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Hyperglycemia is a significant prognostic factor of hepatocellular carcinoma after curative therapy

World Journal of Gastroenterology 2013年第2期19卷 249-257页

作者： Takanori Hosokawa Masayuki Kurosaki Kaoru Tsuchiya Shuya Matsuda Masaru Muraoka Yuichiro Suzuki Nobuharu Tamaki Yutaka Yasui Toru Nakata Takashi Nishimura Shoko Suzuki Ken Ueda Hiroyuki Nakanishi Jun Itakura yuka takahashi Namiki Izumi Division of Gastroenterology and Hepatology Musashino Red Cross HospitalTokyo 180-8610Japan

AIM:To evaluate whether metabolic factors are related to distant recurrence of hepatocellular carcinoma(HCC) and survival after curative ***:This retrospective study included 344 patients whose HCC was treated curatively by radiofrequency ablation(RFA) *** mean age was 67.6 years and the mean observation period was 4.04 *** etiological background of liver disease was hepatitis B virus infection in 30,hepatitis C virus infection in 278,excessive alcohol drinking in 9,and other in 27 *** Child-Pugh classification grade was A(n = 307) or B(n = 37).The number of HCC nodules was one in 260,two in 61,and three in 23 *** surveillance of HCC recurrence after curative therapy with RFA,patients were radiologically evaluated every 3 *** associated with distant recurrence of HCC or survival were ***:Inadequate maintenance of blood glucose in diabetic patients was associated with higher incidence of distant *** 1-,2-,and 3-year recurrence rates were significantly higher in diabetic patients with inadequate maintenance of blood glucose compared with the others:50.6% vs 26.8%,83.5% vs 54.4%,and 93.8% vs 73.0%,respectively(P = 0.0001).Inadequate maintenance of blood glucose was an independent predictor of distant recurrence [adjusted relative risk 1.97(95%CI,1.33-2.91),(P = 0.0007)] after adjustment for other risk factors,such as number of HCC nodules [2.03(95%CI,1.51-2.73),P < 0.0001] and initial level of serum alpha fetoprotein(AFP) [1.43(95%CI,1.04-1.97),P = 0.028].Obesity was not an independent predictor of *** incidence of distant recurrence did not differ between diabetic patients with adequate maintenance of blood glucose and non-diabetic *** 232 patients who had HCC recurrence,138 had a second *** 1-,2-,and 3-year rates of second recurrence were significantly higher in diabetic patients with inadequate maintenance of blood glucose than in the others:9.0% vs 5.9%,53.1

关键词： Hyperglycemia Hepatocellular carcinoma Recurrence Radio frequency ablation Survival

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Distinctive magnetic resonance imaging findings of hepatocellular carcinoma after hepatitis C virus eradication with direct-acting antivirals

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Hepatoma Research 2020年第3期6卷 41-49页

作者： Takao Shimizu Kaoru Tsuchiya Masayuki Kurosaki Yutaka Yasui Sakura Kirino Keiya Watakabe Leona Osawa Mao Okada Wan Wang Mayu Higuchi Kenta Takaura Shun Kaneko Nobuharu Tamaki Hiroyuki Nakanishi Jun ltakura yuka takahashi Tadakazu Hisamatsu Namiki lzumi Department of Gastroenterology and Hepatology Musashino Red Cross HospitalTokyo 180-8610Japan Department of Gastroenterology and Hepatology Kyorin University HospitalTokyo 180-8610Japan

Aim:The aim of the present study was to evaluate the characteristics of the magnetic resonance imaging features of hepatocellular carcinoma(HCC)that developed early after the eradication of hepatitis C virus(HCV)by direct-acting antiviral(DAA)***:This study included 26 patients who achieved sustained viral response with DAA and developed HCC thereafter within one year(DAA-SVR HCC).The radiologic characteristics of these patients were evaluated by contrast-enhanced magnetic resonance imaging,including diffusion-weighted imaging(DWI)and T2-weighted imaging(T2WI).For comparison,80 HCC patients with positive HCV RNA(HCV-positive HCC)were *** 42 patients where tumor biopsy was available,histological grade and radiologic findings were ***:The rates of high intensity on DWI and T2WI were significantly higher in DAA-SVR HCC compared to HCV-positive HCC(DWI:100%vs.67.5%,P<0.001T2WI:92.6%vs.67.5%,P=0.01).HCC with high intensity on DWI or T2WI was more likely to have moderately or poorly differentiated HCC compared to well-differentiated HCC(DWI:69.7%vs.30.3%,P=0.02;T2WI:66.7%vs.27.3%,P=0.03).Conclusion:High intensity on DWI and hyperintensity on T2WI were distinctive features of HCC that developed within one year after the end of DAA treatment.

