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Is Dose Adjustment Based on Several Factors of Body Size Descriptors Effective for Prevention of Thrombocytopenia by Linezolid Therapy in Hemodialysis Patients?

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Pharmacology & Pharmacy 2016年第10期7卷 417-423页

作者： Hideo Kato Mao Hagihara yuka yamagishi Yukihiro Hamada Jun Hirai Naoya Nishiyama Yusuke Koizumi Katsuhiko Matsuura Hiroshige Mikamo Department of Infection Control and Prevention Aichi Medical University School of Medicine Nagakute Japan Department of Pharmacy Aichi Medical University School of Medicine Nagakute Japan

Previous study suggested that low body weight was one of the risk factors of thrombocytopenia induced by linezolid in non-hemodialysis patients. However, there have been little investigations for the linezolid-induced thrombocytopenia in hemodialysis patients. This study was to evaluate the association between several factors of body size descriptors and thrombocytopenia in hemodialysis-patients. No factor of body size descriptors showed significant correlation with linezolid-induced thrombocytopenia (patients with thrombocytopenia vs patients without thrombocytopenia: body weight;60.0 kg vs 55.3 kg, p = 0.82: body mass indices;21.1 kg/m2 vs 21.2 mg/m2, p = 0.44: ideal body weight;61.2 kg vs 59.5 kg, p = 0.21: lean body weight;50.1 kg vs 45.7 kg, p = 0.64: dosage amount;20.0 mg/kg vs 21.7 mg/kg, p = 0.74: body surface area;1.65 m2 vs 1.54 m2, p = 0.43). There were not significant differences in the body size descriptors between linezolid therapy for more than 14 days and for less than 13 days (more than 14 days vs less than 13 days: body weight;53.5 kg vs 56.8 kg, p = 0.75: body mass indices;20.9 kg/m2 vs 21.1 mg/m2, p = 0.47: ideal body weight;60.3 kg vs 59.9 kg, p = 0.17: lean body weight;44.3 kg vs 47.7 kg, p = 0.56: dosage amount;22.4 mg/kg vs 21.1 mg/kg, p = 0.67: body surface area;1.51 m2 vs 1.59 m2, p = 0.37). Our data suggested that dosage adjustment of linezolid based on body weight was not recommended in hemodialysis-patients.

关键词： Linezolid Thrombocytopenia Body Weight

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Superconducting joints using reacted multifilament MgB_(2)wires:A technology toward cryogen-free MRI magnets

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Journal of Magnesium and Alloys 2024年第1期12卷 159-170页

作者： Dipak Patel Akiyoshi Matsumoto Hiroaki Kumakura yuka Hara Toru Hara Minoru Maeda Hao Liang Yusuke Yamauchi Seyong Choi Jung Ho Kim Md Shahriar A.Hossain School of Mechanical and Mining Engineering The University of QueenslandSt LuciaQueensland 4072Australia National Institute for Materials Science(NIMS) 1-2-1 SengenTsukubaIbaraki 305-0047Japan Department of Electrical Engineering and Kangwon High Magnetic Field Center Institute of Quantum Convergence TechnologyKangwon National UniversityGangwon 24341Republic of Korea Australian Institute for Bioengineering and Nanotechnology(AIBN) The University of QueenslandSt LuciaQueensland 4072Australia Department of Materials Process Engineering Graduate School of EngineeringNagoya UniversityNagoyaAichi 464-8603Japan Institute for Superconducting and Electronic Materials Australian Institute for Innovative MaterialsUniversity of WollongongNorth WollongongNew South Wales 2500Australia

The development of superconducting joining technology for reacted magnesium diboride(MgB_(2))conductors remains a critical challenge for the advancement of cryogen-free MgB_(2)-based magnets for magnetic resonance imaging(MRI).Herein,the fabrication of superconducting joints using reacted carbon-doped multifilament MgB_(2)wires for MRI magnets is *** achieve successful superconducting joints,the powder-in-mold method was employed,which involved tuning the filament protection mechanism,the powder compaction pressure,and the heat treatment *** fabricated joints demonstrated clear superconducting-to-normal transitions in self-field,with effective magnetic field screening up to 0.5 T at 20 *** evaluate the interface between one of the MgB_(2)filaments and the MgB_(2)bulk within the joint,serial sectioning was conducted for the first time in this type of superconducting *** serial sectioning revealed space formation at the interface,potentially caused by the volume shrinkage associated with the MgB_(2)formation or the combined effect of the volume shrinkage and the different thermal expansion coefficients of the MgB_(2)bulk,the filament,the mold,and the sealing *** findings are expected to be pivotal in developing MgB_(2)superconducting joining technology for MRI magnet applications through interface engineering.

