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Endoscopic submucosal dissection for early esophageal neoplasms using the stag beetle knife

World Journal of Gastroenterology 2018年第15期24卷 1632-1640页

作者： Toshio Kuwai Toshiki Yamaguchi Hiroki Imagawa Ryoichi Miura yuki Sumida Takeshi Takasago yuki Miyasako Tomoyuki Nishimura Sumio Iio Atsushi Yamaguchi Hirotaka Kouno Hiroshi Kohno Sauid Ishaq Department of Gastroenterology National Hospital Organization Kure Medical Center and Chugoku Cancer Center Department of Gastroenterology DGH SGU WI Birmingham City University

AIM To determine short-and long-term outcomes of endoscopic submucosal dissection(ESD) using the stag beetle(SB) knife, a scissor-shaped *** Seventy consecutive patients with 96 early esophageal neoplasms, who underwent ESD using a SB knife at Kure Medical Center and Chugoku Cancer Center, Japan, between April 2010 and August 2016, were retrospectively evaluated. Clinicopathological characteristics of lesions and procedural adverse events were assessed. Therapeutic success was evaluated on the basis of en bloc, histologically complete, and curative or non-curative resection rates. Overall and tumor-specific survival, local or distant recurrence, and 3-and 5-year cumulative overall metachronous cancer rates were also *** Eligible patients had dysplasia/intraepithelial neoplasia(22%) or early cancers(squamous cell carcinoma, 78%). The median procedural time was 60 min and on average, the lesions measured 24 mm in diameter, yielding 33-mm tissue defects. The en bloc resection rate was 100%, with 95% and 81% of dissections deemed histologically complete and curative, respectively. All procedures were completed without accidental incisions/perforations or delayed bleeding. During follow-up(mean, 35 ± 23 mo), no local recurrences or metastases were observed. The 3-and 5-year survival rates were 83% and 70%, respectively, with corresponding rates of 85% and 75% for curative resections and 74% and 49% for noncurative resections. The 3-and 5-year cumulative rates of metachronous cancer in the patients with curative resections were 14% and 26%, *** ESD procedures using the SB knife are feasible, safe, and effective for treating early esophageal neoplasms, yielding favorable short-and long-term outcomes.

关键词： Neoplasms Stag beetle knife Esophageal Endoscopic submucosal dissection Outcome measures

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Leukocyte function-associated antigen-1 deficiency impairs responses to polymicrobial sepsis

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World Journal of Clinical Cases 2015年第9期3卷 793-806页

作者： Jia-Ren Liu Xiaohui Han Sulpicio G Soriano Koichi yuki Department of Anesthesiology Perioperative and Pain MedicineBoston Children’s Hospital Department of Anaesthesia Harvard Medical School

AIM: To determine the role of leukocyte functionassociated antigen-1(LFA-1) in polymicrobial sepsis model in ***: Cecal ligation and puncture model was used to study polymicrobial sepsis in wild type and LFA-1 knockout(KO)(= CD11 a KO) mice. Their survivals were examined. Neutrophil recruitment to the abdominal cavity, bacterial tissue load and bacterial killing by neutrophils, tissue cytokine profiles, and serum cytokines were examined. Apoptosis of tissues was assessed using cleaved-caspase 3 and TUNNEL staining. The recruitment of neutrophils to various tissues was assessed using myeloperoxidase staining or measuring myeloperoxidase activity. RESULTS: LFA-1 deficiency significantly decreased survival(P = 0.0024) with the reduction of neutrophil recruitment to the abdominal cavity and higher bacterial load in blood. It was also associated with increased apoptosis in spleen and more organ injuries probed by interleukin-6 m RNA level. However, the deficiency of LFA-1 did not prevent neutrophil recruitment to lung, liver, spleen or kidney, which suggested the existence of LFA-1 independent recruitment mechanism in these organs. CONCLUSION: LFA-1 deficiency did not attenuate neutrophil recruitment to various organs to adequately mitigate secondary tissue injury in sepsis. It was associated with decreased neutrophil recruitment to the abdominal cavity, higher bacterial load, leading to increased mortality in an abdominal, polymicrobial sepsis.

