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Bioactive materials from berberine-treated human bone marrow mesenchymal stem cells promote alveolar bone regeneration by regulating macrophage polarization

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Science China(Life Sciences) 2024年第5期67卷 1010-1026页

作者： Ziyue Qin Yanxing Han Yifei Du Yixuan Zhang Yifeng Bian Ruyu wang Haoran wang Fanyi Guo Hua Yuan Yongchu Pan Jianliang Jin Qigang Zhou yuli wang Feng Han Yan Xu Jiandong Jiang Department of Oral and Maxillofacial Surgery The Affiliated Stomatological Hospital of Nanjing Medical UniversityNanjing 210029China Jiangsu Province Key Laboratory of Oral Diseases Nanjing Medical UniversityNanjing 210029China Jiangsu Province Engineering Research Center of Stomatological Translational Medicine Nanjing 210029China State Key Laboratoryof BioactiveSubstances andFunction of Natural Medicine Instituteof Materia MedicaChinese Academyof MedicalSciencesandPeking Union MedicalCollegeBeijing100050China Gusu school Nanjing medical universitySuzhou 215002China Key Laboratory of Cardiovascular&Cerebrovascular Medicine Drug Target and Drug Discovery CenterSchool of PharmacyNanjing Medical UniversityNanjing 211166 China Department of Orthodontics The Affiliated Stomatological Hospital of Nanjing Medical UniversityNanjing 210029China Department of Human Anatomy Research Centre for Bone and Stem CellsKey Laboratory for Aging&DiseaseThe State Key Laboratory of Reproductive MedicineNanjing Medical UniversityNanjing 211166China Department of Clinical Pharmacology School of PharmacyNanjing Medical UniversityNanjing Jiangsu211166China Department of Periodontology The Affiliated Stomatological Hospital of Nanjing Medical UniversityNanjing 210029China Department of Virology Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Alveolar bone regeneration has been strongly linked to macrophage polarization.M1 macrophages aggravate alveolar bone loss,whereas M2 macrophages reverse this process.Berberine(BBR),a natural alkaloid isolated and refined from Chinese medicinal plants,has shown therapeutic effects in treating metabolic disorders.In this study,we first discovered that culture supernatant(CS)collected from BBR-treated human bone marrow mesenchymal stem cells(HBMSCs)ameliorated periodontal alveolar bone loss.CS from the BBR-treated HBMSCs contained bioactive materials that suppressed the M1 polarization and induced the M2 polarization of macrophages in vivo and in vitro.To clarify the underlying mechanism,the bioactive materials were applied to different animal models.We discovered macrophage colony-stimulating factor(M-CSF),which regulates macrophage polarization and promotes bone formation,a key macromolecule in the CS.Injection of pure M-CSF attenuated experimental periodontal alveolar bone loss in rats.Colony-stimulating factor 1 receptor(CSF1R)inhibitor or anti-human M-CSF(M-CSF neutralizing antibody,Nab)abolished the therapeutic effects of the CS of BBR-treated HBMSCs.Moreover,AKT phosphorylation in macrophages was activated by the CS,and the AKT activator reversed the negative effect of the CSF1R inhibitor or Nab.These results suggest that the CS of BBR-treated HBMSCs modulates macrophage polarization via the M-CSF/AKT axis.Further studies also showed that CS of BBR-treated HBMSCs accelerated bone formation and M2 polarization in rat teeth extraction sockets.Overall,our findings established an essential role of BBR-treated HBMSCs CS and this might be the first report to show that the products of BBR-treated HBMSCs have active effects on alveolar bone regeneration.

关键词： berberine human bone marrow mesenchymal stem cells alveolar bone regeneration macrophage colony-stimulating factor AKT phosphorylation

Molecular events in the jaw vascular unit:A traditional review of the mechanisms involved in inflammatory jaw bone diseases

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生物医学研究杂志:英文版 2023年第5期37卷 313-325页

作者： Ruyu wang Haoran wang Junyu Mu Hua Yuan Yongchu Pang yuli wang Yifei Du Feng Han Department of Oral and Maxillofacial Surgery the Affiliated Stomatological Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Jiangsu Province Key Laboratory of Oral Diseases Nanjing Medical UniversityNanjingJiangsu 210029China Jiangsu Province Engineering Research Center of Stomatological Translational Medicine NanjingJiangsu 210029China International Joint Laboratory for Drug Target of Critical Illnesses Key Laboratory of Cardiovascular and Cerebrovascular MedicineSchool of PharmacyNanjing Medical UniversityNanjingJiangsu 211166China Department of Orthodontics the Affiliated Stomatological Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China.

