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Behavioral assessment of hippocampal function following dietary intervention

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Food Science and Human Wellness 2018年第3期7卷 229-233页

作者： Klaus W.Lange Ewelina Stollberg yukiko Nakamura Joachim Hauser Department of Experimental Psychology University of Regensburg93040 RegensburgGermany

Pattern separation keeps items distinct in memory and is mediated by the hippocampus.A relationship between hippocampal function and diet quality has been suggested by findings in both humans and *** the present study,rats were fed over seven generations a diet containing increased amounts of sugar and saturated fatty acids,reduced levels of polyunsaturated fatty acids and an increased ratio of omega-6/omega-3 fatty acids(“Western”diet).Spatial pattern separation(or local discrimination)performance of these animals was compared with that of rats fed a standard diet.A separation-dependent difference between the standard and Western diet groups was found in the number of discriminations performed in the pattern separation task,with rats of the“Western”group performing fewer *** present results suggest that behavioral assessment of spatial pattern separation can detect effects of dietary interventions in rats and that pattern separation can be impaired by transgenerational administration of a“Western”*** studies should determine which components of this diet induce the memory impairments related to the *** translational relevance of these findings in regard to mental disorders such as dementia and depression needs to be investigated.

关键词： Memory Hippocampus Western diet Fatty acids Sugar

Emphysematous cholecystitis with massive gas in the abdominal cavity

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World Journal of Gastroenterology 2013年第4期19卷 604-606页

作者： Hiroyuki Miyahara Dai Shida Hiroki Matsunaga yukiko Takahama Sachio Miyamoto Department of Surgery Tokyo Metropolitan Bokutoh Hospital Colorectal Surgery Division National Cancer Center Hospital

Emphysematous cholecystitis is a rare variant of acute cholecystitis with a high mortality *** combination of emphysematous cholecystitis and pneumoperitoneum is also *** herein describe a case of emphysematous cholecystitis with massive gas in the abdominal cavity.A 77-year-old male presented with epigastric pain and lassitude lasting for one week.A computed tomography scan demonstrated massive gas in the abdominal *** was also detectable inside the *** ascites as well as a pleural effusion were also *** the diagnosis of perforation of the digestive tract,we performed emergency *** our expectations,the perforation site was not in the alimentary tract,but rather in the *** then diagnosed the patient with emphysematous cholecystitis with perforation,and performed cholecystectomy.A pathological examination of the resected gallbladder revealed necrosis in the mucosa and thinning of the *** of the ascites detected Clostridium perfringens,a gas-producing microorganism.

关键词： Emphysematous cholecystitis Pneumoperitoneum Clostridium perfringens

A case of nodular posterior scleritis simulating intraocular tumor

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International Journal of Ophthalmology(English edition) 2019年第4期12卷 685-688页

作者： yukiko Shibata Satoru Kase Kenichi Namba Susumu Ishida Department of Ophthalmology Social Medical Corporation Tokeidai Memorial Hospital Department of Ophthalmology Faculty of Medicine and Graduate School of Medicine Hokkaido University

Dear Editor,I am Dr. yukiko Shibata, from the Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University. I write to present the case of posterior scleritis simulating intrao... 详细信息

关键词： nodular posterior scleritis intraocular tumor

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Tea and depression

Food Science and Human Wellness 2022年第3期11卷 476-482页

作者： Klaus W.Lange yukiko Nakamura Katharina M.Lange Hui Zhao Department of Experimental Psychology University of RegensburgRegensburg 93040Germany Tianjin Key Laboratory of Food and Biotechnology University of CommerceTianjin 300134China

The available evidence,which derives from studies investigating mechanistic effects of tea,research on animal models as well as epidemiological studies and intervention trials in humans,suggests that compounds contained in tea may have the potential to aid in the prevention of depression or in its treatment as an addition to established therapies.A wide range of potentially antidepressive biological activities of tea components have been ***,the mechanisms of tea phytochemicals possibly capable of decreasing the risk of depressive symptoms are complex,multifaceted and not well *** pharmacological effects on circumscribed neurobiological systems may be produced not by individual tea components but rather by the synergistic action of various compounds on multiple pathophysiological mechanisms involved in *** epidemiological studies have generally demonstrated beneficial effects of tea consumption on mood and depressive symptoms,cross-sectional studies are unable to prove a cause-effect *** positive effects on mood could be firmly established,tea drinking could support mental ***,the moderate antidepressive effects observed in healthy people are not necessarily indicative of possible clinical effects in major depressive *** controlled intervention studies are needed to establish a causal relationship between bioactive compounds in tea and depression.

