检索结果-南通市图书馆

Direct Correlation among Telomere Length, Cellular Aging, and Rejuvenation Effects of Honey Child Powder

Journal of Biosciences and Medicines 2024年第7期12卷 55-70页

作者： Naofumi Shiomi Keiko Watanabe yuki fujiwara Takae Yamasaki Hideto Matsuyama Research Center for Membrane and Film Technology Kobe University Kobe Japan School of Human Sciences Kobe College Nishinomiya Japan Department of Chemical Science and Engineering Kobe University Kobe Japan

Purpose: Telomere length (TL) is an indicator of age;however, hormonal influences complicate individual aging. It remains unclear whether TL shortening is a direct factor in both individual and cellular aging. Therefore, we examined the direct relationship between TL and cellular senescence at the cellular level. Methods: Telomerase activity, TL, and gene expression were measured in cultured human lung-, fetal-, and skin-derived fibroblasts, human skin keratinocytes, and telomerase reverse transcriptase (TERT) gene-immortalized cells using detection kits, Cawthon’s method, and reverse transcription-quantitative polymerase chain reaction, respectively. Novel substances that elongate telomeres were screened to confirm cell rejuvenation effects. Results: Long-term cell culture of TIG-1-20 normal human fibroblasts resulted in TL shortening, decreased division rate, and senescence progression, whereas in OUMS-36T-2 cells, TL elongation via TERT gene transfer increased the division rate, reduced endoplasmic reticulum stress, and upregulated genes associated with young individuals, indicating that cellular rejuvenation occurs via TL elongation. In addition, a honey child powder (HCP) extract was found through screening, and the HCP extract strongly suppressed the menin gene, resulting in increased telomerase activity and extended cell lifespan. Upon addition of the HCP extract to skin fibroblasts, gene expression of moisturizing components, including collagen, hyaluronic acid, and elastin, increased, and exhibited a rejuvenating effect with an increase in elastin amount. Conclusions: TL elongation or shortening is involved in cell proliferation rate and cellular aging, and TL elongation rejuvenates cells. In addition, HCP extract has a rejuvenating effect on cells and is expected to be a rejuvenating compound.

关键词： Telomere Cellular Aging Telomerase Reverse Transcriptase Gene Rejuvenation Honey Child Powder

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Isolated pancreatic metastasis from a malignant pleural mesothelioma diagnosed using endoscopic ultrasonography-guided fne needle aspiration biopsy

引用

Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 196-198页

作者： yuki Ishikawa-Kakiya Hirotsugu Maruyama Kojiro Tanoue Shusei Fukunaga Yasuaki Nagami Yasuhiro fujiwara Department of Gastroenterology Osaka City University Graduate School of Medicine1-4-3AsahimachiAbeno-kuOsaka 545-8585Japan

To the Editor:Malignant pleural mesothelioma is a rare and aggressive form of cancer with a poor prognosis [1].Its progression is mainly a direct invasion from the primary lesion,and metastasis to distant regions rarely *** was found that metastasis of malignant pleural mesothelioma may occur in the liver,adrenal glands,and kidneys in autopsy cases [2].

关键词： metastasis pleural needle

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Throughfall and stemflow chemical dynamics of Satoyama, a traditional secondary forest system under threat in Japan

引用

Journal of Forestry Research 2022年第3期33卷 813-826页

作者： Satoshi Asaoka Fuyuhiko Sumikawa Yoshifumi Watanabe Waqar Azeem Jadoon Masaki Ohno Nobumichi Shutoh yuki Wakamatsu Lawrence M.Liao Akane Kanazawa Yuka Sato Natsumi fujiwara Graduate School of Integrated Sciences for Life Hiroshima University1-4-4 KagamiyamaHigashi-Hiroshima739-8528Japan Research Center for Inland Seas Kobe University5-1-1 FukaeminamiHigashinadaKobe658-0022Japan Naragakuen Senior High School 430 YamadaYamatokoriyamaNara639-1093Japan Department of Environmental Sciences Faculty of Natural and Computational SciencesHazara UniversityDhodiaMansehra21130Khyber PakhtunkhwaPakistan Niigata University of Pharmacy and Applied Life Sciences 265-1 HigashijimaAkihaNiigata956-8603Japan Faculty of Science and Engineering Kindai University3-4-1 KowakaeHigashi-OsakaOsaka577-8502Japan Department of Maritime Science and Technology Japan Coast Guard Academy5 WakabaKureHiroshima737-8512Japan

