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Adrenocorticotropic hormone-secreting pancreatic neuroendocrine carcinoma with multiple organ infections and widespread thrombosis:A case report

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World Journal of Clinical Cases 2022年第17期10卷 5723-5731页

作者： Akihiro Yoshihara Kota Nishihama Chisa Inoue yuko okano Kazuhito Eguchi Soichiro Tanaka Kanako Maki Valeria Fridman D'Alessandro Atsuro Takeshita Taro Yasuma Mei Uemura Toshinari Suzuki Esteban C Gabazza Yutaka Yano Department of Diabetes and Endocrinology Japan Community Health care Organization Yokkaichi Hazu Medical CenterYokkaichi 510-0016MieJapan Department of Diabetes Metabolismand EndocrinologyMie UniversityTsu 514-8507MieJapan Department of Immunology Mie UniversityTsu 514-8507MieJapan Department of Immunology Faculty and Graduate School of MedicineMie UniversityTsu 514-8507MieJapan Department of Immunology and Department of Diabetes Metabolismand EndocrinologyMie UniversityTsu 514-8507MieJapan Department of Immunology Mie University School of MedicineMie UniversityTsu 514-8507MieJapan

BACKGROUND Ectopic adrenocorticotropic hormone(ACTH)-secreting neuroendocrine tumors are rare *** with ACTH-secreting pancreatic neuroendocrine carcinomas have a poor *** and coagulopathies have been reported as the cause of ***,detailed clinical descriptions of the morbid complications of ACTH-secreting neuroendocrine carcinomas have not been *** SUMMARY A 78-year-old Japanese woman consulted a medical center due to systemic edema and epigastric *** analysis revealed hypercortisolemia with increased ACTH secretion without diurnal variation in serum cortisol *** enhanced computed tomography(CT)scan revealed a 3-cm tumor in the pancreatic *** cytological material from endoscopic ultrasound-guided fine-needle aspiration was compatible with ACTHsecreting pancreatic neuroendocrine *** Ki-67 index was 40%.She was transferred to Mie University Hospital for surgical *** patient was diagnosed with urinary tract infection,cytomegalovirus hepatitis,esophageal candidiasis,pulmonary infiltrates suspicious for Pneumocystis carinii pneumonia,peripheral deep vein thrombosis,pulmonary embolism,and disseminated intravascular *** multiple organ infections and thromboses responded well to antimicrobial and anticoagulant *** studies disclosed a pancreatic tumor and a metastatic lesion in the liver,whereas somatostatin receptor scintigraphy showed negative findings,suggesting the primary and metastatic tumors were poorly differentiated.A CT scan before admission showed no metastatic liver lesion,suggesting that the pancreatic tumor was rapidly *** of surgery,antitumor chemotherapy was *** patient was transferred to another hospital to initiate ***,she died four months later due to the rapidly progressive *** ACTH-secreting pancreatic neuroendocrine neoplasm is a rare disease with a very poor ***

关键词： Neuroendocrine tumors Cushing's syndrome Ectopic adrenocorticotropic hormone syndrome Pneumocystis pneumonia Pulmonary embolism Infections Case report

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Sodium-glucose co-transporter-2 inhibitor-associated euglycemic diabetic ketoacidosis that prompted the diagnosis of fulminant type-1 diabetes:A case report

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World Journal of Clinical Cases 2021年第13期9卷 3163-3169页

作者： Taro Yasuma yuko okano Soichiro Tanaka Kota Nishihama Kazuhito Eguchi Chisa Inoue Kanako Maki Akihiro Uchida Mei Uemura Toshinari Suzuki Corina N D'Alessandro-Gabazza Esteban C Gabazza Yutaka Yano Department of Diabetes Metabolismand Endocrinology and ImmunologyMie UniversityTsu 514-8507Japan Department of Diabetes Metabolismand EndocrinologyMie UniversityTsu 514-8507Japan Department of Immunology Mie University School of MedicineMie UniversityTsu 514-8507Japan Department of Immunology Mie University Faculty and Graduate School of MedicineTsu 514-8507Japan Department of Diabetes Mie University Graduate School of MedicineTsu 514-8507Japan

