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取代的氨基甲酰胺甲基氨基醋酸衍生物作为独特的NEP抑制剂

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乙醛醋酸化工 2014年第4期 53-53页

作者： Iwaki yuki

本发明提供了分子式Ⅰ的化合物;或者它的药物可接受的盐,式中R1,R2,R3,R4,R6,A1,A2,X1,s和m是确定的。本发明还涉及到制造发明化合物的方法和它的治疗用途。本发明还提供了药物活性剂和药物配方。

关键词：药物配方甲酰胺 NEP 酸衍生物

Design and Construction of a Low-Force Stylus Probe for On-machlne Tool Cutting Edge measurement

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Nanomanufacturing and metrology 2020年第4期3卷 282-291页

作者： Hiraku matsukuma Bo Wen Shinichi Osawa Sho Sekine yuki Shimizu Wei Gao Department of Finemechanics Graduate School of EngineeringTohoku UniversitySendaiJapan

A new on-machine profiler employing a cantilever beam was proposed and developed to measure the sharp micro-cutting edges of precision cutting tools with low measuring force of 0.1 *** proposed profiler consists of a probe unit and a positioning *** probe unit employs a stylus mounted on the free end of a hollow triangular cantilever beam and a laser displacement sensor to detect the detlection of the cantilever *** positioning unit consists of two single-axis DC servo motor stages for precise positioning of the probe *** cantilever is designed with the assistance of the finite element *** order to demonstrate the feasibility of the proposed measurement system,experiments are conducted and the measurement result for a micro-cutting edge is compared with that by a commercial ***,a method to com-pensate for the measurement error caused by the lateral displacement of the cantilever beam is *** compensated measurement results show good agreement within±2μm with those obtained by the commercial profler.

关键词： On-machine measurement Surface profiler micro-cutting edge Low-force measurement Cantilever beam

孤立性外展神经麻痹是吉兰-巴雷综合征的局部变异型

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世界核心医学期刊文摘(神经病学分册) 2006年第8期 28-28页

作者： Tatsumoto m. Odaka m. Hirata K yuki N. 陈海 Department of Neurology Dokkyo University School of Medicine Kitakobayashi 880 Mibu Shimotsuga Tochigi 321- 0293 Japan

The authors reviewed clinical profiles and laboratory findings for 100 cases of abducens nerve paresis without impairment of the other cranial nerves, limb weakness, and ataxia throughout the clinical course. Review of the medical records of 9300 patients referred to our neuoroimmunological laboratory for serum anti- ganglioside antibody testing. Information was obtained from each primary physician on symptoms of preceding infection; initial symptoms; neurological signs during the illness; the clinical course; treatment provided; and outcome. Isolated abducens nerve paresis was present in 100 patients and bilateral paresis in 29. Tentative diagnoses made by the primary physicians on request of anti- ganglioside antibody testing were abducens nerve palsy (n = 68), Fisher syndrome (n = 14), acute ophthalmoparesis without ataxia (n = 14). Symptoms of infection anteceded in 63. Tendon reflexes were absent or decreased in 27. Distal paresthesias were experienced by seven. Serum anti- GQ1b antibody was positive in 25. These findings suggest that some cases of isolated abducens nerve palsy can be categorized as a regional variant of Guillain- Barré syndrome or mild form of Fisher syndrome.

关键词：巴雷吉兰外展神经孤立性变异型综合征综合病症

单侧外展神经麻痹作为吉兰-巴雷综合征的局部变异

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世界核心医学期刊文摘（眼科学分册） 2006年第8期2卷 7-7页

作者： Tatsumoto m. Odaka m. Hirata K. yuki N. 潘佳鸿 Department of Neurology Dokkyo University School of Medicine Kitakobayashi 880 Mibu Shimotsuga Tochigi 321- 0293 Japan

The authors reviewed clinical profiles and laboratory findings for 100 cases of abducens nerve paresis without impairment of the other cranial nerves, limb weakness, and ataxia throughout the clinical course. Review of the medical records of 9300 patients referred to our neuoroimmunological laboratory for serum anti-ganglioside antibody testing. Information was obtained from each primary physician on symptoms of preceding infection; initial symptoms; neurological signs during the illness; the clinical course; treatment provided; and outcome. Isolated abducens nerve paresis was present in 100 patients and bilateral paresis in 29. Tentative diagnoses made by the primary physicians on request of anti-ganglioside antibody testing were abducens nerve palsy (n=68), Fisher syndrome (n=14), acute ophthalmoparesis without ataxia (n=14). Symptoms of infection anteceded in 63. Tendon reflexes were absent or decreased in 27. Distal paresthesias were experienced by seven. Serum anti-GQ1b antibody was positive in 25. These findings suggest that some cases of isolated abducens nerve palsy can be categorized as a regional variant of Guillain-Barré syndrome or mild form of Fisher syndrome.

