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Vitamin D and calcium signaling in epidermal stem cells and their regeneration

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World Journal of Stem Cells 2020年第7期12卷 604-611页

作者： yuko Oda Daniel D Bikle Department of Medicine University of California San FranciscoCA 94158United States Endocrine Research Veterans Affairs Medical Center San FranciscoCA 94158United States

Epidermal stem cells(SCs)residing in the skin play an essential role for epidermal regeneration during cutaneous wound *** injury,distinct epidermal SCs residing in the interfollicular epidermis and/or hair follicles are activated to ***,SCs and progeny migrate,differentiate and restore the *** review a role of the vitamin D signaling through its receptor of vitamin D receptor(Vdr)in these *** conditional knockout(cKO)mouse skin experiences a delay in wound re-epithelialization under low dietary calcium conditions,stimulating our efforts to examine a cooperative role of Vdr with calcium signaling through the calcium sensing receptor in the *** review the role of vitamin D and calcium signaling in different processes essential for injury induced epidermal regeneration during cutaneous wound ***,we discuss their roles in self-renewal of epidermal SCs through β-catenin ***,we describe epidermal remodeling,in which SCs and progeny migrate and differentiate to restore the epidermis,events controlled by the Ecadherin mediated adherens junction ***,we discuss the potential mechanisms for vitamin D and calcium signaling to regulate injury induced epidermal regeneration mutually and interdependently.

关键词： Vitamin D Calcium Stem cells Epidermis Regeneration Wound healing

Adsorption of urea,creatinine,and uric acid from three solution types using spherical activated carbon and its recyclability

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Chinese Journal of Chemical Engineering 2020年第12期28卷 2993-3001页

作者： Tomohito Kameda Kazuya Horikoshi Shogo Kumagai yuko Saito Toshiaki Yoshioka Graduate School of Environmental Studies Tohoku University6-6-07 AobaAramakiAoba-kuSendai 980-8579Japan

In this paper,we propose that the urinary toxins from the wastewater be adsorbed on an adsorbent such as spherical activated carbon and the latter be regenerated by subjecting it to high temperatures to recycle activated carbon and also to recycle the water used in *** studied the adsorption of artificial waste dialysate,which is a mixed solution of urea,creatinine,and uric acid,and the separate solutions for each of these and found that their extents of adsorption onto the spherical activated carbon material were nearly *** amount of adsorption was approximately 1.4 mg·g^−1 for urea,18 mg·g^−1 for creatinine,and 20 mg·g^−1 for uric *** urea,creatinine,and uric acid adsorbed onto the spherical activated carbon decomposed on heat treatment at 500℃,and the adsorption capacity of the spherical activated carbon was *** study successfully demonstrated that the spherical activated carbon can be recycled in the waste dialysate treatment process.

关键词： Adsorption Dialysate Spherical activated carbon Recycling

Effect of seismic retrofit of bridges on transportation networks

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Earthquake Engineering and Engineering Vibration 2003年第2期2卷 169-179页

作者： Masanobu Shinozuka yuko Murachi Michal J.Orlikowski Department of Civil and Environmental Engineering University of CaliforniaIrvineUSA Distinguished Professor and Chair Department of Civil and Environmental Engineering University of CaliforniaIrvineUSA Research Associate Department of Civil and Environmental Engineering Princeton UniversityUSA Undergraduate Student.

The objective of this research is to determine the effect earthquakes have on the performance of transportation network *** do this,bridge fragility curves,expressed as a function of peak ground acceleration(PGA)and peak ground velocity(PGV),were *** damage was evaluated under the 1994 Northridge earthquake and scenario earthquakes.A probabilistic model was developed to determine the effect of repair of bridge damage on the improvement of the network performance as days passed after the *** an example,the system performance degradation measured in terms of an index,'Drivers Delay,'is calculated for the Los Angeles area transportation system,and losses due to Drivers Delay with and without retrofit were estimated.

关键词： fragility curves seismic retrofit probabilistic model bridges transportation networks drivers delay performance index Northridge earthquake.

