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The role of the CNOT1 subunit of the CCR4-NOT complex in mRNA deadenylation and cell viability

Protein & Cell 2011年第9期2卷 755-763页

作者： Kentaro ito Akinori Takahashi Masahiro Morita Toru Suzuki Tadashi Yamamoto Division of Oncology Department of Cancer BiologyInstitute of Medical ScienceUniversity of TokyoTokyo 108-8639Japan Cell Signal Unit Okinawa Institute of Science and Technology1919-1Okinawa 904-0412Japan

The human CCR4-NOT deadenylase complex consists of at least nine enzymatic and non-enzymatic *** evidence suggests that the non-enzymatic subunits are involved in the regulation of mRNA deadenylation,although their precise roles remain to be *** this study,we addressed the function of the CNOT1 subunit by depleting its expression in HeLa *** cytometric analysis revealed that the sub G1 fraction was increased in CNOT1-depleted ***,the same level of the sub G1 fraction was seen when cells were treated with a mixture of siRNAs targeted against all enzymatic subunits,suggesting that CNOT1 depletion induces apoptosis by destroying the CCR4-NOT-associated deadenylase *** analysis revealed that CNOT1 depletion leads to a reduction in the amount of other CCR4-NOT ***,the specific activity of the CNOT6L immunoprecipitates-associated deadenylase from CNOT1-depleted cells was less than that from control *** formation of P-bodies,where mRNA decay is reported to take place,was largely suppressed in CNOT1-depleted ***,CNOT1 has an important role in exhibiting enzymatic activity of the CCR4-NOT complex,and thus is critical in control of mRNA deadenylation and mRNA *** further showed that CNOT1 depletion enhanced CHOP mRNA levels and activated caspase-4,which is associated with endoplasmic reticulum ER stress-induced *** together,CNOT1 depletion structurally and functionally deteriorates the CCR4-NOTcomplex and induces stabilization of mRNAs,which results in the increment of translation causing ER stress-mediated *** conclude that CNOT1 contributes to cell viability by securing the activity of the CCR4-NOT deadenylase.

关键词： deadenylation CCR4-NOT small interfering RNA P-bodies apoptosis

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Evaluation of thermal sprayed coating using ultrasonic inspection by means of bottom echo back reflection

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中国有色金属学会会刊：英文版 2009年第4期19卷 984-987页

作者： Toshifumi KUBOHORI Toru ito Wahidul lah WAHI Yasuyuki INUI Toshiro IKUTA School of Science and Engineering Kinki University

Thermal spraying technique is widely used in various mechanical parts as a surface reforming ***,as demand to maintain superior mechanical performance in harsh operating environment increases,the need for non-destructive evaluation method for thermal spray coating becomes more *** this purpose,we thinned the thickness of the thermal sprayed coating by abrasion with blasting and used ultrasonic inspection by means of bottom echo reflection for effective measurement of abrasion quantity in thermal sprayed *** results obtained are summarized as *** the thickness of thermal sprayed coating becomes thin,the echo height *** is because thermal sprayed coatings absorb ultrasonic *** energy absorbed by Al2O3 is smaller compared with Fe-13Cr *** sprayed coatings submerged in water have a lower echo height compared with *** mentioned above,the thermal sprayed coating thickness can be estimated using ultrasonic inspection by means of bottom echo back reflection.

关键词：超声波检测热喷涂层评价方法声反射底部热喷涂涂层涂层厚度能量吸收

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小田岳夫先生与中国文学

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杭州师范大学学报（社会科学版） 2024年第3期46卷 45-51页

作者： [日]伊藤虎丸颜淑兰(译) 日本东京女子大学日本东京1670041 中国社会科学院文学研究所北京100732

伊藤虎丸通过对与小田岳夫交往的回忆,从小田岳夫的“人品”切人,探讨其思想与文学,尤其阐明了小田岳夫《鲁迅传》的价值,进而重新评价了竹内好的《鲁迅》。伊藤先生指出,作为日本第一部严格意义上的鲁迅传记,小田《鲁迅传》是划时代的... 详细信息

伊藤虎丸通过对与小田岳夫交往的回忆,从小田岳夫的“人品”切人,探讨其思想与文学,尤其阐明了小田岳夫《鲁迅传》的价值,进而重新评价了竹内好的《鲁迅》。伊藤先生指出,作为日本第一部严格意义上的鲁迅传记,小田《鲁迅传》是划时代的,竹内《鲁迅》是建立在其基础之上。相较小田提出的“‘爱国’者”鲁迅,竹内提出的“文学者”鲁迅则包含某种倒退乃至妥协。

