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基于ADMM-GBS考虑故障影响的互联微电网多时间尺度优化调度

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电力自动化设备 2024年第6期44卷 127-134,144页

作者：王怡聪柯方超周航林毓军张东寅杨东俊苗世洪国网湖北省电力有限公司经济技术研究院湖北武汉430077 华中科技大学电气与电子工程学院强电磁技术全国重点实验室湖北武汉430074 电力安全与高效湖北省重点实验室湖北武汉430074

极端事件攻击微电网可能造成负荷电能供应不足导致大停电事故。针对互联微电网系统,提出了一种考虑极端事件的分布式多时间尺度故障优化调度策略。在故障条件下以系统用户侧削减负荷量最小为目标,建立了互联微电网系统日前-日内两阶段... 详细信息

极端事件攻击微电网可能造成负荷电能供应不足导致大停电事故。针对互联微电网系统,提出了一种考虑极端事件的分布式多时间尺度故障优化调度策略。在故障条件下以系统用户侧削减负荷量最小为目标,建立了互联微电网系统日前-日内两阶段滚动调度模型;基于鲁棒思想,考虑极端事件的时空特性以及故障线路的不确定性,采用分层随机抽样形成故障集,将其作为初始数据确定系统最恶劣故障场景;针对该场景进行线路加固后,采取高斯回代交替方向乘子法(ADMM-GBS)得到最优故障调度策略。通过算例分析验证了所提模型和调度策略的有效性。

关键词：互联微电网系统极端事件分布式调度多时间尺度

ERMAP is a B7 family-related molecule that negatively regulates T cell and macrophage responses

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Cellular & Molecular Immunology 2021年第8期18卷 1920-1933页

作者： Min Su yujun lin Cheng Cui Xiaohong Tian Laijun Lai Department of Human Histology and Embryology School of Basic Medical SciencesStem Cell and Tissue Engineering Research CentreGuizhou Medical UniversityGuiyangGuizhouChina Department of Allied Health Sciences University of ConnecticutStorrsCTUSA University of Connecticut Stem Cell Institute University of ConnecticutStorrsCTUSA

T cell activation and tolerance are tightly regulated by costimulatory and coinhibitory molecules.B7 family members play a crucial role in regulating immune *** this study,we identified erythroid membrane-associated protein(ERMAP)as a novel T cell inhibitory *** shares significant sequence and structural homology with existing B7 family members in its extracellular *** ERMAP protein is expressed on the cell surface of resting and activated antigen-presenting cells(APCs)and in some tumor *** putative ERMAP receptor is expressed on activated CD4 and CD8 T cells and *** mouse and human ERMAP-IgG2a Fc(ERMAP-Ig)fusion proteins inhibit T cell functions in *** of ERMAP-Ig protein ameliorates autoimmune diseases,including experimental autoimmune encephalomyelitis and type 1 diabetes,in ***-ERMAP antibody enhances macrophage phagocytosis of cancer cells in ***,administration of an anti-ERMAP antibody inhibits tumor growth in mice likely by blocking the inhibitory effects of ERMAP on T cells and *** results suggest that therapeutic interaction with the ERMAP inhibitory pathway may represent a novel strategy for treating patients with autoimmune disease or cancer.

关键词： T cells T cell inhibitory molecules autoimmunity EAE

肺结核及并发肺外结核患者淋巴细胞亚群变化的研究及其临床意义

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结核与肺部疾病杂志 2024年第4期5卷 294-304页

作者：陈燕玲吴迪陈秀平林宇君陈晓红福建省福州肺科医院结核科福州350008 福建省肿瘤医院药剂科福州350014

目的:探讨肺结核及并发肺外结核患者淋巴细胞亚群的变化及其临床意义。方法:收集2019年1月1日至2023年1月1日在福建省福州肺科医院确诊的256例肺结核及75例肺结核并发肺外结核患者,对比肺结核与肺外结核组及其各亚组间外周血中淋巴细胞... 详细信息