关键词： Mg B2 superconducting joint MgB_(2)conductor MRI applications Cryogen-free magnet Persistent-mode operation

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Effect of Wearing a Maxillofacial Prosthesis on Masticatory Rhythm Improvement in Mandibulectomy Patients

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Health 2024年第7期16卷 717-729页

作者： Xuewei Han Mihoko Haraguchi yuka I. Sumita Marwa Ahmed Aboelez Noriyuki Wakabayashi Department of Advanced Prosthodontics Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University (TMDU) Tokyo Japan Department of Partial and Complete Denture School of Life Dentistry at Tokyo The Nippon Dental University Tokyo Japan Department of Prosthodontics Faculty of Dentistry Mansoura University Mansoura Egypt

Background: Recording jaw movement rhythms in patients with jaw defects is challenging using conventional tracking devices. However, masticatory rhythm is crucial for masticatory performance and nutritional intake. This study aimed to explore the impact of using a maxillofacial prosthesis to restore masticatory rhythm in mandibulectomy patients with a novel wearable device. Methods: Twelve patients who underwent mandibulectomy and were rehabilitated with maxillofacial prosthesis were recruited. Chewing rate, cycle durations, coefficient of variation of cycle durations (CV), changing times of skin morphology on the back of the ear pinna area (SM), and masticatory performance were measured during gum chewing without and with a denture using a wearable jaw movement rhythm tracking device. A paired t-test and the Pearson correlation coefficient were used for statistical analysis. Results: The chewing rate increased by 8.6 cycles/min with dentures (P P = 0.01). The CV and SM decreased with dentures (P = 0.004 and P = 0.01, respectively). Significant correlations were found between the CV and SM without dentures (P = 0.004). Conclusion: 1. Wearing maxillofacial prostheses can improve masticatory rhythm in patients who undergo mandibulectomy with Eichner B2 occlusal supports. 2. The wearable device is available for measuring masticatory rhythm in patients with jaw defects in clinics. 3. Changing times of the skin morphology on the back of the ear pinna indicate jaw movement stability through a simpler process than the coefficient of variation of cycle durations.

关键词： Masticatory Rhythm Jaw Movement Rhythm Tracking Device Maxillofacial Prosthesis Head and Neck Tumor Mandibulectomy

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A preliminary study on rectal dose reduction associated with hyaluronic acid implantation in brachytherapy for prostate cancer

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Asian Journal of Urology 2024年第2期11卷 286-293页

作者： Tairo Kashihara yuka Urago Hiroyuki Okamoto Mihiro Takemori Hiroki Nakayama Shohei Mikasa Tetsu Nakaichi Kotaro Iijima Takahito Chiba Junichi Kuwahara Satoshi Nakamura Weishan Chang Yoshiyuki Matsui Hiroshi Igaki Department of Radiation Oncology National Cancer Center Hospital5-1-1 TsukijiChuo-kuTokyoJapan Radiation Safety and Quality Assurance Division National Cancer Center Hospital5-1-1 TsukijiChuo-kuTokyoJapan Department of Radiological Sciences Graduate School of Human Health SciencesTokyo Metropolitan University7-2-10 Higashi-OguArakawa-kuTokyoJapan Department of Radiological Technology National Cancer Center Hospital5-1-1 TsukijiChuo-kuTokyoJapan Department of Urological Oncology National Cancer Center Hospital5-1-1 TsukijiChuo-kuTokyoJapan