Inflammatory jaw bone diseases are common in stomatology,including periodontitis,peri-implantitis,medication-related osteonecrosis of the jaw,radiation osteomyelitis of the jaw,age-related osteoporosis,and other specific infections.These diseases may lead to tooth loss and maxillofacial deformities,severely affecting patients'quality of life.Over the years,the reconstruction of jaw bone deficiency caused by inflammatory diseases has emerged as a medical and socioeconomic challenge.Therefore,exploring the pathogenesis of inflammatory diseases associated with jaw bones is crucial for improving prognosis and developing new targeted therapies.Accumulating evidence indicates that the integrated bone formation and dysfunction arise from complex interactions among a network of multiple cell types,including osteoblast-associated cells,immune cells,blood vessels,and lymphatic vessels.However,the role of these different cells in the inflammatory process and the'rules'with which they interact are still not fully understood.Although many investigations have focused on specific pathological processes and molecular events in inflammatory jaw diseases,few articles offer a perspective of integration.Here,we review the changes and mechanisms of various cell types in inflammatory jaw diseases,with the hope of providing insights to drive future research in this field.

关键词： inflammatory diseases osteogenesis-related cells immune cells blood vessels lymphatic vessels jaw vascular unit

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关于“戏剧情境”的现象学思考

戏剧艺术 2024年第1期 10-22页

作者：汪余礼武汉大学艺术学院

从现象学视野来看,“戏剧情境”是以人物处境为基底,以角色内外生命运动为核心内容且主客交融、内外交合、虚实相生、不断流动的综合生命体。在戏剧中,人与情境缘发构成,每个人物总是在其意识到或体验到的情境中生成动机发出动作,而这... 详细信息

从现象学视野来看,“戏剧情境”是以人物处境为基底,以角色内外生命运动为核心内容且主客交融、内外交合、虚实相生、不断流动的综合生命体。在戏剧中,人与情境缘发构成,每个人物总是在其意识到或体验到的情境中生成动机发出动作,而这里的“情境”既有人心缘发构造的成分,亦有主体活态创造的成分,因而情境必然带有一定的生命意味。如果进一步发挥现象学的求真精神,那么会发现:戏剧情境归根到底是戏剧家身心共造之境,其中既有实的要素,也有虚的氛围;戏剧情境的运动固然跟剧中人物性格、人物处境有关,但也跟创作者的生命体验与艺术智慧有关。基于现象学视野重构后的“戏剧情境论”,对于戏剧创作、戏剧评论、戏剧研究具有多重启示意义,有助于中国特色戏剧学话语的建构。

关键词：戏剧情境现象学戏剧本体戏剧规律戏剧学话语

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新感性、新思维与福瑟戏剧的新模式

外国文学研究 2024年第2期46卷 20-32页

作者：汪余礼武汉大学艺术学院

约恩·福瑟的戏剧创作,相对于从古希腊到易卜生的欧洲传统戏剧而言,不是局部创新,而是根本革新。其根本革新主要体现在:欧洲传统戏剧创作基于“理念论”哲学传统,最重视的是“看”,而福瑟的戏剧创作则基于后形而上学的“存在论-解构论... 详细信息

约恩·福瑟的戏剧创作,相对于从古希腊到易卜生的欧洲传统戏剧而言,不是局部创新,而是根本革新。其根本革新主要体现在:欧洲传统戏剧创作基于“理念论”哲学传统,最重视的是“看”,而福瑟的戏剧创作则基于后形而上学的“存在论-解构论”新传统,最重视的是“听”;通过转向以倾听为主的后形而上学感知范式,福瑟重构了一种把诗性、音乐性、神性与戏剧性融合在一起的“新感性”,又化用了海德格尔、德里达等人的哲学思想,孕成他自己的新思维,进而创造了一种将极简戏剧、音乐诗剧、静默戏剧、灵知戏剧、留白戏剧等融为一体的新戏剧,形成了一种独特的戏剧创作模式。其创作模式的内核,是在倾听中直呈人类的处境与本质,在危机、忧惧、向死而生中逼出人的“存在与时间”。约恩·福瑟的戏剧创作模式,既体现出后形而上学时代艺术家对于“倾听”的倚重,也体现出直呈本质的极简书写的巨大活力,还反映出接受者的“创造性合作”在当代艺术活动中的特殊重要性。