关键词： Leukocyte function-associated antigen-1 Tissue injury Neutrophil recruitment Polymicrobial sepsis Apoptosis

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Sphingosine kinase 1 is upregulated with lysophosphatidic acid receptor 2 in human colorectal cancer

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World Journal of Gastroenterology 2016年第8期22卷 2503-2511页

作者： Dai Shida Satoru Inoue yuki Yoshida Atsushi Kodaka Tsutomu Tsuji Makoto Tsuiji Colorectal Surgery Division National Cancer Center Hospital Department of Surgery Tokyo Metropolitan Bokutoh Hospital Department of Microbiology Hoshi University School of Pharmaceutical Sciences

AIM: To examine the expression of SphK1, an oncogenic kinase that produces sphingosine 1-phosphate (S1P), and its correlation with the expression of LPAR2, a major lysophosphatidic acid (LPA) receptor overexpressed in various cancers, in human colorectal ***: Real-time reverse-transcription polymerase chain reaction was used to measure the mRNA expression of SphK1, LPAR2, and the three major S1P receptors in 27 colorectal cancer samples and corresponding normal tissue samples. We also examined the correlation between the expression of SphK1 and ***: Colorectal cancer tissue in 22 of 27 patients had higher levels of SphK1 mRNA than in normal tissue. In two-thirds of the samples, SphK1 mRNA expression was more than two-fold higher than in normal tissue. Consistent with previous reports, LPAR2 mRNA expression in 20 of 27 colorectal cancer tissue samples was higher compared to normal tissue samples. Expression profiles of all three major S1P receptors, S1PR1, S1PR2, and S1PR3, varied without any trend, with no significant difference in expression between cancer and normal tissues. A highly significant positive correlation was found between SphK1 and LPAR2 expression [Pearson’s correlation coefficient (r) = 0.784 and P < 0.01]. The mRNA levels of SphK1 and LPAR2 did not correlate with TNM ***: Our findings suggest that S1P and LPA may play important roles in the development of colorectal cancer via the upregulation of SphK1 and LPAR2, both of which could serve as new therapeutic targets in the treatment of colorectal cancer.

关键词： Sphingosine kinase 1 Lysophosphatidic acid receptor 2 Carcinogenesis Colorectal cancer Sphingosine 1-phosphate

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Particle selectivity of filtering by C. elegans

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Theoretical & Applied Mechanics Letters 2019年第2期9卷 61-65页

作者： yuki Suzuki Kenji Kikuchi Keiko Tsuruta-Numayama Takuji Ishikawa Graduate School of Engineering Tohoku University

A nematode Caenorhabditis elegans(C. elegans) is a filter feeder, which draws a suspension of bacteria and separates bacteria from the solvent by using pharyngeal pumping motions and specific mouth parts. This mechanism has not been fully understood. We investigated the mechanism of filtering of bacteria in the pharynx of C. elegans by visualization by fluorescent particles and dyed E. coli. We succeeded in quantifying the selectivity of bacteria-sized particles by C. elegans. The most accumulated particles were those of 0.5 μm in diameter. The quantity of accumulated particles of 0.2 μm or 1.0 μm in diameter was about one third of that of particles of 0.5μm in diameter. The least accumulated particles were those of 0.05 μm in diameter. These results suggest that the pharyngeal structures of C. elegans would be suitable for eating bacteria because the size of bacteria ingested by C. elegans worms is about 0.5 μm in diameter. We also succeeded in visualizing pharyngeal structures and pumping motions and flow in the pharynx. We found that there were phase differences in the motions among procorpus, metacorpus and isthmus. This result suggests filtering would occur at the two tips of procorpus and isthmus by the phase differences. We found that bacteria-sized particles and bacteria were flowed and trapped in the channels, which existed along the central lumen from tip of procorpus to isthmus. From our results, we proposed the novel mechanism of filtering of bacteria through the channels for flowing and trapping. In future, this selective filtering mechanism of C. elegans would be applied to development of microfluidic filtration devices for medical and biological equipment.

