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World Journal of Gastroenterology 2007年第27期13卷 3758-3759页

作者： Shintaro Tsukinaga Hiroo Imazu yujiro uchiyama Hiroshi Kakutani Akira Kuramoti Masayuki Kato Keisuke Kanazawa Tsuyoshi Kobayashi Yasuyuki Searashi Hisao Tajiri Department of Endoscopy Jikei University School of Medicine Tokyo Japan Division of Gastroenterology and Hepatology Department of Internal Medicine Jikei University School of Medcine Japan

We report a case of primary sclerosing cholangitis (PSC) with benign lyphadenopathy which was diagnosed with endosonography guided fine needle aspiration (EUS-FNA). A 65-year-old woman was admitted to Jikei University Hospital with severe jaundice. Although endoscopic retrograde cholangiography and liver biopsy revealed the findings consistent with PSC, abdominal computed tomography revealed numerous large perihepatic lymph nodes with a maximum diameter of more than 3 cm. Therefore, EUS-FNA was done in order to exclude malignant lymphadenopathy, and adequate specimens obtained by EUS-FNA showed reactive hyperplasia of lymphnode. The patients were scheduled to undergo liver transplantation.

关键词： Endosonography guided fine needle aspiration Primary sclerosing cholangitis Lymphadenopathy

Personalized immunotherapy in cancer precision medicine

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Cancer Biology & Medicine 2021年第4期18卷 955-965页

作者： Kazuma Kiyotani yujiro Toyoshima Yusuke Nakamura Project for Immunogenomics Cancer Precision Medicine CenterJapanese Foundation for Cancer ResearchTokyo 135-8550Japan

With the significant advances in cancer genomics using next-generation sequencing technologies,genomic and molecular profilingbased precision medicine is used as a part of routine clinical test for guiding and selecting the most appropriate treatments for individual cancer *** many molecular-targeted therapies for a number of actionable genomic alterations have been developed,the clinical application of such information is still limited to a small proportion of cancer *** this review,we summarize the current status of personalized drug selection based on genomic and molecular profiling and highlight the challenges how we can further utilize the individual genomic *** immunotherapies,including immune checkpoint inhibitors,would be one of the potential approaches to apply the results of genomic sequencing most *** cancer-specific antigens derived from somatic mutations,the so-called neoantigens,occurring in individual cancers have been in focus *** immunotherapies,which target neoantigens,could lead to a precise treatment for cancer patients,despite the challenge in accurately predicting neoantigens that can induce cytotoxic T cells in individual *** prediction of neoantigens should accelerate the development of personalized immunotherapy including cancer vaccines and T-cell receptor-engineered T-cell therapy for a broader range of cancer patients.

关键词： Personalized medicine cancer precision medicine neoantigen personalized immunotherapy immune checkpoint blockade cancer vaccine adoptive T cell therapy

Distribution of modified Circumpolar Deep Water and its threat in Vincennes Bay,East Antarctica

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Journal of Oceanology and Limnology 2024年第5期42卷 1399-1414页

作者： Wenjun YE Lingqiao CHENG yujiro KITADE Song HU Juncheng ZUO College of Oceanography and Ecological Science Shanghai Ocean UniversityShanghai 201306China Key Laboratory of Marine Ecological Monitoring and Restoration Technologies Ministry of Natural ResourcesShanghai 201306China Department of Ocean Sciences Tokyo University of Marine Science and TechnologyTokyo 108-8477Japan

The Antarctic Bottom Water formation site Vincennes Bay,East Antarctica is experiencing a substantial intrusion of modified Circumpolar Deep Water(mCDW),which may inhibit the formation of Dense Shelf Water(DSW)and drive basal melting of the ice *** on hydrographic data obtained from March to November in 2012,we evaluated the spatial spread of mCDW over the continental shelf region of Vincennes Bay and the associated temporal evolution of water properties,as well as the sea ice formation effect on water column in the coastal *** show that two branches of mCDW occupied the deep layers of the continental shelf,distinguished by the potential density(smaller than 27.8 kg/m^(3) or not)when potential temperatureθ=0.5°C in theθ-salinity *** warmer and less dense branch observed on the east plateau,accessed the eastern ice shelves in the coastal polynya to drive basal melting of ice *** contrast,the other colder and denser branch in the mid-depression reached the western Underwood Ice *** formation was detectable in the coastal polynya during September-November,proving the occurrence of deep *** heat loss and brine rejection during the intensive sea ice formation contributed to the destratification of the water column in the coastal *** was estimated that at least 1.11±0.79 TW heat carried by mCDW into the inner part of the polynya.