目的:探讨肺结核及并发肺外结核患者淋巴细胞亚群的变化及其临床意义。方法:收集2019年1月1日至2023年1月1日在福建省福州肺科医院确诊的256例肺结核及75例肺结核并发肺外结核患者,对比肺结核与肺外结核组及其各亚组间外周血中淋巴细胞亚群绝对计数以判断其临床价值。结果:肺结核组患者CD3^(+)T淋巴细胞[902.50(608.25,1269.75)]、CD4^(+)T淋巴细胞[539.00(357.75,765.50)]、CD8^(+)T淋巴细胞[337.50(209.00,472.00)]、B细胞[159.00(82.00,257.50)]、NK细胞[160.00(88.50,244.50)]的数量均显著高于肺结核并发肺外结核组[729.50(468.25,975.50)]、[378.00(171.50,562.00)]、[276.00(152.00,412.00)]、[84.00(57.75,167.75)]、[128.00(51.00,192.00)],差异有统计学意义(Z=-3.074,P=0.002;Z=-4.488,P<0.0001;Z=-8.283,P=0.0341;Z=-2.954,P=0.003;Z=-2.115,P=0.034)。继发性肺结核组与其他亚组相比,CD3^(+)T淋巴细胞的数量[995.00(668.25,1409.75)]显著高于血行播散性肺结核组[709.50(391.00,975.00](Z=2.829,P=0.014)和继发性肺结核并发结核性胸膜炎组[764.00(527.25,1075.00)](Z=3.215,P=0.004)、继发性肺结核并发结核性脑膜炎[778.00(537.50,976.00)](Z=2.915,P=0.011)、继发性肺结核并发多种肺外结核[642.00(244.25,830.50)](Z=2.994,P=0.008)。CD4^(+)T淋巴细胞数量[604.00(384.50,853.00)]显著高于继发性肺结核并发结核性胸膜炎[485.00(309.00,641.00)](Z=2.684,P=0.022)、继发性肺结核并发结核性脑膜炎[378.00(181.50,571.50)](Z=3.780,P=0.0005)、继发性肺结核并发多种肺外结核[277.50(98.00,469.00)](Z=3.445,P=0.002)。CD8^(+)T淋巴细胞数量[382.50(227.75,496.25)]显著高于继发性肺结核并发结核性胸膜炎[273.00(170.25,406.25)](Z=2.995,P=0.008)。B细胞的数量[177.00(94.00,287.00)]显著高于血行播散性肺结核组[104.50(74.00,138.00)](Z=2.700,P=0.021)、继发性肺结核并发结核性胸膜炎组[132.00(66.00,200.00)](Z=2.761,P=0.017)、继发性肺结核并发多种肺外结核[75.00(55.50,115.75)](Z=3.038,P=0.007)。NK细胞的数量[177.00(103.75,264.00)]显著高于血行播散性肺结核组[128.50(48.00,175.75)](Z=2.822,P=0.014)、继发性肺结核并发结核性胸膜炎组[127.00(72.00,245.00)](Z=3.078,P=0.006)。结论:继发性肺结核并发其他类型肺结核或肺外结核时表现出比单纯继发性肺结核更低的CD3^(+)T、CD4^(+)T淋巴细胞、B细胞和NK细胞数量,反映了一种相对抑制的免疫状态。

关键词：结核,肺免疫,细胞淋巴细胞亚群

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The innate interfacial elastic strain field of a transformable B2 precipitate embedded in an amorphous matrix

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npj Computational Materials 2023年第1期9卷 41-48页

作者： Xiaoling Fu yujun lin Mixun Zhu Kai Wang Jiaqing Wu Xing Tong Wenli Song Ming Jen Tan Yuanzheng Yang Jun Shen Gang Wang Chan Hung Shek Robert O.Ritchie School of Materials and Energy Guangdong University of TechnologyGuangzhou 510006China Songshan Lake Materials Laboratory Dongguan 523808China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China Singapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingapore 639798Singapore School of Materials Science and Engineering Fujian University of TechnologyFuzhou 350118China Institute of Materials Shanghai UniversityShanghai 200444China Department of Materials Science and Engineering City University of Hong KongKowloon TongHong Kong SARChina Department of Materials Science&Engineering University of CaliforniaBerkeleyCA 94720USA

When a transformable B2 precipitate is embedded in an amorphous matrix,it is often experimentally observed that the crystalline-amorphous interface not only serves as an initiation site for the martensitic transformation due to local stress concentrations,but also as an inhibitor to stabilize the transformation,the latter being attributed to the“confinement effect”exerted by the amorphous matrix,according to the Eshelby *** two seemingly incongruous factors are examined in this study using molecular dynamics simulations from an atomic interaction *** innate strain gradient in the vicinity of the crystalline-amorphous interface is *** actual interface,the compressive/dilatative transition,and the interfacial maximum strain are investigated to differentiate from the conventional“interface”located within a distance of a few *** innate interfacial elastic strain field model is applicable for the design of materials with a higher degree of martensitic transformation and controllable stress concentration,even in cryogenic environments.

