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circRNAs in drug resistance of breast cancer

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Oncology Research 2022年第4期30卷 157-172页

作者： SEMA MISIR SERAP OZER YAMAN NINA PETROVIĆ CEREN SUMER CEYLAN HEPOKUR yuksel aliyazicioglu Department of Biochemistry Faculty of PharmacySivas Cumhuriyet UniversitySivas58010Turkey Department of Medical Biochemistry Karadeniz Technical University Faculty of MedicineTrabzon61000Turkey Laboratory for Radiobiology and Molecular genetics “VINČA”Institute of Nuclear Sciences-National Institute of the Republic of SerbiaUniversity of BelgradeBelgrade11000Serbia Department of Experimental Oncology Institute for Oncology and Radiology of SerbiaBelgrade11000Serbia Comprehensive Cancer Center Faculty of Life Science&MedicineKing’s College LondonLondonSE11ULUnited Kingdom

Breast cancer(BC)is the most common heterogeneous disease in women and one of the leading causes of cancer-related ***,chemotherapy,radiotherapy,hormone,and targeted therapy are the gold standards for BC *** of the significant challenges during the treatment of BC represents resistance to chemotherapeutics,resistance that severely limits the use and effectiveness of the drugs used for BC ***,it is essential to develop new strategies to improve therapeutic *** RNAs(circRNAs)are a large group of non-coding RNAs that covalently form closed circular loops by joining their 5′,and 3′;*** evidence suggests that circRNAs have a vital role in cancer development,progression,and BC resistance to *** purpose of this review is to discuss the biological properties of circRNAs,and how circRNAs induce resistance to conventional therapeutic anti-cancer drugs used in BC treatment,by emphasizing and summarizing the potential roles of circRNAs in mechanisms of drug resistance,such as drug efflux,apoptosis dysfunction,autophagy,and DNA damage *** are associated with drug resistance via ATP-binding cassette(ABC)efflux transporters,while some others by inhibition of cell apoptosis,thus leading to resistance to tamoxifen in BC *** contrast,others are involved in the promotion of BC cells chemoresistance by doxorubicininduced *** may have clinical significance in regulating or overcoming BC drug resistance and may give directions towards a novel approach to personalized BC *** may significantly contribute to the identification of new therapeutic targets for the prevention of BC chemoresistance.

关键词： Breast cancer Chemotherapy circRNAs Drug resistance Non-coding RNA

Cytotoxic effect of Rosa canina extract on human colon cancer cells through repression of telomerase expression

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Journal of Pharmaceutical Analysis 2018年第6期8卷 394-399页

作者： Ibrahim Turan Selim Demir Kagan Kilinc Serap Ozer Yaman Sema Misir Hanife Kara Berna Genc Ahmet Mentese yuksel aliyazicioglu Orhan Deger Department of Genetic and Bioengineering Faculty of Engineering and Natural Sciences Gumushane University Medicinal Plants Traditional Medicine Practice and Research Center Gumushane University Department of Nutrition and Dietetics Faculty of Health Sciences Karadeniz Technical University Department of Medical Biochemistry Faculty of Medicine Karadeniz Technical University Department of Biochemistry Faculty of Pharmacy Cumhuriyet University Program of Medical Laboratory Techniques Vocational School of Health Sciences Karadeniz Technical University

Rosa canina is a member of the genus Rosa that has long been used for medical objectives. Several studies have reported cytotoxic effects of different Rosa species, but there has been only limited investigation of the cytotoxic effect of R. canina. The purpose of the current study was to examine the potential effect of *** extract on cell viability, the cell cycle, apoptosis, and the expression of telomerase in human colon cancer(WiDr) cells. The cytotoxic effect of the extract was determined using MTT assay. The mechanism involved in the cytotoxic effect of the extract was then evaluated in terms of apoptosis and the cell cycle using flow cytometry. Mitochondrial membrane potential(MMP) was investigated using the fluorometric method, and expression levels of telomerase were studied using RT-PCR. R. canina extract exhibited a selective cytotoxic effect on WiDr cells compared with normal colon cells. The extract induced cell cycle arrest at the S phase and apoptosis via reduced MMP in WiDr cells. R. canina extract significantly repressed telomerase expressions at treatment times of 48 and 72 h in WiDr cells. Our results suggest that R. canina may have considerable potential for development as a novel natural product-based anticancer agent.

