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Recent progress and future directions of the research on nanoplastic-induced neurotoxicity

Neural Regeneration Research 2024年第2期19卷 331-335页

作者： Seung-Woo Han Jinhee Choi Kwon-yul Ryu Department of Life Science University of SeoulSeoulSouth Korea School of Environmental Engineering University of SeoulSeoulSouth Korea

Many types of plastic products,including polystyrene,have long been used in commercial and industrial *** and nanoplastics,plastic particles derived from these plastic products,are emerging as environmental pollutants that can pose health risks to a wide variety of living organisms,including ***,it is not well understood how microplastics and nanoplastics affect cellular functions and induce stress *** can be exposed to polystyrene-microplastics and polystyrene-nanoplastics through ingestion,inhalation,or skin *** ingested plastics are excreted from the body,but inhaled plastics may accumulate in the lungs and can even reach the brain via the nose-to-brain ***-sized polystyrene-nanoplastics can enter cells by endocytosis,accumulate in the cytoplasm,and cause various cellular stresses,such as inflammation with increased pro-inflammatory cytokine production,oxidative stress with generation of reactive oxygen species,and mitochondrial *** induce autophagy activation and autophagosome formation,but autophagic flux may be impaired due to lysosomal *** permanently exposed to polystyrene-nanoplastics,they can be removed from cells by exocytosis and subsequently restore cellular ***,neurons are very susceptible to this type of stress,thus even acute exposure can lead to neurodegeneration without *** review focuses specifically on recent advances in research on polystyrene-nanoplastic-induced cytotoxicity and ***,in this review,based on mechanistic studies of polystyrene-nanoplastics at the cellular level other than neurons,future directions for overcoming the negative effects of polystyrene-nanoplastics on neurons were suggested.

关键词： autophagy cellular stress cytotoxicity endocytosis exocytosis inflammation microplastics nanoplastics neurotoxicity oxidative stress polystyrene

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Cavity-agnostic acoustofluidic manipulations enabled by guided flexural waves on a membrane acoustic waveguide actuator

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Microsystems & Nanoengineering 2024年第2期10卷 153-171页

作者： Philippe Vachon Srinivas Merugu Jaibir Sharma Amit Lal Eldwin J.Ng yul Koh Joshua E.-Y.Lee Chengkuo Lee Department of Electrical and Computer Engineering National University of SingaporeSingaporeSingapore institute of Microelectronics Agency for ScienceTechnology and Research(A*STAR)SingaporeSingapore SonicMEMS Laboratory School of Electrical and Computer EngineeringCornell UniversityIthacaNYUSA School of Electrical and Data Engineering University of Technology SydneyUltimoNSWAustralia

This article presents an in-depth exploration of the acoustofluidic capabilities of guided flexural waves(GFWs)generated by a membrane acoustic waveguide actuator(MAWA).By harnessing the potential of GFWs,cavity-agnostic advanced particle manipulation functions are achieved,unlocking new avenues for microfluidic systems and lab-on-a-chip *** localized acoustofluidic effects of GFWs arising from the evanescent nature of the acoustic fields they induce inside a liquid medium are numerically investigated to highlight their unique and promising *** traditional acoustofluidic technologies,the GFWs propagating on the MAWA’s membrane waveguide allow for cavity-agnostic particle manipulation,irrespective of the resonant properties of the fluidic ***,the acoustofluidic functions enabled by the device depend on the flexural mode populating the active region of the membrane *** demonstrations using two types of particles include in-sessile-droplet particle transport,mixing,and spatial separation based on particle diameter,along with streaming-induced counter-flow virtual channel generation in microfluidic PDMS *** experiments emphasize the versatility and potential applications of the MAWA as a microfluidic platform targeted at lab-on-a-chip development and showcase the MAWA’s compatibility with existing microfluidic systems.

关键词： waveguide fluid cavity

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The CUL3A–LFH1–UBC15 ubiquitin ligase complex mediates SHORT VEGETATiVE PHASE degradation to accelerate flowering at high ambient temperature

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Plant Communications 2024年第4期5卷 224-238页

作者： Suhyun Jin Geummin Youn Sun Young Kim Taewook Kang Hyun-young Shin Ji-yul Jung Pil Joon Seo Ji Hoon Ahn Department of Life Sciences Korea UniversitySeoul 02841Republic of Korea Department of Chemistry Seoul National UniversitySeoul 08826Republic of Korea These authors contributed equally to this article.

