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In situ direct reprogramming of astrocytes to neurons via polypyrimidine tract-binding protein 1 knockdown in a mouse model of ischemic stroke

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Neural Regeneration Research 2024年第10期19卷 2240-2248页

作者： Meng Yuan Yao Tang Tianwen huang Lining Ke En huang Key Laboratory of Brain Aging and Neurodegenerative Diseases of Fujian Province Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Human Anatomy School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Scientific Research Center School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology Fujian Medical University Union HospitalFuzhouFujian ProvinceChina Fujian Key Laboratory of Vascular Aging Fujian Medical UniversityFuzhouFujian ProvinceChina

In situ direct reprogramming technology can directly convert endogenous glial cells into functional neurons in vivo for central nervous system repair. Polypyrimidine tract-binding protein 1(PTB) knockdown has been shown to reprogram astrocytes to functional neurons in situ. In this study, we used AAV-PHP.e B-GFAP-sh PTB to knockdown PTB in a mouse model of ischemic stroke induced by endothelin-1, and investigated the effects of GFAP-sh PTB-mediated direct reprogramming to neurons. Our results showed that in the mouse model of ischemic stroke, PTB knockdown effectively reprogrammed GFAP-positive cells to neurons in ischemic foci, restored neural tissue structure, reduced inflammatory response, and improved behavioral function. These findings validate the effectiveness of in situ transdifferentiation of astrocytes, and suggest that the approach may be a promising strategy for stroke treatment.

关键词： astrocyte in situ direct reprogramming ischemic stroke miR-30 based shRNA neuron polypyrimidine tract-binding protein 1 transdifferentiation

人乳多不饱和脂肪酸含量与婴儿食物过敏关系的研究

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中国儿童保健杂志 2011年第1期19卷 65-67页

作者：黄于娟黎海芪重庆医科大学附属儿童医院儿童保健科重庆400014

【目的】研究人乳多不饱和脂肪酸（polyunsaturated fatty acid,PUFA）含量与婴儿发生食物过敏的关系。【方法】采集3~6月人乳喂养婴儿母亲的乳汁,高效液相色谱法法检测其中-αLNA、DHA（n-3组）和LA、AA含量（n-6组）;按***标准确立婴... 详细信息

【目的】研究人乳多不饱和脂肪酸（polyunsaturated fatty acid,PUFA）含量与婴儿发生食物过敏的关系。【方法】采集3~6月人乳喂养婴儿母亲的乳汁,高效液相色谱法法检测其中-αLNA、DHA（n-3组）和LA、AA含量（n-6组）;按***标准确立婴儿食物过敏,比较食物过敏与正常婴儿母亲乳汁中PUFA含量的差异性。【结果】31例3~6月龄人乳喂养婴儿中10例发生食物过敏,过敏婴儿母亲乳汁中LA、AA及-αLNA含量增高（P〈0.05）、DHA含量差异无统计学意义。【结论】食物过敏婴儿的母亲乳汁中-αLNA、LA、AA含量升高,提示人乳PUFA代谢异常可能与婴儿发生食物过敏有关。

关键词：人乳多不饱和脂肪酸食物过敏婴儿

Quantum phase transition of the Jaynes-Cummings model

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 1-9页

作者： Cheng Liu Jin-Feng huang Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Key Laboratory for Matter Microstructure and Function of Hunan ProvinceDepartment of Physics and Synergetic Innovation Center for Quantum Effects and ApplicationsInstitute of Interdisciplinary StudiesHunan Normal UniversityChangsha 410081China

Herein,we propose an experimentally feasible scheme to show the quantum phase transition of the Jaynes-Cummings(JC)model by modulating the transition frequency of a two-level system in a quantum Rabi model with strong *** tuning the modulation frequency and amplitude,the ratio of the effective coupling strength of the rotating terms to the effective cavity(atomic transition)frequency can enter the deep-strong coupling regime,while the counter-rotating terms can be ***,a deep-strong JC model is *** ratio of the coupling strength to resonance frequencies in the deep-strong JC model is two orders of magnitude larger than the corresponding ratio in the original quantum Rabi *** scheme can be employed in atom-cavity resonance and off-resonance cases,and it is valid over a broad *** nonzero average cavity photons of the ground state indicate the emergence of a quantum phase ***,we demonstrate the dependence of the phase diagram on the atom-cavity detuning and modulation *** the parameters used in our scheme are within the reach of current experimental *** scheme provides a new mechanism for investigating the critical phenomena of finite-sized systems without requiring classical field limits,thereby opening a door for studying fundamental quantum phenomena occurring in the ultrastrong and even deep-strong coupling regimes.