Objectives: Hydrogel spacer (HS) was developed to reduce rectal toxicities caused by radiotherapy, but has been reported to cause major adverse events. Our institute has attempted to introduce a hyaluronic acid (HA) as an alternative spacer. This study aimed to compare rectal doses and geometric distributions between the HS and HA implantation in prostate ***: HS and HA were inserted in 20 and 18 patients undergoing high-dose brachytherapy, respectively. The rectum spacer volumes injected were 10 mL and 22 mL, respectively. In the treatment planning system, 13.5 Gy was administered with common catheter positions. The rectal dose indices were assessed between the spacer groups for dosimetry evaluation. Distances between the prostate and rectum and configurations of the spacers were ***: The mean doses irradiated to 0.1 and 2 mL of the rectum were 10.45 Gy and 6.71 Gy for HS, and 6.73 Gy and 4.90 Gy for HA (p<0.001). The mean minimum distances between the prostate and rectum were 1.23 cm and 1.79 cm for HS and HA, respectively (p<0.05). Geometrical configuration comparisons revealed that HA has a higher ability to expand the space than ***: The rectal dose reduction ability of HA is significantly greater than that of HS, suggesting its potential as a new spacer.

关键词： Brachytherapy Hyaluronicacid Hydrogel Prostaticneoplasm Radiotherapy

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Emotion Measurement Using Biometric Signal

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Health 2024年第5期16卷 395-404页

作者： Yukina Miyagi Saori Gocho yuka Miyachi Chika Nakayama Shoshiro Okada Kenta Maruyama Taeyuki Oshima College of Pharmacy Kinjo Gakuin University Nagoya Japan Graduate School of Medicine Aichi Medical University Nagakute Japan Department of Pharmacy Nagoya Ekisaikai Hospital Nagoya Japan Department of Pharmacy Gifu University of Medical Science Kani Japan

In recent years, research on the estimation of human emotions has been active, and its application is expected in various fields. Biological reactions, such as electroencephalography (EEG) and root mean square successive difference (RMSSD), are indicators that are less influenced by individual arbitrariness. The present study used EEG and RMSSD signals to assess the emotions aroused by emotion-stimulating images in order to investigate whether various emotions are associated with characteristic biometric signal fluctuations. The participants underwent EEG and RMSSD while viewing emotionally stimulating images and answering the questionnaires. The emotions aroused by emotionally stimulating images were assessed by measuring the EEG signals and RMSSD values to determine whether different emotions are associated with characteristic biometric signal variations. Real-time emotion analysis software was used to identify the evoked emotions by describing them in the Circumplex Model of Affect based on the EEG signals and RMSSD values. Emotions other than happiness did not follow the Circumplex Model of Affect in this study. However, ventral attentional activity may have increased the RMSSD value for disgust as the β/θ value increased in right-sided brain waves. Therefore, the right-sided brain wave results are necessary when measuring disgust. Happiness can be assessed easily using the Circumplex Model of Affect for positive scene analysis. Improving the current analysis methods may facilitate the investigation of face-to-face communication in the future using biometric signals.

关键词： Biometric Signals Electroencephalogram Electrocardiogram Emotion Communication

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Symptomatic COVID-19 in University Students: A School-Wide Web-Based Questionnaire Survey during the Omicron Variant Outbreak

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Advances in Infectious Diseases 2024年第1期14卷 133-146页

作者： Mai Kitahara Hisami Sameshima Rie Tanuma Kumi Setoyama yuka Yamaguchi Akiyo Kamachi Satoko Nakamura Mayuko Sakuma Yoichi Kawaike Tamotsu Furuya Shinji Ijichi Health Service Center Kagoshima University Kagoshima Japan Center for Management of Information Technologies Kagoshima University Kagoshima Japan