关键词： Apoptosis Colon cancer Cytotoxicity Rosa canina Telomerase

Flow structure at the downstream of a one-line riparian emergent tree along the floodplain edge in a compound open-channel flow

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Journal of Hydrodynamics 2018年第3期30卷 470-480页

作者： Ayse yuksel Ozan Civil Engineering Department Engineering Faculty Adnan Menderes University

This study focuses on the effects of one-line emergent natural tree（Cupressus Macrocarpa） planted at the edge of the floodplain in a compound open-channel flow. The flow velocity and water level are measured and used to analyze the flow structure. The time averaged and depth-averaged streamwise velocity distributions with root mean square（rms） and time series of streamwise velocity distrbution are analyzed. The velocity distribution considerably changes along the compound channel. The streamwise velocity distribution fits with logarithmic distribution in the non-vegetated case, but for vegetated cases, the streamwise velocity distribution shows S shaped profile at the 1/3 part of floodplain（/3）B_f and main channel（/3）B_m close to the boundary between floodplain and main channel. Additionally, it is obtained that the presence of tree line increases turbulence intensity over the compound open-channel. Moreover, an oscillation period is obtained in the flow caused by tree line by analyzing time series of the streamwise velocity distribution. The oscillation is present everywhere in the floodplain and present at almost/3 B_m part of the main channel which is close to the junction between floodplain and main channel.

关键词： Floodplain natural vegetation open channel flow compound channel velocity profile

Relationship between Exposure to Low Dose of x-ray and DNA Hypomethylation in Solid Tumors and Hematological Malignancies

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Biomedical and Environmental Sciences 2020年第7期33卷 528-537页

作者： yuksel Selin DINNER Yildiz Department of Medical Biochemistry Cerrahpasa Medical FacultyIstanbul University-CerrahpasaIstanbulTurkey

X-rays are used in diagnostic and interventional radiology, and for treatment of certain benign and malignant diseases. Although these procedures utilize only low doses of radiation, the long term effects of exposure ... 详细信息

关键词： doses utilize malignant

Enzymatic Synthesis and Characterization of Biodegradable Poly(w-pentadecalactone-co-ε-caprolactone)Copolymers

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Journal of Renewable Materials 2018年第6期6卷 591-598页

作者： Cansu Ulker yuksel Guvenilir Istanbul Technical University Department of Chemical Engineering34469IstanbulTurkey

As an alternative biodegradable aliphatic polyester,poly(w-pentadecalactone-co-ε-caprolactone)copolymer was synthesized via enzymatic ring-opening polymerization.A new biocatalyst,Candida antarctica lipase B,immobilized onto rice husk ash was used for *** were carried out at various temperatures and periods for varied copolymer compositions in order to obtain the highest molecular weight *** best reaction parameters were found to be 80℃ and 6 hours and molecular weights increased proportionally with the amount of w-pentadecalactone(w-PDL).The molecular structure of copolymer with 75%weight ratio of w-PDL(Mn=19720 g/mol)was characterized by proton and carbon nuclear magnetic resonance spectroscopies(^1H-NMR and ^13C-NMR).Thermal properties of the same copolymer and homopolymers were investigated by differential scanning calorimetry(DSC)and thermogravimetric analysis(TGA).Improved thermal features were shown by addition of w-PDL to the structure and compared with poly(ε-caprolactone)(PCL).Consequently,poly(w-pentadecalactone-co-ε-caprolactone)copolymers were found to be good alternatives to widely used polyester,PCL,with their rapid polymerization tendency,higher molecular weights,and improved thermal features.

关键词： Candida antarctica lipase B immobilized lipase rice husk ash copolymerization enzymatic ring-opening polymerization lactones ε-caprolactone ω-pentadecalactone

Reflection and Transmission of Regular Waves from/Through Single and Double Perforated Thin Walls

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China Ocean Engineering 2017年第4期31卷 466-475页

作者： Nadji CHIOUKH Esin CEVIK Yalcin yuksel Department of Civil Engineering University of Djillali Liabes Sidi Bel-Abbes 22000 Algeria Laboratory of Naval Aero-Hydrodynamics Department of Maritime Engineering USTO MB Oran 31000 Algeria Department of Civil Engineering Yildiz Technical University Istanbul Turkey

In this paper, reflection and transmission coefficients of regular waves from/through perforated thin walls are investigated. Small scale laboratory tests have been performed in a wave flume firstly with single perforated thin Plexiglas plates of various porosities. The plate is placed perpendicular to the flume with the height from the flume bottom to the position above water surface. With this thin wall in the flume wave overtopping is prohibited and incident waves are able to transmit. The porosities of the walls are achieved by perforating the plates with circular holes. Model settings with double perforated walls parallel to each other forming so called chamber system, have been also examined. Several parameters have been used for correlating the laboratory tests’ results. Experimental data are also compared with results from the numerical model by applying the multi-domain boundary element method （MDBEM） with linear wave theory. Wave energy dissipation due to the perforations of the thin wall has been represented by a simple yet effective porosity parameter in the model. The numerical model with the MDBEM has been further validated against the previously published data.

