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Physiological Response Mechanism and Drought Resistance Evaluation of Passiflora edulis Sims under Drought Stress

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Phyton-International Journal of Experimental Botany 2024年第6期93卷 1345-1363页

作者： Binyang Zhao Fengchan Wu guojun Cai Peiyu Xi yulin guo Anding Li College of Forestry Guizhou UniversityGuiyang550025China Guizhou Institute of Biology Guizhou Academy of SciencesGuiyang550009China College of Resources and Environment Hunan Agricultural UniversityChangsha410128China

In order to explore the response mechanism of Passiﬂora edulis Sims to drought stress,the changes in morpho-logical and physiological traits of Passiﬂora edulis Sims under different drought conditions were studied.A total of 7 germplasm resources of Passiﬂora edulis Sims were selected and tested under drought stress by the pot culture method under 4 treatment levels:75%–80%(Control,CK)of maximumﬁeld water capacity,55%–60%(Light Drought,LD)of maximumﬁeld water capacity,i.e.,mild drought,40%–45%(Moderate Drought,MD)of max-imumﬁeld water capacity,i.e.,moderate drought and 30%–35%(Severe Drought,SD)of maximumﬁeld water capacity,i.e.,severe drought.On the 40th day of drought treatment,13 indices,including seedling growth mor-phology,physiology,and biochemistry,were measured.The results showed that under drought stress,the height and ground diameter of P.edulis Sims gradually decreased with increasing drought stress,and there were signiﬁ-cant differences in seedling height and ground diameter among the treatments.Drought stress signiﬁcantly inhib-ited the growth of seven P.edulis Sims varieties.The contents of soluble sugar(SS),soluble protein(SP),proline(Pro),and other substances in P.edulis Sims basically increased with increasing drought stress.With the aggrava-tion of drought stress,the malondialdehyde(MDA)content of P.edulis Sims tended to increase to different degrees,the superoxide dismutase(SOD)activity and peroxidase(POD)activity both tended to increase atﬁrst and then decrease,and the change in catalase(CAT)activity mostly showed a gradual increasing trend.The con-tents of endogenous hormones in P.edulis Sims signiﬁcantly differed under different degrees of drought stress.With the aggravation of drought stress,the abscisic acid(ABA)content of P.edulis Sims tended to increase,whereas the contents of gibberellin(GA),indoleacetic acid(IAA),and zeatin nucleoside(ZR)exhibited a down-ward trend.A comprehensive evaluation of the drought resistance of seven P.edulis Sims varieties was conducted based on the principal

关键词： Drought resistance water stress phytohormone morphological trait physiological traits

Puerarin mediated miR-30b-5p targeting fibroblast activation protein against oral submucous fibrosis

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BIOCELL 2024年第4期48卷 591-599页

作者： SAIFEI XIE HUI XIE JINCAI guo JIN TAN yulin YU MINYI ZHANG SHANG WEN Department of Periodontal Mucosa Hunan University of Chinese MedicineChangshaChina Department of Periodontal Mucosa Changsha Stomatology HospitalChangshaChina Department of Pharmacy Changsha Stomatology HospitalChangshaChina Department of Stomatology The First Hospital of Hunan University of Chinese MedicineChangshaChina