关键词： Depression Tea L-theanine Prevention Treatment

Gastric cancer mortality related to direct radiographic and endoscopic screening:A retrospective study

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World Journal of Gastroenterology 2021年第33期27卷 5595-5609页

作者： Hiroaki Hagiwara Fumitaka Moki yukiko Yamashita Kazuki Saji Keigo Iesaki Hiromitsu Suda Department of Internal Medicine Hagiwara ClinicMaebashi 379-2106GunmaJapan Maebashi Medical Association Maebashi 371-0035GunmaJapan Gunma Health Foundation Maebashi 371-0005GunmaJapan Department of Internal Medicine and Surgery Yamashita ClinicMaebashi 371-0016GunmaJapan Department of Internal Medicine Saji ClinicMaebashi 371-0133GunmaJapan Department of Internal Medicine Iesaki ClinicMaebashi 371-0805GunmaJapan Department of Pediatrics Suda Kids ClinicMaebashi 371-0813GunmaJapan

BACKGROUND Despite its decreased incidence in Japan,gastric cancer continues among the leading causes of cancer-related deaths in both men and ***,efforts are still required to lower the mortality rate of gastric cancer in *** City introduced endoscopic gastric cancer screening in 2004,and participants are able to choose between direct radiography and ***,we expected to see a decrease in mortality rate from gastric cancer after introducing endoscopic screening and a difference in mortality rate reduction between screening *** To evaluate the impact on gastric cancer mortality rate of two types of gastric cancer screening in Maebashi City,*** Participants aged 40 to 79 years of the Maebashi City gastric cancer screening program in 2006 who were screened by direct radiography(n=11155)or endoscopy(n=10747)were *** were followed until March 31,2012,by cross-referencing their data against the Gunma Prefecture cancer registry *** compared the detection rate of gastric ***,we compared the mortality rate between the two *** Cox proportional hazards model was used to estimate the hazard ratio(HR)of gastric cancer ***,the reduction in gastric cancer mortality rate associated with each screening method was *** Gastric cancer was detected in 22 participants undergoing direct radiography(detection rate,0.20%)and in 52 participants undergoing endoscopy(detection rate,0.48%).However,most gastric cancers detected by endoscopic screening were early cancers that may not have resulted in *** found no significant difference in gastric cancer mortality rate between participants receiving annual screening and those who do *** the number of gastric cancer deaths in the direct radiography group was set as 1 in the Cox proportional hazard analysis,the HR of gastric cancer death was 1.368(95%CI:0.7308-2.562)in the overall group of *** results showed no s

关键词： Gastric cancer Radiography Endoscopy Population-based cancer screening Mortality reduction

Cisplatin-induced activation of TGF-βsignaling contributes to drug resistance

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Oncology Research 2024年第1期32卷 139-150页

作者： SAYAKA IMATSUJI yukiko UJIE HIROYUKI ODAKE MASAYA IMOTO SUSUMU ITOH ETSU TASHIRO Department of Biosciences and Informatics Faculty of Science and TechnologyKeio UniversityYokohama223-8522Japan Department of Neurology Juntendo University Graduate School of MedicineTokyo113-8421Japan Laboratory of Biochemistry Showa Pharmaceutical UniversityTokyo194-8543Japan

Growing evidence suggests an association between epithelial-mesenchymal transition(EMT),a hallmark of tumor malignancy,and chemoresistance to a number of anti-cancer ***,the mechanism of EMT induction in the process of acquiring anti-cancer drug resistance remains *** address this issue,we obtained a number of cisplatin-resistant clones from LoVo cells and found that almost all of them lost cell-cell *** these clones,the epithelial marker E-cadherin was downregulated,whereas the mesenchymal marker N-cadherin was ***,the expression of EMT-related transcription factors,including Slug,was *** the other hand,the upregulation of other mesenchymal marker Vimentin was weak,suggesting that the mesenchymal-like phenotypic changes occurred in these cisplatin-resistant *** mesenchymal-like features of cisplatin-resistant clones were partially reversed to parental epithelial-like features by treatment with transforming growth factor-β(TGF-β)receptor kinase inhibitors,indicating that TGF-βsignaling is involved in cisplatin-induced the mesenchymallike phenotypic ***,cisplatin was observed to enhance the secretion of TGF-βinto the culture media without influencing TGF-βgene *** results suggest that cisplatin may induce the mesenchymal-like phenotypic changes by enhancing TGF-βsecretion,ultimately resulting in drug resistance.