关键词：鲁迅小田岳夫《鲁迅传》竹内好《鲁迅》

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Neoadjuvant therapy for resectable pancreatic cancers

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Hepatobiliary Surgery and Nutrition 2022年第4期11卷 583-585页

作者： Yosuke Inoue Hiromichi ito Yu Takahashi Division of Hepato-Biliary-Pancreatic Surgery Cancer Institute HospitalJapanese Foundation for Cancer ResearchTokyoJapan

Pancreatic cancer(PC)is a potentially systemic disease with more diverse biology than generally *** present,surgical resection is the only curative therapy available for patients with PC,and its indications have long been discussed based on anatomical resectability.A recent consensus recommends neoadjuvant therapy(NAT)for anatomically borderline resectable(BR)cancers(1)as well as induction therapy for unresectable locally advanced(UR-LA)or metastatic(UR-M)cancers.

关键词： cancers therapy curative

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Human PBMC-transferred murine MHC class I/II-deficient NOG mice enable long-term evaluation of human immune responses

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Cellular & Molecular Immunology 2018年第11期15卷 953-962页

作者： Tomonori Yaguchi Asuka Kobayashi Takashi Inozume Kenji Morii Haruna Nagumo Hiroshi Nishio Takashi Iwata Yuyo Ka Ikumi Katano Ryoji ito Mamoru ito Yutaka Kawakami Division of Cellular Signaling Institute for Advanced Medical ResearchKeio University School of MedicineTokyo 160-8582Japan Department of Dermatology Yamanashi University School of MedicineYamanashi 409-3898Japan Department of Obstetrics and Gynecology Keio University School of MedicineTokyo 160-8582Japan Central Institute for Experimental Animals Kanagawa 210-0821Japan

Immunodeficient mice engrafted with human peripheral blood cells are promising tools for in vivo analysis of human patient individual immune ***,when human peripheral blood mononuclear cells(PBMCs)are transferred into NOG(NOD/Shi-scid,IL-2rg null)mice,severe graft versus host disease(GVHD)hinders long term detailed *** of human PBMCs into newly developed murine MHC class I-and class II-deficient NOG(NOG-dKO;NOG-Iab,B2m-double-knockout)mice showed sufficient engraftment of human immune cells with little sign of *** with influenza vaccine resulted in an increase in influenza-specific human IgG Ab,indicating induction of antigen-specific B cells in the NOG-dKO *** with human dendritic cells pulsed with HLA-A2 restricted cytomegalovirus peptide induced specific cytotoxic T cells,indicating the induction of antigen-specific T cells in the NOG-dKO *** cell therapies(ACTs)using melanoma antigen recognized by T cells(MART-1)-specific TCR-transduced activated T cells showed strong tumor growth inhibition in NOG-dKO mice without any sign of GVHD accompanied by preferential expansion of the transferred MART-1-specific T *** using cultured human melanoma infiltrating T cells also showed anti-tumor effects against autologous melanoma cells in NOG-dKO mice,in which changes in human cancer phenotypes by immune intervention,such as increased CD271 expression,could be ***,NOG-dKO mice are useful tools for more detailed analysis of both the induction and effector phases of T-cell and B-cell responses for a longer period than regular NOG mice.

关键词： adoptive cell therapy humanized mouse vaccine

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Seemingly maladaptive refraining from infanticidal probing at the third parasitism attack by the semi-solitary parasitoid Echthrodelphax fairchildii （Hymenoptera： Dryinidae）

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Insect Science 2006年第3期13卷 229-233页

作者： EMI ito YOSHIHIRO Y. YAMADA Insect Ecology Laboratory Faculty of Bioresources Mie University Tsu Mie Japan

We assessed the adaptiveness of refraining from infanticidal probing at the third attack under triple parasitism in the parasitoid Echthrodelphaxfairchildii Perkins, by comparing fitness returns from the third attack with and without probing. Fitness returns were assessed in terms of the survival rate, mean developmental time, and mean adult head width of the progenies. Not probing was maladaptive under triple parasitism with oviposition intervals of 1/24 and 24/24 hours （where the numbers before and after the slash refer to the first-to-second and second-to-third oviposition intervals, respectively）, although no significant difference was detected in fitness returns for oviposition intervals of 24/1 hours. We suggest that the cost of probing （especially the decrease in the chance of future ovipositions） is a reason for the seemingly maladaptive absence of probing.

