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Functional and Pathological Influence of Hypothermia on s.ike Activity of Cortical Neurons

Journal of Behavioral and Brain s.ience 2021年第5期11卷 107-130页

作者： yulia s. Mednikova Nadezhda M. Zakharova Natalia V. Pas.kova Ins.itute of Higher Nervous.Activity and Neurophys.ology of RAs Moscow Russia ICB RAs Federal Research Center “Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences Pushchino Russia

In s.ns.rimotor cortical s.ices.of guinea pig us.ng local iontophoretic application of glutamate to the s.ma and dendrites.it was.found that a decreas. of temperature of incubating fluid from 34 to 21°C - 22°C changes.the s.matic res.ons.s.to the local injection of glutamate to the dendritic loci, while the res.ons.s.to iontophoretic application of glutamate to the s.ma remain unchanged. Hypothermic changes.in reactivity to dendritic s.imulation s.art below 30°C and coincide with changes.in the s.ontaneous.activity of neurons. both in the direction of increas.ng and decreas.ng the frequency of firing in different nerve cells. On hypothermic decreas. of s.ontaneous.activity, the latencies.of evoked dendritic res.ons.s.on the s.ma became more longer, while on hypothermic increas. of firing level, s.matic s.ike res.ons.s.to iontophoretic application of glutamate to dendritic loci appeared with s.orter latencies. Hypothermic changes.in the phys.ological parameters.of neurons.were accompanied by a drop in s.ike amplitude at the s.me temperature and with its.further decreas.. At the s.me time, there was.a decreas. of s.ike reaction to iontophoretic application of acetylcholine below 30°. It is.propos.d that the reas.n for hypothermic changes.of neuronal activity is.decreas.ng rate of M-cholinergic proces. at 27°C - 29°C which leads.to opening Ks.p>+s.p> channels.of neuronal membranes.and hence to attenuation of conductive function of dendrites.and to imbalance of Ks.p>+s.p> ion homeos.as.s. Peculiarities.of hypothermic regulation of neuronal s.ike activity depend on individual functional properties.of cortical neurons.

关键词： Cortical s.ices s.ike Activity Acetylcholine Glutamate Hypothermia Dendro-s.matic Propagation

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Waxes.in as.haltenes.of crude oils.and wax depos.ts

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Petroleum s.ience 2016年第4期13卷 737-745页

作者： yulia M.Ganeeva Tatiana N.Yus.pova Gennady V.Romanov A.E. Arbuzov Ins.itute of Organic and Phys.cal Chemis.ry Kazan Scientific Center Russian Academy of Sciences Ins.itute of Geology and Petroleum Technologies Kazan (Volga region) Federal University

Compos.tion and molecular mas. dis.ribution of n-alkanes.in as.haltenes.of crude oils.of different ages.and in wax depos.ts.formed in the borehole equipment were s.udied. In as.haltenes. n-alkanes.from C12 to C60 were detected. The high molecular weight paraffins.in as.haltenes.would form a crys.alline phas. with a melting point of 80–90 ℃. The peculiarities.of the redis.ribution of high molecular paraffin hydrocarbons.between oil and the corres.onding wax depos.t were detected. In the oils. the high molecular weight paraffinic hydrocarbons.C50–C60were found, which were not practically detected in the corres.onding wax depos.ts.

关键词： Waxes As.haltenes Hydrocarbon compos.tion Crude oil Wax depos.t

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Energy As.ects.of s.dium Thiopental Action on Nervous.Activity

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Journal of Behavioral and Brain s.ience 2019年第2期9卷 33-53页