Molecular evidence for biochemical diversification of phenolamide biosynthesis in rice plants

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Journal of Integrative Plant Biology 2016年第11期58卷 903-913页

作者： Kimiaki Tanabe yuko Hojo Tomonori Shinya Ivan galis Institute of Plant Science and Resources Okayama University Kurashiki 710-0046 Japan

Two phenolamides （PAs）, p-coumaroylputrescine and feruloylputrescine strongly accumulate in rice （Oryza sativa cv. Nipponbare） leaves subjected to attack of chewing and sucking herbivores. Here we identified and characterized in vitro three novel rice genes that mediated coumaroyI-CoA/ feruloyI-CoA conjugation to polyamines, putrescine and agmatine. Interestingly, two genes were highly specific for their polyamine substrates, encoding putresdne N-hydrox- ycinnamoyltransferase and agmatine N-hydroxycinnamoyl- transferase, while the third enzyme could use both polyamines and it was therefore annotated as putrescine/ agmatine N-hydroxycinnamoyltransferase. All genes were preferentially expressed in rice roots and developing flowers, and in addition, the putrescine/agmatine N-hydroxycinnamoyl- transferase transcripts were strongly induced by wounding in the young rice leaves. Because the wound response of this gene was only partially suppressed in the jasmonoyI-L-isoleucine deficient plants （Osjarl）, it suggests that its upregulation （as well as inducible PAs in rice） may be largely independent of jasmonoyI-L-isoleucine signaling pathway. The finding of three closely related genes with a similar and/or overlapping activity in PA biosynthesis provides another striking example of rapid diversification of plant metabolism in response to environmental stresses in nature.

关键词： Acyltransferase p-coumaroylputrescine defense feruloylputrescine phenolamides rice (Oryza sativa)

Optimal Total Sleep Duration per Day to Maintain Health-Related Quality of Life in Male Collegiate Athletes:A Cross-Sectional Study

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Journal of Science in Sport and Exercise 2023年第4期5卷 360-368页

作者： yuko Morita Taeko Sasai-Sakuma Institute of Arts and Sciences Tokyo University of Science6-3-1NiijukuKatsushika-kuTokyo 125-8585Japan Department of Clinical Laboratory Science Faculty of Medical TechnologyTeikyo University2-11-1KagaItabashi-kuTokyo 173-8605Japan

Purpose This study investigated the optimal total sleep duration per day required by collegiate athletes to maintain the physical and mental health-related quality of life(HRQOL),compared with non-athlete *** In this cross-sectional study,a questionnaire survey was conducted to assess demographic variables,lifestyle and sleep habits,and HRQOL in 392 collegiate students(non-athletes,n=174;athletes,n=218).Physical component summary(PCS)and mental component summary(MCS)were assessed using the short-form-8 health *** with both good PCS and MCS were defined as having a good *** confirm an association between the total sleep duration per day and good HRQOL,logistic regression analyses were conducted in non-athlete students and collegiate athletes ***,receiver-operating curve(ROC)analyses were performed for the detection of the cut-off point of total sleep duration per day sufficient to maintain a good *** The average total sleep duration per day was 7 h 19 min for collegiate athletes,and 78.9%of them had a worse *** cut-off point of total sleep duration per day to maintain good HRQOL for collegiate athletes was 7.92 h(area under ROC,0.64;P=0.038;sensitivity,75.4%;specificity,57.9%),which was longer than 6.79 h for non-athlete *** Collegiate athletes required longer nocturnal sleep than non-athlete ***,their habitual nocturnal sleep duration was shorter compared to their optimal duration;around 70%of them faced chronic insufficient *** sleep habits and sleep education is important in maintaining their good health-related quality of life.

关键词： Athlete Sleep duration Health-related quality of life Insufficient sleep

Comparison of Effect of Brassinosteroid and Gibberellin Biosynthesis Inhibitors on Growth of Rice Seedlings

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Rice science 2016年第1期23卷 51-55页

作者： Tadashi MATUSMOTO Kazuhiro YAMADA yuko YOSHIZAWA Keimei OH Department of Biotechnology Akita Prefectural University

Brassinosteroid（BR） and gibberellin（GA） are two predominant plant hormones that regulate plant cell elongation. Mutants disrupt the biosynthesis of these hormones and display different degrees of dwarf phenotypes in rice. Although the role of each plant hormone in promoting the longitudinal growth of plants has been extensively studied using genetic methods, their relationship is still poorly understood. In this study, we used two specific inhibitors targeting BR and GA biosynthesis to investigate the roles of BR and GA in growth of rice seedlings. Yucaizol, a specific inhibitor of BR biosynthesis, and Trinexapac-ethyl, a commercially available inhibitor of GA biosynthesis, were used. The effect of Yucaizol on rice seedlings indicated that Yucaizol significantly retarded stem elongation. The IC_（50） value was found to be approximately 0.8 μmol/L. Yucaizol also induced small leaf angle phenocopy in rice seedlings, similarly to BR-deficient rice, while Trinexapac-ethyl did not. When Yucaizol combined with Trinexapac-ethyl was applied to the rice plants, the mixture of these two inhibitors retarded stem elongation of rice at lower doses. Our results suggest that the use of a BR biosynthesis inhibitor combined with a GA biosynthesis inhibitor may be useful in the development of new technologies for controlling rice plant height.