Aim: To detect risk and preventive factors associated with the Omicron variant infection in university students, a combination of a web-based survey and multivariate logistic regression analysis was introduced as the front-line initiatives by the school health practitioners. Design: Questionnaire survey. Methods: The school-wide web-based questionnaire survey was conducted among our university students as a part of the annual health check-up in April, 2023. The positive outcome was confined to the first symptomatic COVID-19 onset during the Omicron variant outbreak. Results: In this self-administered survey, risk or protective associations were merely estimated statistically in university students (n = 5406). In measured factors, karaoke and club/group activities could maintain the statistical significance in adjusted odds ratios (ORs) as relative risk factors, and science course, measles/ rubella (MR) vaccination, and COVID-19 vaccination remained as relative protective factors in adjusted OR analyses. Club/group activities with member gathering and karaoke sing-along sessions in university students may frequently have WHO’s three Cs. These risk factors are still important topics for the infection control of COVID-19 in university students. Together with some recent reports from other researchers, the significant protective role of MR vaccine in our survey warrants further clinical investigation. If the breakthrough infection continuously constitutes the majority of infection, real data in test-negative case-control or web-based questionnaire design continue to be important for statistical analysis to determine the minimal requirement of our strategies which may be equivalent to or replace COVID-19 vaccines.

关键词： Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Coronavirus Disease 2019 (COVID-19) Omicron Variant Risk Behaviors Protective Factors

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High temperature enhances anthocyanin coloration in Asiatic hybrid lily flowers via upregulation of the MYB12 positive regulator

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Horticultural Plant Journal 2022年第6期8卷 769-776页

作者： Masumi yamagishi Research Faculty of Agriculture Hokkaido UniversityN9W9Kita-kuSapporo 060-8589Japan

Although high atmospheric temperatures suppress anthocyanin accumulation in most plant species,we show that high temperatures accelerate anthocyanin pigmentation in flower tepals of Asiatic hybrid lilies(Lilium spp.).After incubation at high temperatures(35℃)for two days,anthocyanin color became deeper in the most of tepal parts of two Asiatic hybrid lily cultivars,although the basal parts of’Montreux’tepals and top parts of’Toronto’outer tepals were *** stimuli often affect the expression of R2R3-MYB positive regulators that control anthocyanin *** their expression is often suppressed by hot temperatures in other species,the expression of lily MYB12 in tepals was upregulated by high ***828(miR828),which suppresses the action of MYB12 post-transcriptionally,exhibited reduced accumulation levels under high temperature,indicating that miR828 regulation is involved in MYB12 *** addition,transcription levels of MYB12,estimated by unspliced MYB12 transcript accumulation,were also activated by high ***,both suppressed miR828 accumulation and increased MYB12 transcription are likely to be involved in MYB12 activation at high *** the whitened basal parts of’Montreux’tepals at 35℃,expression of bHLH2 was severely suppressed while that of MYB12 was not *** present results demonstrate that plants display diverse responses to hot climatic conditions and shed new light on anthocyanin regulation under various environmental conditions.

关键词： Lilium spp Anthocyanin biosynthesis bHLH2 Global atmospheric warming microRNA828 R2R3-MYB

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Differences in dinucleotide frequencies of thermophilic genes encoding water soluble and membrane proteins

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第6期12卷 419-427页

作者： Hiroshi NAKASHIMA yuka KURODA Department of Clinical Laboratory Science Graduate Course of Medical Science and TechnologySchool of Health SciencesKanazawa University

The occurrence frequencies of the dinucleotides of genes of three thermophilic and three mesophilic species from both archaea and eubacteria were investigated in this study. The genes encoding water soluble proteins were rich in the dinucleotides of purine dimers, whereas the genes encoding membrane proteins were rich in pyrimidine dimers. The dinucleotides of purine dimers are the counterparts of pyrimidine dimers in a double-stranded DNA. The purine/pyrimidine dimers were favored in the thermophiles but not in the mesophiles, based on comparisons of observed and expected frequencies. This finding is in agreement with our previous study which showed that purine/pyrimidine dimers are positive factors that increase the thermal stability of DNA. The dinucleotides AA, AG, and GA are components of the codons of charged residues of Glu, Asp, Lys, and Arg, and the dinucleotides TT, CT, and TC are components of the codons of hydrophobic residues of Leu, Ile, and Phe. This is consistent with the suitabilities of the different amino acid residues for water soluble and membrane proteins. Our analysis provides a picture of how thermophilic species produce water soluble and membrane proteins with distinctive characters: the genes encoding water soluble proteins use DNA sequences rich in purine dimers, and the genes encoding membrane proteins use DNA sequences rich in pyrimidine dimers on the opposite strand.

