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Regulatory Effect of JAK2/STAT3 on the Immune Function of Endotoxin-tolerant Dendritic Cells and its Involvement in Acute Liver Failure

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Journal of Clinical and Translational Hepatology 2022年第5期10卷 879-890页

作者： yukai chen Chaochen Hou Naibin Yang Yanyan Yang Youran chen Deyong Kong Yuchun Jiang Minghao Lin Sijie Zheng Shanshan Li Mingqin Lu Ningbo Puji Hospital NingboZhejiangChina Department of Infectious Diseases The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Department of Infectious Diseases Ningbo First HospitalNingboZhejiangChina

Background and Aims:Acute liver failure(ALF)is a potentially fatal clinical syndrome with no effective *** study aimed to explore the role of Janus kinase 2/signal transducer and activator of transcription 3(JAK2/STAT3)pathway in modulating the phenotype and immune function of endotoxin-tolerant dendritic cells(ETDCs).In addition,we explored the use of EDTCs in an experimental model of ALF and investigated the associated ***:In the in vitro experiment,ETDCs were transfected with adenovirus to induce SOCS1^(+/+)ETDCs and SOCS1^(−/−)***,costimulatory molecules and mixed lymphocyte reaction were *** mice were randomly divided into normal control,ALF,ALF+mock-ETDCs,ALF+SOCS1^(+/+)ETDCs,ALF+AG490,and ALF+AG490+SOCS1^(+/+)ETDCs *** examined the therapeutic effect of adoptive cellular immunotherapy by tail-vein injection of target ETDCs 12 h before ALF ***490,a JAK2/STAT3 inhibitor,was used in the in vivo experiment to further explore the protective mechanism of SOCS1^(+/+)***:Compared with control ETDCs,SOCS1^(+/+)ETDCs had lower expression of costimulatory molecules,weaker allostimulatory ability,lower levels of IL-6 and TNF-αexpression and higher IL-10 ***1^(−/−)ETDCs showed the opposite *** the in vivo experiments,the ALF+SOCS1^(+/+)ETDCs and ALF+AG490+SOCS1^(+/+)ETDCs groups showed less pathological damage and suppressed activation of JAK2/STAT3 *** changes were more pronounced in the ALF+AG490+SOCS1^(+/+)ETDCs *** of SOCS1^(+/+)ETDCs had a protective effect against ALF possibly via inhibition of JAK2 and STAT3 ***:The SOCS1 gene had an important role in induction of endotoxin ***1^(+/+)ETDCs alleviated lipopolysaccharide/D-galactosamine-induced ALF by downregulating the JAK2/STAT3 signaling pathway.

关键词： Liver failure Acute Janus kinase 2/signal transducers and activators of transcription 3(JAK2/STAT3) Endotoxin tolerance Dendritic cells

Hybrid Modulation Strategy with Voltage Balancing Control for Four-level Neutral-point Clamped Converters

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Chinese Journal of Electrical Engineering 2024年第3期10卷 25-36页

作者： Ning Xie Wei Zhao Wenzhi Lin Zhenglei Wang yukai chen chengzhi Li Jianfei chen Digital Grid Research Institute Co. Ltd.China Southern Power GridGuangzhou 510700China School of Electrical Engineering and Automation Wuhan UniversityWuhan 430072China

Capacitor voltage imbalance in four-level(4L)neutral-point clamped(NPC)converters is a direct factor hindering their *** particular,when they are applied in motor drives,space vector pulse-width modulation(SVPWM)is a more popular scheme,but conventional 4L SVPWM cannot achieve the voltage balancing control of DC-link capacitors,is complex to implement,and requires costly computation.A hybrid modulation method with capacitor voltage-balancing control for 4L NPC converters is *** proposed method is achieved using three-level(3L)SVPWM and two-level(2L)carrier-based pulse-width modulation(CPWM)based on the concept of"4L=3L+2L".Thus,it can be easily implemented on a digital chip because the modulation process is nearly identical to that of 3L SVPWM without the more cumbersome 4L SVPWM ***,any proven optimization scheme of 3L SVPWM can be directly applied to the proposed method to further improve *** and experimental results for a 4L active NPC converter demonstrate the effectiveness of the proposed method.

关键词： 4L NPC converters 3L SVPWM 2L CPWM voltage balancing control

Disturbance Observer-Based Prescribed-Time Tracking Control for Robotic Manipulators with Uncertainties and Disturbances

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Disturbance Observer-Based Prescribed-Time Tracking Control ...

第43届中国控制会议

作者： Zixiang Fang yukai chen Ziwei Li School of Automation Southeast University

This paper proposes a prescribed-time tracking control scheme combined with a disturbance observer, ensuring prescribed time convergence for n-link rigid robotic manipulators, while considering both internal uncertainties and external disturbances. Initially, we respectively employ a finite-time function and correction terms to facilitate the design of the controller and disturbance observer, guaranteeing convergence of the system within a predetermined time. In order to address the adverse effects of persistent uncertainties, a prescribed-time disturbance observer is constructed to estimate these uncertainties and ensure that the estimation error converges to zero within the predefined time. Furthermore, in conjunction with the disturbance observer,a prescribed-time controller is formulated via backstepping derivation, executed through refining the virtual tracking *** Lyapunov's direct method, the proposed controller demonstrates outstanding convergence of full-state tracking errors within a predetermined convergence time, irrespective of initial conditions. Finally, the efficacy of the proposed approach is validated through simulations of a two-link robotic manipulator.