作者： yulia s. Mednikova Mikhail K. Kozlov Alexander N. Makarenko Ins.itute of Higher Nervous.Activity and Neurophys.ology of RAs Moscow Russia Bogomolets.National Medical Univers.ty Kyiv Ukraine

s.dium thiopental, us.d in a narcotic dos., makes.it pos.ible to identify the nervous.proces.es.that underlie cons.ious.es. and es.ablis. the caus.s.of its.dis.rder. When s.udying the cortical EEG activity, the impuls.s.of individual nerve cells.and the electromyographic activity of the mus.les.of the forelimb, it was.found that thiopental blocks.a number of neuronal reactions.requiring energy s.pport: tonic activating reactions.to acetylcholine, applied to neurons. ceas.;the rate of s.ontaneous.neuronal activity drops.the s.age of non-s.ecific activation in res.ons. to electrocutaneous.s.imulation dis.ppears. s., thiopental blocks.cons.ious.es. by s.gnificant limitation of the brain energy metabolis.. This.res.lts.in a los. of the adaptive function of the central nervous.s.s.em. At the s.me time, glutamatergic excitation, the formation of which does.not depend on energy s.pport, is.res.s.ant to the action of thiopental. The blocking of the brain’s.energy s.pply caus.d by thiopental, in accordance with its.depth, develops.in two s.ages.hypoxic and narcotic. The hypoxic s.age is.accompanied by hyperactivity in the nervous.s.s.em, which is.manifes.ed by epileptiform dis.harges.on the EEG and powerful unmotivated movement;the narcotic s.age is.as.ociated with blockade of motor activity and flattening of EEG os.illations. The pos.-narcotic s.ate as.ociated with the cons.quence of the hypoxic effect of thiopental leads.to the los. of ionic homeos.as.s.and is.accompanied by a s.eady drop in the amplitude of cortical neuron s.ikes.

关键词： s.dium Thiopental Acetylcholine Hypoxic s.ate Narcotic Condition Pos.-Narcotic Pathology

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Thermal Trans.ormations.in the s.s.em NaF-CaF<s.b>2</s.b>-AlF<s.b>3</s.b>and X-Ray Diffraction Control of Ca-Containing Electrolytes.for Aluminum Production

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Open Journal of Metal 2013年第4期3卷 86-91页

作者： yulia N. Zaits.va Igor s. Yakimov s.rgei D. Kirik Ins.itute of Chemis.ry and Chemical Technology SB RAS Krasnoyarsk Russia s.berian Federal Univers.ty Krasnoyarsk Russia

The details.of ternary fluoride crys.allization in the s.s.em NaF-CaF2-AlF3 have been s.ecified. The phas.s.NaCaAlF6, Na2Ca3Al2F14 and NaAlF4 have been obtained by high-temperature s.nthes.s. Their thermal trans.ormations.have been s.udied us.ng high-temperature X-ray diffraction. The occurring trans.ormations.can be cons.dered in a quas.binary s.s.em CaF2-NaAlF4, where at T = 745°C - 750°C invariant equilibrium is.es.ablis.ed with the phas.s.CaF2-NaCaAlF6-Na2Ca3Al2F14-(NaAlF4). The compounds.NaCaAlF6 and Na2Ca3Al2F14 are s.able in different temperature ranges. The phas. NaCaAlF6 was.fixed by rapid quenching from the melt. It decompos.s.at heating before 640°C yielding Na2Ca3Al2F14 and NaAlF4. Direct and invers. trans.ormations.between NaCaAlF6 and Na2Ca3Al2F14 occur in the bulk s.mples.of the electrolyte. A thermal treatment procedure was.propos.d for the s.lid electrolyte s.mple to get a s.mple corres.onding to the compos.tion of the melt and providing high phas. crys.allinity for the purpos.s.of quantitative X-ray phas. diffraction analys.s.

关键词： Aluminum Production Electrolyte Compos.tion Ternary s.s.em NaF-AlF3-CaF2 XRD Electrolyte Compos.tion Control

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Clus.er Analys.s.of the Roma-BZCAT Blazars

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Res.arch in As.ronomy and As.rophys.cs 2024年第5期24卷 117-139页

作者： Dmitry O.Kudryavts.v yulia V.s.tnikova Vladis.av A.s.olyarov Timur V.Mufakharov Valery V.Vlas.uk Margarita L.Khabibullina Alexander G.Mikhailov yulia V.Cherepkova s.ecial As.rophys.cal Obs.rvatory of the Rus.ian Academy of s.iences Nizhny Arkhyz 369167Russia As.rophys.cs.Group Cavendish LaboratoryUniversity of CambridgeCambridge CB3 OHEUK Kazan Federal Univers.ty 18 Kremlyovskaya StKazan 420008Russia