Ambient temperature affects flowering time in plants,and the MADS-box transcription factor SHORT VEGETATiVE PHASE(SVP)plays a crucial role in the response to changes in ambient *** protein stability is regulated by the 26S proteasome pathway and decreases at high ambient temperature,but the details of SVP degradation are ***,we show that SVP degradation at high ambient temperature is mediated by the CULLiN3–RiNG E3 ubiquitin ligase(CRL3)complex in Arabidopsis *** identified a previously uncharacterized protein that interacts with SVP at high ambient temperature and contains a BTB/POZ *** named this protein LATE FLOWERiNG AT HiGH TEMPERATURE 1(LFH1).Single mutants of LFH1 or CULLiN3A(CUL3A)showed late flowering specifically at 27***1 protein levels increased at high ambient *** found that LFH1 interacts with CUL3A in the cytoplasm and is important for SVP–CUL3A complex *** in CUL3A and/or LFH1 led to increased SVP protein stability at high ambient temperature,suggesting that the CUL3–LFH1 complex functions in SVP *** E2 ubiquitin-conjugating enzymes(UBCs)using RiNG-BOX PROTEiN 1(RBX1),a component of the CRL3 complex,as bait identified ***15 mutants also showed late flowering at high ambient *** vitro and in vivo ubiquitination assays using recombinant CUL3A,LFH1,RBX1,and UBC15 showed that SVP is highly ubiquitinated in an ATP-dependent ***,these results indicate that the degradation of SVP at high ambient temperature is mediated by a CRL3 complex comprising CUL3A,LFH1,and UBC15.

关键词： temperature-responsiveflowering SVP CUL3 proteasomal degradation ubiquitination

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“深度翻译”理论在藏汉翻译中的应用价值和策略

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攀登（藏文版） 2024年第3期 126-135页

作者：尤拉才让青海省藏语系佛学院青海民族大学

哈佛大学文化和翻译学者阿皮亚提出“深度翻译”,其理论源自阐释人类学和哲学的“深描理论”,其实践主要通过文前添加译序、文间添加注释、文后添加附录和索引等方式实现。“深度翻译”能为目标语读者有效展示源语文化背景和语言风格,... 详细信息

哈佛大学文化和翻译学者阿皮亚提出“深度翻译”,其理论源自阐释人类学和哲学的“深描理论”,其实践主要通过文前添加译序、文间添加注释、文后添加附录和索引等方式实现。“深度翻译”能为目标语读者有效展示源语文化背景和语言风格,应用在藏族优秀传统文化的阐释及藏文典籍的国家通用语言文字翻译中,具有保留文化特色、体现学术特征、有助于文化理解、拓宽传播渠道等优势。

关键词：藏汉翻译深度翻译应用价值策略

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Free ubiquitin: a novel therapeutic target for neurodegenerative diseases

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Neural Regeneration Research 2021年第9期16卷 1781-1782页

作者： Chul-Woo Park Kwon-yul Ryu Department of Life Science University of SeoulSeoulRepublic of Korea

Neurodegenerative diseases are widespread and the increasing number of patients with these diseases can no longer be ignored. Dementia is a symptom of many neurodegenerative diseases, and Alzheimer's disease(AD), which is associated with memory and learning disabilities, accounts for approximately 60 to 80% of all dementia cases(Wyss-Coray, 2016).

关键词： diseases degenerative Alzheimer

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Using Echo Ultrasound from Schooling Fish to Detect and Classify Fish Types

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Journal of Bionic Engineering 2009年第3期6卷 264-269页

作者： Yeffry Handoko yul.Y.Nazaruddin Huosheng Hu Department of Engineering Physics Bandung Institute of Technology School of Computer Science and Electronic Engineering University of Essex

Fish finders have already been widely available in the fishing market for a number of ***,the sizes of these fish finders are too big and their prices are expensive to suit for the research of robotic fish or *** goal of this research is to propose a low-cost fish detector and classifier which suits for underwater robot or submarine as a proximity sensor. With some pre-condition in hardware and algorithms,the experimental results show that the proposed design has good per- formance,with a detection rate of 100 % and a classification rate of 94 %.Both the existing type of fish and the group behavior can be revealed by statistical interpretations such as hovering passion and sparse swimming mode.

