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Ferruginol alleviates inflammation in dextran sulfate sodium-induced colitis in mice through inhibiting COX-2, MMP-9 and NF-κB signaling

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Asian Pacific Journal of Tropical Biomedicine 2020年第7期10卷 308-315页

作者： Xiao-Yan Zhu Chun-ling Zhang yukiat lin Min-Yan Dang Department of Gastroenterology Jinan Central Hospital Affiliated to Shandong UniversityJinan250013Shandong ProvinceChina Department of Emergency Taian City Central HospitalTaian271000Shandong ProvinceChina Innoscience Research Sdn Bhd Subang Jaya47650SelangorMalaysia

Objective:To assess the anti-inflammatory efficacy of ferruginol on dextran sulfate sodium(DSS)stimulated ulcerative colitis ***:Ulcerative colitis was induced in C57 BL/6 J mice by administering 2%of DSS through drinking water for 7 *** mice in the treatment group were treated with DAA+50 mg/kg/day ferruginol *** the positive control group,sulfasalazine(50 mg/kg/day)was used alongside with *** induction,the bodyweight,character of stool and feces occult blood were recorded daily,the disease activity index was calculated,and the colon length,colon weight,and spleen weight were *** myeloperoxidase activity was assayed by ***(IL)-6,IL-1β,and tumor necrosis factor-αwere determined by ELISA method,and nuclear factor-κB,cyclooxygenase-2,matrix metalloproteinases-9,and inducible nitric oxide synthase by Western blotting ***:Ferruginol significantly increased the bodyweight,colon weight,colon length,and decreased disease activity index and spleen *** exhibited anti-inflammatory activity against DSS induced ulcerative colitis in mice by reducing the activities of myeloperoxidase,tumor necrosis factor-α,nuclear factor-κB,IL-1β,cyclooxygenase-2,matrix metalloproteinases-9,IL-6,and inducible nitric oxide ***:Ferruginol could be used to treat ulcerative colitis by attenuating the inflammation in colon cells and maintaining colonic mucosal barrier integrity.

关键词： Ferruginol Dextran sulfate sodium Inflammation Sulfasalazine Ucerative colitis

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