关键词： Nematode C.elegans Pharynx Pumping Filtering Selectivity

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Recurrence of unilateral angioedema of the tongue:A case report

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World Journal of Clinical Cases 2023年第27期11卷 6603-6612页

作者： yuki Matsuhisa Tsuneaki Kenzaka Hironori Shimizu Hideo Hirose Tadao Gotoh Department of General Medicine Center for Community Medicine in North-Western Gifu Prefecture National Health Insurance Shirotori HospitalGujo 501-5122Japan Department of Pediatrics Center for Community Medicine in North-Western Gifu Prefecture National Health Insurance Shirotori HospitalGujo 501-5122Japan Department of Internal Medicine Hyogo Prefectural Tamba Medical CenterTamba 669-3495Japan Division of Community Medicine and Career Development Kobe University Graduate School of MedicineKobe 652-0032Japan

BACKGROUND Angioedema is a disorder characterized by edema of the face,lips,tongue,and extremities due to increased vascular *** of the tongue usually occurs bilaterally,and the incidence of unilateral angioedema of the tongue is *** study reports a rare case of unilateral angioedema of the tongue with no identifiable cause and repeated recurrence even after discontinuation of an angiotensin-converting enzyme *** SUMMARY The patient was a 65-year-old woman with pre-existing hypertension and hyperlipidemia and had been receiving 20 mg/d of *** was diagnosed with angioedema due to unilateral swelling of the *** airway obstruction was observed,and the symptoms improved following the administration of 0.3 mg of epinephrine intramuscularly and 125 mg of methylprednisolone *** lisinopril was discontinued,unilateral angioedema of the tongue continued to recur every 2-5 mo,with the symptoms improving following the administration of prednisolone and an *** oral administration of 500 mg of tranexamic acid after dinner prevented the recurrence of *** Careful monitoring and identification of the underlying mechanism play a crucial role in the treatment of angioedema.

关键词： Angioedema Tongue Unilateral Bradykinin Tranexamic acid Case report

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Feasibility study of cyclodextrins as active pharmaceutical ingredients for the treatment of GM1-gangliosidosis

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 183-184页

作者： yuki Maeda Keiichi Motoyama Taishi Higashi Yuka Horikoshi Toru Takeo Naomi Nakagata yuki Kurauchi Hiroshi Katsuki yuki Kondo Yoichi Ishitsuka Tetsumi Irie Takumi Erad Hidetoshi Arima Graduate School of Pharmaceutical Sciences Kumamoto University5-1 Oe-honmachiChuo-kuKumamotoJapan Program for Leading Graduate Schools“HIGO(Health life science:Interdisciplinary and Glocal Oriented)Program” Kumamoto University5-1 Oe-honmachiChuo-kuKumamotoJapan Center for Animal Resources and Development Kumamoto University2-2-1 HonjoChou-kuKumamotoJapan Institute of Molecular Embryology and Genetics Kumamoto University2-2-1 HonjoChou-kuKumamotoJapan

GM1-gangliosidosis is a rare lysosomal storage disorder characterized clinically by a wide range of variable neurovisceral,ophthalmological and dysmorphic features. Without enough functionalβ-galactosidase, GM1-gangliosides cannot be degraded in lysosomes, and accumulate to toxic levels in many tissues and organs, particularly in the brain. In spite of several approaches for the treatment of GM1-gangliosidosis.

