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Fundamental Research 2024年第3期4卷 697-698页

作者： yujuan zhu Sanwen Huang Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenGuangdong 518120China State Key Laboratory of Tropical Crop Breeding Chinese Academy of Tropical Agricultural SciencesHaikouHainan 571101China

As global warming accelerates,soil degradation,exacerbated by extreme weather,has become a significant environmental issue worldwide.China,in particular,is grappling with a yearly reduction in arable land due to soil degradation,acidification,and salinization,posing potential threats to food security.The country has a vast area of saline-alkaline land,over half of which are high-pH soda saline soils.These lands often experience simultaneous salt and alkali stress,severely inhibiting plant growth and crop yield.Therefore,finding ways to utilize this marginal and saline-alkaline land for food production is a critical scientific challenge.In this context,Chinese scientists have achieved a breakthrough towards harnessing saline-alkaline land.

关键词： alkaline utilize breakthrough

Sensors-integrated organ-on-a-chip for biomedical applications

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Nano Research 2023年第7期16卷 10072-10099页

作者： Hanxu Chen Zhiqiang Luo Xiang Lin yujuan zhu Yuanjin Zhao Department of Rheumatology and Immunology Nanjing Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325001China

As a promising new micro-physiological system,organ-on-a-chip has been widely utilized for in vitro pharmaceutical study and tissues engineering based on the three-dimensional constructions of tissues/organs and delicate replication of in vivo-like microenvironment.To better observe the biological processes,a variety of sensors have been integrated to realize in-situ,realtime,and sensitive monitoring of critical signals for organs development and disease modeling.Herein,we discuss the recent research advances made with respect to sensors-integrated organ-on-a-chip in this overall review.Firstly,we briefly explore the underlying fabrication procedures of sensors within microfluidic platforms and several classifications of sensory principles.Then,emphasis is put on the highlighted applications of different types of organ-on-a-chip incorporated with various sensors.Last but not least,perspective on the remaining challenges and future development of sensors-integrated organ-on-a-chip are presented.

关键词： organ-on-a-chip(OOC) micro-physiological system tissue engineering sensors biomedical

Hyperglycemia activates FGFR1 via TLR4/c-Src pathway to induce inflammatory cardiomyopathy in diabetes

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1693-1710页

作者： Xiong Chen Jinfu Qian Shiqi Liang Jianchang Qian Wu Luo yujuan Shi Hong zhu Xiang Hu Gaojun Wu Xiaokun Li Guang Liang Department of Endocrinology the First Affiliated HospitalWenzhou Medical UniversityWenzhou 325035China Chemical Biology Research Center School of Pharmaceutical SciencesWenzhou Medical UniversityWenzhou 325035China Department of Wound Repair the First Affiliated HospitalWenzhou Medical UniversityWenzhou 325035China Department of Cardiology the First Affiliated HospitalWenzhou Medical UniversityWenzhou 325035China School of Pharmaceutical Sciences Hangzhou Medical CollegeHangzhou 311399China

Protein tyrosine kinases (RTKs) modulate a wide range of pathophysiological events in several non-malignant disorders, including diabetic complications. To find new targets driving the development of diabetic cardiomyopathy (DCM), we profiled an RTKs phosphorylation array in diabetic mouse hearts and identified increased phosphorylated fibroblast growth factor receptor 1 (p-FGFR1) levels in cardiomyocytes, indicating that FGFR1 may contribute to the pathogenesis of DCM. Using primary cardiomyocytes and H9C2 cell lines, we discovered that high-concentration glucose (HG) transactivates FGFR1 kinase domain through toll-like receptor 4 (TLR4) and c-Src, independent of FGF ligands. Knocking down the levels of either TLR4 or c-Src prevents HG-activated FGFR1 in cardiomyocytes. RNA-sequencing analysis indicates that the elevated FGFR1 activity induces pro-inflammatory responses via MAPKs–NFκB signaling pathway in HG-challenged cardiomyocytes, which further results in fibrosis and hypertrophy. We then generated cardiomyocyte-specific FGFR1 knockout mice and showed that a lack of FGFR1 in cardiomyocytes prevents diabetes-induced cardiac inflammation and preserves cardiac function in mice. Pharmacological inhibition of FGFR1 by a selective inhibitor, AZD4547, also prevents cardiac inflammation, fibrosis, and dysfunction in both type 1 and type 2 diabetic mice. These studies have identified FGFR1 as a new player in driving DCM and support further testing of FGFR1 inhibitors for possible cardioprotective benefits.