关键词： modified circumpolar deep water evolution of water properties coastal polynya ice shelf Vincennes Bay

Hydrothermal Formation of Lath-Shaped Trioctahedral Smectite with High Crystallinity

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Acta Geologica Sinica(English Edition) 2006年第2期80卷 290-295页

作者： Hirohisa YAMADA Kenji TAMURA Shingo YOKOYAMA yujiro WATANABE Ecomaterials Center Nuclear Fuel Cycle Back-end Research Center College of Environmental Engineering and Architecture

Lath-shaped and highly crystalline trioctahedral smectites were synthesized under hydrothermal conditions. The quenched glasses with stoichiometrically dehydrated Na-smectite compositions were treated at （a） 500℃ and 100 MPa for 1 and 11 days; and （b） 300℃ and 100 MPa for 7 days. The crystallinity and particle size of products were dependent on the chemical composition of the starting glass, synthetic temperature and duration of hydrothermal treatment. The high structural ordering and large dimensions of the products were confirmed from the sharpness of XRD peaks; and hydration behavior under controlled relative humidity. Transmission electron microscopy was also performed for the characterization of the particle size of product. Particle sizes vary from ca. 10 nm to a few pm by changing the chemical compositions of the starting materials. The product with the highest structural ordering and largest dimension was obtained from Nao.33（Mg1.83Al0.67）Si4O11 glass treated at 500℃ and 100 MPa for 1 day. The obtained results also confirmed the metastability and compositional dependency in the formation of highly crystalline trioctahedral smectite at hydrothermal conditions.

关键词： high crystallinity hydration behavior hydrothermal formation lath-shaped trioctahedral smectite

Reduced Sputtering Yields Induced by Fast Neutrons

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Chinese Physics Letters 1999年第11期16卷 844-846页

作者： YE Bang-jiao FAN Yang-mei Yoshimi KASUGAI yujiro IKEDA ZHOU Xian-yi HAN Rong-dian Department of Modern Physics University of Science and Technology of ChinaHefei 230026 Center of Neutron Science Japan Atomic Energy Research InstituteTokai-muraNaka-gunIbaraki-ken 319-1 IJapan International Centre for Materials Physics Chinese Academy of SciencesShenyang 110015

The reduced sputtering yield (y_(n)^(R)) of materials induced by fast neutron is presented. Based on the experimental (y_(n)^(R)) results for (n, 2n), (n, p), (n, α) and (n, np) reactions, the value of (y_(n)^(R)) for (n, non-elastic) reaction is deduced by using data of cross sections in JENDL-3.2 and ENDF/B-VI. The value of (y_(n)^(R)) for (n, n) reaction is predicted by relation between (y_(n)^(R)) and the mean projected ranges of recoil nuclides. Combining both (y_(n)^(R)) for (n, n) and (n, non-elastic) reactions, the total (y_(n)^(R)) is obtained. Systematics of (y_(n)^(R)) for (n, non-elastic), (n, n) and (n, total) reactions have been demonstrated.

关键词： value deduced projected

Novel zinc alloys for biodegradable surgical staples

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World Journal of Clinical Cases 2020年第3期8卷 504-516页

作者： Hizuru Amano Koichi Miyake Akinari Hinoki Kazuki Yokota Fumie Kinoshita Atsuko Nakazawa yujiro Tanaka Yasuhiro Seto Hiroo Uchida Department of Pediatric Surgery Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan Mitsui Mining and Smelting Co. Ltd.Tokyo 141-0032Japan Department of Pediatric Surgery Nagoya University Graduate School of MedicineNagoya 466-8550Japan Department of Advanced Medicine Nagoya University HospitalNagoya 466-8560Japan Department of Clinical Research Saitama Children’s Medical CenterSaitama 330-8777Japan

