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Association of ITPA polymorphism with outcomes of peginterferon-α plus ribavirin combination therapy

World Journal of Gastrointestinal Pharmacology and Therapeutics 2013年第3期4卷 54-60页

作者： Tatsuya Fujino Yoko Aoyagi Mariko Takahashi Ryoko Yada Naoko Yamamoto yuki ohishi Akihiko Nishiura Motoyuki Kohjima Tsuyoshi Yoshimoto Kunitaka Fukuizumi Manabu Nakashima Masaki Kato Kazuhiro Kotoh Makoto Nakamuta Munechika Enjoji Laboratory for Clinical Investigation National Hospital Organization Nagasaki Medical CenterOhmuraNagasaki 856-8562Japan Clinical Research Institute National Hospital Organization Kyushu Medical CenterFukuoka 814-0180Japan Faculty of Pharmaceutical Sciences Fukuoka UniversityFukuoka 814-0180Japan Department of Medicine and Bioregulatory Science Graduate School of Medical SciencesKyushu UniversityFukuoka 814-0180Japan

AIM:To analyzed the association between inosine triphosphatase(ITPA)(rs1127354) genotypes and sustained virological response(SVR) rates in peginterferon(Peg-IFN)α + ribavirin(RBV) ***:Patients who underwent Peg-IFNα + RBV combination therapy were enrolled(n = 120) and they had no history of other IFN-based *** in hemoglobin levels during therapy,cumulative reduction of RBV dose,frequency of treatment withdrawal,and SVR rates were investigated in each ITPA ***:In patients with ITPA CC genotype,hemoglobin decline was significantly greater and the percentage of patients in whom total RBV dose was < 60% of standard and/or treatment was withdrawn was significantly higher compared with CA/AA ***,SVR rates were equivalent between CC and CA/AA genotypes,and within a subset of patients with Interleukin 28B(IL28B)(rs8099917) TT genotype,SVR rates tended to be higher in patients with ITPA CC genotype,although the difference was not ***:ITPA CC genotype was a disadvantageous factor for Peg-IFNα + RBV treatment in relation to completion rates and RBV ***,CC genotype was not inferior to CA/AA genotype for SVR *** full-length treatment is accomplished,it is plausible that more SVR is achieved in patients with ITPA CC variant,especially in a background of IL28B TT genotype.

关键词： Chronic hepatitis C Interleukin 28B Inosine triphosphatase Peginterferon Ribavirin

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