关键词： Jaynes-Cummings model quantum phase transition frequency modulation

Associations of daily sedentary behavior,physical activity,and sleep with irritable bowel syndrome:A prospective analysis of 362,193 participants

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Journal of Sport and Health Science 2024年第1期13卷 72-80页

作者： Xu Gao Sifan Tian Ninghao huang Gang Sun Tao huang Department of Occupational and Environmental Health Sciences School of Public HealthPeking UniversityBeijing 100191China Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Department of Gastroenterology and Hepatology First Medical Center of People's Liberation Army General HospitalBeijing 100853China

Background:Irritable bowel syndrome(IBS)substantially affects quality of life and requires early *** study aimed to elucidate the relationships between IBS and daily behaviors,including sedentary behavior(SB),physical activity(PA),and *** particular,it seeks to identify healthy behaviors to reduce IBS risk,which previous studies have rarely ***:Daily behaviors were retrieved from self-reported data of 362,193 eligible UK Biobank *** cases were determined by self-report or health care data according to RomeⅣ***:A total of 345,388 participants were IBS-free at baseline,during a median follow-up of 8.45 years,19,885 incident IBS cases were *** examined individually,SB and shorter(≤7 h/day)or longer(>7 h/day)sleep duration were each positively associated with increased IBS risk,and PA was associated with lower IBS *** isotemporal substitution model suggested that replacing SB with other activities could provide further protective effects against IBS *** people sleeping≤7 h/day,replacing 1 h of SB with equivalent light PA,vigorous PA,or sleep was associated with 8.1%(95%confidence interval(95%CI):0.901-0.937),5.8%(95%CI:0.896-0.991),and 9.2%(95%CI:0.885-0.932)reduced IBS risk,*** people sleeping>7 h/day,light and vigorous PA were associated with a 4.8%(95%CI:0.926-0.978)and a 12.0%(95%CI:0.815-0.949)lower IBS risk,*** benefits were mostly independent of genetic risk for ***:SB and unhealthy sleep duration are risk factors for IBS.A promising way to mitigate IBS risk for individuals sleeping≤7 h/day and for those sleeping>7 h/day appears to be by replacing SB with adequate sleep or vigorous PA,respectively,regardless of the genetic predisposition of IBS.

关键词： Irritable bowel syndrome Isotemporal substitution model Physical activity Sedentary behavior Sleep

Sub-Nyquist sampling-based wideband spectrum sensing:a compressed power spectrum estimation approach

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Frontiers of Computer Science 2024年第2期18卷 139-145页

作者： Jilin WANG Yinsen huang Bin WANG National Key Laboratory of Science and Technology on Communications University of Electronic Science and Technology of ChinaChengdu 611731China

In this paper,we introduce a sub-Nyquist sampling-based receiver architecture and method for wideband spectrum *** of recovering the original wideband analog signal,the proposed method aims to directly reconstruct the power spectrum of the wideband analog signal from sub-Nyquist *** that power spectrum alone is sufficient for wideband spectrum *** only the covariance matrix of the wideband signal is needed,the proposed method,unlike compressed sensing-based methods,does not need to impose any sparsity requirement on the frequency *** proposed method is based on a multi-coset sampling *** exploiting the inherent sampling structure,a fast compressed power spectrum estimation method whose primary computational task consists of fast Fourier transform(FFT)is *** results are presented to show the effectiveness of the proposed method.

关键词： wideband spectrum sensing sub-Nyquist multicoset sampling FCPSE

Tactile-sensing-based robotic grasping stability analysis

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Science China(Technological Sciences) 2024年第6期67卷 1817-1828页

作者： huang YanJiang WANG HaoNan ZHANG XianMin Guangdong Provincial Key Laboratory of Precision Equipment and Manufacturing Technology South China University of TechnologyGuangzhou510640China

Tactile signals play a crucial role in enabling robots to successfully manipulate unfamiliar *** robots to grasp unknown objects securely and without causing damage,it is essential that they can analyze grasping stability in real time through tactile signals and respond *** study introduces a novel method for analyzing the stability of robotic hand grasping,utilizing the Wilcoxon signed rank *** efficacy of this method is demonstrated through its static and dynamic performance,and evaluated across a series of *** findings of this research highlight the method’s ability to accurately detect when an object begins to slip from the robot’s *** this method allows the gripper to maintain a secure hold on objects by applying the minimal necessary *** also enables the gripper to dynamically adjust the force it applies in real time,thus preventing the object from slipping during the movement of the robotic ***,the gripper demonstrates the ability to stably grasp objects of varied weights and with unknown characteristics,showcasing the versatility and effectiveness of the proposed method.