关键词： Cyclodextrins GM1-gangliosidosis Fibroblasts,Lysosomes

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KDM2B promotes cell viability by enhancing DNA damage response in canine hemangiosarcoma

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Journal of Genetics and Genomics 2021年第7期48卷 618-630页

作者： Kevin Christian Montecillo Gulay Keisuke Aoshima yuki Shibata Hironobu Yasui Qin Yan Atsushi Kobayashi Takashi Kimura Laboratory of Comparative Pathology Department of Clinical SciencesFaculty of Veterinary MedicineHokkaido UniversitySapporoHokkaido 060-0818 Japan Laboratory of Radiation Biology Department of Applied Veterinary SciencesFaculty of Veterinary MedicineHokkaido UniversitySapporoHokkaido 060-0818 Japan Department of Pathology Yale School of MedicineNew HavenCT 06510USA

Epigenetic regulators have been implicated in tumorigenesis of many types of cancer;however,their roles in endothelial cell cancers such as canine hemangiosarcoma(HSA)have not been *** this study,we find that lysine-specific demethylase 2 b(KDM2 B)is highly expressed in HSA cell lines compared with normal canine endothelial *** of KDM2 B in HSA cells results in increased cell death in vitro compared with the scramble control by inducing apoptosis through the inactivation of the DNA repair pathways and accumulation of DNA ***,doxycycline-induced KDM2 B silencing in tumor xenografts results in decreased tumor sizes compared with the ***,KDM2 B is also highly expressed in clinical cases of *** hypothesize that pharmacological KDM2 B inhibition can also induce HSA cell death and can be used as an alternative treatment for *** treat HSA cells with GSK-J4,a histone demethylase inhibitor,and find that GSK-J4 treatment also induces apoptosis and cell *** addition,GSK-J4 treatment decreases tumor ***,we demonstrate that KDM2 B acts as an oncogene in HSA by enhancing the DNA damage ***,we show that histone demethylase inhibitor GSK-J4 can be used as a therapeutic alternative to doxorubicin for HSA treatment.

关键词： DNA repair Epigenetics Hemangiosarcoma KDM2B Oncogene

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地震引起的边坡灾害风险评估(英文)

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岩石力学与工程学报 2008年第12期27卷 2488-2493页

作者：陈光齐 ZEN Kouki KASUYA yuki 九州大学土木与结构工程系

2005年日本福冈县7级地震引起大量边坡破坏。震中附近的志贺岛的环岛公路由于其上方边坡崩塌导致交通中断达1.5 a之久。其原因是崩塌边坡上方出现了较大的沉降裂缝,有可能受将来的暴雨或地震的触发再次导致边坡崩塌。根据钻孔资料及实... 详细信息

2005年日本福冈县7级地震引起大量边坡破坏。震中附近的志贺岛的环岛公路由于其上方边坡崩塌导致交通中断达1.5 a之久。其原因是崩塌边坡上方出现了较大的沉降裂缝,有可能受将来的暴雨或地震的触发再次导致边坡崩塌。根据钻孔资料及实验室实验结果,对该边坡未来可能发生的崩塌规模产生3种意见:小规模表层崩塌(A)、中规模中层崩塌(B)及大规模深层崩塌(C)。而边坡修复费用则根据所想定的可能崩塌规模从几千万日元到几十亿日元不等。为了合理决定对策规模,对3种可能的崩塌规模分别进行风险评估。结果表明,大规模深层崩塌(C)由于发生概率较小使得其风险远远小于小规模表层崩塌(A)和中规模中层崩塌(B),因而在修复中可以不予考虑。另外,虽然小规模表层崩塌(A)和中规模中层崩塌(B)的风险相当,但考虑到对策效果(加固后的风险减少与投入的加固资金费用之比),认为以小规模表层崩塌为对象制定修复计划较为合理,但在部分区域可考虑有关针对中规模中层崩塌的对策。本提案被相关部门所采用。

关键词：边坡工程风险评估地震灾害非连续变形分析

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Low skeletal muscle mass and high visceral adiposity are associated with recurrence of acute cholecystitis after conservative management:A propensity score-matched cohort study

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 64-70页

作者： Yudai Koya Michihiko Shibata yuki Maruno Yoshitaka Sakamoto Shinji Oe Koichiro Miyagawa Yuichi Honma Masaru Harada Department of Gastroenterology Kyushu Rosai HospitalMoji Medical Center3-1 HigashiminatomachiMoji-kuKitakyushu 801-8502Japan Third Department of Internal Medicine School of MedicineUniversity of Occupational and Environmental HealthKitakyushu 807-8555Japan Department of Surgery Kyushu Rosai Hospital Moji Medical CenterKitakyushu 801-8502Japan