关键词： brassinosteroid gibberellin plant hormone plant growth regulator rice

Population structures and spatial patterns of two unpalatable Arisaema species(Araceae) with and without clonal reproduction in a riparian forest intensively grazed by Sika deer

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Journal of Forestry Research 2020年第1期31卷 155-162页

作者： Tetsuya K.Matsumoto Muneto Hirob Yasuaki Akaji yuko Miyazaki Graduate School of Environmental and Life Science Okayama UniversityTsushima-Naka 1-1-1Kita-kuOkayama 700-8530Japan Present Address:Center for Environmental Biology and Ecosystem Studies National Institute for Environmental StudiesOnogawa 16-2Tsukuba 305-8506Japan

General decline of understory cover can result from increased abundance of and foraging pressure by *** population size and degree of aggregation can increase for unpalatable understory plants that escape foraging *** reproduction can enable unpalatable plant species to increase their population sizes while trending toward spatially aggregated ***,the details of the relationship between clonal reproduction in unpalatable plants and their dynamics under intensive deer herbivory are not *** compared the population structures and spatial patterns of two coexisting unpalatable plant species,Arisaema ovale(with clonal reproduction)and ***(without clonal reproduction)in a riparian forest intensively grazed by Sika deer,and examined the null hypothesis that the extent of spatial aggregation and local population size would not differ between the clonal and non-clonal Arisaema *** a 0.36-ha plot,*** had a larger population size(1087 individuals)with a higher abundance ratio of small plants(p<0.01)than ***(84 individuals).Analyses of spatial point processes showed that both populations were spatially aggregated(p<0.05).The spatial aggregation of ***,however,became weaker than that of ***,when we excluded one dense patch originating from irregular seed *** results,excluding the aggregated distribution observed in ***,suggested a substantial contribution of clonal reproduction to the expansion of the local *** population following intensive grazing by Sika deer.

关键词： Arisaema ovale Arisaema peninsulae Deer herbivory Spatial pattern Unpalatable plant

Skeletal muscle generated from induced pluripotent stem cells-induction and application

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World Journal of Stem Cells 2017年第6期9卷 89-97页

作者： yuko Miyagoe-Suzuki Shin’ichi Takeda Department of Molecular Therapy National Institute of NeuroscienceNational Center of Neurology and PsychiatryKodairaTokyo 187-8502Japan

Human induced pluripotent stem cells(hiPS cells or hiPSCs) can be derived from cells of patients with severe muscle disease. If skeletal muscle induced from patientiPSCs shows disease-specific phenotypes, it can be useful for studying the disease pathogenesis and for drug development. On the other hand, human iPSCs from healthy donors or hereditary muscle diseaseiPSCs whose genomes are edited to express normal protein are expected to be a cell source for cell therapy. Several protocols for the derivation of skeletal muscle from human iPSCs have been reported to allow the development of efficient treatments for devastating muscle diseases. In 2017, the focus of research is shifting to another stage:(1) the establishment of mature myofibers that are suitable for study of the pathogenesis of muscle disease;(2) setting up a highthroughput drug screening system; and(3) the preparation of highly regenerative, non-oncogenic cells in large quantities for cell transplantation, etc.

关键词： Human induced pluripotent stem cells Skeletal muscle Transplantation Disease Modeling Muscle progenitors Muscular dystrophy MYOD

Fundamental studies on enhancement and blinking mechanism of surface-enhanced Raman scattering （SERS） and basic applications of SERS biological sensing

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Frontiers of physics 2014年第1期9卷 31-46页

作者： yuko S. Yamamoto Mitsuru Ishikawa Yukihiro Ozaki Tamitake Itoh Nano-Bioanalysis Research Group Health Research Institute National Institute of Advanced Industrial Science and Technology (AIST) Takamatsu Kagawa 761-0395 Japan Department of Chemistry Josai University Itado Saitama 350-0295 Japan Department of Chemistry School of Science and Technology Kwansei Gakuin University Sanda Hyogo 669-1337 Japan

We review recent our results in the fundamental study of surface-enhanced Raman scattering （SERS） with emphasis on experiments that attempted to identify the enhancement and blinking mechanism using single Ag nanoparticle dimers attached to dye molecules. These results are quantitatively discussed in the framework of electromagnetic mechanism. We also review recent our results in basic SERS applications for biological sensing regarding detections of cell surface molecules and distinction of disease marker molecules under single cell and single molecule level.

关键词： plasmonics surface-enhanced Raman scattering (SERS) surface-enhanced fluorescence,Ag nanoparticle