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Novel re-intervention device for occluded multiple uncovered self-expandable metal stent(with video)

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Hepatobiliary & Pancreatic Diseases International 2023年第4期22卷 434-436页

作者： Takeshi Ogura yuki Uba Mitsuki Tomita Kimi Bessho Hiroki Nishikawa 2nd Department of Internal Medicine Osaka Medical and Pharmaceutical University2-7 DaigakuchouTakatsukishiOsaka 569-8686Japan

To the Editor:Obstructive jaundice due to unresectable malignant hilar obstruction can be treated by deployment of bilateral uncovered self-expandable metal stents(UCSEMSs),which enable longer stent patency to be obtained compared with multiple plastic stents[1-3].However,re-intervention is needed if obstructive jaundice occurs after bilateral UCSEMS *** re-intervention procedures,insertion of the stent delivery system across the mesh of a UCSEMS and into the bile duct can be challenging.A novel drill dilator has recently become available in Japan(Tornus ES;Asahi Intecc,Nagoya,Japan)(Fig.1)[4].The tract is easily dilated using a clockwise *** herein describe a successful re-intervention using this device for a patient with occluded bilateral UCSEMSs.

关键词： stent struction Asahi

Endoscopic hemostasis using self-expandable metal stent combinedwith PuraStat® for patient with high risk of post-endoscopicsphincterotomy bleeding (with video)

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 94-96页

作者： Takeshi Ogura yuki Uba Masahiro Yamamura Nobu Nishioka Hiroki Nishikawa 2nd Department of Internal Medicine Osaka Medical and Pharmaceutical UniversityOsakaJapan

To the Editor:Endoscopic sphincterotomy(EST)is an established technique for removal of bile duct stones and self-expandable metal stent(SEMS)***,bleeding can be considered an adverse event after EST,particularly for patients with high risk of bleeding such as those on *** the various techniques reported for obtaining endoscopic hemostasis[1-3].

关键词： bleeding stasis endoscopic

Disruption of the TWEAK/Fn14 pathway prevents 5-fluorouracil-induced diarrhea in mice

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World Journal of Gastroenterology 2017年第13期23卷 2294-2307页

作者： Takuhito Sezaki yuki Hirata Teruki Hagiwara yuki I Kawamura Tadashi Okamura Rieko Takanashi Kenta Nakano Miwa Tamura-Nakano Linda C Burkly Taeko Dohi Department of Gastroenterology Research Center for Hepatitis and ImmunologyResearch InstituteNational Center for Global Health and Medicine Research Center for Hepatitis and Immunology Research InstituteNational Center for Global Health and Medicine 2~(nd)Department of Internal Medicine Osaka Medical College Section of Animal Models Department of Infectious DiseasesResearch InstituteNational Center for Global Health and Medicine Communal Laboratory Research InstituteNational Center for Global Health and Medicine Biogen

AIM To clarify the roles of TWEAK and its receptor Fn14 in 5-fluorouracil(5-FU)-induced *** Diarrhea was induced in wild-type(WT), Fn14 knockout(KO), and IL-13 receptor(IL-13R)α1 KO BALB/c mice using a single injection of 5-FU. Histological analysis, cytokine analysis, and flow cytometry was performed on ileal tissues and cells. Murine colon carcinomabearing mice were co-treated with an anti-TWEAK antibody and 5-FU. Embryonic fibroblast response to cytokines was also ***5-FU induced high Fn14 expression in epithelial cells. The severity of 5-FU-induced diarrhea was lower in Fn14 KO mice compared with WT mice. Administration of anti-TWEAK antibody reduced 5-FU-induced diarrhea without affecting the antitumor effects of 5-FU in vivo. 5-FU-induced expression of IL-13, IL-17 A, TNF-α, and IFN-γ in the ileum was Fn14 dependent. The severity of 5-FU-induced diarrhea was lower in IL-13Rα1 KO mice, indicating major role for IL-13 signaling via IL-13Rα1 in pathogenesis. We found that IL-13Rα2, an IL-13 neutralizing/cell protective receptor, was strongly induced by IL-33 in vitro and in vivo. IL-13Rα2 was upregulated in the ileum of 5-FU-treated Fn14 KO mice. Thus, the deletion of Fn14 upregulated IL-13Rα2 expression, which reduced IL-13 expression and activity. CONCLUSION Disruption of the TWEAK/Fn14 pathway affects several interconnected pathways, including those associated with IL-13, IL-33, and IL-13Rα2, to attenuate 5-FUinduced intestinal side effects.

