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Regulation of Vascular Development by CLE Peptide-receptor Systems

Journal of Integrative Plant Biology 2010年第1期52卷 8-16页

作者： Yuki hirakawa yuki Kondo Hiroo Fukuda Department of Biological Sciences Graduate School of ScienceThe University of Tokyo

Cell division and differentiation of stem cells are controlled by non- cell-autonomous signals in higher organisms. The plant vascular meristem is a stem-cell tissue comprising procambial cells that produce xylem cells on one side and phloem cells on the other side. Recent studies have revealed that TDIF （tracheary element differentiation inhibitory factor）/CLE41/CLE44 peptide signal controls the procambial cell fate in a non-cell-autonomous manner. TDIF produced in and secreted from phloem cells is perceived by TDR/PXY, a leucine-rich repeat receptor kinase located in the plasma membrane of procambial cells. This signal suppresses xylem cell differentiation of procambial cells and promotes their proliferation. In addition to TDIF, some other CLE peptides play roles in vascular development. Here, we summarize recent advances in CLE signaling governing vascular development.

关键词： TDIF Regulation of Vascular Development by CLE Peptide-receptor Systems

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Arterial steroid injection therapy can inhibit the progression of severe acute hepatic failure toward fulminant liver failure

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World Journal of Gastroenterology 2006年第41期12卷 6678-6682页

作者： Kazuhiro Kotoh Munechika Enjoji Makoto Nakamuta Tsuyoshi Yoshimoto Motoyuki Kohjima Shusuke Morizono Shinsaku Yamashita yuki Horikawa Kengo Yoshimitsu Tsuyoshi Tajima Yoshiki Asayama Kousei Ishigami Masakazu hirakawa Department of Medicine and Bioregulatory Science Graduate School of Medical Science Kyushu University3-1-1 MaidashiHigashi-kuFukuoka 812-8582Japan Department of Clinical Radiology Graduate School of Medical ScienceKyushu University3-1-1 MaidashiHigashi-kuFukuoka 812-8582Japan

AIM: To utilize transcatheter arterial steroid injection therapy (TASIT) via the hepatic artery to reduce hepatic macrophage activity in patients with severe acute hepatic failure.METHODS: Thirty-four patients with severe acute hepatic failure were admitted to our hospital between June 2002 to June 2006 providing for the possibility of liver transplantation (LT). Seventeen patients were treated using traditional liver supportive procedures, and the other 17 patients additionally underwent TASIT with 1000 mg methylprednisolone per day for 3 continuous days. RESULTS: Of the 17 patients who received TASIT, 13 were cured without any complications, 2 died, and 2 underwent LT. Of the 17 patients who did not receive TASIT, 4 were self-limiting, 7 died, and 6 underwent LT. Univariate logistic analysis revealed that ascites, serum albumin, prothrombin time, platelet count, and TASIT were significant variables for predicating the prognosis. Multivariate logistic regression analysis using stepwise variable selection showed that prothrombin time, platelet count, and TASIT were independent predictive factors. CONCLUSION: TASIT might effectively prevent the progression of severe acute hepatic failure to a fatal stage of fulminant liver failure.

关键词：动脉疾病病理治疗临床肝疾病

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