creating different microstructural changes in the filtering blebs,Phaco-ExPRESS produced a higher complete success rate(84.9%vs.41.2%,P<0.01)and significant decrease in the number of anti-glaucoma medications(P<0.01)when compared with those in ***,the qualified success showed no significant difference between the two groups(

关键词： POAG Ex-PRESS Phacoemulsification Confocal microscopy