Background:Puerarin(Pue)has been reported to be a natural active ingredient with multiple antiﬁbrotic properties.This work aimed at exploring the function of Pue in oral submucousﬁbrosis(OSF)treatment.Methods:Human oral mucosaﬁbroblasts(hOMF)were induced with transforming growth factor beta1(TGF-β1)and intervened with Pue.Expressions ofﬁbrosis-related markers were analyzed by Western blot and IF staining.Cell viability was characterized by the CCK-8 assay.Expressions of miR-30 family members were quantiﬁed by qRT-PCR.The correlation betweenﬁbroblast activation protein(FAP)and miR-30 family expression was evaluated by the Pearson correlation coefﬁcient.Bioinformatics prediction and dual-luciferase reporter assay were employed to verify the regulation between FAP and miR-30b-5p.The speciﬁc mechanism of Pue on OSF was explored through the promotion or inhibition of miR-30b-5p.Results:After induction by TGF-β1,hOMF showed upregulated Collagen I,Collagen III,and FAP expressions,while miR-30 family expression was downregulated with miR-30b-5p being the most signiﬁcant.Pue intervention inhibited the excessive proliferation of TGF-β1-induced hOMF,downregulated FAP,collagen type 3(COL3A1),collagen type 1(COL1A1),matrix metalloproteinase 1(MMP1),and matrix metalloproteinase 3(MMP3)expressions,and restored miR-30 family expression.Bioinformatics prediction and dual-luciferase reporter assay revealed that miR-30b-5p selectively inhibited FAP expression.Mechanistically,miR-30b-5p mimic suppressed the excessive proliferation of TGF-β1-induced hOMF and declinedﬁbrosis levels.Pue intervention signiﬁcantly reversed the promotion of TGF-β1-induced OSF by miR-30b-5p inhibition.Conclusion:Pue mediated miR-30b-5p targeting FAP against OSF,which provided a theoretical basis for the pathogenesis research and Pue application in OSF.

关键词： Puerarin miR-30b-5p FAP Oral submucous fibrosis

Single-cell transcriptomics reveals the ameliorative effect of rosmarinic acid on diabetic nephropathy-induced kidney injury by modulating oxidative stress and inflammation

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1661-1676页

作者： Junhui Chen Qian Zhang Jinan guo Di Gu Jing Liu Piao Luo Yunmeng Bai Jiayun Chen Xinzhou Zhang Sheng Nie Chunbo Chen yulin Feng Jigang Wang National Pharmaceutical Engineering Center for Solid Preparation of Chinese Herbal Medicine Jiangxi University of Chinese MedicineNanchang 330006China Department of Pulmonary and Critical Care Medicine Shenzhen Institute of Respiratory Diseasesand Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalFirst Affiliated Hospital of Southern University of Science and TechnologySecond Clinical Medical College of Jinan UniversityShenzhen 518020China School of Traditional Chinese Medicine and School of Pharmaceutical Sciences Southern Medical UniversityGuangzhou 510515China Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's Hospitalthe First Affiliated HospitalSouthern University of Science and TechnologyShenzhen 518020China Department of Urology the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510230China Department of Nephrology Shenzhen Key Laboratory of Kidney Diseasesand Shenzhen Clinical Research Centre for GeriatricsShenzhen People's Hospitalthe First Affiliated HospitalSouthern University of Science and TechnologyShenzhen 518020China Department of Nephrology Nanfang Hospitalthe First Affiliated Hospital of Southern Medical UniversityGuangzhou 510515China Department of Critical Care Medicine Shenzhen People's Hospital(the Second Clinical Medical CollegeJinan Universitythe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen 518020China State Key Laboratory for Quality Esurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China Department of Oncology the Affiliated Hospital of Southwest Medical UniversityLuzhou 646000China

Diabetic nephropathy(DN)is a severe complication of diabetes,characterized by changes in kidney structure and function.The natural product rosmarinic acid(RA)has demonstrated therapeutic effects,including anti-inflammation and anti-oxidative-stress,in renal damage or dysfunction.In this study,we characterized the heterogeneity of the cellular response in kidneys to DN-induced injury and RA treatment at single cell levels.Our results demonstrated that RA significantly alleviated renal tubular epithelial injury,particularly in the proximal tubular S1 segment and on glomerular epithelial cells known as podocytes,while attenuating the inflammatory response of macrophages,oxidative stress,and cytotox-icity of natural killer cells.These findings provide a comprehensive understanding of the mechanisms by which RA alleviates kidney damage,oxidative stress,and inflammation,offering valuable guidance for the clinical application of RA in the treatment of DN.