关键词： Tracking control prescribed-time disturbance observer robotic manipulators

来源： cnki会议评论

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稀土超磁致伸缩换能器等效热网络建模研究

电工技术学报 2022年第14期37卷 3464-3474,3565页

作者：张智贺杨鑫陈钰凯湖南大学国家电能变换与控制工程技术研究中心长沙410082

超磁致伸缩换能器的工作特性与温度密切相关,快速准确地对换能器温度分布进行分析计算与预测是换能器设计与性能评估的关键。凭借仿真速度快、准确性高等显著优势,热网络建模广泛用于换能器热分析,但多聚焦于稳态建模研究,忽略超磁致伸... 详细信息

超磁致伸缩换能器的工作特性与温度密切相关,快速准确地对换能器温度分布进行分析计算与预测是换能器设计与性能评估的关键。凭借仿真速度快、准确性高等显著优势,热网络建模广泛用于换能器热分析,但多聚焦于稳态建模研究,忽略超磁致伸缩棒由于热导率低所导致的明显的瞬态温度梯度。为此,该文以纵振式超磁致伸缩换能器为研究对象,计及超磁致伸缩棒作为热源的特殊性和对棒材温度空间分布的影响,建立超磁致伸缩换能器瞬态等效热网络模型。首先基于换能器的结构和工作原理,对其进行热分析;然后重点对超磁致伸缩棒进行建模,根据换能器内部传热过程,建立换能器瞬态热网络模型并对模型参数进行计算;最后搭建有限元仿真模型和换能器温升实验平台,从仿真和实验两方面验证了所提热网络模型对换能器温度时空分析的准确性和有效性。

关键词：超磁致伸缩换能器等效热网络瞬态模型参数计算有限元模型温度分布

考虑超磁致伸缩材料非均匀性的大功率电声换能器阻抗特性

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电工技术学报 2021年第10期36卷 1999-2006页

作者：赵能桐杨鑫陈钰凯罗安国家电能变换与控制工程技术研究中心(湖南大学) 长沙410082

为了辐射更高的声功率,大功率超磁致伸缩电声换能器常采用多根超磁致伸缩棒材组合的结构,从而辐射更高声功率。现有的阻抗分析方式一般将超磁致伸缩棒材视作均匀一致的个体进行计算,然而该材料所采用的定向凝固制备方法存在固有缺陷,导... 详细信息

为了辐射更高的声功率,大功率超磁致伸缩电声换能器常采用多根超磁致伸缩棒材组合的结构,从而辐射更高声功率。现有的阻抗分析方式一般将超磁致伸缩棒材视作均匀一致的个体进行计算,然而该材料所采用的定向凝固制备方法存在固有缺陷,导致材料性能一致性不高,因此将棒材性能均匀化处理的阻抗分析并不准确。该文首先利用有限元仿真展示四根棒材参数互异所带来的阻抗影响。在使用分布参数法进行阻抗分析的基础上,进一步考虑每个棒材不同位置参数的差异。然后将棒材按单位长度进行微分,探究棒材不同位置参数互异带来的影响,以相同参数所占微元进行积分求和,进而分析得到换能器整体的阻抗。通过与传统集总参数模型和实验数据的拟合效果进行对比,可知该文所提出阻抗分析方法更准确,对换能器的设计有重要的指导意义。

关键词：超磁致伸缩电声换能器超磁致伸缩材料有限元分析阻抗分析换能器设计

Efficient charge relay steering in Pd nanoparticles coupled with the heterojunction for boosting CO_(2)photoreduction to C_(2)H_(6)

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Science China Materials 2024年第9期67卷 2949-2956页

作者： Jiaojiao Fang chengyang Zhu Lincan Fang yukai chen Huiling Hu Yan Wu Qingqing chen Junjie Mao Key Laboratory of Functional Molecular Solids Ministry of EducationCollege of Chemistry and Materials ScienceAnhui Normal UniversityWuhu241002China Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology Advanced Catalysis and Green Manufacturing Collaborative Innovation CenterSchool of Petrochemical EngineeringChangzhou UniversityChangzhou213164China

