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生物技术 1992年第3期2卷 17-19页

作者：张凤蕴一濑勇规哈尔滨医科大学免疫学教研室日本大阪大学微生物病研究所微生物基因学部

本文报导了由编码细胞角蛋白的基因组DNA文库中筛选的克隆的特点,介绍了其亚克隆和核苷酸序列分析.序列分析发现,Endo B基因由七个外显子和六个内含子组成.Endo B 基因家族至少由一个结构基因和一个假基因组成.

关键词：细胞角蛋白 EndoB 序列分析

接受干扰素治疗的HCV感染患者的循环可溶性Fas水平

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世界核心医学期刊文摘（胃肠病学分册） 2005年第5期1卷 48-48页

作者： Kakiuchi Y. yuki N. Iyoda K. 姜志茹 Department of Gastroenterology Osaka National Hospital 2-1-14 Hoenzaka Chuo-ku Osaka 540-0006 Japan

Background: The clinical relevance of the circulating soluble form of the Fas-Receptor (sFas) was investigated in patients with hepatitis C receiving type 1 interferon (IFN) therapy. Methods: sFas was quantified by enzyme-linked immunosorbent assay in 66 hepatitis C virus (HCV) carriers and 30 HCV-naive or previously infected controls. The levels were then monitored during enhanced treatment with type 1 IFNs in 15 chronic hepatitis C patients. Results: The HCV carriers had high levels of sFas compared with controls (3.8 ±1.3 vs 2.7 ±0.8ng/ml; P < 0.001). sFas levels in patients with chronic HCV infection were directly related to serum alanine aminotransferase levels (r = 0.440; P < 0.001) and the histological grade (r = 0.403; P = 0.019). Among necroinflammatory reactions, only piecemeal necrosis showed a correlation with sFas levels (r = 0.556; P = 0.001). Pretreatment sFas levels, however, were not predictive of therapeutic outcomes. A sustained virological response to enhanced IFN therapy showed a relation to only the pretreatment HCV load. Interestingly, circulating sFas was upregulated when IFN-βwas administered at short intervals (3MU/every 12h). This upregulation was accompanied by parallel aminotransferase elevation, which was observed regardless of a virological response. Conclusions: sFas elevation, in parallel with the severity of liver injury, suggests the possible upregulation of hepatic Fas expression and the Fas-mediated pathway in both HCV-and type 1 IFN-induced liver injury. The essential function of sFas to protect hepatocytes against Fas-mediated liver injury was not evident in these clinical settings.

关键词：干扰素治疗 Fas HCV感染持续病毒学应答携带者慢性丙型肝炎丙型肝炎患者既往感染临床相关性预治疗

孤立性外展神经麻痹是吉兰-巴雷综合征的局部变异型

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世界核心医学期刊文摘(神经病学分册) 2006年第8期 28-28页

作者： Tatsumoto M. Odaka M. Hirata K yuki N. 陈海 Department of Neurology Dokkyo University School of Medicine Kitakobayashi 880 Mibu Shimotsuga Tochigi 321- 0293 Japan

The authors reviewed clinical profiles and laboratory findings for 100 cases of abducens nerve paresis without impairment of the other cranial nerves, limb weakness, and ataxia throughout the clinical course. Review of the medical records of 9300 patients referred to our neuoroimmunological laboratory for serum anti- ganglioside antibody testing. Information was obtained from each primary physician on symptoms of preceding infection; initial symptoms; neurological signs during the illness; the clinical course; treatment provided; and outcome. Isolated abducens nerve paresis was present in 100 patients and bilateral paresis in 29. Tentative diagnoses made by the primary physicians on request of anti- ganglioside antibody testing were abducens nerve palsy (n = 68), Fisher syndrome (n = 14), acute ophthalmoparesis without ataxia (n = 14). Symptoms of infection anteceded in 63. Tendon reflexes were absent or decreased in 27. Distal paresthesias were experienced by seven. Serum anti- GQ1b antibody was positive in 25. These findings suggest that some cases of isolated abducens nerve palsy can be categorized as a regional variant of Guillain- Barré syndrome or mild form of Fisher syndrome.