关键词： grasping stability manipulation tactile sensors

Research on light dark matter particle from evaporating primordial black hole in CDEX-10 experiment

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Science China(Physics,Mechanics & Astronomy) 2024年第10期67卷 168-169页

作者： Qing-Guo huang School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUCASHangzhou 310024China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China

Dark matter is an essential component of the universe,accounting for approximately 85%of all ***,what the nature of dark matter actually is remains a huge *** far,all evidence for the existence of dark matter has come from gravitational *** gravitational interactions are universal,it is challenging to reveal the nature of dark matter through gravitational *** unravel the mystery of dark matter,it is essential to directly detect dark matter.

关键词： approximate particle gravitational

Scientific and technological innovations of wastewater treatment in China

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Frontiers of Environmental Science & Engineering 2024年第6期18卷 43-48页

作者： Hui huang Rui Ma Hongqiang Ren State Key Laboratory of Pollution Control and Resource Reuse School of the EnvironmentNanjing UniversityNanjing 210023China

The“dual-carbon”strategy promotes the development of the wastewater treatment sector and is an important tool for leading science and technology *** on the global climate change and the new policies introduced by China,this paper described the new needs for the development of wastewater treatment science and *** offered a retrospective analysis of the historical trajectory of scientific and technological advancements in this *** bibliometrics,it delineated the research hotspots within wastewater treatment,notably highlighting materials genomics,artificial intelligence,and synthetic ***,it posited that,in the future,the field of wastewater treatment should follow the paths of technological innovations with multi-dimensional needs,such as carbon reduction,pollution reduction,health,standardisation,and *** purpose of this paper was to provide references and suggestions for scientific and technological innovations in the field of wastewater treatment,and to contribute to the common endeavor of moving toward a Pollution-Free Planet.

关键词： Wastewater treatment Dual-carbon strategy Technological innovation Carbon reduction

Spray characteristics of different regions downstream of a swirl cup

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Chinese Journal of Aeronautics 2024年第8期37卷 124-143页

作者： Donghui WANG Yong huang Hongzhou ZHANG Collaborative Innovation Center of Advanced Aero-Engine School of Energy and Power EngineeringBeihang UniversityBeijing 102206China National Key Laboratory of Science and Technology School of Energy and Power EngineeringBeihang UniversityBeijing 102206China

The spray characteristics of different regions downstream of swirl cups play a critical role in cold start and re-ignition of gas *** spray measurements were performed at the fuel pressures of 0.5,0.8,1.0,1.5,and 2.0 MPa and the fuel temperatures of-23,-13,-3,7,17 and 27℃,*** droplet size,droplet velocity,droplet number,and instantaneous spatial spray image of sprays from an aviation kerosene Jet-A were measured using a two-component phase Doppler particle analyzer and a digital off-axis holography *** the fuel pressure and temperature increase,the Sauter Mean Diameter(SMD)and spray non-uniformity of the Spray Shear Layer(SSL)gradually *** the fuel pressure increases,the SMD and spray non-uniformity of the Central Toroidal Recirculation Zone(CTRZ)gradually decrease,and the slopes of these curves both *** the fuel pressure increases,the SMD and spray nonuniformity of the CTRZ rapidly decrease at the fuel temperature of23℃,while slightly decrease at the fuel temperature of 27℃.The droplets in the CTRZ come from 3 different sources:simplex nozzle,venturi,and outside the *** the fuel pressure increases,the proportion of droplets recirculated from outside the CTRZ *** study proposed the concept of the“pressure critical point”for the swirl *** the fuel temperature decreases,the proportion of droplets recirculated from outside the CTRZ increases below the critical pressure,while decreases above the critical *** addition,through the models of liquid film formation and breakup on the curved cylindrical wall,a semi-theoretical model was established to predict the SMD of SSL for swirl *** prediction uncertainty of this model is less than 6%for all 14 conditions in this paper.

关键词： Swirl cup Sauter Mean Diameter(SMD) Spray non-uniformity Atomizing regions Semi-theoretical prediction Spray nozzles