Fulminant type 1 diabetes mellitus(FT1DM)is a subtype of type 1 diabetes mellitus characterized by an abrupt onset and a rapid and complete functional loss of isletβ*** is a very rare disease generally associated with ketoacidosis and the absence of circulating pancreatic islet-related *** ketoacidosis with normal blood glucose levels has been reported during sodiumglucose co-transporter 2(SGLT2)inhibitor *** SUMMARY The patient was a 43-year-old woman that consulted a medical practitioner for malaise,thirst,and *** analysis showed high blood glucose levels(428 mg/dL),a mild increase of hemoglobin A1c(6.6%),and increased ketone bodies in *** patient was diagnosed with type 2 diabetes *** patient was initially treated with insulin,which was subsequently changed to an oral SGLT2 *** to glutamic acid decarboxylase were *** days after receiving oral SGLT2 inhibitor,she consulted at Mie University Hospital,complaining of fatigue and *** analysis revealed diabetic ketoacidosis with almost normal blood glucose *** endogenous insulin secretion was markedly low,and the serum levels of islet-related autoantibodies were *** made the diagnosis of FT1DM with concurrent SGLT2 inhibitor-associated euglycemic diabetic *** patient's general condition improved after therapy with intravenous insulin and withdrawal of oral *** was discharged on day 14 with an indication of multiple daily insulin *** This patient is a rare case of FT1DM that developed SGLT2 inhibitor-associated diabetic ketoacidosis with almost normal blood glucose *** case report underscores the importance of considering the diagnosis of FT1DM in patients with negative circulating autoantibodies and a history of hyperglycemia that subsequently develop euglycemic diabetic ketoacidosis following treatment with a SGLT2 inhibitor.

关键词： Euglycemic diabetic ketoacidosis Sodium-glucose cotransporter 2 inhibitors Fulminant type 1 diabetes Case report

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Protective role of electrophile-reactive glutathione for DNA damage repair inhibitory effect of dibromoacetonitrile

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Journal of Environmental Sciences 2022年第7期34卷 305-314页

作者： Yukako Komaki Koki Suganuma yuko Ibuki Graduate Division of Nutritional and Environmental Sciences University of ShizuokaShizuoka 422-8526Japan

Dibromoacetonitrile(DBAN) is a disinfection byproduct(DBP) and linked with cancer in rodents, but the mechanism of its carcinogenicity has not been fully elucidated. We recently reported that DBAN induced inhibition of nucleotide excision repair(NER). In this study, we investigated if glutathione(GSH) is involved in the DBAN-induced inhibition of NER. Human keratinocytes Ha Ca T were pretreated with L-buthionine-(S,R)-sulfoximine(BSO) to deplete intracellular GSH. BSO treatment markedly potentiated the DBAN-induced NER inhibition as well as intracellular oxidation. The recruitment of NER proteins(transcription factor IIH, and xeroderma pigmentosum complementation group G) to DNA damage sites was inhibited by DBAN, which was further exacerbated by BSO treatment. Our results suggest that intracellular GSH protects cells from DBAN-induced genotoxicity including inhibition of DNA damage repair.

关键词： Disinfection byproducts Haloacetonitriles Pyrimidine dimers Glutathione DNA damage repair

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Robust Surface Reconstruction of Plant Leaves from 3D Point Clouds

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Plant Phenomics 2021年第1期3卷 28-42页

作者： Ryuhei Ando yuko Ozasa Wei Guo Graduate School of Science and Technology Keio UniversityJapan School of System Design and Technology Tokyo Denki UniversityJapan International Field Phenomics Research Laboratory Institute for Sustainable Agro-ecosystem ServicesGraduate School of Agricultural and Life SciencesThe University of TokyoTokyoJapan

The automation of plant phenotyping using 3D imaging techniques is ***,conventional methods for reconstructing the leaf surface from 3D point clouds have a trade-off between the accuracy of leaf surface reconstruction and the method’s robustness against noise and missing *** mitigate this trade-off,we developed a leaf surface reconstruction method that reduces the effects of noise and missing points while maintaining surface reconstruction accuracy by capturing two components of the leaf(the shape and distortion of that shape)separately using leaf-specific *** separation simplifies leaf surface reconstruction compared with conventional methods while increasing the robustness against noise and missing *** evaluate the proposed method,we reconstructed the leaf surfaces from 3D point clouds of leaves acquired from two crop species(soybean and sugar beet)and compared the results with those of conventional *** result showed that the proposed method robustly reconstructed the leaf surfaces,despite the noise and missing points for two different leaf *** evaluate the stability of the leaf surface reconstructions,we also calculated the leaf surface areas for 14 consecutive days of the target *** result derived from the proposed method showed less variation of values and fewer outliers compared with the conventional methods.