关键词：巴雷吉兰外展神经孤立性变异型综合征综合病症

Present state of endoscopic ultrasonography-guided fine needle aspiration for the diagnosis of autoimmune pancreatitis type 1

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World Journal of Meta-Analysis 2019年第5期7卷 218-223页

作者： Mitsuru Sugimoto Tadayuki Takagi Rei Suzuki Naoki Konno Hiroyuki Asama yuki Sato Hiroki Irie Ko Watanabe Jun Nakamura Hitomi Kikuchi Mika Takasumi Minami Hashimoto Takuto Hikichi Hiromasa Ohira Department of Gastroenterology Fukushima Medical UniversitySchool of MedicineFukushima 960-1247Japan Department of Endoscopy Fukushima Medical University HospitalFukushima 960-1247Japan

Autoimmune pancreatitis(AIP)is defined as pancreatitis caused by irregular narrowing of the pancreatic duct accompanied by pancreatic swelling,fibrosis and lymphocyte infiltration,events that are related to autoimmune *** 2010 International Consensus Diagnostic Criteria for AIP defined pancreatitis as“type 1”when increased levels of serum IgG4 were present and other organs were involved;lymphoplasmacytic sclerosing pancreatitis was the main histological *** from surgery,endoscopic ultrasonographyguided fine needle aspiration(EUS-FNA)is the only method for the histological diagnosis of AIP;however,this method is *** use of larger-diameter FNA needles and trucut biopsy did not improve the diagnostic performance of EUS-FNA,but it has improved *** this review,we look back at past efforts to improve the diagnostic performance of EUS-FNA and reveal the present state of EUS-FNA for the histological diagnosis of AIP type 1.

关键词： Autoimmune pancreatitis type 1 Endoscopic ultrasonography-guided fine needle aspiration IgG4-related disease Lymphoplasmacytic sclerosing pancreatitis

Prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis using pancreatic stents: A review of efficacy, diameter and length

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World Journal of Meta-Analysis 2019年第6期7卷 259-268页

作者： Mitsuru Sugimoto Tadayuki Takagi Rei Suzuki Naoki Konno Hiroyuki Asama yuki Sato Hiroki Irie Ko Watanabe Jun Nakamura Hitomi Kikuchi Mika Takasumi Minami Hashimoto Takuto Hikichi Hiromasa Ohira Department of Gastroenterology Fukushima Medical UniversitySchool of Medicine Fukushima 9601247Japan Department of Endoscopy Fukushima Medical University HospitalFukushima 9601295Japan

Although endoscopic retrograde cholangiopancreatography (ERCP) is an important procedure for the diagnosis and treatment of pancreaticobiliary diseases, post-ERCP pancreatitis (PEP) is the most frequent adverse event that can sometimes be fatal. However, prophylactic pancreatic stent (PS) insertion has been performed to prevent PEP in high-risk patients. In some randomized controlled trials (RCTs) and meta-analyses, the efficacy of prophylactic PS insertion has been shown to prevent PEP. In addition, several types of stents have been used to decrease PEP. In this review, we introduce the details of these RCTs and meta-analyses and reveal the specifications for stent placement, for example, the stent diameter and length and the pancreatic region into which the stent should be inserted.

关键词： Endoscopic retrograde cholangiopancreatography Post-endoscopic retrograde cholangiopancreatography pancreatitis Prophylactic pancreatic stent

Pancreatic stents to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis: A meta-analysis

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World Journal of Meta-Analysis 2019年第5期7卷 249-258页

作者： Mitsuru Sugimoto Tadayuki Takagi Rei Suzuki Naoki Konno Hiroyuki Asama yuki Sato Hiroki Irie Ko Watanabe Jun Nakamura Hitomi Kikuchi Mika Takasumi Minami Hashimoto Takuto Hikichi Hiromasa Ohira Department of Gastroenterology Fukushima Medical UniversitySchool of MedicineFukushima CityFukushima Prefecture 960-1295Japan Department of Endoscopy Fukushima Medical University HospitalFukushima CityFukushima Prefecture 960-1295Japan

BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP)plays a major role in the investigation and treatment of pancreaticobiliary ***,post-ERCP pancreatitis(PEP)is a severe adverse *** meta-analyses have shown that prophylactic PS was useful for preventing ***,abstract reports and patients who underwent endoscopic ampullectomy were included in the previous *** addition,two meta-analyses involved non-randomized controlled trials(RCTs).The efficacy of PS for preventing severe PEP was different in each ***,we performed the current metaanalysis,which included only full-text articles,and added new *** To reveal the efficacy of prophylactic pancreatic stent(PS)placement for preventing *** We searched the MEDLINE,Cochrane Library and PubMed databases for related *** the reports retrieved,11 studies were included in this *** full-text articles were published between 1993 and 2016.A total of 1475 patients were enrolled in the included studies;of these patients,734 had a PS inserted,and 741 did not have a PS *** and severe PEP occurrence were evaluated in this *** PEP was observed in all studies and occurred in 39(5.3%)patients who received a *** the other hand,PEP occurred in 141(19%)patients who did not receive a *** occurrence of PEP was significantly lower in the patients who underwent PS placement than in the patients who did not receive a PS(OR=0.32;95%CI:0.23-0.45;P<0.001).In addition,the occurrence of severe PEP was ***,the occurrence of severe PEP was not observed in the stent group;however,the occurrence of severe PEP was observed in 8(1.3%)patients who did not have a PS *** PEP occurred significantly less often in the stent group than in the no stent group(OR=0.24;95%CI:0.06-0.94;P=0.04).CONCLUSION In conclusion,prophylactic PS placement is useful for preventing PEP and severe PEP.

关键词： Endoscopic retrograde cholangiopancreatography Pancreatic stent Postendoscopic retrograde cholangiopancreatography pancreatitis Meta-analysis

单侧外展神经麻痹作为吉兰-巴雷综合征的局部变异

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世界核心医学期刊文摘（眼科学分册） 2006年第8期2卷 7-7页

作者： Tatsumoto M. Odaka M. Hirata K. yuki N. 潘佳鸿 Department of Neurology Dokkyo University School of Medicine Kitakobayashi 880 Mibu Shimotsuga Tochigi 321- 0293 Japan

The authors reviewed clinical profiles and laboratory findings for 100 cases of abducens nerve paresis without impairment of the other cranial nerves, limb weakness, and ataxia throughout the clinical course. Review of the medical records of 9300 patients referred to our neuoroimmunological laboratory for serum anti-ganglioside antibody testing. Information was obtained from each primary physician on symptoms of preceding infection; initial symptoms; neurological signs during the illness; the clinical course; treatment provided; and outcome. Isolated abducens nerve paresis was present in 100 patients and bilateral paresis in 29. Tentative diagnoses made by the primary physicians on request of anti-ganglioside antibody testing were abducens nerve palsy (n=68), Fisher syndrome (n=14), acute ophthalmoparesis without ataxia (n=14). Symptoms of infection anteceded in 63. Tendon reflexes were absent or decreased in 27. Distal paresthesias were experienced by seven. Serum anti-GQ1b antibody was positive in 25. These findings suggest that some cases of isolated abducens nerve palsy can be categorized as a regional variant of Guillain-Barré syndrome or mild form of Fisher syndrome.