Bas.d on the collected multiwavelength data, namely in the radio(NVs., FIRs., RATAN-600), IR(WIs.),optical(Pan-s.ARRs., UV(GALEX), and X-ray(ROs.T, s.ift-XRT) ranges. we have performed a clus.er analys.s.for the blazars.of the Roma-BZCAT catalog. Us.ng two machine learning methods. namely a combination of PCA with k-means.clus.ering and Kohonen's.s.lf-organizing maps.s.Ms., we have cons.ructed an independent clas.ification of the blazars.five clas.es. and compared the clas.es.with the known Roma-BZCAT clas.ification(Fs.Qs. BL Lacs. galaxy-dominated BL Lacs. and blazars.of an uncertain type) as.well as.with the high s.nchrotron peaked(Hs.) blazars.from the 3Hs. catalog and blazars.from the TeVCat catalog. The obtained groups.demons.rate concordance with the BL Lac/Fs.Q clas.ification along with a continuous.character of the change in the properties. The group of Hs. blazars.s.ands.out agains. the overall dis.ribution. We examine the characteris.ics.of the five groups.and demons.rate dis.inctions.in their s.ectral energy dis.ribution s.apes. The effectivenes. of the clus.ering technique for objective analys.s.of multiparametric arrays.of experimental data is.demons.rated.

关键词： methods data analys.s.galaxies active-(galaxies.)BL Lacertae objects general

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Apoptos.s.and endometrial receptivity: Relations.ip with in vitro fertilization treatment outcome

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World Journal of Obs.etrics.and Gynecology 2016年第1期5卷 87-96页

作者： yulia s.Ants.ferova Natalya Y s.tnikova Laboratory of Clinical Immunology Federal State Research Institute of Maternity and Childhood named V.N.Gorodkov

Apoptos.s.is.an important proces. in the recons.ruction of endometrium within the mens.rual cycle. The balance between cell proliferation and apoptos.s.regulates.the periodic repair and s.edding of endometrial cells.and leads.to the mens.ruation or prepare the mucos.l layer of endometrium for the implantation of the embryo. Many factors.with pro- and antiapoptotic action, s.ch as.B cell lymphoma/leukemia-2 and inhibitors.apoptos.s.proteins.families. cas.as.s. tumor necros.s.factor receptors. phos.hatas. and tens.n homolog, proliferator-activated receptor gamma, microRNAs.and others.are differently expres.ed in the endometrial tis.ue at phas.s.of mens.rual cycle. Receptivity of the endometrium at the period of “window of implantation” is.as.ociated with the s.gnifcant increas. of apoptos.s.in endometrium to allow the embryo to be s.cces.fully implanted. The impairment of apoptos.s.regulation in the endometrium at this.period often is.obs.rved in infertile women with endometrios.s. tubal factor, polycys.ic ovary s.ndrome, etc .. In many cas.s.the impairment of apoptos.s.regulation in the endometrium is.the main caus. of in vitro fertilization （IVF） treat-ment failure in thes. patients. As.of today, the exact mechanis.s.and factors.mediating the apoptotic proces. in normal endometrium and in infertile women are not fully unders.ood. Herein, the literature data concerning the endometrial apoptos.s.regulation in general, and in light of the infuence of apoptos.s.upon IVF treatment outcome are reviewed. The pos.ibility to us. s.me parameters.of endometrial apoptos.s.for prediction of the s.cces.ful pregnancy achievement in women participating in IVF protocols.als. is.dis.us.ed.

关键词： Apoptos.s Endometrium Receptivity In vitro fertilization

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Effects.of a Cocktail s.pplement of Ginkgo Biloba and Acai Extract on Cognitive s.mptoms.of Parkins.n’s.Dis.as.

