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Semantic Segmentation of Lumbar vertebrae Using Meijering U-Net(MU-Net)on Spine Magnetic Resonance Images

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 733-757页

作者： Lakshmi S v v Shiloah Elizabeth Darmanayagam Sunil Retmin Raj Cyril Department of Computer Science and Engineering College of Engineering GuindyAnna UniversityChennai600025India Department of Information Technology Madras Institute of TechnologyAnna UniversityChrompetChennai600044India

Lower back pain is one of the most common medical problems in the world and it is experienced by a huge percentage of people *** to its ability to produce a detailed view of the soft tissues,including the spinal cord,nerves,intervertebral discs,and vertebrae,Magnetic Resonance Imaging is thought to be the most effective method for imaging the *** semantic segmentation of vertebrae plays a major role in the diagnostic process of lumbar *** is difficult to semantically partition the vertebrae in Magnetic Resonance Images from the surrounding variety of tissues,including muscles,ligaments,and intervertebral discs.U-Net is a powerful deep-learning architecture to handle the challenges of medical image analysis tasks and achieves high segmentation *** work proposes a modified U-Net architecture namely MU-Net,consisting of the Meijering convolutional layer that incorporates the Meijering filter to perform the semantic segmentation of lumbar vertebrae L1 to L5 and sacral vertebra ***-colour mask images were generated and used as ground truth for training the *** work has been carried out on 1312 images expanded from T1-weighted mid-sagittal MRI images of 515 patients in the Lumbar Spine MRI Dataset publicly available from Mendeley *** proposed MU-Net model for the semantic segmentation of the lumbar vertebrae gives better performance with 98.79%of pixel accuracy(PA),98.66%of dice similarity coefficient(DSC),97.36%of Jaccard coefficient,and 92.55%mean Intersection over Union(mean IoU)metrics using the mentioned dataset.

关键词： Computer aided diagnosis(CAD) magnetic resonance imaging(MRI) semantic segmentation lumbar vertebrae deep learning U-Net model

Satellite Measurements of the Madden–Julian Oscillation in Wintertime Stratospheric Ozone over the Tibetan Plateau and East Asia

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Advances in Atmospheric Sciences 2015年第11期32卷 1481-1492页

作者： ZHANg yuli.LIU Yi LIU Chuanxi v.F.SOFIEvA Key Laboratory of Middle Atmosphere and global Environment Observation Institute of Atmospheric PhysicsChinese Academy of Sciences University of Chinese Academy of Sciences Joint Center for global Change Studies Finnish Meteorological Institute

We investigate the Madden-Julian Oscillation （MJO） signal in wintertime stratospheric ozone over the Tibetan Plateau and East Asia using the harmonized dataset of satellite ozone profiles. Two different MJO indices -- the all-season Real-Time multivariate MJO index （RMM） and outgoing longwave radiation-based MJO index （OMI） -- are used to compare the MJO- related ozone anomalies. The results show that there are pronounced eastward-propagating MJO-related stratospheric ozone anomalies （mainly within 20-200 hPa） over the subtropics, The negative stratospheric ozone anomalies are over the Tibetan Plateau and East Asia in MJO phases 4-7, when MJO-related tropical deep convective anomalies move from the equatorial Indian Ocean towards the western Pacific Ocean. Compared with the results based on RMM, the MJO-related stratospheric column ozone anomalies based on OM1 are stronger and one phase ahead. Further analysis suggests that different sampling errors, observation principles and retrieval algorithms may be responsible for the discrepancies among different satellite measurements. The MJO-related stratospheric ozone anomalies can be attributed to the MJO-related circulation anomalies, i.e., the uplifted tropopanse and the northward shifted westerly jet in the upper troposphere. Compared to the result based on RMM, the upper tropospheric westerly jet may play a less important role in generating the stratospheric column ozone anomalies based on OMI. Our study indicates that the circulation-based MJO index （RMM） can better characterize the MJO- related anomalies in tropopause pressure and thus the MJO influence on atmospheric trace gases in the upper troposphere and lower stratosphere, especially over subtropical East Asia.