关键词： Diabetic cardiomyopathy Protein tyrosine kinases FGFR1 Cardiomyocytes Inflammatory responses Toll-like receptor4 c-Src NFkB

Bamboo‑Inspired Gasotransmitter Microfibres for Wound Healing

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Advanced Fiber Materials 2023年第1期5卷 388-399页

作者： Cheng Zhao Jiahui Guo Han Zhang Min Nie Caihong Yang yujuan zhu Yuanjin Zhao Liping Zhong Department of Rheumatology and Immunology Institute of Translational MedicineThe Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210002China National Center for International Biotargeting Theranostics Guangxi Key Laboratory of Biotargeting TheranosticsCollaborative Innovation Center for Targeting Tumour TheranosticsGuangxi Medical UniversityGuangxi 530021China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China

Diabetic wounds have become a major clinical problem that cannot be ignored.Gases,such as hydrogen sulphide(H_(2)S),have demonstrated value in inducing angiogenesis and accelerating wound healing,while their effective delivery is still challenging.Here,inspired by the continuous-independent hollow structure of bamboo,we propose novel gasotransmitter microfibres with septal H_(2)S bubbles using microfluidic spinning for diabetic wound healing.Benefitting from the exact control of microfluidics,gasotransmitter microfibres with different bubble sizes and morphologies could be generated successfully and continuously.Under the dual effects of drugs in the shell and gas in the core,the wound healing process could be accelerated.Furthermore,the controllable release of drugs could be achieved by adding responsive materials into the microfiber shell,which would promote continuous effects of contents on demand.Based on in vitro and in vivo stud-ies,we have proven that these gasotransmitter microfibres have a positive impact on inducing angiogenesis and promoting cell proliferation during wound healing.Thus,it is believed that the bamboo-inspired gasotransmitter microfibres will have important value in gasotransmitter research and clinical applications.

关键词： Microfluidics Hydrogel Wound healing Bioinspired Gasotransmitter

ARF2 coordinates with PLETHORAs and PINs to orchestrate ABA-mediated root meristem activity in Arabidopsis

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Journal of Integrative Plant Biology 2017年第1期59卷 30-43页

作者： Sujittra Promchuea yujuan zhu Zhizhong Chen Jing Zhang Zhizhong Gong State Key Laboratory of Plant Physiology and Biochemistry College of Biological SciencesChina Agricultural UniversityBeijing 100193China National Center for Plant Gene Research Beijing 100193China

Multiple hormones, including abscisic acid（ABA） and auxin, regulate cell division and differentiation of Arabidopsis root meristems. AUXIN RESPONSE FACTOR2（ARF2） functions as a negative regulator of ABA responses, as seed germination and primary root growth of arf2 mutants are hypersensitive to ABA. In this study, we found that ABA treatment reduced the expression levels of the PIN-FORMEDs（PIN） auxin efflux carriers, PIN1, PIN3,PIN4, and PIN7, to a greater extent in the root meristems of arf2-101 mutant than in the wild type. Also, arf2-101 pin1 and arf2-101 pin4 double mutants show less ABA-induced inhibition of root meristem activity than the arf2-101 mutants. Furthermore, ARF2 positively mediates the transcripts of transcription factor PLETHORA 1（PLT1）gene but negatively mediates PLT2 at protein level in root meristems. Using a dexamethasone（DEX）-inducible transgenic line, Pro35S：PLT2-GR, we showed that PLT2 greatly promotes cell division and completely inhibits cell differentiation in root meristems of the arf2-101 mutant once PLT2 is induced by DEX, which can be partially reversed by ABA treatment, suggesting that ABA regulates root meristem activity in both ARF2-dependent and independent pathways. Our results uncover a complex regulatory architecture in which ARF2 coordinates with PLTs and PINs to orchestrate ABA-mediated regulation of root meristem activity in Arabidopsis.