关键词： shape separation sugar

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Coordination of Legal Systems by the Recognition of Foreign Judgments-Rethinking Reciprocity in Sino-Japanese Relationships

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Frontiers of Law in China-Selected Publications from Chinese Universities 2019年第2期14卷 193-230页

作者： yuko Nishitani School of Law Heidelberg UniversityHeidelbergGermany International Private and Business Law Graduate School of LawKyoto UniversityKyoto 606-8501Japan

In the era of globalization,commercial transactions readily gain international dimensions and are increasingly *** a view to establishing effective dispute resolution mechanisms,it is desirable that judgments rendered in one state be recognized and enforced in other *** is especially important in East Asia,as cross-border business activities are rapidly expanding along with its economic *** paper aims to examine the recognition and enforcement of judgments in civil and commercial matters in East Asia with a focus on Sino-Japanese relationships,where the establishment of a reciprocal relationship has posed a considerable *** is worth considering how we can gradually pave the way towards the mutual recognition and enforcement of judgments to achieve coordination among legal systems.

关键词： recognition and enforcement of foreign judgments reciprocity East Asia China Korea Japan

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Could we remain simply applying discount rate to evaluate the life quality of our future generations?

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Chinese Journal of Population,Resources and Environment 2013年第2期11卷 168-173页

作者： yuko Arayama Graduate School of Economics Nagoya University

When we try to estimate future environmental costs resulting from our current economic activities,we usually calculate the present value of the consequences for our future generations by utilizing a discount rate as a standard economic *** popularity of this procedure is solely supported by its simplicity which assumes:(1)a perfect financial market over even 100 years,and(2)existence of a stable time preference between two consecutive periods for an individual *** apparent deficiency of this approach is that the present value of life quality of future generations varies to a large extent along an arbitrarily chosen discount *** a matter of fact,the discount rate,which could reflect the time preference as2%or 5%,matters when we predict current strategies of environmental protection for future *** applying a discount rate to evaluate the quality of our future generation,without clarifying the actual production mechanism behind this,is almost to the same as ignoring the fact that all of the goods are produced through an actual production process and that environmental degradation reduces the efficiency of that *** greatest concern for our future generations should not be given by an assumed discount rate,since the discount rate itself is determined by financial market conditions at certain points in time.

关键词： time preference discount rate negative externalities future generations

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Vitamin D and calcium signaling in epidermal stem cells and their regeneration

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World Journal of Stem Cells 2020年第7期12卷 604-611页

作者： yuko Oda Daniel D Bikle Department of Medicine University of California San FranciscoCA 94158United States Endocrine Research Veterans Affairs Medical Center San FranciscoCA 94158United States

Epidermal stem cells(SCs)residing in the skin play an essential role for epidermal regeneration during cutaneous wound *** injury,distinct epidermal SCs residing in the interfollicular epidermis and/or hair follicles are activated to ***,SCs and progeny migrate,differentiate and restore the *** review a role of the vitamin D signaling through its receptor of vitamin D receptor(Vdr)in these *** conditional knockout(cKO)mouse skin experiences a delay in wound re-epithelialization under low dietary calcium conditions,stimulating our efforts to examine a cooperative role of Vdr with calcium signaling through the calcium sensing receptor in the *** review the role of vitamin D and calcium signaling in different processes essential for injury induced epidermal regeneration during cutaneous wound ***,we discuss their roles in self-renewal of epidermal SCs through β-catenin ***,we describe epidermal remodeling,in which SCs and progeny migrate and differentiate to restore the epidermis,events controlled by the Ecadherin mediated adherens junction ***,we discuss the potential mechanisms for vitamin D and calcium signaling to regulate injury induced epidermal regeneration mutually and interdependently.