关键词： fish detection classincation artificial neural network ultrasound sensor

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Design and implementation of Paired Pectoral Fins Locomotion of Labriform Fish Applied to a Fish Robot

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Journal of Bionic Engineering 2009年第1期6卷 37-45页

作者： Patar Ebenezer Sitorus yul Yunazwin Nazaruddin Edi Leksono Agus Budiyono Department of Engineering Physics Bandung Institute of TechnologyBandung 40132Indonesia Smart Robot Center Department of Aerospace EngineeringKonkuk UniversitySeoul 143-701Korea

in present,there are increasing interests in the research on mechanical and control system of underwater *** ongoing research efforts are motivated by more pervasive applications of such vehicles including seabed oil and gas explorations, scientific deep ocean surveys,military purposes,ecological and water environmental studies,and also entertainments. However,the performance of underwater vehicles with screw type propellers is not prospective in terms of its efficiency and *** main weaknesses of this kind of propellers are the production of vortices and sudden generation of thrust forces which make the control of the position and motion difficult. On the other hand,fishes and other aquatic animals are efficient swimmers,posses high maneuverability,are able to follow trajectories,can efficiently stabilize themselves in currents and surges,create less wakes than currently used underwater vehicle, and also have a noiseless *** fish's locomotion mechanism is mainly controlled by its caudal fin and paired pectoral *** are classified into Body and/or Caudal Fin(BCF)and Median and/or paired Pectoral Fins(MPF).The study of highly efficient swimming mechanisms of fish can inspire a better underwater vehicles thruster design and its mechanism. There are few studies on underwater vehicles or fish robots using paired pectoral fins as *** work presented in this paper represents a contribution in this area covering study,design and implementation of locomotion mechanisms of paired pectoral fins in a fish *** performance and viability of the biomimetic method for underwater vehicles are highlighted through in-water experiment of a robotic fish.

关键词： fish robot pectoral fins servos rowing flapping feathering

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Graphene platform for neural regenerative medicine

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Neural Regeneration Research 2016年第6期11卷 894-895页

作者： Tasneem Bouzid Alexander Sinitskii Jung yul Lim Department of Mechanical and Materials Engineering University of Nebraska-Lincoln Department of Chemistry University of Nebraska-Lincoln Graduate School of Dentistry Kyung Hee University

Graphene is a material composed of a single layer of carbon atoms arranged in a two-dimensional honeycomb lattice. The unique elec- trical, optical, thermal, and mechanical properties of graphene are extensively explo... 详细信息

关键词： Graphene platform for neural regenerative medicine NFL cell FAK RA

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Effect of polyethylene glycol on electrochemically deposited trivalent chromium layers

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中国有色金属学会会刊：英文版 2009年第4期19卷 819-823页

作者： Joo-yul LEE Man Ki M Sik-Chol KWON Department of Surface Technology Korea Institute of Materials Science

The structural characteristics of the trivalent chromium deposits and their interfacial behavior in the plating solution with and without polyethylene glycol molecules were observed by using various electrochemical methods such as cyclic voltammetry,open circuit potential transition,electrochemical impedance spectroscopy,scanning electron microscopy and X-ray photoelectron *** is shown that the polyethylene glycol molecules make the reductive current density lower in the trivalent chromium plating system and promote a hydrogen evolution reaction through their adsorption on the electrode *** the trivalent chromium layer formed from the polyethylene glycol-containing solution has somewhat higher density of cracks on its surface and results in a lower film resistance,lower polarization resistance,and higher capacitance in a corrosive *** is also revealed that the formation of chromium carbide layer is facilitated in the presence of polyethylene glycol,which means easier electrochemical codeposition of chromium and carbon,not single chromium deposition.

关键词：聚乙二醇电沉积层三价铬扫描电子显微镜电化学阻抗谱电极表面电化学方法乙二醇溶液

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Ubiquitin homeostasis: from neural stem cell differentiation to neuronal development

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Neural Regeneration Research 2015年第8期10卷 1209-1210页

作者： Han-Wook Ryu Kwon-yul Ryu Department of Life Science University of Seoul

Ubiquitin（Ub）is a well-known eukaryotic protein that exerts diverse signaling functions inside the cells,including targeting its substrates for proteasomal degradation（Hershko and Ciechanover,1998）.

关键词： Ubiquitin neuronal homeostasis eukaryotic sequential targeting diverse suppression maintain impaired

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