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Does Obesity without Hyperglycemia Delay Wound Healing in an Obese Mouse Model Induced by a High-Fat Diet?

Health 2017年第12期9卷 1660-1679页

作者： Tamae Urai Yukari Nakajima Kanae Mukai Kimi asano Mayumi Okuwa Junko Sugama Toshio Nakatani Advanced Health Care Science Research Unit Innovative Integrated Bio-Research Core Institute for Frontier Science Initiative Kanazawa University Ishikawa Japan Department of Clinical Nursing Graduate Course of Nursing Science Division of Health Sciences Graduate School of Medical Sciences Kanazawa University Ishikawa Japan Faculty of Health Sciences Institute of Medical Pharmaceutical and Health Sciences Kanazawa University Ishikawa Japan

It was unclear that wound healing was delayed in obesity without hyperglycemia. The purpose of this study was to compare the wound healing process between obese and non-obese mice without hyperglycemia by attaching a splint. Three-week-old male mice (C57BL/6N) were fed high-fat diets (60% of calories from fat) in the obesity group, and commercial diets in the control group for 15 weeks. Two circular (4 mm in diameter) full-thickness wounds were made on the dorsal skin. Body weights and serum leptin levels were significantly higher in the obesity group than in the control group until day 15 after wounding. Fasting blood glucose levels before wounding were lower in the obesity group than in a hyperglycemic rodent model. The macrophage infiltration into subcutaneous fat before wounding in the obesity group was negligible. The ratios of the wound area were not significantly different between the two groups. No significant differences were observed in the number of neutrophils or macrophages or new blood vessels and ratio of myofibroblasts or collagen fibers between the two groups. Our results demonstrated that cutaneous wound healing was not delayed in the obesity group without hyperglycemia and macrophage infiltration into the subcutaneous fat and with high serum leptin levels.

关键词： Obesity Mouse Cutaneous Wound Healing Splint Inflammation

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Analysis on the mechanism of the nucleocytoplasmic movement of CRM1, a leucine-rich NES receptor.

Analysis on the mechanism of the nucleocytoplasmic movement ...

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Third Congress of the Asian-Pacific Organization for Cell Biology

作者： Makoto Fukuda Shiro asano Nobuaki Kudo Minoru Yoshida Eisuke Nishida Dept. Biophys. Grad. Sch. of ScienceKyoto Univ.Sakyo-kuKyoto 606Japan Dept. of Biotec. Grad. Sch. of Agriculture and Life ScienceUniv. of TokyoBunkyo-kuTokyo 113Japan

The discovery of nuclear export signals (NESs) in a number of proteins revealed the signal-dependent transport of proteins from the nucleus to the cytoplasm. It has recently been revealed

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重组G—csF在骨髓移植中的应用

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山西白血病 1992年第4期1卷 236-237页

作者： S asano 王波

骨髓移植后主要的问题是化疗副作用、持续的移植物抗宿主病和排斥反应以及由于恶性细胞清除不彻底所致的复发。重组的人G-csF(RHG-CSF)可能具有改善这些问题的潜在应用价值。

关键词： G-csF 骨髓移植重组移植物抗宿主病化疗副作用恶性细胞排斥反应应用价值移植后

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AOD转炉用新风口砖的研制

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国外耐火材料 1992年第7期17卷 41-45页

作者： asano,S 吕峻

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The Relationship between Cutaneous Wounds Made on Obese Mice or Those with Decreased Body Weight and Serum Leptin Level

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Health 2016年第11期8卷 1015-1028页

作者： Tamae Urai Haryanto Kanae Mukai Tatsuhiko Matsushita Kimi asano Yukari Nakajima Mayumi Okuwa Junko Sugama Toshio Nakatani Department of Clinical Nursing Graduate Course of Nursing Science Division of Health Sciences Graduate School of Medical Sciences Kanazawa University Kanazawa Japan Faculty of Health Sciences Institute of Medical Pharmaceutical and Health Sciences Kanazawa University Kan-azawa Japan Division of Clinical Radiology Service Kyoto University Hospital Kyoto Japan Wellness Promotion Science Center Institute of Medical Pharmaceutical and Health Sciences Kanazawa Uni-versity Kanazawa Japan

Purpose: Not all obese people have hyperglycemia. We wondered about the healing progress in obese people without hyperglycemia. The purpose of this study is to observe the cutaneous wound healing process. Methods: Three-week-old male mice were fed high-fat diets (containing 60% fat) in the diet group, and commercial diets in the control group, ad libitum for 15 weeks. Circle-full-thickness cutaneous wounds were made on the dorsal skin of mice. From day 0 to day 15 after wounding, we analyzed wound healing process. We measured the blood concentration of leptin, and observed the distribution of leptin-positive cells in each wound. Results: Mean body weight, the areas of subcutaneous fat and visceral fat, and the weight of epididymal fat in the diet group were significantly greater than those in the control group at 15 weeks after feeding. The diet group did not feed on the diet after wounding;their body weight decreased remarkably to the level of the control group. The ratio of wound area, re-epithelialization, and collagen fibers did not differ between the diet and control groups on each day. The blood concentration of leptin in the diet group was significantly greater than that in the control group before wounding and until day 6 after wounding (day 0, 10 hour and day 1: p < 0.01, day 6: p < 0.05). Conclusion: The results show that the wound healing process is similar between obese and non-obese mice, and that the decrease in the leptin level in the obese mouse to that in the non-obese mouse may depend on the decrease of body weight of obese mouse.