关键词： strain transformation martensitic

Codelivery of anti-CD47 antibody and chlorin e6 using a dual pH-sensitive nanodrug for photodynamic immunotherapy of osteosarcoma

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Oncology Research 2024年第4期32卷 691-702页

作者： JIJIE XIAO HONG XIAO yujun CAI JIANWEI LIAO JUE LIU lin YAO SHAOlin LI Department of Radiology The Fifth Affiliated Hospital of Sun Yat-Sen UniversityZhuhai510900China Department of Ultrasound The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou528405China PCFM Lab of Ministry of Education School of Materials Science and EngineeringGuangzhou510275China

Osteosarcoma is a malignant tumor originating from bone tissue that progresses rapidly and has a poor patient *** has shown great potential in the treatment of ***,the immunosuppressive microenvironment severely limits the efficacy of osteosarcoma *** dual pH-sensitive nanocarrier has emerged as an effective antitumor drug delivery system that can selectively release drugs into the acidic tumor ***,we prepared a dual pH-sensitive nanocarrier,loaded with the photosensitizer Chlorin e6(Ce6)and CD47 monoclonal antibodies(aCD47),to deliver synergistic photodynamic and immunotherapy of *** laser irradiation,Ce6 can generate reactive oxygen species(ROS)to kill cancer cells directly and induces immunogenic tumor cell death(ICD),which further facilitates the dendritic cell maturation induced by blockade of CD47 by ***,both calreticulin released during ICD and CD47 blockade can accelerate phagocytosis of tumor cells by macrophages,promote antigen presentation,and eventually induce T lymphocyte-mediated antitumor ***,the dual pH-sensitive nanodrug loaded with Ce6 and aCD47 showed excellent immune-activating and anti-tumor effects in osteosarcoma,which may lay the theoretical foundation for a novel combination model of osteosarcoma treatment.

关键词： Immunotherapy Osteosarcoma Nanodrug Photodynamic therapy CD47

Enrichment characteristics of normal-pressure marine shale gas in the complex tectonic zone: a case study of the Lower Cambrian Niutitang Formation in northern Guizhou

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Journal of Earth Science 2024年

作者： Wenjibin Sun Zhonghu Wu yujun Zuo Chao Pan Hao Liu Baofeng Lan Jianyun lin Bin Chen Qinggang Chen Guizhou Energy Industry Research Institute Co.， Ltd Mining College， Guizhou University College of Resource and Environmental Engineering， Guizhou University College of Civil Engineering， Guizhou University

The Lower Cambrian Niutitang Formation is a crucial stratum for the exploration of normal-pressure marine shale gas in southern China， with great development potential. To research the normal-pressure shale gas accumulation of the Niutitang Formation in the complex tectonic zone， the shale cores in northern Guizhou were subjected to X-ray diffraction (XRD) and field emission scanning electron microscopy (FE-SEM) observation， and tests were conducted to determine total organic content (TOC)， bitumen reflectance， and nitrogen isotopes. The results indicate that the equivalent vitrinite reflectance of cores varies from 2.30% to 3.73%， and the TOC content of cores varies from 3.8% to 7.8%. The total gas content of three wells in northern Guizhou is 0.5 m3/t， 0.3 m3/t， and 1.4 m3/t， respectively. The TOC content of the shale in the syncline structure is higher than that of the shale in the anticline structure. Nitrogen in shale gas originates primarily from the thermal ammoniation of organic matter， the atmosphere， and the deep crust. Shale gas preservation is favourable in regions with a large range of lifting， and small lifting differences. The syncline is broad and gentle with few faults have better gas accumulation conditions. The Niutitang Formation in the residual syncline of the study area has better gas content than that of other structures. Exploration of shale gas accumulation sweet spots in northern Guizhou should focus on the broad-gentle synclines with minimal changes in stratigraphic lifting， few faults， and no hydrothermal activity at the edges of paleo-uplifts.