关键词： cost of reproduction Echthrodelphax fairchildii infanticide ovicide,superparasitism triple parasitism

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A sustainable way of agricultural livelihood:edible bird’s nests in Indonesia

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Ecosystem Health and Sustainability 2021年第1期7卷 332-341页

作者： Yutaka ito Ken’ichi Matsumoto Aswin Usup Yuki Yamamoto Faculty of Regional Policy The University of ShimaneMatsueJapan Faculty of Economics Toyo UniversityTokyoJapan Faculty of Agriculture University of Palangka RayaPalangkarayaIndonesia Graduate School of Fisheries and Environmental Sciences Nagasaki UniversityNagasakiJapan

Edible birds’nests(EBNs)have traditionally been produced in Southeast *** farmers construct buildings for swiftlets and harvest their *** farming does not directly degrade forest resources and is therefore considered a sustainable means of production,whereas the expansion of other agricultural activities often relies on the degradation of natural *** study examines the relationship between natural resources and agricultural livelihoods,focusing on Indonesian EBN *** survey data that we collected in 2017,combined with satellite information on the extent of the forest in Central Kalimantan,Indonesia,we measured production efficiency and identified the natural and social factors that enhance production *** results show that a forest extent ranging between 2,000 and 6,000 meters from nesting building is positively associated with the production efficiency of EBN farming,perhaps because extensive forest could help swiftlets to collect food and build ***,while EBN farming is a sustainable and profitable option,the initial costs of constructing buildings to house swiftlets may deter farmers from participating in the process.

关键词： Edible bird’s nest swiftlet Indonesia forest natural habitat ecosystem services satellite data

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The right hepatic artery syndrome

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World Journal of Gastroenterology 2005年第19期11卷 3008-3009页

作者： Kazumi Miyashita Katsuya Shiraki Takeshi ito Hiroki Taoka Takeshi Nakano First Department of Internal Medicine Mie University School of Medicine TsuMie 514-8507Japan First Department of Surgery Mie University School of Medicine TsuMie 514-8507Japan

Various benign and malignant conditions could cause biliary obstruction. Compression of extrahepatic bile duct (EBD) by right hepatic artery was reported as a right hepatic artery syndrome but all cases were compressed EBD from stomach side. Our case compressed from dorsum was not yet reported, so it was thought to be a very rare case. We present here the first case of bile duct obstruction due to the compression of EBD from dorsum by right hepatic artery.

关键词： Right hepatic artery syndrome Obstructive jaundice Extrahepatic bile duct Right hepatic artery Endoscopic retrograde cholangiography Cholangioen-terostomy

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Difference between low-volume and high-volume Andersen samplers in measuring atmospheric aerosols

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Particuology 2008年第3期6卷 218-222页

作者： Fengfu Fu Nobuo Shinohaya Mitsuo ito Xueqin Xu Mincong Shen Liangjun Xu Key Lab of Analysis and Detecting Technology for Food Safety (Fuzhou University) of Ministry of Education Department of Chemistry Fuzhou University Fuzhou Fujian 350002 China Division of Environment and Radiation Sciences Japan Atomic Energy Agency (JAEA) Tokai-mura Naka-gun lbaraki 319-1195 Japan

The mass concentration and size distribution of aerosols in Tokaimura were investigated using a high-volume and a low-volume Andersen sampler. A difference was found using the two samplers： the concentration of total aerosols determined with the high-volume sampler is smaller than that of the low-volume sampler by 70-90% throughout the year. Compared to the high-volume sampler, low-volume sampler gave lower concentration for aerosols 〉7 μm, higher concentration for aerosols of 3.3-7.0 μm and 〈 1.1 μm, though similar results for aerosols of 1.1-3.3 μm. The low-volume sampler was found to have better separation efficiency and higher accuracy.

关键词： Aerosols Cascade impactor Andersen air sampler Atmospheric particles

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High-precision group-delay dispersion measurements of optical fibers via fingerprint-spectral wavelength-to-time mapping

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Photonics Research 2016年第1期4卷 13-16页

作者： Takashi ito Ondrej Slezak Masahiro Yoshita Hidefumi Akiyama Yohei Kobayashi Institue for Solid State Physics University of Tokyo HiLASE Centre Institute of Physics ASCR

The group-delay dispersion of an optical fiber was measured with the time-of-flight method, using fingerprint-like characteristic spectra from a mode-locked fiber laser source. To determine the group-delay dispersion up to the fourth order, least-squares fitting was applied to the overall time waveform mapped on the time axis for the fingerprint-spectral broadband pulses through a long optical fiber. The analysis of all 4003 data points reduced statistical uncertainty, and provided second-, third-, and fourth-order dispersion with uncertainties of 0.02%, 0.4%, and 4%,respectively.

关键词： length time High-precision group-delay dispersion measurements of optical fibers via fingerprint-spectral wavelength-to-time mapping

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