关键词： Water soluble and membrane proteins Purine/pyrimidine dimers Thermophilic and mesophilic species Dinucleotide frequencies

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Glycer-AGEs-RAGE signaling enhances the angiogenic potential of hepatocellular carcinoma by upregulating VEGF expression

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World Journal of Gastroenterology 2012年第15期18卷 1781-1788页

作者： Junichi Takino Shoichi yamagishi Masayoshi Takeuchi Department of Biochemistry Faculty of Pharmaceutical SciencesHiroshima International UniversityHiroshima 737-0112Japan Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications Kurume University School of MedicineKurume 830-0011Japan Department of Advanced Medicine Medical Research InstituteKanazawa Medical UniversityIshikawa 920-0293Japan

AIM:To investigate the effect of glyceraldehyde-derived advanced glycation end-products(Glycer-AGEs) on hepatocellular carcinoma(HCC)***:Two HCC cell lines(Hep3B and HepG2 cells)and human umbilical vein endothelial cells(HUVEC)were *** viability was determined using the WST-8 *** blotting,enzyme linked immunosorbent assay,and real-time reverse transcriptionpolymerase chain reactions were used to detect protein and *** was evaluated by assessing the proliferation,migration,and tube formation of ***:The receptor for AGEs(RAGE)protein was detected in Hep3B and HepG2 ***2 cells werenot affected by the addition of *** markedly increased vascular endothelial growth factor(VEGF)mRNA and protein expression,which is one of the most potent angiogenic *** with the control unglycated bovine serum albumin(BSA) treatment,VEGF mRNA expression levels induced by the Glycer-AGEs treatment were 1.00±0.10 vs 1.92 ±0.09(P<0.01).Similarly,protein expression levels induced by the Glycer-AGEs treatment were 1.63±0.04 ng/mL vs 2.28±0.17 ng/mL for the 24 h treatment and 3.36±0.10 ng/mL vs 4.79±0.31 ng/mL for the 48 h treatment,respectively(P<0.01).Furthermore,compared with the effect of the control unglycated BSA-treated conditioned medium,the Glycer-AGEstreated conditioned medium significantly increased the proliferation,migration,and tube formation of HUVEC,with values of 122.4%±9.0%vs 144.5%±11.3%for cell viability,4.29±1.53 vs 6.78±1.84 for migration indices,and 71.0±7.5 vs 112.4±8.0 for the number of branching points,respectively(P<0.01).CONCLUSION:These results suggest that Glycer-AGEs-RAGE signaling enhances the angiogenic potential of HCC cells by upregulating VEGF expression.

关键词： Advanced glycation end-products Angiogenesis Glyceraldehyde Hepatocellular carcinoma Nonalcoholic steatohepatitis

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An experimental investigation of transient cavitation control on a hydrofoil using hemispherical vortex generators

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Journal of Hydrodynamics 2021年第6期33卷 1139-1147页

作者： Ebrahim Kadivar Takaho Ochiai yuka Iga Ould el Moctar Ship Technology Ocean Engineering and Transport SystemsUniversity of Duisburg-EssenDuisburgGermany Institute of Fluid Scienece Tohoku UniversitySendaiJapan

Unsteady cavitation causes noise,damage,and performance decline in the marine engineering and fluid machinery ***,finding a method to control the cavitation and its destructive effects is important for the industrial *** this work,we proposed a passive method to control the unsteady behavior of transient cavitation at the medium Reynolds *** this aim,we performed an experimental study using a high-speed camera to analyze the effects of hemispherical vortex generators(VGs)on the cavitation dynamics around a hydrofoil *** addition,the pressure pulsations induced by the collapse of the cavity structures in the wake region of the hydrofoil were captured with a pressure transducer mounted on the wall downstream of the *** results showed that the instability behaviors of the cavity structures on the hydrofoil were mitigated using the proposed cavitation passive control *** addition,the pressure pulsations in the wake region of the hydrofoil were reduced *** can be concluded that the suppression of cavitation instabilities can improve the operating life and reliability of the marine and hydraulic systems.

关键词： Hydrodynamic cavitation cavitation passive control hemispherical vortex generators pressure pulsations high speed observation

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