The term 'Satoyama' refers to traditional and unique secondary forests in Japan that occupy intermediate zones between villages ('sato') and hills or mountains ('yama'). Satoyama landscapes help sustain ecosystem services and the diversity of secondary natural environments. As Japan relies more heavily on foreign timber imports, the traditional role of Satoyama in providing forest products has diminished, and this has led to their abandonment and poor management. The chemical behavior of cations, anions, and dissolved organic matter in throughfall and stemflow from one such threatened Satoyama system in central Japan was investigated. From autumn to winter, the atmospheric deposition of sulfates and nitrates was 2.5–6.0 times higher compared to the amounts in summer due to the intrusion of air masses from the Asian continent. The dissolved organic matter in the throughfall and stemflow was composed mainly of humic substances and protein derivatives. The deposition fluxes of dissolved organic carbon from throughfall (7.31–10.1 g m^(−2) a^(−1)) and stemflow (1.79–3.84 g m^(−2) a^(−1)) in this study were within ranges seen in temperate forests in previous studies. The deposition flux of sulfates was low compared to that in other forest types because canopy interaction was lower, suggesting higher canopy openness than in primary forests. If a shift from a mixed species Satoyama forest to a conifer-dominated forest occurs after the mass mortality of oak, the deposition flux of dissolved organic carbon and K^(+) might decrease by 33% and 62%, respectively, while NO_(3)^(−) might increase by 20%. In the near future, the degradation of Satoyama landscapes might change the levels of dissolved organic carbon and nitrogen loads, resulting in imbalances in river-ocean linkages affecting forested catchments and aquatic ecosystems in Japan.

关键词： Atmospheric deposition Dissolved organic matter Humic substance Mass mortality Oak trees Sustainable development goals

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Influence of the water jet system vs cavitron ultrasonic surgical aspirator for liver resection on the remnant liver

引用

World Journal of Clinical Cases 2022年第20期10卷 6855-6864页

作者： Takehiko Hanaki Ayumi Tsuda Teppei Sunaguchi Keisuke Goto Masaki Morimoto yuki Murakami Kyoichi Kihara Tomoyuki Matsunaga Manabu Yamamoto Naruo Tokuyasu Teruhisa Sakamoto Toshimichi Hasegawa Yoshiyuki fujiwara Division of Gastrointestinal and Pediatric Surgery Department of SurgeryTottori University Faculty of MedicineYonago 683-8504TottoriJapan

BACKGROUND Several methods,such as finger fracture,Pean crush,cavitron ultrasonic surgical aspirator(CUSA),and water jet(WJ),are used for hepatic parenchymal dissection in liver *** is the conventional method in *** is a relatively novel method for parenchymal *** it has several advantages,such as lower volume of blood loss and shorter operative time,the effect of the WJ system for hepatic dissection on the remnant liver has not yet been *** To investigate and compare the effect of the WJ method vs CUSA on the remnant liver cut *** This observational study compared the two types of parenchymal transection methods(WJ vs CUSA)in liver *** total,24 and 40 patients who underwent hepatectomy using the WJ method and CUSA,respectively,were included in the ***,the clinicopathological characteristics and clinical outcomes of 24 and 40 patients were ***,postoperative contrast-enhanced computed tomography(CT)scan was performed to assess the cut surface length of the remnant liver and the degenerative thickness of the areas with a reduced contrast effect in the dissected ***,the two groups were *** On CT scan,the median areas of denaturation in the liver dissection planes were 522(range:109.5-1242)mm^(2) in the CUSA group and 324(range:93.6-1529)mm^(2) in the WJ *** area did not significantly differ between the two groups;however,the denaturation thickness of the WJ group was significantly lower than that of the CUSA group[5.8(range:0.7-11.1)mm vs 3.3(range:1.7-10.4)mm,P<0.001].CONCLUSION The WJ group had significantly thinner contrast-enhanced areas in the post hepatectomy detached section than the CUSA group.