Solar-driven CO_(2)conversion to prepare value-added products is highly desirable but *** to the achievement of multi-carbon products via CO_(2)photoconversion is to break the bottlenecks of C-C coupling and multi-electron ***,a charge relay system consisting of Pd-decorated BiOCl-wrapped CuBi_(2)O_(4)is reported by taking advantage of the synergy of Pd nanoparticles(PdNPs)and heterojunction for efficient CO_(2)-to-C_(2)H_(6)*** C_(2)H_(6)production rate reached 167.1µmol g^(-1)h^(-1)with the electron selectivity of 81.1%in the absence of any sacrificial *** spectroscopic characterizations indicated that BiOCl nanosheets,acting as the charge relay,directionally transferred the photogenerated electrons from itself and CuBi2O4 nanorods to PdNPs for C-C *** coordinated ensemble of PdNPs and heterojunction significantly elevated the charge separation and transfer ***,the in-situ spectroscopic analysis supported by theoretical simulations demonstrated that the electron-rich PdNPs generated by the charge relay of PdNPs and heterojunction optimized the CO_(2)-to-C_(2)H_(6)reaction pathway and reduced the energy barrier of the key*CHOCO *** work develops an innovative strategy to design the multifunctional catalysts for the photoconversion of CO_(2)to value-added carbon products.

关键词： charge relay Pd nanoparticles heterojunction CO_(2)photoreduction C_(2)H_(6)

Design of a ZnO/Poly(vinylidene fluoride)inverse opal film for photon localization-assisted full solar spectrum photocatalysis

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Chinese Journal of Catalysis 2021年第1期42卷 184-192页

作者： yukai chen Yu Wang Jiaojiao Fang Baoying Dai Jiahui Kou Chunhua Lu Yuanjin Zhao State Key Laboratory of Materials-Oriented Chemical Engineering College of Materials Science and EngineeringNanjing Tech UniversityNanjing 210009JiangsuChina Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites Nanjing Tech UniversityNanjing 210009JiangsuChina Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM) Nanjing Tech UniversityNanjing 210009JiangsuChina State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096JiangsuChina

Owing to its photonic band gap(PBG)and slow light effects,aniline black(AB)-poly(vinylidene fluoride)(PVDF)inverse opal(IO)photonic crystal(PC)was constructed to promote the utility of light and realize photothermal synergetic *** a highly efficient reaction platform with the capability of restricting heat,a microreactor was introduced to further amplify the photothermal effects of near infrared(NIR)*** photocatalytic efficiency of ZnO/0.5AB-PVDF IO(Z0.5A)increases 1.63-fold compared to that of pure ZnO film under a full solar spectrum,indicating the effectiveness of synergetic promotion by slow light and photothermal ***,a 5.85-fold increase is achieved by combining Z0.5A with a microreactor compared to the film in a *** photon localization effect of PVDF IO was further exemplified by finite-difference time-domain(FDTD)*** conclusion,photonic crystal-microreactor enhanced photothermal catalysis has immense potential for alleviating the deteriorating water environment.

关键词： Photothermal catalysis Photonic crystal Inverse opal Microreactor ZnO

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空气底部间隔装药对爆破效果的影响

轻金属 2003年第1期 7-12页

作者：陈玉凯代方军中铝股份贵州分公司石灰石矿贵州贵阳550058 中铝股份贵州分公司矿山处

贵铝石灰石矿用空气底部间隔装药的方法进行爆破 ,使爆破能量传递均匀 ,降低了初始爆破压力 ,改善爆破效果 ,减少大块率 ,提高电铲作业效率。

关键词：空气底部间隔装药爆破效果爆轰压力延米爆破量炸药单耗深孔爆破

计及漏磁的堆栈式超磁致伸缩制动器多物理场耦合建模研究

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电工技术学报 2023年第9期38卷 2277-2288页

作者：李姝汛杨鑫陈泽坤陈钰凯张智贺国家电能变换与控制工程技术研究中心(湖南大学) 长沙410082

堆栈式超磁致伸缩制动器(SGMA)因其能量密度高、响应速度快且便于提供稳定的偏置磁场而得到广泛应用。由于永磁体和超磁致伸缩材料相对磁导率极低,磁路中存在明显的磁场空间分布不均匀的现象,磁-机耦合导致其动力学相较于传统结构的制... 详细信息

堆栈式超磁致伸缩制动器(SGMA)因其能量密度高、响应速度快且便于提供稳定的偏置磁场而得到广泛应用。由于永磁体和超磁致伸缩材料相对磁导率极低,磁路中存在明显的磁场空间分布不均匀的现象,磁-机耦合导致其动力学相较于传统结构的制动器更为复杂。为了准确地预测SGMA的输出特性,该文基于有限元仿真搭建了计及漏磁的等效磁路,并结合Jiles-Atherton模型、非线性本构模型及考虑分布特性的结构动力学模型,借助Pspice电路仿真软件建立了超磁致伸缩制动器多物理场耦合动态模型。相较于传统的制动器多场耦合模型,所提模型能够更精准地分析磁路中的漏磁行为,并反映由磁场不均匀引起的力学分布特性。最后搭建制动器输出位移测试平台以验证模型的准确性,模型计算结果与实验结果吻合度良好,证明了所建立模型能有效表征SGMA的输入-输出特性。

关键词：堆栈式超磁致伸缩制动器多场耦合模型漏磁动态特性 Pspice电路仿真软件