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World Journal of Clinical Cases 2025年第1期13卷 56-61页

作者： Saori kondo Takashi Suzuki Kanato Yoshiike Sakura Yamanaka Kenta Sonehara Hiroshi Nabeshima Osamu Oguchi Department of Obstetrics and Gynecology Saku Central Hospital Advanced Care CenterSaku City 385-0051NaganoJapan

BACKGROUND Malignant transformation(MT)of mature cystic teratoma(MCT)has a poor prognosis,especially in advanced *** chemoradiotherapy(CCRT)has an inhibitory effect on *** SUMMARY Herein,we present a case in which CCRT had a reduction effect preoperatively.A 73-year-old woman with pyelonephritis was referred to our *** tomography revealed right hydronephrosis and a 6-cm pelvic *** ultrasound-guided fine-needle biopsy(EUS-FNB)revealed squamous cell *** patient was diagnosed with MT of *** to her poor general con-dition and renal malfunction,we selected CCRT,expecting fewer adverse *** CCRT,her performance status improved,and the tumor size was reduced;surgery was *** months postoperatively,the patient developed dis-semination and lymph node *** chemotherapy was *** died 18 months after treatment *** EUS-FNB was useful in the diagnosis of MT of MCT;CCRT suppressed the disea-se and improved quality of life.

关键词： Mature cystic teratoma Malignant transformation Squamous cell carcinoma Concurrent chemoradiotherapy Endoscopic ultrasound-guided fine-needle biopsy Case report

Differences in dinucleotide frequencies of thermophilic genes encoding water soluble and membrane proteins

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第6期12卷 419-427页

作者： Hiroshi NAKASHIMA yuka KURODA Department of Clinical Laboratory Science Graduate Course of Medical Science and TechnologySchool of Health SciencesKanazawa University

The occurrence frequencies of the dinucleotides of genes of three thermophilic and three mesophilic species from both archaea and eubacteria were investigated in this study. The genes encoding water soluble proteins were rich in the dinucleotides of purine dimers, whereas the genes encoding membrane proteins were rich in pyrimidine dimers. The dinucleotides of purine dimers are the counterparts of pyrimidine dimers in a double-stranded DNA. The purine/pyrimidine dimers were favored in the thermophiles but not in the mesophiles, based on comparisons of observed and expected frequencies. This finding is in agreement with our previous study which showed that purine/pyrimidine dimers are positive factors that increase the thermal stability of DNA. The dinucleotides AA, AG, and GA are components of the codons of charged residues of Glu, Asp, Lys, and Arg, and the dinucleotides TT, CT, and TC are components of the codons of hydrophobic residues of Leu, Ile, and Phe. This is consistent with the suitabilities of the different amino acid residues for water soluble and membrane proteins. Our analysis provides a picture of how thermophilic species produce water soluble and membrane proteins with distinctive characters: the genes encoding water soluble proteins use DNA sequences rich in purine dimers, and the genes encoding membrane proteins use DNA sequences rich in pyrimidine dimers on the opposite strand.

关键词： Water soluble and membrane proteins Purine/pyrimidine dimers Thermophilic and mesophilic species Dinucleotide frequencies

An experimental investigation of transient cavitation control on a hydrofoil using hemispherical vortex generators

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Journal of Hydrodynamics 2021年第6期33卷 1139-1147页

作者： Ebrahim Kadivar Takaho Ochiai yuka Iga Ould el Moctar Ship Technology Ocean Engineering and Transport SystemsUniversity of Duisburg-EssenDuisburgGermany Institute of Fluid Scienece Tohoku UniversitySendaiJapan

Unsteady cavitation causes noise,damage,and performance decline in the marine engineering and fluid machinery ***,finding a method to control the cavitation and its destructive effects is important for the industrial *** this work,we proposed a passive method to control the unsteady behavior of transient cavitation at the medium Reynolds *** this aim,we performed an experimental study using a high-speed camera to analyze the effects of hemispherical vortex generators(VGs)on the cavitation dynamics around a hydrofoil *** addition,the pressure pulsations induced by the collapse of the cavity structures in the wake region of the hydrofoil were captured with a pressure transducer mounted on the wall downstream of the *** results showed that the instability behaviors of the cavity structures on the hydrofoil were mitigated using the proposed cavitation passive control *** addition,the pressure pulsations in the wake region of the hydrofoil were reduced *** can be concluded that the suppression of cavitation instabilities can improve the operating life and reliability of the marine and hydraulic systems.