BACKGROUND The development of biodegradable surgical staples is desirable as non-biodegradable Ti alloy staples reside in the human body long after wound healing, which can cause allergic/foreign-body reactions, adhesion, or other adverse effects. In order to develop a biodegradable alloy suitable for the fabrication of surgical staples, we hypothesized that Zn, a known biodegradable metal, could be alloyed with various elements to improve the mechanical properties while retaining biodegradability and biocompatibility. Considering their biocompatibility, Mg, Ca, Mn, and Cu were selected as candidate alloying elements, alongside Ti, the main material of clinically available surgical *** To investigate the in vitro mechanical properties and degradation behavior and in vivo safety and feasibility of biodegradable Zn alloy *** Tensile and bending tests were conducted to evaluate the mechanical properties of binary Zn alloys with 0.1–6 wt.% Mg, Ca, Mn, Cu, or Ti. Based on the results,three promising Zn alloy compositions were devised for staple applications(wt.%): Zn-1.0Cu-0.2Mn-0.1Ti(Zn alloy 1), Zn-1.0Mn-0.1Ti(Zn alloy 2), and Zn-1.0Cu-0.1Ti(Zn alloy 3). Immersion tests were performed at 37℃ for 4 wk using fed-state simulated intestinal fluid(Fe SSIF) and Hank’s balanced salt solution(HBSS). The corrosion rate was estimated from the weight loss of staples during immersion. Nine rabbits were subjected to gastric resection using each Zn alloy staple, and a clinically available Ti staple was used for another group of nine rabbits. Three in each group were sacrificed at 1, 4, and 12 wk *** Additions of ≤1 wt.% Mn or Cu and 0.1 wt.% Ti improved the yield strength without excessive deterioration of elongation or bendability. Immersion tests revealed no gas evolution or staple fracture in any of the Zn alloy staples. The corrosion rates of Zn alloy staples 1, 2, and 3 were 0.02 mm/year in HBSS and 0.12, 0.11, and 0.13 mm/year, respective

关键词： Zinc alloy Surgical staple Gastric resection Biodegradability,Biocompatibility Mechanical Strength

Integration of body-mounted ultrasoft organic solar cell on cyborg insects with intact mobility

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npj Flexible Electronics 2022年第1期6卷 726-734页

作者： yujiro Kakei Shumpei Katayama Shinyoung Lee Masahito Takakuwa Kazuya Furusawa Shinjiro Umezu Hirotaka Sato Kenjiro Fukuda Takao Someya Center for Emergent Matter Science RIKEN2-1 HirosawaWakoSaitama 351-0198Japan Department of Integrative Bioscience and Biomedical Engineering Center for Advanced Biomedical SciencesTWIns Waseda Univerisity2-2 Wakamatsu-choShinjuku-kuTokyo 162-8480Japan Department of Modern Mechanical Engineering Waseda University3-4-1 OkuboShinjuku-kuTokyo 169-8555Japan Department of Applied Chemistry and Food Science Faculty of Environmental and Information SciencesFukui University of Technology3-6-1 GakuenFukui 910-8505Japan School of Mechanical and Aerospace Engineering Nanyang Technological UniversityN3.2-01-2065 Nanyang DriveSingapore 637460Singapore Thin-Film Device Laboratory RIKEN2-1 HirosawaWakoSaitama 351-0198Japan Electrical and Electronic Engineering and Information Systems The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8656Japan

Cyborg insects have been proposed for applications such as urban search and ***-mounted energy-harvesting devices are critical for expanding the range of activity and functionality of cyborg ***,their power outputs are limited to less than 1 mW,which is considerably lower than those required for wireless locomotion *** area and load of the energy harvesting device considerably impair the mobility of tiny ***,we describe the integration of an ultrasoft organic solar cell module on cyborg insects that preserves their motion *** quantified system design strategy,developed using a combination of ultrathin film electronics and an adhesive-nonadhesive interleaving structure to perform basic insect motion,successfully achieved the fundamental locomotion of traversing and *** body-mounted ultrathin organic solar cell module achieves a power output of 17.2 *** demonstrate its feasibility by displaying the recharging wireless locomotion control of cyborg insects.

关键词： mounted harvesting considerably

The Community,the Market and the State in Economic Development

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The Community,the Market and the State in Economic Developme...

Traditional Culture and English Education

北京论坛（2004）文明的和谐与共同繁荣

作者： yujiro Hayami The Foundation for Advanced Studies in International Development

Traditionally,economists have classified economic systems according to combinations of the market and the state ranging from the "liberal market system" to the "central planned system".In this paper I propose to include the community as one of three major pillars of the economic *** my definition a "community" is a group of people tied by mutual trust based on intense personal *** market is the organization that coordinates profit seeking individuals through competition under the signal of parametric price *** state is the organization that forces people to adjust their resource allocations by the command of *** the other hand,the community is the organization that guides community members to voluntary cooperation based upon close personal ties and mutual *** designing the economic development strategy it is critically important to search for the optimum combination of these three organizations.

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Traditional Culture and English Education

From the Megalopolis-Centered System to the Rural-Urban Balanced Growth

北京论坛（2011）文明的和谐与共同繁荣--传统与现代、变革与转型

作者： yujiro Suzuki Keio University Faculty of Economics

As the world becomes more and more integrated thanks to globalization and technological advancements,it becomes all the more important to understand,inherit,and revitalize traditional cultures of both the home country... 详细信息

关键词： Traditional Culture and English Education

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From the Megalopolis-Centered System to the Rural-Urban Bala...