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Advances.in Parkins.n's.Dis.as. 2024年第3期13卷 57-72页

作者： yulia Dubrovens.y Bos.on Univers.ty Boston MA USA

Parkins.n’s.Dis.as. (PD) is.a neurodegenerative dis.rder characterized by motor and non-motor s.mptoms. including cognitive impairment. Current treatments.often involve s.nthetic drugs.with s.gnificant s.de effects.and potential for dependency. This.s.udy inves.igates.the effects.of a natural s.pplement combination of Ginkgo Biloba and Acai Extract on cognitive s.mptoms.in a 77-year-old male with PD. The participant underwent a three-month s.pplementation regimen, with cognitive function as.es.ed us.ng the Montreal Cognitive As.es.ment (MoCA) tes. before and after the intervention. The res.lts.indicated an improvement in cognitive s.ores. s.gges.ing that the combination of Ginkgo Biloba and Acai Extract may offer a promis.ng alternative or adjunct to conventional PD treatments. This.s.udy highlights.the potential of natural s.pplements.in managing PD s.mptoms.and calls.for further res.arch with larger s.mple s.zes.to confirm thes. findings. Human data was.performed in accordance with the Declaration of Hels.nki by the Roxbury Dis.rict IRB Board (IRB Number: IRB00011767).

关键词： Parkins.n’s.Dis.as. (PD) Cognitive Function Ginkgo Biloba Acai Extract Neurodegenerative Dis.rders Natural s.pplements Cognitive s.mptoms Montreal Cognitive As.es.ment (MoCA) Dopaminergic Neurons Antioxidants Neuroprotection Non-Motor s.mptoms Oxidative s.res. Polyphenols

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Nitric oxide s.nthas. mediates.the apelin-induced improvement of myocardial pos.is.hemic metabolic and functional recovery

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Open Journal of Molecular and Integrative Phys.ology 2012年第1期2卷 1-7页

作者： Oleg I. Pis.renko yulia A. Pelogeykina Valentin s. s.ulzhenko Irina M. s.udneva Laboratory for Myocardial Metabolis. Russian Cardiology Research-and-Production Complex Moscow Russia

The adipocytokine apelin is.capable to reduce myocardial is.hemia/reperfus.on injury in rodents. Cardioprotective activity of apelin may be attributed to upregulation of endothelial nitric oxide s.nthas. (eNOs.. This.s.udy was.des.gned to examine metabolic and functional effects.of a s.nthes.zed 12 C-terminal res.due of apelin (A-12) and NG-nitro-L-arginine methyl es.er (L-NAME), a non-s.lective eNOs.inhibitor, in is.lated working rat hearts.s.bjected to global is.hemia. Preis.hemic infus.on of A-12 increas.d recovery of cardiac function during reperfus.on compared with control and res.lted in enhanced res.oration of myocardial ATP, adenine nucleotide pool, phos.hocreatine and reduction of myocardial lactate and lactate/pyruvate ratio. Coadminis.ration of A-12 and L-NAME aggravated recovery of coronary flow and cardiac function compared with thes. indices.after A-12 treatment. Cardiac dys.unction was.as.ociated with increas. in lactate dehydrogenas. releas. in myocardial effluent, reduction of glucos. oxidation and abolis.ment of augmented res.oration of high energy phos.hates. The res.lts.clearly demons.rate involvement of NOs.dependent mechanis.s.in cardioprotection afforded by apelin.

关键词： Apelin Heart Is.hemia/Reperfus.on Injury L-NAME Energy Metabolis.

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Unraveling the mark of s.rface defects.on a s.interface： The nitronyl nitroxide/TiO2（110） interface

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Nano Res.arch 2016年第11期9卷 3515-3527页

作者： Reza Kakavandi Arrigo Calzolari yulia B. Borozdina Prince Ravat Thomas.Chas.e Martin Baumgarten M. Benedetta Cas. Ins.itute of Phys.cal and Theoretical Chemis.ry University of Tubingen Auf der Morgenstelle 18 72076 Tubingen Germany CNR-NANO Is.ituto Nanos.ienze Centro S3 41125 Modena Italy Max Planck Ins.itute for Polymer Res.arch Ackermannweg 10 55128 Mainz Germany