关键词：约恩·福瑟艺术革新新感性新思维新模式

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谭霈生的戏剧评论及其启示意义

四川戏剧 2024年第1期 56-60页

作者：汪余礼武汉大学艺术学院

谭霈生先生的戏剧评论具有三个鲜明特点:一是学理性、专业性很强;二是透视性、对话性很强;三是针对性、引导性很强。谭先生经常针对新时期戏剧创作中存在的突出问题,多管齐下、细致剖析、引导审美、启发创作。在此过程中谭霈生先生形成... 详细信息

谭霈生先生的戏剧评论具有三个鲜明特点:一是学理性、专业性很强;二是透视性、对话性很强;三是针对性、引导性很强。谭先生经常针对新时期戏剧创作中存在的突出问题,多管齐下、细致剖析、引导审美、启发创作。在此过程中谭霈生先生形成了自己的一套戏剧评论话语,也生成了一系列经验与智慧。谭先生的戏剧评论对于引导当前戏剧创作和建构文艺评论话语体系具有重要的启示意义。

关键词：谭霈生戏剧评论话语学理性透视性引导性

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列宁宗教观的生成逻辑

科学与无神论 2024年第1期 38-46,122页

作者：王玉立北京物资学院马克思主义学院

列宁宗教观是基于俄国国情将马克思恩格斯关于宗教的基本原理应用于无产阶级革命运动的实践过程中所形成的科学理论成果.列宁宗教观的生成,蕴含着深刻的现实逻辑、历史逻辑和理论逻辑.从现实逻辑看,服从于无产阶级革命的现实需要;从历... 详细信息

列宁宗教观是基于俄国国情将马克思恩格斯关于宗教的基本原理应用于无产阶级革命运动的实践过程中所形成的科学理论成果.列宁宗教观的生成,蕴含着深刻的现实逻辑、历史逻辑和理论逻辑.从现实逻辑看,服从于无产阶级革命的现实需要;从历史逻辑看,立足于俄国的政治文化传统;从理论逻辑看,继承了马克思主义宗教观的理论精髓.

关键词：列宁宗教观无产阶级政党

Taxifolin attenuates inflammation via suppressing MAPK signal pathway in vitro and in silico analysis

维普期刊数据库评论

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Chinese Herbal Medicines 2022年第4期14卷 554-562,F0002页

作者： Xingyan Zhang Xiaoyan Lian Huling Li Wenjing Zhao Xin Li Fujun Zhou Yutong Zhou Tao Cui yuli wang Changxiao Liu Key Laboratory of Quality-marker of Traditional Chinese Medicines Tianjin Institute of Pharmaceutical Research Co.Ltd.Tianjin 300462China Center for Drug Evaluation National Medical Products AdministrationBeijing 100022China Department of Pharmacology Tianjin Medical UniversityTianjin 300070China State Key Laboratory of Drug Delivery Technology and Pharmacokinetics Tianjin Institute of Pharmaceutical Research Co.Ltd.Tianjin 300462China Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemistry Engineering and TechnologyTianjin UniversityTianjin 300072China Research Unit for Drug Metabolism Chinese Academy of Medical SciencesBeijing 100730China Pharmaceuticai Armaceuticai DA REN TANG Group Corporation Limited Traditional Chinese Pharmacy Researchinstitute Tianjin 300457China Tianjin Key Laboratory of Quality Control in Chinese Medicine Tianjin 300457China