关键词： Madden-Julian Oscillation stratospheric ozone tropopause subtropical jet stream

Autism spectrum disorder:difficulties in diagnosis and microRNA biomarkers

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Neural Regeneration Research 2025年第10期20卷 2776-2786页

作者： Bridget Martinez Philip v.Peplow Department of Pharmacology University of Nevada-RenoRenoNVUSA Department of Medicine University of Nevada-RenoRenoNVUSA Department of Anatomy University of OtagoDunedinNew Zealand

We performed a PubMed search for microRNAs in autism spectrum disorder that could serve as diagnostic biomarkers in patients and selected 17 articles published from January 2008 to December 2023,of which 4 studies were performed with whole blood,4 with blood plasma,5 with blood serum,1 with serum neural cell adhesion molecule L1-captured extracellular vesicles,1 with blood cells,and 2 with peripheral blood mononuclear *** of the studies involved children and the study cohorts were largely *** of the studies had performed microRNA sequencing or quantitative polymerase chain reaction assays to measure microRNA *** five studies had used real-time polymerase chain reaction assay to validate microRNA expression in autism spectrum disorder subjects compared to *** microRNAs that were validated in these studies may be considered as potential candidate biomarkers for autism spectrum disorder and include miR-500a-5p,-197-5p,-424-5p,-664a-3p,-365a-3p,-619-5p,-664a-3p,-3135a,-328-3p,and-500a-5p in blood plasma and miR-151a-3p,-181b-5p,-320a,-328,-433,-489,-572,-663a,-101-3p,-106b-5p,-19b-3p,-195-5p,and-130a-3p in blood serum of children,and miR-15b-5p and-6126 in whole blood of *** important limitations were identified in the studies reviewed,and need to be taken into account in future *** studies are warranted with children and adults having different levels of autism spectrum disorder severity and consideration should be given to using animal models of autism spectrum disorder to investigate the effects of suppressing or overexpressing specific microRNAs as a novel therapy.

关键词： autism spectrum disorder biomarker blood cells blood plasma blood serum diagnosis microRNA peripheral blood mononuclear cells serum neural cell adhesion molecule L1-captured extracellular vesicles whole blood

MicroRNAs as potential diagnostic biomarkers for bipolar disorder

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Neural Regeneration Research 2025年第6期20卷 1681-1695页

Abnormal expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of bipolar disorder. We performed a PubMed search for microRNA biomarkers in bipolar disorder and found 18 original research articles on studies performed with human patients and published from January 2011 to June 2023. These studies included microRNA profiling in bloodand brain-based materials. From the studies that had validated the preliminary findings,potential candidate biomarkers for bipolar disorder in adults could be miR-140-3p,-30d-5p,-330-5p,-378a-5p,-21-3p,-330-3p,-345-5p in whole blood, miR-19b-3p,-1180-3p,-125a-5p, let-7e-5p in blood plasma, and miR-7-5p,-23b-5p,-142-3p,-221-5p,-370-3p in the blood serum. Two of the studies had investigated the changes in microRNA expression of patients with bipolar disorder receiving treatment. One showed a significant increase in plasma miR-134 compared to baseline after 4 weeks of treatment which included typical antipsychotics, atypical antipsychotics, and benzodiazepines. The other study had assessed the effects of prescribed medications which included neurotransmitter receptorsite binders(drug class B) and sedatives, hypnotics, anticonvulsants, and analgesics(drug class C) on microRNA results. The combined effects of the two drug classes increased the significance of the results for miR-219 and-29c with miR-30e-3p and-526b* acquiring significance. MicroRNAs were tested to see if they could serve as biomarkers of bipolar disorder at different clinical states of mania, depression, and euthymia. One study showed that upregulation in whole blood of miR-9-5p,-29a-3p,-106a-5p,-106b-5p,-107,-125a-3p,-125b-5p and of miR-107,-125a-3p occurred in manic and euthymic patients compared to controls, respectively, and that upregulation of miR-106a-5p,-107 was found for manic compared to euthymic patients. In two other studies using blood plasma,downregulation of miR-134 was observed i