关键词： Rosmarinic acid Diabetic nephropathy scRNA sequencing Injury Oxidative stress Infiammation Proteomics

IGFBP-3 promotes cachexia-associated lipid loss by suppressing insulin-like growth factor/insulin signaling

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Chinese Medical Journal 2023年第8期136卷 974-985页

作者： Xiaohui Wang Jia Li Wei Zhang Feng Wang Yunzi Wu yulin guo Dong Wang Xinfeng Yu Ang Li Fei Li Yibin Xie Department of General Surgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Gastrointestinal Surgery Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China Department of Pancreatic and Gastric Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Pharmacology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China

Background:Progressive lipid loss of adipose tissue is a major feature of cancer-associated cachexia.In addition to systemic immune/inflammatory effects in response to tumor progression,tumor-secreted cachectic ligands also play essential roles in tumor-induced lipid loss.However,the mechanisms of tumor-adipose tissue interaction in lipid homeostasis are not fully understood.Methods:The yki-gut tumors were induced in fruit flies.Lipid metabolic assays were performed to investigate the lipolysis level of different types of insulin-like growth factor binding protein-3(IGFBP-3)treated cells.Immunoblotting was used to display phenotypes of tumor cells and adipocytes.Quantitative polymerase chain reaction(qPCR)analysis was carried out to examine the gene expression levels such as Acc1,Acly,and Fasn et al.Results:In this study,it was revealed that tumor-derived IGFBP-3 was an important ligand directly causing lipid loss in matured adipocytes.IGFBP-3,which is highly expressed in cachectic tumor cells,antagonized insulin/IGF-like signaling(IIS)and impaired the balance between lipolysis and lipogenesis in 3T3-L1 adipocytes.Conditioned medium from cachectic tumor cells,such as Capan-1 and C26 cells,contained excessive IGFBP-3 that potently induced lipolysis in adipocytes.Notably,neutralization of IGFBP-3 by neutralizing antibody in the conditioned medium of cachectic tumor cells significantly alleviated the lipolytic effect and restored lipid storage in adipocytes.Furthermore,cachectic tumor cells were resistant to IGFBP-3 inhibition of IIS,ensuring their escape from IGFBP-3-associated growth suppression.Finally,cachectic tumor-derived ImpL2,the IGFBP-3 homolog,also impaired lipid homeostasis of host cells in an established cancer-cachexia model in Drosophila.Most importantly,IGFBP-3 was highly expressed in cancer tissues in pancreatic and colorectal cancer patients,especially higher in the sera of cachectic cancer patients than non-cachexia cancer patients.Conclusion:Our study demonstrates that tumor-derived IGFBP-3 plays

关键词： Biomarker Cancer Cachexia Insulin-like growth factor binding protein-3 Lipid loss

HAN基电控固体推进剂电化学性能对燃烧性能的影响

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固体火箭技术 2024年第3期47卷 341-347页

作者：郭昊琪杨玉林哈尔滨工业大学化工与化学学院哈尔滨150001

硝酸羟胺(HAN)基电控固体推进剂是一种以HAN为主要氧化剂的新型智能推进剂,通过外加电源控制其燃烧速率与启停。为探索电化学性能与燃烧性能间的关系,在研究推进剂的离子迁移率、过电位的变化规律的基础上,将其与推进剂的点火电压、点... 详细信息

硝酸羟胺(HAN)基电控固体推进剂是一种以HAN为主要氧化剂的新型智能推进剂,通过外加电源控制其燃烧速率与启停。为探索电化学性能与燃烧性能间的关系,在研究推进剂的离子迁移率、过电位的变化规律的基础上,将其与推进剂的点火电压、点火延迟进行关联。研究发现,推进剂在外加低电压(1.6~2.8 V)刺激下,离子迁移率与电压大小正相关,推进剂基体的改良在提高离子迁移率方面的效果大于离子掺杂。在燃烧性能方面,离子迁移率影响点火电压,过电位决定点火延迟;离子迁移率越高,点火时,推进剂的电流密度与反应活性越高;当迁移率由0.09 mm^(2)·s^(-1)·V^(-1)升高至0.16 mm^(2)·s^(-1)·V^(-1)时,点火电压由210 V降至70 V,有利于拓宽电控固体推进剂的应用范围;点火电压一定时,推进剂过电位越小,电分解速率越大,点火延迟越小,当过电位由0.67 V降至0.51 V时,点火延迟由1.68 s降至0.31 s,有利于推进剂满足快速响应的战略需求。