关键词： Obesity High-Fat Diet Wound Healing Leptin Tension

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Rainfall and Runoff Observations in the Subtropical Forest of Okinawa Island, Japan

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Journal of Water Resource and Protection 2014年第6期6卷 625-634页

作者： Naoki Kabeya Akira Shimizu Takanori Shimizu Hitoshi Ikuzawa Takuya Arakaki Hiroshi Furugen Yashuhiro Ohnuki Shiho asano Forestry and Forest Products Research Institute Tsukuba Japan Incorporated Okinawa Prefecture Environment Science Centre Urazoe Japan Kyushu Research Centre Forestry and Forest Products Research Institute Kumamoto Japan Okinawa Prefecture Forest Resource Research Centre Nago Japan

We set up two experimental catchments to provide an improved understanding of hydrological processes in a subtropical forested area in the northern part of Okinawa Island, Japan. We calculated runoff using water level data (recorded by a pressure-type water level gauge installed in a box culvert) and a discharge rating curve (derived from in situ observations). Water balance calculations for 2010 showed that the rainfall, runoff and evapotranspiration losses (= rainfall – runoff) were 3403.6 mm, 2285.7 mm and 1117.4 mm, respectively. This result was in agreement with previous results from other forested experimental catchments in this region. Direct runoff, as a proportion of event total rainfall, can be expressed by the empirical equation (Qdirect = 0.0048, Pevent 1.7971, R2 = 0.9599). When Pevent was 100 mm or less, the ratios of Qdirect to Pevent were less than 15% in general. When Pevent exceeded 100 mm, the ratios were 20% - 30%.

关键词： Direct Runoff Forested Watershed Okinawa Island Rainfall-Runoff Observation Sub-Tropical Forest Water Balance

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A novel visual test for hydrogen sulfide on the tongue dorsum

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Open Journal of Stomatology 2012年第4期2卷 314-321页

作者： Takashi Kanehira Hirohisa Hongo Junji Takehara Kozo asano Kazumi Osada Hiroshi Izumi Yoshihiro Fujii Wataru Sakamoto Applied Microbiology Applied Bioscience Graduate School of Agricul-ture Hokkaido University Sapporo Japan Department of Physiology School of Dentistry Health Sciences University of Hokkaido Ishikari-Tobetsu Japan Division of Preventive Dentistry Graduate School of Dental Medicine Hokkaido University Sapporo Japan Institute of QOL Fuji Women’s University Ishikari Japan

Objective: The purpose of this study was to develop a novel colorimetric system for direct detection of hydrogen sulfide on the tongue dorsum from subjects with complaints of halitosis. Method: An assay system comprised of a cotton swab impregnated with zinc sulfate, attached chromatography paper, stabilizing solution, and coloring reagents for the methylene blue technique was developed. Using this system we investigated on the visualization of the hydrogen sulfide on the solid phase and possibility for evaluating the origin of oral malodor on the tongue dorsum. Results: The assay system made possible visualization of a linear curve ranging from 5.3 ng to 85 ng of hydrogen sulfide, with low reagent consumption and miniaturization. However, the sensitivity was different for gaseous and fluid samples. The biofilm of the tongue dorsum from subjects with complaints of halitosis showed different shades of methylene blue depending on the concentration of hydrogen sulfide. A positive correlation was found between hydrogen sulfide on the tongue dorsum and the concentration of VSC hydrogen sulfide in mouth breath as measured using an Oral Chroma semiconductor gas sensor. Conclusion: The results of this study suggest that the novel assay system can be used as a visual warning sensor for halitosis by measuring hydrogen sulfide on the tongue dorsum.

关键词： Halitosis Tongue dorsum VSC Hydrogen Sulfide Methylene Blue

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日本：提高化纤产品测试标准化 003

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中国纺织报

作者： Toshio asano

2014年，日本纺织生产指数较2013年下滑1%。从上下游产业情况看，化纤市场维持不变，面料市场稳定，服饰及纺纱市场低迷。2014年，日本纺织产业出口值为88亿美元，同比减少1%；进口值为403亿美元，同比减少6%，贸易逆差创下新纪录达到31...

2014年，日本纺织生产指数较2013年下滑1%。从上下游产业情况看，化纤市场维持不变，面料市场稳定，服饰及纺纱市场低迷。2014年，日本纺织产业出口值为88亿美元，同比减少1%；进口值为403亿美元，同比减少6%，贸易逆差创下新纪录达到315亿美元。非服饰领域纤维消费量约?

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Role of circulating tumor cell clusters in patients with metastatic hormone-sensitive prostate cancer receiving a gonadotropin-releasing hormone antagonist: A pilot study

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Asian Journal of Urology 2023年第2期10卷 210-212页

作者： Yuki Kohada Hiroki Kusumoto Takashi Kukimoto Jotaro Mikami Jun Ito Katsutoshi asano Toru Yaegashi Kanichi Nakagawara Jun Teishima Yasuhiro Kaiho Nobuyuki Hinata Yasuhiro Nakamura Makoto Sato Division of Urology Faculty of MedicineTohoku Medical and Pharmaceutical UniversitySendaiJapan Department of Urology Hiroshima University Graduate School of Biomedical SciencesHiroshimaJapan Nihon Gene Research Laboratories Inc SendaiJapan Division of Pathology Faculty of MedicineTohoku Medical and Pharmaceutical UniversitySendaiJapan

Dear Editor,Prostate cancer is the most common cancer among men[1].Androgen deprivation therapy(ADT)has remained the primary treatment of metastatic-hormone-sensitive prostate cancer(mHSPC),providing a temporary disease control in the majority of *** initial ADT response,castration-resistance prostate cancer(CRPC)still *** study have attempted to determine possible biomarkers for poor prognosis in patients with CRPC[2].

关键词： patients metastatic cancer

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新日铁火焰喷补炉衬技术

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钢铁工艺 1991年第2期 28-31页

作者： asano.,K 吕鹏

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