关键词： biomarker bipolar disorder blood leukocytes blood plasma blood plasma extracellular vesicles/exosomes blood serum brain tissue brain tissue extracellular vesicles/exosomes lymphoblastoid cell lines microRNA neural progenitor cells whole blood

MicroRNAs as potential biomarkers for diagnosis of post-traumatic stress disorder

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Neural Regeneration Research 2025年第7期20卷 1957-1970页

Post-traumatic stress disorder is a mental disorder caused by exposure to severe traumatic life ***,there are no validated biomarkers or laboratory tests that can distinguish between trauma survivors with and without post-traumatic stress *** addition,the heterogeneity of clinical presentations of post-traumatic stress disorder and the overlap of symptoms with other conditions can lead to misdiagnosis and inappropriate *** suggests that this condition is a multisystem disorder that affects many biological systems,raising the possibility that peripheral markers of disease may be used to diagnose post-traumatic stress *** performed a PubMed search for microRNAs(miRNAs)in post-traumatic stress disorder(PTSD)that could serve as diagnostic biomarkers and found 18 original research articles on studies performed with human patients and published January 2012 to December *** included four studies with whole blood,seven with peripheral blood mononuclear cells,four with plasma extracellular vesicles/exosomes,and one with serum *** of these studies had also used whole *** studies were excluded as they did not involve microRNA *** of the studies had collected samples from adult male veterans who had returned from deployment and been exposed to combat,and only two were from recently traumatized adult *** measuring miRNA expression levels,many of the studies had used microarray miRNA analysis,miRNA Seq analysis,or NanoString *** six studies had used real time polymerase chain reaction assay to determine/validate miRNA expression in PTSD subjects compared to *** miRNAs that were found/validated in these studies may be considered as potential candidate biomarkers for PTSD and include miR-3130-5p in whole blood;miR-193a-5p,-7113-5p,-125a,-181c,and-671-5p in peripheral blood mononuclear cells;miR-10b-5p,-203a-3p,-4488,-502-3p,-874-3p,-5100,and-7641 in plasma extracellular vesicles/

关键词： biomarker diagnosis microRNA peripheral blood mononuclear cells plasma extracellular vesicles/exosomes post-traumatic stress disorder serum exosomes whole blood whole plasma

Cross-sectional deformation behavior of double-ridged rectangular tube with fillers in different stages of H-typed bending

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Chinese Journal of Aeronautics 2020年第6期33卷 1799-1811页

作者： Chunmei LIU yuli.LIU Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057China State Key Laboratory of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi'an 710072China

The bent double-ridged rectangular tube(DRRT)with high forming quality is helpful to improve the microwave transmission *** reducing the cross-sectional deformation in the H-typed bending process,in addition to using rigid mandrel to support the inside of tube,ridge groove fillers are also added to restrict the deformation of ridge *** of the change of stress and strain state of bent tube in bending,rigid mandrel retracting and specially twicespringback stages,and the springback of fillers,the cross-sectional deformation of tube in each stage may be ***,based on the ABAQUS platform,the finite element models(FEM)for H-typed bending,mandrel retracting and twice-springback stages of H96 DRRT with fillers were established and *** is found that,for the height and width deformation of tube and spacing deformation of ridge grooves,retraction of mandrel can make the distribution of these deformations more uniform along the bending *** first springback can reduce these deformations significantly,which should be *** the second springback only increases them by less amount,which can be *** smaller height deformation of ridge groove and filler can be neglected.

关键词： Cross-sectional deformation FE simulation H96 double-ridged rectangular tube H-typed rotary draw bending Ridge groove fillers Twice-springback stage

A discretely damped SDOF model for the rocking response of freestanding blocks

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Earthquake Engineering and Engineering vibration 2022年第3期21卷 729-740页

作者： Liu Hanquan Huang yuli.Qu Zhe Key Laboratory of Earthquake Engineering and Engineering vibration Institute of Engineering MechanicsChina Earthquake AdministrationKey Laboratory of Earthquake Disaster MitigationMinistry of Emergency ManagementHarbin 150080China Sanhe 065201China Arup San FranciscoCA 94105USA

This paper presents a single-degree-of-freedom(SDOF)constitutive model for assessing the performance of freestanding block contents of *** model incorporates a bespoke damper to account for energy dissipation associated with *** is advantageous in its direct correlation,via energy conservation,to the restitution coefficient for impact during rocking.A comparative study with the existing SDOF rocking models shows that the proposed model significantly improves the accuracy of free-rocking simulations,in which inherent damping predominantly affects *** provides a promising and efficient tool for computationally intensive performance evaluation of nonstructural components.