Background:Recurrent acute cholecystitis(RAC)can occur after non-surgical treatment for acute cholecystitis(AC),and can be more severe in comparison to the first episode of *** skeletal muscle mass or adiposity have various effects in several *** aimed to clarify the relationship between RAC and body ***:Patients with AC who were treated at our hospital between January 2011 and March 2022 were *** psoas muscle mass and adipose tissue area at the third lumbar level were measured using computed tomography at the first episode of *** areas were divided by height to obtain the psoas muscle mass index(PMI)and subcutaneous/visceral adipose tissue index(SATI/VATI).According to median VATI,SATI and PMI values by sex,patients were divided into the high and low PMI *** performed propensity score matching to eliminate the baseline differences between the high PMI and low PMI groups and analyzed the cumulative incidence and predictors of ***:The entire cohort was divided into the high PMI(n=81)and low PMI(n=80)*** the propensity score-matched cohort there were 57 patients in each *** Kaplan-Meier analysis,the low PMI group and the high VATI group had a significantly higher cumulative incidence of RAC than their counterparts(log-rank P=0.001 and 0.015,respectively).In a multivariate Cox regression analysis,the hazard ratios of low PMI and low VATI for RAC were 5.250(95%confidence interval 1.083-25.450,P=0.039)and 0.158(95%confidence interval:0.026-0.937,P=0.042),***:Low skeletal muscle mass and high visceral adiposity were independent risk factors for RAC.

关键词： Acute cholecystitis Low skeletal muscle mass Recurrent acute cholecystitis Sarcopenia Visceral adiposity

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Comparison of self-report and objective measures of male sexual dysfunction in a Japanese primary care setting:a cross-sectional,self-administered mixed methods survey

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Family Medicine and Community Health 2021年第1期9卷 18-27页

作者： yuki Takeuchi Ryohei Otsuka Hajime Kojima Michael D Fetters Teine Family Medicine Clinic Teine Keijinkai HospitalSapporoHokkaidoJapan Mixed Methods Program Department of Family MedicineUniversity of MichiganAnn ArborMichiganUSA

Objectives Erectile dysfunction(ED)is a common problem among middle-aged males and men often do not talk about sexual problems with their primary care physicians(PCPs).We hypothesised that many Japanese men who meet the criteria for ED would not recognise their condition based on responses to an internationally validated *** secondary aims were to examine potential barriers to seeking treatment for ED by their *** sought to elucidate their perspectives about male sexual dysfunction *** merging of the quantitative and qualitative findings,we sought an enhanced understanding of the factors affecting sexual dysfunction *** A cross-sectional,self-administered mixed methods survey was distributed at a suburban family medicine clinic in Sapporo,*** participants were 40 to 69-year old men who came for routine scheduled visits from 5 November to 21 December *** the office visit,participants completed a confidential 11-item survey addressing sexual dysfunction including the 5-item version of the International Index of Erectile Function scale and open-ended *** Teine Family Medicine Clinic,a suburban family medicine clinic in Sapporo,*** We enroled 66 male patients aged 40-69 years who presented for routine outpatient care in the Teine Family Medicine *** Of surveyed participants,39%(26/66)reported having sexual dysfunction,but 92%(61/66)met ED *** respondents,48%(16/33)had desire for treatment,but only one man had discussed sexual dysfunction with his *** the 12 desiring treatment from PCPs,the main barriers to discussing were shame(n=7)and lack of awareness that PCPs can treat ED(n=5).These men’s perspectives about sexual dysfunction included viewing sexual dysfunction as normal ageing,attributing sexual dysfunction to decreased libido,considering sexual activity for a healthy life,having good rapport with PCPs,having incomplete knowledge about treatment and l

关键词： routine sectional measures

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