关键词： Cancer chemotherapy Interleukin-13 Interleukin-33 Interleukin-13 receptor α2

Infrasound observations at Syowa Station,East Antarctica:Implications for detecting the surface environmental variations in the polar regions

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Geoscience Frontiers 2015年第2期6卷 285-296页

作者： Yoshiaki Ishihara Masaki Kanao Masa-yuki Yamamoto Shigeru Toda Takeshi Matsushima Takahiko Murayama National Institute of Advanced Industrial Science and Technology National Institute of Polar Research Research Organization of Information and Systems Kochi University of Technology Faculty of Education Aichi Education University Faculty of Sciences Kyushu University Japan Weather Association

Characteristic infrasound waves observed at Antarctic stations demonstrate physical interaction involving environmental changes in the Antarctic continent and the surrounding oceans. A Chaparraltype infrasound sensor was installed at Syowa Station （SYO; 39°E, 69°S）, East Antarctica, as one of the projects of the International Polar Year （IPY2007-2008）. Data continuously recorded during the three seasons in 2008-2010 clearly indicate a contamination of the background oceanic signals （microbaroms） with peaks between 4 and 10 s observed during a whole season. The peak amplitudes of the microbaroms have relatively lower values during austral winters, caused by a larger amount of sea-ice extending around the Lutzow-Holm Bay near SYO, with decreasing ocean wave loading effects. Micro- baroms measurements are useful tool for characterizing ocean wave climate, complementing other oceanographic and geophysical data. A continuous monitoring by infrasound sensors in the Antarctic firmly contributes to the Comprehensive Nuclear-Test-Ban Treaty （CTBT） in the southern high latitude, together with the Pan-Antarctic Observations System （PAntOS） under the Scientific Committee on Antarctic Research （SCAR）. Detailed measurements of the infrasound waves in Antarctica, consequently, could be a new proxy for monitoring regional environmental change as well as the temporal climate variations in the polar regions.

关键词： lnfrasound Antarctica Microbaroms Environment Global network

Synthesis of CuInS_2 nanocrystals and their structural transformation triggered by ligand exchange

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Chinese Science Bulletin 2009年第21期54卷 4005-4008页

作者： KATSUHIRO Nose yuki Soma TAKAHISA Omata SHINYA Otsuka-Yao-Matsuo Division of Materials and Manufacturing Science Graduate School of Engineering Osaka University 2-1 Ymadaoka Suita 565-0871 Japan

Chalcopyrite-type CuInS2 NCs was synthesized by the hot-soap method. Mixed solutions, CuI and InCl3 dissolved in the mixture of the tri-octylphosphite and 1-octadecene and the sulfur dissolved in tri-phenylphosphite, were used as source solutions; the hexadecylamine was additionally mixed as a surfactant before the reaction. It was observed that the product CuInS2 NCs structurally transformed from the chalcopyrite(CP)-or zincblende(ZB)-to the wurtzite(WZ)-type depending on the amount of the surfactant and a storage time after the surfactant addition. Very weak photoluminescence in the near-infrared region was observed for the CP-or ZB-type NCs. This band was attributable to the electronhole recombination via defect levels. No photoluminescence was detected for the wurtzite-type NCs.

关键词：电脑合成脑结构配体交换纳米晶体红外光致发光表面活性剂网络电脑引发

Design and Construction of a Low-Force Stylus Probe for On-machlne Tool Cutting Edge Measurement

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Nanomanufacturing and Metrology 2020年第4期3卷 282-291页

作者： Hiraku Matsukuma Bo Wen Shinichi Osawa Sho Sekine yuki Shimizu Wei Gao Department of Finemechanics Graduate School of EngineeringTohoku UniversitySendaiJapan

A new on-machine profiler employing a cantilever beam was proposed and developed to measure the sharp micro-cutting edges of precision cutting tools with low measuring force of 0.1 *** proposed profiler consists of a probe unit and a positioning *** probe unit employs a stylus mounted on the free end of a hollow triangular cantilever beam and a laser displacement sensor to detect the detlection of the cantilever *** positioning unit consists of two single-axis DC servo motor stages for precise positioning of the probe *** cantilever is designed with the assistance of the finite element *** order to demonstrate the feasibility of the proposed measurement system,experiments are conducted and the measurement result for a micro-cutting edge is compared with that by a commercial ***,a method to com-pensate for the measurement error caused by the lateral displacement of the cantilever beam is *** compensated measurement results show good agreement within±2μm with those obtained by the commercial profler.