关键词：电控固体推进剂硝酸羟胺离子迁移率过电位电控燃烧

GaAsBi半导体材料的制备及应用研究进展

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人工晶体学报 2024年第1期53卷 25-37页

作者：马玉麟郭祥丁召贵州大学大数据与信息工程学院贵阳550025 贵州省微纳电子与软件技术重点实验室贵阳550025 半导体功率器件可靠性教育部工程研究中心贵阳550025

稀铋Ⅲ-Ⅴ半导体材料在电子和光电子领域具有广泛的应用前景,其制备方法主要有分子束外延法(MBE)和金属有机物气相外延法(MOVPE)。本文聚焦于具有较大带隙收缩、温度不敏感以及强自旋轨道分裂等特殊物理特性的GaAs_(x)Bi_(1-x)半导体材... 详细信息

稀铋Ⅲ-Ⅴ半导体材料在电子和光电子领域具有广泛的应用前景,其制备方法主要有分子束外延法(MBE)和金属有机物气相外延法(MOVPE)。本文聚焦于具有较大带隙收缩、温度不敏感以及强自旋轨道分裂等特殊物理特性的GaAs_(x)Bi_(1-x)半导体材料,对其制备方法和研究进展进行了综述。研究人员对GaAsBi材料的研究主要集中在薄膜、多量子阱、纳米线和量子点材料的制备。在薄膜材料方面,侧重于研究制备工艺条件对GaAsBi薄膜的影响,例如低衬底温度、低生长速率和非常规的Ⅴ/Ⅲ束流比;在多量子阱材料方面,采用双衬底温度技术有效减少Bi偏析问题;对于纳米线和量子点材料,金属Bi作为表面活性剂可以改善材料的形貌和光学性能。然而,目前在该材料研究和应用方面仍存在挑战,如薄膜材料的结晶质量恶化和金属Bi分凝团聚,以及量子点材料中Bi的均匀性和形成机制的争议。解决这些问题对于提高GaAs_(x)Bi_(1-x)半导体材料的质量和促进器件发展具有重要意义。

关键词：稀铋Ⅲ-Ⅴ半导体材料 GaAsBi薄膜多量子阱材料量子点材料 MBE MOVPE

Phosphate recovery with granular acid-activated neutralized red mud:Fixed-bed column performance and breakthrough curve modelling

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Journal of Environmental Sciences 2020年第4期32卷 78-86页

作者： Andong Hu guoping Ren Jiangang Che yulin guo Jie Ye Shungui Zhou Fujian Provincial Key Laboratory of Soil Environmental Health and Regulation College of Resources and EnvironmentFujian Agriculture and Forestry UniversityFuzhou350002China

Granular acid-activated neutralized red mud(AaN-RM)has been successfully prepared with good chemical stability and physical strength.However,its potential for industrial application remains unknown.Therefore,the performance of granular AaN-RM for phosphate recovery in a fixed-bed column was investigated.The results demonstrated that the phosphate adsorption performance of granular AaN-RM in a fixed-bed column was affected by various operational parameters,such as the bed depth,flow rate,initial solution pH and initial phosphate concentration.With the optimal empty-bed contact time(EBCT)of 24.27 min,the number of processed bed volumes and the phosphate adsorption capacity reached 496.95 and 84.80 mg/g,respectively.Then,the saturated fixed-bed column could be effectively regenerated with a0.5 mol/L HCl solution.The desorption efficiency remained as high as 83.45%with a low weight loss of 3.57%in the fifth regeneration cycle.In addition,breakthrough curve modelling showed that a 5-9-1 feed-forward artificial neural network(ANN)could be effectively applied for the optimization of the fixed-bed adsorption system;the coefficient of determination(R^2)and the root mean square error(RMSE)evaluated on the validation-testing data were 0.9987 and 0.0183,respectively.Therefore,granular AaN-RM fixed-bed adsorption exhibits promising potential for phosphate removal and recovery from polluted water.