关键词： wave-structure interaction perforated thin walls boundary element experimental tests wave reflection wave transmission

New indication area in intersphincteric resection:transanal total mesorectal excision combined with intersphincteric resection

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Gastroenterology Report 2023年第1期11卷 606-607页

作者： Bulent Cavit yuksel Department of Colon&Rectum General SurgeryAnkara Bilkent City HospitalUniversity of Health ScienceAnkaraTurkey

We read the article by Liu et al.[1]entitled“Transanal total mesorectal excision combined with intersphincteric resection has similar long-term oncological outcomes to laparoscopic abdominoperineal resection in low rectal cancer:a propensity scorematched cohort study.”The article is very interesting and boldly ***,I noticed some areas of the article that I could not find the answers to.

关键词： resection rectal sphincter

Performance Comparison of Commercial and Home-Made Lipases for Synthesis of Poly(δ-Valerolactone)Homopolymers

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Journal of Renewable Materials 2019年第4期7卷 335-343页

作者： Cansu Ulker Zeynep Gok yuksel Guvenilir Istanbul Technical University Department of Chemical EngineeringAyazaga CampusIstanbul34469Turkey

Novozyme 435,which is the commercially available immobilized form of Candida antarctica lipase B,has been successfully conducted ring opening polymerization of lactones in organic *** this paper,it was aimed to introduce an alternative biocatalyst for Novozyme *** antarctica lipase B immobilized onto rice husk ashes via physical adsorption(with a specific activity of 4.4 U/mg)was prepared in previous studies and used as a biocatalyst for poly(δ-valerolactone)synthesis in the present *** reactions were proceeded at various reaction temperatures and periods via both two immobilized enzyme *** resulting products were characterized spectroscopically and *** highest molecular weight(Mn=9010 g/mol)was obtained via Novozyme 435 catalysis at 40℃and 24 *** performance of home-made lipase,which resulted in a molecular weight of 8040 g/mol,was close to commercial one.

关键词： Poly(δ-valerolactone) Candida antarctica lipase B Novozyme 435 immobilization enzymatic ring opening polymerization

Ti3C2Tx MXene-functionalized Hydroxyapatite/Halloysite nanotube filled poly-(lactic acid)coatings on magnesium:In vitro and antibacterial applications

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Journal of Magnesium and Alloys 2024年第9期12卷 3758-3771页

作者： Mehmet Topuz yuksel Akinay Erkan Karatas Tayfun Cetin Department of Mechanical Engineering Van Yuzuncu Yil UniversityVan 65080Turkey Department of Mining Engineering Van Yuzuncu Yil UniversityVan65080Turkey Department of Molecular Biology and Genetics Erzurum Technical UniversityErzurum 25100Turkey Yuksekova Vocational High School Hakkari UniversityHakkari 30110Turkey

Magnesium(Mg)stands out in temporary biomaterial applications due to its biocompatibility,biodegradability,and low Young’s ***,controlling its corrosion through next-generation polymer-based functional coatings is crucial due to the rapid degradation behavior of *** this study,the function of 2D lamellar Ti_(3)C_(2)T_(x)(MXene)in Hydroxyapatite(HA)and Halloysite nanotube(HNT)hybrid coatings in biodegradable poly-(lactic acid)(PLA)was *** morphological and structural characterizations of the coatings on Mg were revealed through HRTEM,XPS,SEM-EDX,XRD,FTIR,and contact angle analyses/*** in vitro corrosion tests(OCP,PDS,and EIS-Nyquist)were conducted for evaluate corrosion resistance under simulated body fluid(SBF)*** bioactivity of the coatings in SBF have been revealed in accordance with the ISO 23,317 ***,antibacterial disk diffusion tests were conducted to investigate the functional effect of MXene in *** has been determined that the presence of MXene in the coating increased not only surface wettability(131°,85°,77°,and 74°for uncoated,pH,PHH,and PHH/MXene coatings,respectively)but also increased corrosion resistance(1857.850,42.357,1.593,and 0.085×10^(-6),A/cm^(2) for uncoated,pH,PHH,and PHH/MXene coatings,respectively).It has been proven that the in vitro bioactivity of PLA-HA coatings is further enhanced by adding HNT and MXene,along with SEM morphologies after ***,2D lamellar MXene-filled coating exhibits antibacterial behavior against both *** and *** bacteria.

关键词： Magnesium Pla coating Ti3c2tx mxene In-vitro bioactivity Disk diffusion