Objective:Taxifolin is a natural flavonoid compound that can be isolated from onions,grapes,oranges and grapefruit.It also acts as a medicine food homology with extraordinary antioxidant and antiinflammatory activity.This study aims to explain the protective effects and potential mechanisms of taxifolin against inflammatory reaction.Methods:Levels of interleukin(IL)-6,IL-1βand intracellular reactive oxygen species(ROS)were assessed in different time after the treatment of taxifolin in RAW264.7 cells induced by lipopolysaccharide(LPS).Subsequently,the m RNA and protein levels of inducible nitric oxide synthase(i NOS),vascular endothelial growth factor(VEGF),cyclooxygenase(COX)-2,tumor necrosis factor(TNF)-a and the phosphorylation expression levels of the MAPK signal pathway were also evaluated.A silico analysis was used to explain the binding situation for the investigation of taxifolin and MAPK signal pathway.And then MAPK inhibitors were used to reveal the expression level of i NOS,VEGF,COX-2 and TNF-a in RAW264.7 cells.Results:It was demonstrated that cell inflammatory damage induced by LPS was significantly alleviated after the treatment of taxifolin.Then,the m RNA and protein levels of i NOS,VEGF,COX-2 and TNF-a were reduced and the phosphorylation expression levels of the MAPK signal pathway were down-regulated remarkably as well.In silico analysis,taxifolin could form a relatively stable combination with MAPK signal pathway.MAPK inhibitors showed increasing or decreasing effect in the m RNA levels of i NOS,VEGF,COX-2 and TNF-a,which suggesting that taxifolin down-regulated i NOS,VEGF,COX-2 and TNF-a expressions were not entirely through the MAPK pathway.Conclusion:This finding demonstrated that taxifolin improved the inflammatory responses that partly involved in the phosphorylation expression level of MAPK signal pathway in RAW264.7 cells exposed to acute stress.

关键词： MAPK signal pathway molecular docking pro-inflammatory cytokines taxifolin

体感渊深处,静透梦影风——自审感通论视域下的福瑟戏剧

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广东外语外贸大学学报 2024年第2期35卷 64-76页

作者：汪余礼武汉大学艺术学院

约恩·福瑟在戏剧创作上的成功,看似偶然,其实跟他严格深邃的多重自审、新奇陌生的精准感通有密切的关系,而自审与感通的融合素来有助于造就经典作品。福瑟以严格的自审,直面人性的种种弱点,同时在静默中用心倾听人心深处的种种声音与... 详细信息

约恩·福瑟在戏剧创作上的成功,看似偶然,其实跟他严格深邃的多重自审、新奇陌生的精准感通有密切的关系,而自审与感通的融合素来有助于造就经典作品。福瑟以严格的自审,直面人性的种种弱点,同时在静默中用心倾听人心深处的种种声音与天地之间的诸多信息,然后以新奇独特的形式将那渊深处的声音、那神秘而幽微的信息暗示出来,形成了高度诗化音乐化、以大量静场说不可说、以灵知叙事探询神性消息、以循环律动反向感通的新型极简戏剧。而且,福瑟所采用的戏剧形式,与易卜生、契诃夫、贝克特、品特、汉德克等人的相比,确有诸多新奇之处;正因新奇,反而愈能感通人心。进而言之,约恩·福瑟的成功表明,一个作家如果能将“深广的自审”与“新奇的感通”很好地融合起来,就有可能创造出伟大的作品。

关键词：约恩·福瑟自审感通论多重自审新奇感通

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戏剧诗境:基本内涵、营构方法与多重价值

信阳师范学院学报（哲学社会科学版） 2024年第3期44卷 102-110页

作者：汪余礼武汉大学艺术学院湖北武汉430070

“戏剧诗境”是戏剧学领域值得探讨的一个重要概念。所谓“戏剧诗境”是指兼具戏剧性与诗性的情境,或者说是戏剧性情境与诗境复合而成的有机整体。它们往往既扣人心弦、引人入胜,又出人意外、耐人寻味,使人进入一个有别于现实生活的、... 详细信息

“戏剧诗境”是戏剧学领域值得探讨的一个重要概念。所谓“戏剧诗境”是指兼具戏剧性与诗性的情境,或者说是戏剧性情境与诗境复合而成的有机整体。它们往往既扣人心弦、引人入胜,又出人意外、耐人寻味,使人进入一个有别于现实生活的、更高远更深邃的灵境之中。有无戏剧诗境对于戏剧作品来说是性命攸关之事:有则可演可传,无则湮没无闻。对于戏剧创作者来说,精心营构戏剧诗境,实现戏剧性与诗性的高度融合,有助于创造出优秀戏剧或一流戏剧;对于戏剧鉴赏者、评论者来说,重点关注戏剧诗境,着重探讨作者营构戏剧诗境的方法,有助于贴近戏剧本体、把握作品精髓。鉴于在事实层面中国戏曲可称为“剧诗”、中国话剧具有“诗化传统”、域外一流戏剧往往戏剧性很强且兼具“诗的境界”的事实,在理论层面上“戏剧诗境”对于戏剧创作、戏剧评论、戏剧美育都具有重要意义,因而完全可以考虑将“戏剧诗境”纳入中国戏剧学话语体系之中。

关键词：戏剧诗境戏剧性诗性戏剧本体戏剧学话语