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第六届全国免疫学学术大会

作者： yuka kanno Ethan M.Shevach Richard Morrig John J.O'Shea Molecular Immunology and Inflammation Branch NIAMS Laboratory of Immunology NIAIDNIHBethesdaMD Ludwig Boltzmann Institute for cancer Research ViennaAustria

Stat family transcription factors regulated multiple aspects of T cell fate.T regulatory cells (Treg cells)are a critical T cell subset that have essential functions in limiting immune responses. Previous studies have...

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A clinicopathological study on IgG4-related ophthalmic disease

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International Journal of Ophthalmology(English edition) 2018年第9期11卷 1539-1544页

作者： yuka Suimon Satoru Kase Kan Ishijima Hiromi kanno-Okada Susumu Ishida Department of Ophthalmology Faculty of Medicine and Graduate School of MedicineHokkaido University Department of Surgical Pathology Hokkaido University Hospital

AIM： To investigate clinicopathological features of immunoglobulin G4-related ophthalmic disease（IgG4-ROD）, and analyze the recurrence rates following systemic corticosteroid ***： We retrospectively searched clinical features, laboratory and histological findings based on the medical records of 21 patients with IgG4-ROD. All the patients examined in this study underwent surgical resection in the ocular adnexal lesions and underwent histological evaluation. This study further investigated clinical and histopathological features of 15 patients who received systemic corticosteroid after the ***： The mean age of the patients consisting of 7 males（33%） and 14 females（67%） was 61y. Fourteen patients were diagnosed as definitive, and 2 and 5 patients were probable and possible IgG4-ROD, respectively. Eyelid swelling was an initial symptom in 11 patients（52%） who did not show systemic involvements at a diagnosis. Fifteen patients received systemic corticosteroid administration, and all showed remission of inflammation. Among them, 10 patients did not recur, whereas 5 patients（33%） recurred during tapering. There were no significant difference between patients with or without recurrence in clinicopathological ***： In this study, female patients are more predominant in IgG4-ROD. While inflammation recurs in one-third of patients, this study do not identify factors associated with recurrence after systemic corticosteroid administration.

关键词： IgG4-related ophthalmic disease corticosteroid histopathology recurrence

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Human B7-H3 binds to Triggering receptor expressed on myeloid cells-like transcript 2 (TLT-2) and enhances T cell responses

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Open Journal of Immunology 2012年第1期2卷 9-16页

作者： Masaaki Hashiguchi yuka Inamochi Shoya Nagai Noriko Otsuki Jinhua Piao Hiroko Kobori Yumiko kanno Hidefumi Kojima Tetsuji Kobata Miyuki Azuma Department of Immunology Dokkyo Medical University School of Medicine Mibu Tochigi Japan Department of Molecular Immunology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan

The B7 family member B7-H3 is broadly expressed in many tissue and tumor types. B7-H3 expression is induced on some immune cells;however, its immunological function remains controversial, because both immunoenhancing and immunoinhibitory effects have been reported in human and mouse systems. We have previously reported the following: 1) murine B7-H3 specifically bound to Triggering receptor expressed on myeloid cells (TREM)-like transcript 2 (TLT-2, TREML2), a member of the TREM family of receptors;and 2) the B7-H3:TLT-2 pathway up-regulated T cell responses. However, the expression and function of human TLT-2 has not yet been clarified. A recent study found no evidence to support the existence of an interacttion between human B7-H3 and TLT-2. In this study, we demonstrated that human B7-H3 binds to TLT-2 and augments T cell responses. Human and mouse B7-H3Ig chimeric proteins cross-interacted with both human and mouse species of TLT-2-transduced cells. Human TLT-2 was expressed on freshly isolated, peripheral blood B cells and monocytes, and subpopulations of CD4+ and CD8+ T cells. Human TLT-2 expression on T cells did not correlate with na?ve or memory phenotypes and was diminished after culture, despite the presence of mitogenic stimuli. Constitutive TLT-2 expression on monocytes was also down-regulated after culture. Human B7-H3 transfectants augment IL-2 production from TLT-2-transduced T cell hybridomas, and IFN-γ production from peripheral blood CD4+ and CD8+ T cells. The enhanced responses were inhibited by the addition of anti-TLT-2 mAbs, suggesting TLT-2-mediated costimulatory effect. Our results demonstrate the existence of a functional interaction between human B7-H3 and TLT-2, and the restricted expression of TLT-2 on T cells and monocytes.

关键词： B7-H3 Co-Signal Molecule T Cell TLT-2

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