关键词：外展神经麻痹急性眼肌麻痹腱反射临床过程共济失调脑神经损伤首诊医师初发症状肢体麻木神

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Alpha-fetoprotein before and after pegylated interferon therapy for predicting hepatocellular carcinoma development

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World Journal of Hepatology 2015年第19期7卷 2220-2228页

作者： Yasuto Takeuchi Fusao Ikeda Toshiya Osawa Yasuyuki Araki Kouichi Takaguchi Youichi morimoto Noriaki Hashimoto Kousaku Sakaguchi Tatsuro Sakata masaharu Ando Yasuhiro makino Shuji matsumura Hiroki Takayama Hiroyuki Seki Shintarou Nanba yuki moritou Tetsuya Yasunaka Hideki Ohnishi Akinobu Takaki Kazuhiro Nouso Yoshiaki Iwasaki Kazuhide Yamamoto Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine Dentistry and Pharma- ceutical Sciences Department of molecular Hepatology Okayama University Graduate School of Medicine Dentistry and Pharma- ceutical Sciences Department of Internal medicine Okayama Saiseikai General Hospital Department of Internal medicine Hiroshima City Hospital Department of Internal medicine Kagawa Prefectural Central Hospital Department of Internal medicine Kurashiki Central Hospital Department of Internal medicine Mihara Red Cross hospital Department of Internal medicine Fukuyama City Hospital Department of Internal medicine National Hospital Organization Fukuyama Clinical Center Department of Internal medicine Mitoyo General Hospital Department of Gastroenterology National Hospital Organization Iwakuni Clinical Center Department of Internal medicine Sumitomo Besshi Hospital Department of Gastroenterology Tsuyama Central Hospital Health Service Center Okayama University

AIm: To investigate factors that accurately predict hepatocellular carcinoma(HCC) development after antiviral therapy in chronic hepatitis C(CHC) patients. mETHODS: CHC patients who received pegylated interferon and ribavirin were enrolled in this cohort study that investigated the ability of alpha-fetoprotein(AFP) to predict HCC development after interferon(IFN) therapy. RESULTS: Of 1255 patients enrolled, 665 developed sustained virological response(SVR) during mean follow-up period of 5.4 years. HCC was occurred in 89 patients, and 20 SVR patients were included. Proportional hazard models showed that HCC occurred in SVR patients showing AFP ≥ 5 ng/m L before therapy and in non-SVR patients showing AFP ≥ 5 ng/m L before and 1 year after therapy besides older age, and low platelet counts. SVR patients showing AFP ≥ 5 ng/m L before therapy and no decrease in AFP to m L 1 year after therapy had significantly higher HCC incidence than non-SVR patients showing AFP ≥ 5 ng/m L before therapy and decreased AFP(P = 0.043). AFP ≥ 5 ng/m L before therapy was significantly associated with low platelet counts and high values of alanine aminotransferase(ALT) in stepwise logistic regression analysis. After age, gender, platelet count, and ALT was matched by propensity score, significantly lower HCC incidence was shown in SVR patients showing AFP m L before therapy than in those showing AFP ≥ 5 ng/m ***: The criteria of AFP m L before and 1 year after IFN therapy is a benefical predictor for HCC development in CHC patients.

关键词： Hepatitis C virus Interferon Hepatocellular carcin

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国际医学放射学杂志 2017年第4期 488-488页

作者： m.Kidoh D.Utsunomiya S.Oda T.Nakaura Y.Funama H.yuki 吕岳华 Department of Diagnostic Radiology Faculty of Life Sciences Kumamoto University

摘要目的研究基于乳腺大小相关扫描剂量估算（SSDE）调整扫描参数以降低胸部CT检查时乳腺扫描剂量的临床应用。材料与方法第1组使用固定CT剂量指数(CTDIvol)（15 mGy）扫描26位女性;第2组使用固定SSDE（15 mGy）方案扫描另外26位女性。...

摘要目的研究基于乳腺大小相关扫描剂量估算（SSDE）调整扫描参数以降低胸部CT检查时乳腺扫描剂量的临床应用。材料与方法第1组使用固定CT剂量指数(CTDIvol)（15 mGy）扫描26位女性;第2组使用固定SSDE（15 mGy）方案扫描另外26位女性。在第2组中,基于CT定位像中病人乳腺大小调整管电流。比较平均乳腺辐射剂量和不同病人间乳腺辐射剂量的差异,并且使用线性回归分

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鼠细胞角蛋白Endo B的核苷酸序列分析

生物技术 1992年第3期2卷 17-19页

作者：张凤蕴一濑勇规哈尔滨医科大学免疫学教研室日本大阪大学微生物病研究所微生物基因学部

本文报导了由编码细胞角蛋白的基因组DNA文库中筛选的克隆的特点,介绍了其亚克隆和核苷酸序列分析.序列分析发现,Endo B基因由七个外显子和六个内含子组成.Endo B 基因家族至少由一个结构基因和一个假基因组成.