关键词： Arabidopsis coordinates mutant auxin hypersensitive transgenic transcripts germination partially regulate

Neurodevelopmental impairment induced by prenatal valproic acid exposure shown with the human cortical organoid-on-a-chip model

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Microsystems & Nanoengineering 2020年第1期6卷 754-767页

作者： Kangli Cui Yaqing Wang yujuan zhu Tingting Tao Fangchao Yin Yaqiong Guo Haitao Liu Fei Li Peng Wang Yuejun Chen Jianhua Qin Division of Biotechnology CAS Key Laboratory of SSACDalian Institute of Chemical PhysicsChinese Academy of Sciences457 Zhongshan RoadDalian 116023China University of Chinese Academy of Sciences Beijing 100049China CAS Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijingChina

Prenatal exposure to environmental insults can increase the risk of developing neurodevelopmental disorders.Administration of the antiepileptic drug valproic acid(VPA)during pregnancy is tightly associated with a high risk of neurological disorders in offspring.However,the lack of an ideal human model hinders our comprehensive understanding of the impact of VPA exposure on fetal brain development,especially in early gestation.Herein,we present the first report indicating the effects of VPA on brain development at early stages using engineered cortical organoids from human induced pluripotent stem cells(hiPSCs).Cortical organoids were generated on micropillar arrays in a controlled manner,recapitulating the critical features of human brain development during early gestation.With VPA exposure,cortical organoids exhibited neurodevelopmental dysfunction characterized by increased neuron progenitors,inhibited neuronal differentiation and altered forebrain regionalization.Transcriptome analysis showed new markedly altered genes(e.g.,KLHL1,LHX9,and MGARP)and a large number of differential expression genes(DEGs),some of which are related to autism.In particular,comparison of transcriptome data via GSEA and correlation analysis revealed the high similarity between VPA-exposed organoids with the postmortem ASD brain and autism patient-derived organoids,implying the high risk of autism with prenatal VPA exposure,even in early gestation.These new findings facilitate a better understanding of the cellular and molecular mechanisms underlying postnatal brain disorders(such as autism)with prenatal VPA exposure.This established cortical organoid-on-a-chip platform is valuable for probing neurodevelopmental disorders under environmental exposure and can be extended to applications in the study of diseases and drug testing.

关键词： markedly inhibited exposure

间歇式红外辅助热泵干燥对龙眼品质及挥发性成分的影响

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中国食品学报 2024年第1期24卷 190-199页

作者：朱经楠彭健谢子权余元善唐道邦辜青青徐玉娟江西农业大学农学院南昌330045 广东省农业科学院蚕业与农产品加工研究所、农业农村部功能食品重点实验室、广东省农产品加工重点实验室广州510610

采用不同干燥温度结合间歇式红外辅助热泵干燥龙眼,研究干燥条件对龙眼干燥特性、色泽、复水性、抗氧化活性以及挥发性成分的影响。结果表明:间歇式红外辅助热泵干燥能显著缩短干燥时间,提升干燥龙眼品质。与单一热泵干燥相比,间歇红外... 详细信息

采用不同干燥温度结合间歇式红外辅助热泵干燥龙眼,研究干燥条件对龙眼干燥特性、色泽、复水性、抗氧化活性以及挥发性成分的影响。结果表明:间歇式红外辅助热泵干燥能显著缩短干燥时间,提升干燥龙眼品质。与单一热泵干燥相比,间歇红外辅助干燥的时间可缩短25%~28.6%,复水比增加2.65%~8.21%;间歇红外辅助干燥龙眼总色差值较单一热泵干燥明显降低,色泽均匀性提升,FRAP铁离子还原力显著提高4.42%~17.95%;干燥使龙眼挥发性成分中醇类、醛类、酮类和酯类物质种类或含量增加,香叶基丙酮、正辛醇、癸酸乙酯等特有挥发性物质仅在间歇式红外辅助干燥龙眼中测得,表明间歇式红外辅助能有效丰富龙眼干的香气种类。结论:60℃热泵条件下每5 min辅助红外2 min是间歇式红外辅助热泵干燥的最优处理条件,有利于龙眼干的品质和挥发性物质的形成。

关键词：间歇式红外热泵干燥龙眼品质挥发性物质

1949—2019年中心经过渤海的北上台风统计分析

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海洋预报 2024年第3期41卷 90-97页

作者：朱男男王科胡田田赵玉娟孙晓磊天津海洋中心气象台天津300074 天津市海洋气象重点实验室天津300074 天津市气象信息中心天津300074

利用中国气象局热带气旋最佳路径数据集、自动站资料和常规观测资料,统计1949—2019年中心经过渤海海域的北上台风,共计25次过程。台风强度统计结果表明44%的台风过程为热带低压,16%为热带风暴,28%为强热带风暴,12%为台风残涡。台风中... 详细信息