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金代镇的若干问题研究

中国历史地理论丛 2009年第2期24卷 116-125页

作者：林玉军韩光辉北京大学城市与环境学院历史地理研究所北京100871

金代镇的数目与其系年问题尚无确论,本文经过研究认为,至章宗泰和八年金代存有镇518个,之前曾有镇578个。金代镇的长官职同宋代的镇监,称为"知镇",被纳入国家职官建制之中;镇上另设有同监、巡检、司吏、提控等官员,与知镇共同负责民事... 详细信息

金代镇的数目与其系年问题尚无确论,本文经过研究认为,至章宗泰和八年金代存有镇518个,之前曾有镇578个。金代镇的长官职同宋代的镇监,称为"知镇",被纳入国家职官建制之中;镇上另设有同监、巡检、司吏、提控等官员,与知镇共同负责民事、词讼、税收、户口、治安、防御等事务。定居人口的增加和镇市建筑的修建表明镇已具有了城镇的完备形态,并承担着经济、行政和军事等诸多职能。

关键词：金代镇数管理人文要素职能

腺病毒抗原检测试剂盒(胶体金法)的生产工艺研究与验证

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生物化工 2023年第6期9卷 27-33页

作者：林育君博迪泰(厦门)生物科技有限公司福建厦门361000

目的:研究腺病毒抗原检测试剂盒(胶体金法)生产工艺参数,确定适宜工艺参数。方法:通过结合垫制备、样品垫制备、包被膜制备、内组装等各工序的生产过程的工艺参数的研究,确定相应的生产工艺参数,以确保产品符合设计要求。结果:结合垫涂... 详细信息

目的:研究腺病毒抗原检测试剂盒(胶体金法)生产工艺参数,确定适宜工艺参数。方法:通过结合垫制备、样品垫制备、包被膜制备、内组装等各工序的生产过程的工艺参数的研究,确定相应的生产工艺参数,以确保产品符合设计要求。结果:结合垫涂布量30 mL、样品垫涂布量35 mL、NC膜喷膜划线速度0.09~0.11μL/mm;干燥参数中烘房温度(37±5)℃,湿度≤30%,干燥12~24 h;搭接尺寸1~2 mm,切条(3.00±0.05)mm;以250~280℃、5~8 mm封袋。产品工艺稳定、可操作性强,可满足本产品生产过程控制并符合产品质量标准。结论:成功确定腺病毒抗原检测试剂盒(胶体金法)生产工艺参数,为持续、稳定生产符合标准要求的产品提供控制方法,为临床准确诊断提供了基础。

关键词：腺病毒胶体金工艺研究

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格林巴利综合征早期神经电生理特征分析

中国卫生标准管理 2017年第13期8卷 51-53页

作者：林玉君烟台市烟台山医院电生理室山东烟台264001

目的探讨格林巴利综合征(GBS)早期神经电生理改变特点。方法回顾性分析我院50例确诊为GBS患者发病2周内神经电生理检测结果。结果 20例(40%)患者运动神经传导速度(MCV)异常,15例(30%)患者复合肌肉动作电位(CMAP)异常,共计25例(50%)患者... 详细信息

目的探讨格林巴利综合征(GBS)早期神经电生理改变特点。方法回顾性分析我院50例确诊为GBS患者发病2周内神经电生理检测结果。结果 20例(40%)患者运动神经传导速度(MCV)异常,15例(30%)患者复合肌肉动作电位(CMAP)异常,共计25例(50%)患者运动神经传导异常;5例(10%)患者感觉神经传导速度异常,4例患者(8%)感觉神经动作电位(SNAP)波幅异常,共计6例(12%)患者感觉神经传导异常;43例(86%)患者F波异常,30例(60%)H反射异常。结果 F波及H反射异常率与运动神经传导异常率差异有统计学意义(P<0.05)。运动神经传导异常率较感觉神经传导异常率差异有统计学意义(P<0.05)。结论 F波及H反射对格林巴利综合征早期诊断具有重要价值。运动神经传导速度检查对格林巴利综合征早期诊断价值高于感觉神经传导速度检查。

关键词：格林巴利综合征 F波 H反射运动神经传导感觉神经传导