关键词： Water jet Cavitron ultrasonic surgical aspirator Energy device Hepatic parenchymal dissection Liver resection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Color representation method using RGB color binary-weighted computer-generated holograms

引用

Chinese Optics Letters 2018年第8期16卷 25-29页

作者： Masato fujiwara Naoki Takada Hiromitsu Araki Shohei Ikawaa yuki Maeda Hiroaki Niwase Minoru Oikawa Takashi Kakue Tomoyoshi Shimobaba Tomoyoshi Ito Graduate School of h~teg＇rated Arts and Sciences Kochi University Kochi 780-8520 Japan 2Science Department Natural Sciences Cluster Research and Education Faculty Kochi University Kochi 780-8520 Japa Faculty of Science Kochi University Kochi 780-8520 .lapan IGraduate School of Engineering Chiba University Chiba 263-8522 Japan

We propose a method for color electroholography using a simple red-green-blue （RGB） gradation representa- tion method without controlling the respective brightness of tile reference RGB-colored lights. The proposed method uses RGB multiple bit planes comprising RGB binary-weighted computer-generated holograms with various light transmittanees. The object points of a given three-dimensional （3D） object are assigned to RGB nmltiple bit planes according to their RGB gradation levels. The RGB multiple bit planes are sequentially displayed in a tim-division-multiplexe- manner. Consequently, the proposed method yields a color gradation representation of a reconstructed 3D object.

关键词： RGB Color representation method using RGB color binary-weighted computer-generated holograms CGH

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gradation representation method using a binary-weighted computer-generated hologram based on pulse-width modulation

引用

Chinese Optics Letters 2017年第6期15卷 46-49页

作者： Masato fujiwara Naoki Takada Hiromitsu Araki Chun Wei Ooi Shohei Ikawa yuki Maeda Hiroaki Niwase Takashi Kakue Tomoyoshi Shimobaba Tomoyoshi Ito Graduate School of Integrated Arts and Sciences Kochi University Kochi 780-8520 Japan Science Department Natural Sciences Cluster Research and Education Faculty Kochi University Kochi 780-8520 Japan Faculty of Science Kochi University Kochi 780-8520 Japan Graduate School of Engineering Chiba University Chiba 263-8522 Japan

We propose a simple gradation representation method using a binary-weighted computer-generated hologram（CGH） to be displayed on a high-speed spatial light modulator that can be controlled by the pulse-width modulation technique. The proposed method uses multiple bit planes comprising binary-weighted CGHs with various pulse widths. The object points of a three-dimensional（3D） object are assigned to multiple bit planes according to their gray levels. The bit planes are sequentially displayed in a time-division-multiplexed ***, the proposed method realizes a gradation representation of a reconstructed 3D object.

关键词： reconstructed displayed gradation modulator sequentially colors manner assigned camera calculating

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fast time-division color electroholography using a multiple-graphics processing unit cluster system with a single spatial light modulator

引用

Chinese Optics Letters 2017年第12期15卷 34-37页

作者： Hiromitsu Araki Naoki Takada Shohei Ikawa Hiroaki Niwase yuki Maeda Masato fujiwara Hirotaka Nakayama Minoru Oikawa Takashi Kakue Tom oyoshi Shim obaba and Tom oyoshi Ito Graduate School of Integrated Arts and Sciences Kochi Universit y Kochi 780-8520 Japan Science Department Natural Sciences Cluster Research and Education Faculty Kochi University Kochi 780-8520 Japan Faculty of Science Kochi University Kochi 780-8520 Japan Center for Computational Astrophysics National Astronomical Observatory of Japan Mitaka-shi 181-8588 Japan Graduate School of Engineering Chiba University Chiba 263-8522 Japan

We demonstrate fast time-division color etectroholography using a multiple-graphics-processing-unit （GPU） cluster system with a spatial light modulator and a controller to switch the color of the reconstructing light. The controller comprises a universal serial bus module to drive the liquid crystal optical shutters. By using the controller, the computer-generated hologram （CGH） display node of the multiple-GPU cluster system synchronizes the display of the CGH with the color switching of the reconstructing light. Fast time-division color electroholography at 20 fps is realized for a three-dimensional object comprising 21,000 points per color when 13 GPUs are used in a multiple-GPU cluster system.