利用中国气象局热带气旋最佳路径数据集、自动站资料和常规观测资料,统计1949—2019年中心经过渤海海域的北上台风,共计25次过程。台风强度统计结果表明44%的台风过程为热带低压,16%为热带风暴,28%为强热带风暴,12%为台风残涡。台风中心进入渤海后,48%的台风强度减弱,28%的强度不变,24%的强度增强。中心经过渤海的台风96%出现在7—8月,其中7月中下旬—8月上旬占总数的64%,8月上旬的台风数目最多,占总数的29%。北上台风中心最大风速在10~30 m/s,台风入海后平均风速减弱2 m/s。台风中心最小气压为970 hPa,中心最大气压为1 004 hPa,平均气压为992 hPa。西北路径台风中88%进入渤海后强度减弱,偏北路径台风中87.5%进入渤海后强度不变,东北路径台风中83.3%进入渤海后强度增强。

关键词：北上台风统计分析聚类分析渤海预报指标

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从“虚气留滞”论治子宫内膜异位症

中医杂志 2024年第9期65卷 954-957页

作者：张瑜娟朱友华赵嘉静杨亚楠卜梦雅方梦鑫黄欲晓北京中医药大学研究生院北京市100029 中国中医科学院西苑医院

认为虚气留滞是子宫内膜异位症的重要病机,“虚气”为发病之本,以脾气亏虚为主;“留滞”为致病之标,以瘀血为主,兼郁、痰、热、毒等病理因素。提出以补虚通滞为治则,主张以益气健脾、化瘀消癥为主要治法,自拟扶正化瘀方为基础方,分为经... 详细信息

认为虚气留滞是子宫内膜异位症的重要病机,“虚气”为发病之本,以脾气亏虚为主;“留滞”为致病之标,以瘀血为主,兼郁、痰、热、毒等病理因素。提出以补虚通滞为治则,主张以益气健脾、化瘀消癥为主要治法,自拟扶正化瘀方为基础方,分为经期与非经期进行随证加减治疗,兼顾运用行气、祛痰、清热、解毒等多法,标本同治。

关键词：子宫内膜异位症虚气留滞益气健脾化瘀消癥

镉对广蜜二号南瓜幼苗生长与镉累积特性的影响

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中国瓜菜 2024年第5期37卷 90-97页

作者：孟琦涛徐颖超朱吉童曾霖根傅曼琴聂呈荣钟玉娟佛山科学技术学院食品科学与工程学院广东佛山528231 广东省蔬菜新技术研究重点实验室·广东省农业科学院蔬菜研究所广州510640 农业农村部功能食品重点实验室·广东省农产品加工重点实验室·广东省农业科学院蚕业与农产品加工研究所广州510610

镉(Cd)是一种毒性强且分布广的重金属污染物,不仅影响植物生长发育,而且危害人类健康。为了更好地了解Cd在南瓜中的迁移规律,深入探究Cd对植物的毒害机制和植物的防御反应,将广蜜二号南瓜在4种不同质量浓度(1、3、5、7 mg·L^(-1))的Cd ... 详细信息

镉(Cd)是一种毒性强且分布广的重金属污染物,不仅影响植物生长发育,而且危害人类健康。为了更好地了解Cd在南瓜中的迁移规律,深入探究Cd对植物的毒害机制和植物的防御反应,将广蜜二号南瓜在4种不同质量浓度(1、3、5、7 mg·L^(-1))的Cd SO_(4)·8H_(2)O溶液中培养28 d,对其生长指标、抗氧化酶活性、Cd吸收转运等特征进行分析。结果表明,随着Cd质量浓度升高,Cd积累量表现为根部高于茎和叶,Cd胁迫提高了广蜜二号南瓜幼苗叶片的超氧化物歧化酶、过氧化物酶、过氧化氢酶活性及丙二醛含量。当溶液中Cd质量浓度较低(1 mg·L^(-1))时,Cd对广蜜二号南瓜幼苗生长无抑制作用,而当溶液中Cd质量浓度≥3 mg·L^(-1)时,对南瓜幼苗的生长抑制程度加重。

关键词：广蜜二号镉幼苗生长生理特性

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