关键词： Cisplatin EMT Chemo-resistance TGF-β

Diet and food in attention-deficit hyperactivity disorder

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Journal of Future Foods 2022年第2期2卷 112-118页

作者： Klaus W.Lange yukiko Nakamura Andreas Reissmann Department of Experimental Psychology University of RegensburgRegensburg 93040Germany

Deficiencies of nutrients,including vitamins,minerals and polyunsaturated fatty acids,and surpluses of food items,such as sucrose and artificial food additives,have not convincingly been shown to be involved in the etiology of *** group level,there is no conclusive evidence supporting dietary interventions for the treatment of *** identification of a role of food compounds in ADHD is hindered by the complex and ill-defined nature of *** view of the heterogeneity of the disorder,potential therapeutic benefits of nutritional interventions could be confined to subpopulations of children with ADHD as yet *** cumulative benefits of the range of ingredients comprising healthy diets may result in better outcomes compared to a supplementation of individual *** and nutrition interact with other lifestyle factors,such as physical activity,and the interrelationship between nutrition and lifestyle should play a more prominent role in research on treatment approaches to *** few-foods or oligoallergenic diet allows the design of individually tailored diets and may offer treatment opportunities in subgroups of children diagnosed with *** research is required to demonstrate the utility of nutrition-related interventions alone or in combination with other treatment approaches in ADHD.

关键词： Attention-deficit hyperactivity disorder Dietary patterns Food Nutrition Oligoallergenic diet

The Relationship of Occupational Health Nurses’ Experiences with Associated Departments in Relation to Project Development of Mental Health Care for Primary Preventive Treatment

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Open Journal of Nursing 2023年第11期13卷 786-799页

作者： yukiko Mochizuki Department of Public Health Nursing Faculty of Nursing Toho University Tokyo Japan

Purpose: The purpose of this study was to clarify the relationship and experiences of occupational health nurses (OHNs) and related departments in project development of mental health care for primary treatment in the Japanese occupational health setting. Method: A total of 235 OHNs who are members of the Japan Academy of Occupational Health Nursing were sent an anonymous self-administered questionnaire survey. The questionnaire included items on the following: the OHN’s background, whether the OHN had experience in project development, the communication between the associated departments, the Japanese version of the Work Engagement Scale (UWES-J), occupational assessments, workplace assessments, and the Transtheoretical Model (TTM) for health promotion in companies and the OHN’s working environment. We performed logistic regression analysis to examine the relationship between experience and these harmonious relationships with other associated departments. Result: Responses from 61 OHNs (valid response rate: 25.9%) were analyzed. The mean number of years of service as an OHN was 18.9, and 82% of respondents had experience in project development. The logistic analysis further revealed that OHNs who had experience in project development of mental health care usually had a harmonious relationship with other associated departments. Conclusion: To promote mental health care for workers, OHNs have the capability to create individual and workplace assessments, enhance their work engagement, and make further improvements to their working environment. .

关键词： Occupational Health Mental Health Care Experience in Project Development of Mental Health Care Occupational Health Nurses

Sport and physical exercise in sustainable mental health care of common mental disorders:Lessons from the COVID-19 pandemic

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Sports Medicine and Health Science 2023年第2期5卷 151-155页

作者： Klaus W.Lange yukiko Nakamura Andreas Reissmann Faculty of Human Sciences(Psychology Education and Sport Science)University of RegensburgRegensburgBavariaGermany

The large-scale disruptions to physical activity during the coronavirus pandemic have been found to be a leading predictor of common mental *** addition,regular physical exercise has been found to alleviate anxiety,sadness and depression during the *** findings,together with numerous studies published before the pandemic on the effects of physical activity on mental health,should be considered in the provision of mental health care following the ***-sectional research has revealed that all types of exercise and sport are associated with a reduced mental health ***,the effectiveness of exercise and sport participation in sustainable mental health care as well as the causal relationship between exercise,psychosocial health and common mental disorders merit further *** activity and sport,with their global accessibility,significant and clinically meaningful efficacy as well as virtual absence of adverse effects,offer a promising option for the promotion of mental health,including the prevention and treatment of common mental *** exercise and sport are likely to become valuable public mental health resources in the future.

关键词： Anxiety Depression Mental health Physical exercise COVID-19