关键词： On-machine measurement Surface profiler Micro-cutting edge Low-force measurement Cantilever beam

Length-Sorted Semiconducting Carbon Nanotubes for High-Mobility Thin Film Transistors

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Nano Research 2011年第10期4卷 963-970页

作者： Yasumitsu Miyata Kazunari Shiozawa yuki Asada Yutaka Ohno Ryo Kitaura Takashi Mizutani Hisanori Shinohara Department of Chemistry and Institute for Advanced Research Nagoya University Nagoya 464-8602 Japan Department of Quantum Engineering Nagoya University Nagoya 464-8603 Japan

We have developed a process for chemical purification of carbon nanotubes for solution-processable thin-film transistors （TFTs） having high mobility. Films of the purified carbon nanotubes fabricated by simple drop coating showed carrier mobilities as high as 164 cm2V-1s -1 normalized transconductances of 0.78 Sm-1 and on/off current ratios of 10^6. Such high performance requires the preparation of a suspension of micrometer-long and highly purified semiconducting single-walled carbon nanotubes （SWCNTs）. Our purification process includes length and electronic-type selective trapping of SWCNTs using recycling gel filtration with a mixture of surfactants. The results provide an important milestone toward printed high-speed and large-area electronics with roll-to-roll and ink-jet device fabrication.

关键词： Single-walled carbon nanotubes separation thin-film transistors gel filtration dispersion optical absorption carrier mobility

Relating brain structure images to personality characteristics using 3D convolution neural network

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CAAI Transactions on Intelligence Technology 2021年第3期6卷 338-346页

作者： Lixian Cao Yanchun Liang Wei Lv Kaechang Park Yasuhiro Miura yuki Shinomiya Shinichi Yoshida Zhuhai Laboratory of Key Laboratory of Symbol Computation and Knowledge Engineering of Ministry of Education Zhuhai College of Jilin UniversityZhuhaiChina Key Laboratory of Symbol Computation and Knowledge Engineering of Ministry of Education College of Computer Science and TechnologyJilin UniversityChangchunChina School of Information&Research Institute Kochi University of TechnologyKochiJapan

The Keras deep learning framework is employed to study MRI brain data in a preliminary analysis of brain structure using a convolutional neural *** results obtained are matched with the content of personality *** Big Five personality traits provide easy differentiation for dividing personalities into different *** now,the highest accuracy obtained from the results of personality prediction from the analysis of brain structure is about 70%.Although there is still no effective evidence to prove a clear relationship between brain structure and personality,the obtained results could prove helpful in understanding the basic relationship between brain structure and personality characteristics.

关键词： convolution structure dividing

Genome-wide Association Study Reveals that the Aquaporin NIP1;1 Contributes to Variation in Hydrogen Peroxide Sensitivity in Arabidopsis thaiiana

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Molecular Plant 2017年第8期10卷 1082-1094页

作者： Ayan Sadhukhan Yuriko Kobayashi yuki Nakano Satoshi luchi Masatomo Kobayashi Lingaraj Sahoo Hiroyuki Koyama Faculty of Applied Biological Sciences Gifu University Gifu 501-1193 Japan Experimental Plant Division RIKEN BioResource Center Tsukuba Ibaraki 305-0074 Japan Department of Biosciences and Bioengineering Indian Institute of Technology Guwahati Guwahati India

Hydrogen peroxide （H202） is a reactive oxygen species that affects cell signaling in various plant defense responses and induces programmed cell death. To identify the new components associated with H202 signaling and tolerance, we conducted a genome-wide association study （GWAS） on the root growth of 133 Arabidopsis thaliana accessions grown in the presence of toxic H2O2 levels. The most significant SNPs were associated with a cluster of chromosome 4 genes encoding an aquaporin NODULIN 26-LIKE INTRINSIC PROTEIN 1; 1 （NIP1;1）, an NB-ARC domain-containing disease resistance protein （AT4G19050）, and a putative membrane lipoprotein （AT4G19070）. The expression level of NIP1;1 was relatively high in A. thaliana accessions sensitive to H2O2. Additionally, overexpression of NIP1;1 in a tolerant accession （e.g., Col-0） increased the sensitivity of transgenic plants to H2O2. An in planta β-glucuronidase reporter assay revealed that variations in the NIP1;1 promoter were responsible for the differences of its expression level in H2O2-tolerant and -sensitive accessions. Cell death was extensive and H2O2 levels were high in the roots of H2O2-sensitive and NIP1;1-overexpressing accessions. Together, our results indicate that the aquaporin NIP1;1 is a key determinant of the sensitivity ofA. thaliana to H2O2, and contributes to the phenotypic variations detected by our GWAS.

关键词： aquaporin GWAS hydrogen peroxide programmed cell death root length signaling