关键词： contents rigid block equivalent viscous damping free rocking forced rocking single-degree-of-freedom system

Cross-sectional deformation of H96 brass double-ridged rectangular tube in rotary draw bending process with different yield criteria

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Chinese Journal of Aeronautics 2020年第6期33卷 1788-1798页

作者： Yangyang XIA yuli.LIU Mengmeng LIU Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057China State Key Laboratory Solidification Process School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi'an 710072China

Different yield criterion has great difference in predicting the deformation of tube with different *** order to improve the prediction accuracy of the cross-sectional deformation of the double-ridged rectangular tube(DRRT)during rotary draw bending(RDB)process,Mises isotropic yield criterion,Hill’48 and Barlat/Lian anisotropic yield criteria commonly used in practical engineering are introduced to simulate RDB of *** inverse method combining uniaxial tensile test of whole tube and response surface methodology was proposed to identify the parameters of Hill’48 and Barlat/Lian yield criteria of small-sized H96 brass extrusion DRRT as *** based on ABAQUS/Explicit platform,the FE models of RDB process of DRRT considering Mises,Hill’48 and Barlat/Lian yield criteria were *** results show that:The variation trend of cross-sectional deformation ratio is same when using different yield *** cross-sectional deformation ratio by using Mises yield criterion is close to that by using Hill’48 yield ***,there is a quite difference between by using Barlat/Lian yield criterion and by using Mises or Hill’48 yield *** prediction values of cross-sectional height deformation by using three yield criteria all underestimate the experiment ones,and the prediction values of cross-sectional width deformation overestimate the experiment *** comparing the simulation results of cross-sectional deformation of the DRRT with different yield criteria and experiment ones,Barlat/Lian yield criterion is found to be suitable for describing the RDB process of DRRT.

关键词： Anisotropy yield criterion Cross-sectional deformation H96 double-ridged rectangular tube H-type rotary draw bending Inverse method

Effects of geometrical parameters on wrinkling of thin-walled rectangular aluminum alloy wave-guide tubes in rotary-draw bending

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Chinese Journal of Aeronautics 2013年第1期26卷 242-248页

作者： Tian Shan Liu yuli.Yang He State Key Laboratory of Solidification Processing Northwestern Polytechnical University

Inner flange and side wrinkling often occur in rotary-draw bending process of rectangular aluminum alloy wave-guide tubes, and the distribution and magnitude of wrinkling is related to geometrical parameters of the tubes. In order to study the effects of geometrical parameters on wrinkling of rectangular wave-guide tubes, a 3D-FE model for rotary-draw bending processes of thin-walled rectangular aluminum alloy wave-guide tubes was built based on the platform of ABA-QUS/Explicit, and its reliability was validated by experiments. Simulation and analysis of the influence laws of geometrical parameters on the wave heights of inner flange and side wrinkling were then carried out. The results show that inner flange wrinkling is the main wrinkling way to rectan- gular wave-guide tubes in rotary-draw bending processes, but side wrinkling cannot be neglected because side wrinkling is 2/3 of inner flange wrinkling when b and h are smaller. Inner flange and side wrinkling increase with increasing b and h; the influence of b on side wrinkling is larger than that of h, while both b and h affect inner flange wrinkling greatly. Inner flange and side wrinkling decrease with increasing R/h; the influence of h on inner flange and side wrinkling is larger than that of R.

关键词： geometrical parameters Inner flange wrinkling Side wrinkling Simulation Thin-walled rectangular wave-guide tube Rotary-draw bending