关键词： Red mud Fixed-bed column Bed volume Artificial neural network Regeneration

淬火-回火工艺对高速翻转犁用28MnB5铁基合金的组织及性能影响

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稀有金属 2024年第2期48卷 187-195页

作者：郭顺倪豪豪黄豪常亚南鞠玉琳江苏大学材料科学与工程学院江苏镇江212013 郑州市龙丰农业机械装备制造有限公司河南郑州450041

为了解决现有国产高速翻转犁入土部件因硬度和强度不足而导致的服役寿命偏低的问题,对28MnB5铁基合金采用了淬火-回火(QT)的热处理工艺,并探讨了该工艺对28MnB5铁基合金微观组织与力学性能的影响机制。结果表明,热轧态28MnB5铁基合金的... 详细信息

为了解决现有国产高速翻转犁入土部件因硬度和强度不足而导致的服役寿命偏低的问题,对28MnB5铁基合金采用了淬火-回火(QT)的热处理工艺,并探讨了该工艺对28MnB5铁基合金微观组织与力学性能的影响机制。结果表明,热轧态28MnB5铁基合金的组织主要由铁素体和珠光体交替分布而成的带状组织组成。与热轧态28MnB5铁基合金显著不同,经淬火-回火工艺处理后(QT态)的28MnB5铁基合金的组织主要由尺寸细小且均匀分布的板条马氏体组成,其单个板条马氏体的面积主要集中在0~5μm^(2)范围内。力学性能测试结果表明,经过淬火-回火处理后的QT态28MnB5铁基合金的硬度和强度具有显著提升,具体表现为屈服强度从561 MPa提高至1451 MPa,抗拉强度从744 MPa提高至1843 MPa,洛氏硬度从HRC 18.8提高至HRC 51.3。这主要归因于28MnB5铁基合金中的B元素在淬火过程中显著提高了铁基合金的淬透性,获得了近乎全马氏体的QT态28MnB5铁基合金。研究成果可望为具备高硬度高强度性能的农机入土部件制造提供可行的技术方案。

关键词： 28MnB5铁基合金马氏体小角度晶界高强度高速翻转犁

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蓝莓酒香气成分及其影响因素研究进展

食品科学 2024年第6期45卷 337-343页

作者：郭志君杨红丽闵卓房玉林茅台学院贵州仁怀564500 西北农林科技大学葡萄酒学院陕西杨凌712100 陕西省葡萄与葡萄酒工程技术研究中心陕西杨凌712100

蓝莓酒因营养成分丰富、风味独特,深受消费者欢迎且市场潜力大。香气是衡量蓝莓酒感官品质的重要指标之一,但目前蓝莓酒存在香气成分研究不充分、香气特征不明确、香气调控手段有限等问题,制约着我国蓝莓酒产品的品质提升。本文对蓝莓... 详细信息

蓝莓酒因营养成分丰富、风味独特,深受消费者欢迎且市场潜力大。香气是衡量蓝莓酒感官品质的重要指标之一,但目前蓝莓酒存在香气成分研究不充分、香气特征不明确、香气调控手段有限等问题,制约着我国蓝莓酒产品的品质提升。本文对蓝莓酒香气物质组成进行阐述,分析各类香气物质的占比及来源;并从香气活度值评价角度分析蓝莓酒的关键呈香物质和特征香气;最后深入讨论品种、酵母菌及工艺条件对蓝莓酒香气的影响,旨在为蓝莓酒香气品质研究、加工技术提升提供一定参考。

关键词：蓝莓酒挥发性成分影响因素