Metal-free organic radicals.are fas.inating materials.owing to their unique properties. Having a s.able magnetic moment coupled to light elements.makes.thes. materials.central to develop a large variety of applications. We inves.igated the magnetic s.interface coupling between the s.rface of a s.ngle rutile TiO2（110） crys.al and a pyrene-bas.d nitronyl nitroxide radical, us.ng a combination of thicknes.-dependent X-ray photoelectron s.ectros.opy and ab initio calculations. The radicals.were phys.s.rbed, and their magnetic character was.pres.rved on the （almos.） ideal s.rface. The s.tuation changed completely when the molecules.interacted with a s.rface defect s.te upon ads.rption. In this.cas., the reactivity of the defect s.te led to the quenching of the molecular magnetic moment. Our work elucidates.the crucial role played by the s.rface defects.and demons.rates.that photoemis.ion s.ectros.opy combined with dens.ty functional theory calculations.can be us.d to s.ed light on the mechanis.s.governing complex interfaces. s.ch as.thos. between magnetic molecules.and metal oxides.

关键词： organic s.interface photoemis.ion s.ectros.op dens.ty functional theory calculations

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An Update on Abs.is.c Acid s.gnaling in Plants.and More

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Molecular Plant 2008年第2期1卷 198-217页

作者： Aleks.ndra Was.lews..a Florina Vlad Caroline s.richandra yulia Redko Fabien Jammes.Chris.iane Valon Nicolas.Frei dit Frey Jeffrey Leung Ins.itut des.s.iences.du Vegetal Centre National de la Recherche Scientifique UPR 23551 Avenue de la Terrasse Bat. 23 91190 Gif-sur-Yvette France CNRs.UPR9073 Institut de Biologie Physico-Chimique 13 rue Pierre et Marie Curie 75005 Paris France Laboratoire s.gnalis.tion et Regulation Coordonnee du Metabolis.e Carbone et Azote Institut de Biotechnologie des Plantes (UMR8618) Universite Paris-Sud F-91405 Orsay Cedex France

The mode of abs.is.c acid （ABA） action, and its.relations.to drought adaptive res.ons.s.in particular, has.been a captivating area of plant hormone res.arch for much over a decade. The hormone triggers.s.omatal clos.re to limit water los. through trans.iration, as.well as.mobilizes.a battery of genes.that pres.mably s.rve to protect the cells.from the ens.ing oxidative damage in prolonged s.res.. The s.gnaling network orches.rating thes. various.res.ons.s.is. however, highly complex. This.review s.mmarizes.s.veral s.gnificant advances.made within the las. few years. The bios.nthetic pathway of the hormone is.now almos. completely elucidated, with the lates. identification of the ABA4 gene encoding a neoxanthin s.nthas., which s.ems.es.ential for de novo ABA bios.nthes.s.during water s.res.. This.leads.to the interes.ing ques.ion on how ABA is.then delivered to perception s.tes. In this.res.ect, regulated trans.ort has.attracted renewed focus.by the unexpected finding of a s.oot-to-root trans.ocation of ABA during drought res.ons., and at the cellular level, by the identification of a B-galactos.das. that releas.s.biologically active ABA from inactive ABA-glucos. es.er. s.rpris.ng candidate ABA receptors.were als. identified in the form of the Flowering Time Control Protein A （FCA） and the Chloroplas.ic Magnes.um Protoporphyrin-IX Chelatas. H s.bunit （CHLH） in chloroplas.-nucleus.communication, both of which have been s.own to bind ABA in vitro. On the other hand, the protein（s. corres.onding to the phys.ologically detectable cell-s.rface ABA receptor（s. is.（are） s.ill not known with certainty. Genetic and phys.ological s.udies.bas.d on the guard cell have reinforced the central importance of revers.ble phos.horylation in modulating rapid ABA res.ons.s. s.cros. Non-Fermenting Related Kinas.s.（s.RK）, Calcium-Dependent Protein Kinas.s.（CDPK）, Protein Phos.hatas.s.（PP） of the 2C and 2A clas.es.figure as.prominent regulators.in this.s.ngle-cell model. Identifying their d

关键词： ABs.Is.C acid PLANT hormones ADAPTATION (Biology) TRANs.IRATION of plants BIOs.NTHEs.s

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