关键词： Hepatocellular carcinoma direct-acting antivirals sustained viral response contrast enhanced magnetic resonance imaging

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Identification of sources of lead in the atmosphere by chemical speciation using X-ray absorption near-edge structure(XANES) spectroscopy

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Journal of Environmental Sciences 2014年第2期26卷 343-352页

作者： Kohei Sakata Aya Sakaguchi Masaharu Tanimizu Yuichi Takaku yuka Yokoyama Yoshio takahashi Department of Earth and Planetary Systems Science Hiroshima University Kochi Institute for Core Sample Research Japan Agency for Marine-Earth Science and Technology Institute for Environmental Sciences

Sources of Pb pollution in the local atmosphere together with Pb species, major ions, and heavy metal concentrations in a size-fractionated aerosol sample from Higashi-Hiroshima （Japan） have been determined by X-ray absorption near-edge structure （XANES） spectroscopy, ion chromatography, and ICP-MS/AES, respectively. About 80% of total Pb was concentrated in fine aerosol particles. Lead species in the coarse aerosol particles were PbC204, 2PbCO3-Pb（OH）2, and Pb（NO3）2, whereas Pb species in the fine aerosol particles were PbC204, PbSO4, and Pb（NO3）2. Chemical speciation and abundance data suggested that the source of Pb in the fine aerosol particles was different from that of the coarse ones. The dominant sources of Pb in the fine aerosol particles were judged to be fly ash from a municipal solid waste incinerator and heavy oil combustion. For the coarse aerosol particles, road dust was considered to be the main Pb source. In addition to Pb species, elemental concentrations in the aerosols were also determined. The results suggested that Pb species in size-fractionated aerosols can be used to identify the origin of aerosol particles in the atmosphere as an alternative to Pb isotope ratio measurement.

关键词： lead lead speciation XAFS spectroscopy size-fractionated aerosol sample

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Fatal liver failure caused by reactivation of lamivudine-resistant hepatitis B virus:A case report

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World Journal of Gastroenterology 2007年第6期13卷 964-969页

作者： yuka Suzuki Hiroshi Yotsuyanagi Chiaki Okuse Yoshihiko Nagase Hideaki takahashi Kyoji Moriya Michihiro Suzuki Kazuhiko Koike Shiro Iino Fumio Itoh Division of Gastroenterology and Hepatology Department of Internal Medicine St. Marianna University School of Medicine 2-16-1 Sugao Miyamae-ku Kawasaki 216-8511 Japan Division of Infectious Diseases Department of Internal Medicine University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-0033 Japan Center for Liver Diseases Seizankai Kiyokawa Hospital 2-31-12 Asagayaminami Suginami Tokyo 166-0004 Japan

We present a case of fetal liver failure caused by the activation of larnivudine-resistant hepatitis B virus （HBV） nine months after lamivudine treatment. A 57-year old man visited our hospital for the treatment of decornpensated chronic hepatitis B. Lamivudine was started in December 2001. Subsequently, serum HBV was negative for HBV DNA with seroconversion from HBeAg to anti-HBe and improvement of liver function. However, HBV DNA and HBeAg were again detected in September 2002. He was complicated by breakthrough hepatitis and admitted to our hospital in November for severely impaired liver function. Vidarabine treatment was started and serum HBV DNA and alanine aminotransferase （ALT） decreased transiently. However, after the start of m-interferon treatment, HBV DNA level increased and liver function deteriorated. He died 1 mo after admission. An analysis of amino acid sequences in the polymerase region revealed that rtM204I/V with rtLSOI/V occurred at the time of viral breakthrough. After the start of antiviral treatment, rtL180M was detected in addition to rtM204I/V and rtLSOI/V, and became predominant in the terminal stage of the disease. HBV clone with a high replication capacity may be produced by antiviral treatment leading to the worsening of liver function. Antiviral therapy for patients with breakthrough hepatitis in advanced liver disease should be carefully performed.

关键词： Hepatitis B virus Lamivudine Polymerase Interferon Tyrosine-methionine-aspartate-aspartate

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Ultrasonic echo signal fetures of dissimilar material bonding joints

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中国有色金属学会会刊：英文版 2004年第6期14卷 1050-1054页

作者：刚铁 Yasuo takahashi State Key Lab of Advanced Welding Production Technology Harbin Institute of Technology Harbin 150001 China JWRI Osaka University Japan

An ultrasonic evaluation method of echo feature of diffusion bond joint between two dissimilar materials is presented. The echo signal was acquired by an automatic ultrasonic C-scan test system. It is found that the intensity of echo and its phase can be used to evaluate the joint quality, and interface products of dissimilar materials bonding can be evaluated by ultrasonic method.