关键词： Hydrodynamic cavitation cavitation passive control hemispherical vortex generators pressure pulsations high speed observation

Surgery for pancreatic tumors in the midst of COVID-19 pandemic

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World Journal of Clinical Cases 2021年第18期9卷 4460-4466页

作者： Hiroyuki Kato Yukio Asano Satoshi Arakawa Masahiro Ito Norihiko Kawabe Masahiro Shimura Chihiro Hayashi Takayuki Ochi Hironobu Yasuoka Takahiko Higashiguchi yuka.kondo Hidetoshi Nagata Akihiko Horiguchi Department of Gastroenterological Surgery Fujita Health University School of Medicine Bantane HospitalNagoya 454-8509Japan

The spread of the new coronavirus(COVID-19)infection in 2020 has had a significant impact on the treatment of cancer *** the COVID-19 pandemic,the biggest challenge for pancreatic surgeons is the difficulty in providing oncological *** this review article,from the standpoint of surgeons,we explain the concept of triaging of patients with pancreatic tumors under the COVID-19 pandemic,and the actual impact of COVID-19 on the treatment of patients with pancreatic *** most vital points in selecting the best therapeutic approach for patients with pancreatic tumors during this pandemic are(1)Oncologists need to tailor the treatment plan based on the COVID-19 phase,tumor malignant potential,and patients’comorbidities;and(2)Optimal treatment for pancreatic cancer should be planned according to the condition of each patient and tumor resectability based on national comprehensive cancer network resectability *** choose the best therapeutic approach for patients with pancreatic tumors during this pandemic,we need to tailor the treatment plan based on elective surgery acuity scale(ESAS).Newly established ESAS for pancreatic tumor and flowchart indicating the treatment strategy of pancreatic cancer,are feasible to overcome this situation.

关键词： COVID-19 Pancreatic ductal adenocarcinoma Surgical treatment Pancreatic tumor Pandemic National comprehensive cancer network resectability criteria

Immunological role of sulfatide in the pathogenesis of multiple sclerosis

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Neural Regeneration Research 2023年第9期18卷 1950-1951页

作者： Mio Hamatani Takayuki kondo Institute for the Advanced Study of Human Biology Kyoto UniversityKyotoJapan Department of Neurology Kansai Medical University Medical CenterMoriguchiJapan

Multiple sclerosis(MS) is a chronic inflammatory demyelinating disease of the central nervous system.A certain population of patients with MS present with a relapse-remitting disease course(RRMS) during the early phase and eventually advance to a progressive course(PMS).While immune modulation therapies have recently seen tremendous success in RRMS,our limited knowledge of pathogenesis hampers the development of effective treatments for PMS.

关键词： pathogenesis sclerosis eventually

Hepatitis C infected patients need vitamin D3 supplementation in the era of direct acting antivirals treatment

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World Journal of Gastroenterology 2017年第8期23卷 1325-1327页

作者： Yasuteru kondo Department of Hepatology Sendai Kousei HospitalAobaSendai City 980MiyagiJapan

It has been reported that the serum level of vitamin D3(Vit D3) could affect the natural course of chronic hepatitis C(CH-C) and the response to treatment with pegylated interferon(Peg-IFN) and ribavirin. Although several mechanisms for the favorable effects of Vit D3 supplementation were reported, the total effect of Vit D3 supplementation remains unclear. Previously, we reported that supplementation with 1(OH)Vit D3 could enhance the Th1 response inducing not only a favorable immune response for viral eradication but also HCC control. Recently, the main treatment of CH-C should be direct acting antivirals(DAAs) without PegIFN. Peg-IFN is a strong immune-modulator. Therefore, an immunological analysis should be carried out to understand the effect of Vit D3 after treatment of DAAs without Peg-IFN. The induction of a favorable immune response by adding Vit D3 might be able to suppress the hepatocarcinogenesis after achieving SVR, especially in children and elderly patients with severe fibrosis lacking sufficient amounts of VitD 3.

关键词： Vitamin D Hepatitis C virus Direct acting antivirals Hepatocarcinogenesis Immune response

Optimization of fuel consumption and NO_(x) emission for mild HEV via hierarchical model predictive control

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Control Theory and Technology 2022年第2期20卷 221-234页

作者： yuka Umezawa Ken Yamauchi Hiroki Seto Toshiro Imamura Toru Namerikawa Graduate School of Science and Technology Keio University3-14-1 HiyoshiKohoku-ku.YokohamaKanagawa 223-8522Japan Isuzu Advanced Engineering Center Ltd 8 TsuchidanaFujisawa.Kanagawa 252-0881.Japan

In this paper,we consider the fuel economy optimization problem for a mild hybrid electric vehicle(HEV)using hierarchical model predictive *** the proposed algorithm,two problems are addressed:eco-driving and torque *** the eco-driving problem,vehicle speed was *** the reduction in fuel consumption and NOx emissions,the torque required to follow the target speed was ***,in the torque distribution problem,the distribution between the engine and motor torques were *** this phase,engine characteristics were *** problems differ in terms of time scales;therefore,a hierarchical model predictive control is ***,the numerical simulation results demonstrated the efficacy of this research.