关键词：细胞角蛋白 EndoB 序列分析

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Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID- 19 pandemic

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Stroke & Vascular Neurology 2021年第4期6卷 542-552,I0026-I0032页

作者： Thanh N Nguyen Diogo C Haussen muhammad m Qureshi Hiroshi Yamagami Toshiyuki Fujinaka Ossama Y mansour mohamad Abdalkader michael Frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer F Eker Laura mechtouff michel Piotin Fabricio Oliveira Lima Francisco mont'Alverne Wazim Izzath Nobuyuki Sakai mahmoud mohammaden Alhamza R Al-Bayati Leonardo Renieri Salvatore mangiafico David Ozretic Vanessa Chalumeau Saima Ahmad Umair Rashid Syed Irteza Hussain Seby John Emma Griffin John Thornton Jose Antonio Fiorot Rodrigo Rivera Nadia Hammami Anna m Cervantes-Arslanian Hormuzdiyar H Dasenbrock Huynh Le Vu Viet Quy Nguyen Steven Hetts Romain Bourcier Romain Guile melanie Walker malveeka Sharma Don Frei Pascal Jabbour Nabeel Herial Fawaz Al-mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi Chandril Chugh Charles matouk Pascale Lavoie Randall Edgell Andre Beer-Furlan michael Chen monika Killer-Oberpfalzer Vitor mendes Pereira Patrick Nicholson Vikram Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun Shin Pedro SC magalhaes Raghid Kikano Santiago Ortega-Gutierrez mudassir Farooqui Amal Abou-Hamden Tatsuo Amano Ryoo Yamamoto Adrienne Weeks Elena A Cora Rotem Sivan-Hoffmann Roberto Crosa markus möhlenbruch Simon Nagel Hosam Al-Jehani Sunil A Sheth Victor S Lopez Rivera James E Siegler Achmad Fidaus Sani Ajit S Puri Anna Luisa Kuhn Gianmarco Bernava Paolo machi Daniel G Abud Octavio m Pontes-Neto Ajay K Wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brijesh P mehta Naoto Kimura mamoru murakami Jin Soo Lee Ji man Hong Robert Fahed Gregory Walker Eiji Hagashi Steve m Cordina Hong Gee Roh Ken Wong Juan F Arenillas mario martinez-Galdamez Jordi Blasco Alejandro Rodriguez Vasquez Luisa Fonseca m Luis Silva Teddy Y Wu Simon John Alex Brehm marios Psychogios William J mack matthew Tenser Tatemi Todaka miki Fujimura Roberta Novakovic Jun Deguchi Yuri Sugiura Hiroshi Tokimura Rakesh Khatri michael Kelly Lissa Peeling Yuichi murayama Hugh Stephen Winters Johnny Wong mohamed Teleb Jeremy Payne Hiroki Fukuda Kosuke miyake Junsuke Shimbo Yusuke Sug Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA Neurology Marcus Stroke&Neuroscience CenterGrady Memorial HospitalEmory University School of MedicineAtlantaGAUSA Radiology Radiation OncologyBoston University School of MedicineBostonMassachusettsUSA Neurology National Hospital Organization Osaka National HospitalOsakaJapan Neurosurgery National Hospital Organization Osaka National HospitalOsakaJapan Neurology Alexandria UniversityAlexandriaEgypt Radiology Boston Medical CenterBostonMassachusettsUSA Department of Neurology Xinqiao HospitalChongqingChina Neurosurgery University of Cape TownRondeboschWestern CapeSouth Africa Neurosurgery Interventional NeuroradiologyClinica La Sagrada FamiliaBuenos AiresArgentina Neuroradiologie Neurologie VasculaireHospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Neurologie Vasculaire Hospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Interventional Neuroradiology Fondation Ophtalmologique Adolphe de RothschildParisÎle-de FranceFrance Neurology Hospital Geral de FortalezaFortalezaBrazil Interventional Neuroradiology Hospital Geral de FortalezaFortalezaBrazil Neuroradiology Nottingham University Hospitals NHS TrustNottinghamUK Department of Neurosurgery Kobe City Medical Center General HospitalKobeHyogoJapan Interventional Neurovascular Unit University Hospital CareggiFirenzeToscanaItaly Neuroradiology University Hospital Centre ZagrebZagrebCroatia Interventional Neuroradiology Hopital BicetreLe Kremlin-BicetreFrance Stroke and Interventional Neuroradiology Lahore General HospitalLahorePakistan Neurological Institute Cleveland Clinic Abu DhabiAbu DhabiUAE Department of Radiology Beaumont HospitalDublinIreland Neurology Stroke UnitHospital-Estadual CentralVitoriaBrazil Neuroradiology Instituto de Neurocirugia Dr AsengoSantiagoChile Interventional Neuroradiology Institut National de NeurologieTunisTunisia Neurology Boston Medical CenterBostonMassachusettsUSA Neurosurgery Boston Medical Center

Background During the COVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were *** study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar *** We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke *** with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases,10th Revision,*** 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 march-31 may *** prior 1-year control period(1 march-31 may 2019)was obtained to account for seasonal *** There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%CI−24.3%to−20.7%,pmbolisation of ruptured aneurysms declined with 1170-1035 procedures,respectively,representing an 11.5%(95%CI−13.5%to−9.8%,p=0.002)relative *** analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%CI−28.0%to−22.1%,pm coiling was noted in low coiling volume hospitals of 41.1%(95%CI 32.3%to 50.6%,p=0.008)despite a decrease in SAH admissions in this *** There was a relative decrease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 *** findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction.

关键词： diagnosis representing subarachnoid