关键词： Vitamin D Calcium Stem cells Epidermis Regeneration Wound healing

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Adsorption of urea,creatinine,and uric acid from three solution types using spherical activated carbon and its recyclability

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Chinese Journal of Chemical Engineering 2020年第12期28卷 2993-3001页

作者： Tomohito Kameda Kazuya Horikoshi Shogo Kumagai yuko Saito Toshiaki Yoshioka Graduate School of Environmental Studies Tohoku University6-6-07 AobaAramakiAoba-kuSendai 980-8579Japan

In this paper,we propose that the urinary toxins from the wastewater be adsorbed on an adsorbent such as spherical activated carbon and the latter be regenerated by subjecting it to high temperatures to recycle activated carbon and also to recycle the water used in *** studied the adsorption of artificial waste dialysate,which is a mixed solution of urea,creatinine,and uric acid,and the separate solutions for each of these and found that their extents of adsorption onto the spherical activated carbon material were nearly *** amount of adsorption was approximately 1.4 mg·g^−1 for urea,18 mg·g^−1 for creatinine,and 20 mg·g^−1 for uric *** urea,creatinine,and uric acid adsorbed onto the spherical activated carbon decomposed on heat treatment at 500℃,and the adsorption capacity of the spherical activated carbon was *** study successfully demonstrated that the spherical activated carbon can be recycled in the waste dialysate treatment process.

关键词： Adsorption Dialysate Spherical activated carbon Recycling

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Effect of seismic retrofit of bridges on transportation networks

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Earthquake Engineering and Engineering Vibration 2003年第2期2卷 169-179页

作者： Masanobu Shinozuka yuko Murachi Michal J.Orlikowski Department of Civil and Environmental Engineering University of CaliforniaIrvineUSA Distinguished Professor and Chair Department of Civil and Environmental Engineering University of CaliforniaIrvineUSA Research Associate Department of Civil and Environmental Engineering Princeton UniversityUSA Undergraduate Student.

The objective of this research is to determine the effect earthquakes have on the performance of transportation network *** do this,bridge fragility curves,expressed as a function of peak ground acceleration(PGA)and peak ground velocity(PGV),were *** damage was evaluated under the 1994 Northridge earthquake and scenario earthquakes.A probabilistic model was developed to determine the effect of repair of bridge damage on the improvement of the network performance as days passed after the *** an example,the system performance degradation measured in terms of an index,'Drivers Delay,'is calculated for the Los Angeles area transportation system,and losses due to Drivers Delay with and without retrofit were estimated.

关键词： fragility curves seismic retrofit probabilistic model bridges transportation networks drivers delay performance index Northridge earthquake.

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Molecular evidence for biochemical diversification of phenolamide biosynthesis in rice plants

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Journal of Integrative Plant Biology 2016年第11期58卷 903-913页

作者： Kimiaki Tanabe yuko Hojo Tomonori Shinya Ivan galis Institute of Plant Science and Resources Okayama University Kurashiki 710-0046 Japan

Two phenolamides （PAs）, p-coumaroylputrescine and feruloylputrescine strongly accumulate in rice （Oryza sativa cv. Nipponbare） leaves subjected to attack of chewing and sucking herbivores. Here we identified and characterized in vitro three novel rice genes that mediated coumaroyI-CoA/ feruloyI-CoA conjugation to polyamines, putrescine and agmatine. Interestingly, two genes were highly specific for their polyamine substrates, encoding putresdne N-hydrox- ycinnamoyltransferase and agmatine N-hydroxycinnamoyl- transferase, while the third enzyme could use both polyamines and it was therefore annotated as putrescine/ agmatine N-hydroxycinnamoyltransferase. All genes were preferentially expressed in rice roots and developing flowers, and in addition, the putrescine/agmatine N-hydroxycinnamoyl- transferase transcripts were strongly induced by wounding in the young rice leaves. Because the wound response of this gene was only partially suppressed in the jasmonoyI-L-isoleucine deficient plants （Osjarl）, it suggests that its upregulation （as well as inducible PAs in rice） may be largely independent of jasmonoyI-L-isoleucine signaling pathway. The finding of three closely related genes with a similar and/or overlapping activity in PA biosynthesis provides another striking example of rapid diversification of plant metabolism in response to environmental stresses in nature.

关键词： Acyltransferase p-coumaroylputrescine defense feruloylputrescine phenolamides rice (Oryza sativa)

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