关键词：超声波测试异金属扩散结合非破坏性演化

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Creep and creep-fatigue behavior of high chromium steel weldment

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Acta Metallurgica Sinica(English Letters) 2011年第3期24卷 175-182页

作者： Yukio takahashi Masaaki TABUCHI Materials Science Laboratory Central Research Institute of Electric Power Industry National Institute of Material Sciences

Strength of welded joints of high chromium steels is one of the important concerns for fabricators and operators of ultra supercritical thermal power plants. A number of creep as well as creep-fatigue tests with tensile hold have been carried out on the welded joints of two types of high chromium steels widely used in Japan, i.e. Grade 91 and 122 steels. It was found that failure occurred in fine grain heat-affected zone in all the creep-fatigue tests, even at a relatively low temperature and fairly short time where failure occurred in plain base metal region in simple creep testing. Four procedures were used to predict failure lives and their results were compared with the test results. A newly proposed energy-based approach gave the best estimation of failure life, without respect of the material and temperature.

关键词： Creep Creep-fatigue High chromium steel Life prediction Welded joint

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Preface of the Special Issue: Queueing Systems and Engineering Applications

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Journal of Systems Science and Systems Engineering 2019年第2期28卷 129-131页

作者： Wuyi Yue Yutaka takahashi Department of Intelligence and Informatics Konan University Kobe 658-8501 Japan Graduate School of Informatics Kyoto University Kyoto 606-8501 Japan

This volume of the Journal of Systems Science and Systems Engineering is devoted to the extended versions of papers selected and presented at the 12th International Conference on Queueing Theory and Network Applicatio... 详细信息

关键词： Systems 12th Applications

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Short-fetch high waves during the passage of 2019 Typhoon Faxai over Tokyo Bay

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Frontiers of Earth Science 2022年第1期16卷 206-219页

作者： Hiroshi TAKAGI Atsuhei takahashi School of Environment and Society Tokyo Institute of TechnologyTokyo 152-8550Japan

The risk of wind waves in a bay is often overlooked,owing to the belief that peninsulas and islands will inhibit high ***,during the passage of a tropical cyclone,a semi-enclosed bay is exposed to twodirectional waves:one generated inside the bay and the other propagated from the outer *** Faxai in 2019 resulted in the worst coastal disaster in Tokyo Bay in the last few *** authors conducted a post-disaster survey immediately after this *** modeling was also performed to reveal the mechanisms of unusual high *** significant high-wave damage occurred on coasts facing the Pacific *** contrast,Fukuura-Yokohama,which faces Tokyo Bay,suffered overtopping waves that collapsed *** precisely reproduce multi-directional waves,the authors developed an extended parametric typhoon model,which was embedded in the JMA mesoscale meteorological model(JMA-MSM).The peak wave height was estimated to be 3.4 m off the coast of Fukuura,in which the contribution of the outer-sea waves was as low as 10%–20%.A fetchlimited wave developed over a short distance in the bay is considered the primary mechanism of the high *** maximum wave occurred on the left-hand side of the typhoon track in the bay,which appears to be contrary to the common understanding that it is safer within the semicircle of a storm than on the opposite *** Faxai was a small typhoon;however,if the radius was tripled,it is estimated that the wave height would exceed 3 m over the entire bay and surpass 4 m off the coasts of Yokohama and Chiba.

关键词： Typhoon Faxai Tokyo Bay high waves short fetch overtopping wave hindcasting parametric typhoon JMA-MSM storm surge

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Challenges for beyond 5G:ultra-densification of radio access network

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通信学报 2020年第11期41卷 1-11页

作者： Fumiyuki Adachi Ryo takahashi Hidenori Matsuo Research Organization of Electrical Communication Tohoku UniversitySendai 980-8577Japan

Ultra-densification of radio access network(RAN)is a key to efficiently support the exponentially growing mobile data traffic in 5 G ***,extremely high frequency band like mm Wave band was utilized to solve the bandwidth shortage ***,untra-dense reusing the same radio resource produced severe *** the mm Wave link was very harsh due to frequent blockage by *** a new RAN architecture needed to be introduced to realize ultra-reliable communications in such a severe radio propagation *** architecture of distributed MIMO based RAN was ***,enhanced interference coordination(e IC)was ***,the effectiveness of distributed MIMO based RAN with e IC by computer simulation was showed.

关键词： 5G advanced systems distributed MIMO radio access network interference coordination cooperative signal transmission

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Numerical analysis of interaction between solute atom and extended dislocation using force multipoles

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Journal of Central South University 2014年第8期21卷 3000-3006页

作者： Hiroaki Morita Akiyuki takahashi Department of Mechanical Engineering Faculty of Science and TechnologyTokyo University of Science

The interaction between a solute atom and an extended dislocation was investigated using a continuum approximation method with force *** dislocation core structure of extended dislocation was modeled with the Peierls-Nabarro model discretized with a number of infinitesimal Volterra *** interaction energy and force between a nickel solute atom and perfect and extended dislocation in copper were successfully calculated using the force *** results clearly show that the core structure of extended dislocation weakens the interaction with solute *** interaction energy and force for extended dislocations are almost the half of those for perfect dislocations.

关键词： solution hardening force multipole solute atom extended dislocation Peierls-Nabarro model

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