关键词：外展神经麻痹急性眼肌麻痹腱反射临床过程共济失调脑神经损伤首诊医师初发症状肢体麻木神

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超声检测技术在鼻骨骨折复位术中的应用

中国美容整形外科杂志 2020年第9期31卷 535-537页

作者：侯俊杰田中隆太郎森田裕紀山本將史門松香一首都医科大学附属北京友谊医院医学美容中心北京100050 日本昭和大学藤丘病院形成外科横滨227-8501

目的探讨超声检测技术在鼻骨骨折复位术中的应用效果。方法 2019年4—12月,对昭和大学藤丘病院就诊的18例鼻骨骨折患者采用软质水囊为媒介的超声检测技术在鼻骨骨折复位术前及术中对鼻骨进行检测,判断鼻骨的移位情况及复位效果。结果超... 详细信息

目的探讨超声检测技术在鼻骨骨折复位术中的应用效果。方法 2019年4—12月,对昭和大学藤丘病院就诊的18例鼻骨骨折患者采用软质水囊为媒介的超声检测技术在鼻骨骨折复位术前及术中对鼻骨进行检测,判断鼻骨的移位情况及复位效果。结果超声检测在鼻骨骨折复位术前可以清晰地判断骨折移位情况,在鼻骨骨折复位术中可以动态评估骨折复位情况,有效地指导复位手术。结论超声检测对于鼻骨骨折的位置判断准确,可以在术中即刻对骨折复位效果进行评估,迅速有效地指导骨折复位。水囊媒介法超声检测技术在评估鼻骨骨折及骨折复位情况中简便易行,值得临床推广应用。

关键词：鼻骨骨折超声辅助技术骨折复位水囊媒介法

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加速器质谱测量^(129)Ⅰ方法的改进

核电子学与探测技术 2007年第4期27卷 740-744页

作者：周本胡長島泰夫姜山吴伟明管永精武绍勇何明袁坚阮向东関李紀笹公和高橋努崎裕貴松四雄騎玉理美智子末木啓介广西大学物理科学与工程技术学院筑波大学应用加速器部中国原子能科学研究院北京102413

在筑波大学的12UD串列加速器上开发了一套改进的129Ⅰ加速器质谱(AMS)测量方法,包括在120°磁铁后安装了一副自行设计制作有静电偏转板,有效改善了对127Ⅰ束流和129Ⅰ计数的测量;采用97MoO2分子导航束稳定加速器端电压,加速器的端电压... 详细信息

在筑波大学的12UD串列加速器上开发了一套改进的129Ⅰ加速器质谱(AMS)测量方法,包括在120°磁铁后安装了一副自行设计制作有静电偏转板,有效改善了对127Ⅰ束流和129Ⅰ计数的测量;采用97MoO2分子导航束稳定加速器端电压,加速器的端电压能稳定在几天内不超过0.1%,结合二次剥离,取得了满意的测量效果。用该方法测得AgI试剂样品的本底水平为7.83×10-13。对129Ⅰ/127Ⅰ比值范围为(4.92~0.28)×10-10的一系列样品的测量不确定度在7%以下,准确度较前有所提高。

关键词：加速器质谱 129I测量静电偏转板二次剥离

熊本城市规划樱町地区第一种市街地再开发事业日本熊本县熊本市

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世界建筑导报 2023年第S2期38卷 46-47页

作者：杉山俊一高桥央甚内有纪藤田健儿无熊本市(摄) 马场道浩(摄) SS(摄) 不详株式会社太宏设计事务所日建设计

连接开放空间,打造城市再生新据点——与熊本城相连的庭院“樱町熊本”诞生了!与熊本城相连的庭院、通过“现代阳春庭”实现城市再生该项目坐落于熊本城的南面,以日本最大的巴士总站为中心,整合商业、文化、住宿和住宅等十余种功能于一... 详细信息

连接开放空间,打造城市再生新据点——与熊本城相连的庭院“樱町熊本”诞生了!与熊本城相连的庭院、通过“现代阳春庭”实现城市再生该项目坐落于熊本城的南面,以日本最大的巴士总站为中心,整合商业、文化、住宿和住宅等十余种功能于一体,是具备防灾功能的大型综合设施。巴士总站在1层,设施的高层部分设在南侧,商业设施等低层部分在北侧,我们还设计了开阔的“樱町花园=现代阳春庭”,它好似覆盖着低层部分的屋顶一样,与地块前面的广小路和花畑公园、花畑广场融为一体。

关键词：城市再生商业设施开放空间城市规划熊本市庭院防灾功能综合设施