关键词： Mild HEV Energy management Model predictive control Hierarchical control

Metal-free catalytic reduction of aldehydes,ketones,aldimines,and ketimines

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Chinese Chemical Letters 2010年第11期21卷 1314-1317页

作者： Hiroaki Matsuoka Kazuhiro kondo Graduate School of Medical Sciences Nagoya City University Graduate School of Pharmaceutical Sciences Nagoya City University

The metal-free combination of catalytic amounts of PPh3,B（C6F5）3,and PhSiH_3 can efficiently hydrosilylate aldehydes, ketones,aldimines and ketimines to afford the corresponding reduction products in good yields.

关键词： Metal-free hydrosilylation Reduction Ketone Ketimine

Identification of sources of lead in the atmosphere by chemical speciation using X-ray absorption near-edge structure(XANES) spectroscopy

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Journal of Environmental Sciences 2014年第2期26卷 343-352页

作者： Kohei Sakata Aya Sakaguchi Masaharu Tanimizu Yuichi Takaku yuka Yokoyama Yoshio Takahashi Department of Earth and Planetary Systems Science Hiroshima University Kochi Institute for Core Sample Research Japan Agency for Marine-Earth Science and Technology Institute for Environmental Sciences

Sources of Pb pollution in the local atmosphere together with Pb species, major ions, and heavy metal concentrations in a size-fractionated aerosol sample from Higashi-Hiroshima （Japan） have been determined by X-ray absorption near-edge structure （XANES） spectroscopy, ion chromatography, and ICP-MS/AES, respectively. About 80% of total Pb was concentrated in fine aerosol particles. Lead species in the coarse aerosol particles were PbC204, 2PbCO3-Pb（OH）2, and Pb（NO3）2, whereas Pb species in the fine aerosol particles were PbC204, PbSO4, and Pb（NO3）2. Chemical speciation and abundance data suggested that the source of Pb in the fine aerosol particles was different from that of the coarse ones. The dominant sources of Pb in the fine aerosol particles were judged to be fly ash from a municipal solid waste incinerator and heavy oil combustion. For the coarse aerosol particles, road dust was considered to be the main Pb source. In addition to Pb species, elemental concentrations in the aerosols were also determined. The results suggested that Pb species in size-fractionated aerosols can be used to identify the origin of aerosol particles in the atmosphere as an alternative to Pb isotope ratio measurement.

关键词： lead lead speciation XAFS spectroscopy size-fractionated aerosol sample

Analysis of molten metal spreading and solidification behaviors utilizing moving particle full-implicit method

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Frontiers in Energy 2021年第4期15卷 959-973页

作者： Ryo YOKOYAMA Masahiro kondo Shunichi SUZUKI Koji OKAMOTO Department of Nuclear Engineering and Management The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8656Japan Research Center for Computational Design of Advanced Functional materials(CD-FMat) Department of Materials and ChemistryNational Institute of Advanced Industrial Science and Technology(AIST)Central 21-1-1UmezonoTsukubaIbaraki 305-8568Japan Institute of Engineering Innovation School of EngineeringThe University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8656Japan Nuclear Professional School The University of Tokyo2-22 ShirakataTokai-muraIbaraki 319-1188Japan

To retrieve the fuel debris in Fukushima Daiichi Nuclear Power Plants(1F),it is essential to infer the fuel debris *** particular,the molten metal spreading behavior is one of the vital phenomena in nuclear severe accidents because it determines the initial condition for further accident scenarios such as molten core concrete interaction(MCCI).In this study,the fundamental molten metal spreading experiments were performed with different outlet diameters and sample amounts to investigate the effect of the outlet for spreading-solidification *** the numerical analysis,the moving particle full-implicit method(MPFI),which is one of the particle methods,was applied to simulate the spreading *** the MPFI framework,the melting-solidification model including heat transfer,radiation heat loss,phase change,and solid fraction-dependent viscosity was developed and *** addition,the difference in the spreading and solidification behavior due to the outlet diameters was reproduced in the *** simulation results reveal the detailed solidification procedure during the molten metal *** is found that the viscosity change and the solid fraction change during the spreading are key factors for the free surface condition and solidified ***,it is suggested that the MPFI method has the potential to simulate the actual nuclear melt-down phenomena in the future.

关键词： molten metal spreading solidification particle method severe accident fuel debris decommissioning