关键词： GPU RGB Fast time-division color electroholography using a multiple-graphics processing unit cluster system with a single spatial light modulator CGH

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Angle of covered self-expandable metallic stents after placement is a risk factor for recurrent biliary obstruction

引用

World Journal of Hepatology 2022年第5期14卷 992-1005页

作者： Kojiro Tanoue Hirotsugu Maruyama yuki Ishikawa-Kakiya Yosuke Kinoshita Kappei Hayashi Masafumi Yamamura Masaki Ominami Yuji Nadatani Shusei Fukunaga Koji Otani Shuhei Hosomi Fumio Tanaka Noriko Kamata Yasuaki Nagami Koichi Taira Toshio Watanabe Yasuhiro fujiwara Department of Gastroenterology Osaka City University Graduate School of MedicineOsaka 545-8585Japan

BACKGROUND Studies have shown that covered self-expandable metallic stents(CSEMS)with a low axial forces after placement can cause early recurrent biliary obstruction(RBO)due to precipitating sludge *** To ascertain whether the angle of CSEMS after placement is a risk factor for RBO in unresectable distal malignant biliary obstruction(MBO).METHODS Between January 2010 and March 2019,261 consecutive patients underwent selfexpandable metallic stent insertion by endoscopic retrograde cholangiopancreatography at our facility,and 87 patients were included in this *** evaluated the risk factors for RBO,including the angle of CSEMS after placement as the primary *** measured the obtuse angle of CSEMS after placement on an abdominal radiograph using the SYNAPSE PACS *** also evaluated technical and functional success,adverse events,time to RBO(TRBO),non-RBO rate,survival time,cause of RBO,and reintervention procedure as secondary *** We divided the patients into two cohorts based on the presence or absence of *** angle of CSEMS after placement(per 1°and per 10°)was evaluated using the multivariate Cox proportional hazard analysis,which was an independent risk factor for RBO in unresectable distal MBO[hazard ratio,0.97 and 0.71;95%confidence interval(CI):0.94-0.99 and 0.54-0.92;P=0.01 and 0.01,respectively].For early diagnosis of RBO,the cut-off value of the angle of CSEMS after placement using the receiver operating characteristic curve was 130°[sensitivity,50.0%;specificity 85.5%;area under the curve 0.70(95%CI:0.57-0.84)].TRBO in the<130°angle group was significantly shorter than that in the≥130°angle group(P<0.01).CONCLUSION This study suggests that the angle of the CSEMS after placement for unresectable distal MBO is a risk factor for *** novel results provide pertinent information for future stent management.

关键词： Covered self-expandable metallic stents Recurrent biliary obstruction Malignant biliary obstruction Endoscopic retrograde cholangiopancreatography Angle Axial force

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

维多利亚和阿尔伯特博物馆·邓迪分馆

引用

城市环境设计 2024年第1期147卷 48-53页

作者：池口由纪 Mucciola Maurizio Piccinelli Maria Chiara 垣副正树片桐和也铃木公雄松长知宏珠玖优喜多啓藤原徹平针谷将史平辻里佳斋藤浩章 Ross Fraser McLean HuftonCrow

英国维多利亚和阿尔伯特博物馆（伦敦）的新建筑坐落在苏格兰北部城市邓迪的海滨。这是苏格兰第一家设计博物馆，预计将作为推广苏格兰文化的一个基地。建筑用地面向流经邓迪河以南的泰河。建筑物悬挑于水面之上，这是我们为一种融合自...

英国维多利亚和阿尔伯特博物馆（伦敦）的新建筑坐落在苏格兰北部城市邓迪的海滨。这是苏格兰第一家设计博物馆，预计将作为推广苏格兰文化的一个基地。建筑用地面向流经邓迪河以南的泰河。建筑物悬挑于水面之上，这是我们为一种融合自然环境和周围景观的新型建筑提出的创意。我们对苏格兰北部奥克尼岛美丽的悬崖很感兴趣，希望通过建筑来传达其自然性，因此我们提出了将多层不同角度的预制混凝土长板堆叠起来的想法，以实现具有微妙细微差别和动态感的立面。当今先进的参数化设计系统使我们能够实现上述目标。

关键词：

来源：博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：