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Upper crustal anisotropy from local shear-wave splitting and crust-mantle coupling of Yunnan,SE margin of Tibetan Plateau

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Geodesy and Geodynamics 2018年第4期9卷 302-311页

作者： Bo Zhang Shuangxi Zhang Tengfei wu yujin Hua Department of Geophysics School of Geodesy and Geomatics Wuhan University Key Laboratory of Geospace Environment and Geodesy of Ministry of Education Wuhan University Collaborative Innovation Center of Geospace Information Science Wuhan University

The upper crustal anisotropy of Yunnan area, SE margin of Tibetan Plateau, is investigated by measuring the shear wave splitting of local earthquakes. The mean value of the measured delay times is 0.054 s and far less than that from Pms splitting analysis, indicating that the crustal anisotropy is contributed mostly from mid-lower crust. The fast polarization directions are mostly sub-parallel to the maximum horizontal compression directions while the stations near fault zones show fault-parallel fast polarization directions, suggesting both stress and geological structure contribute to the upper crust *** fast polarization directions from shear wave splitting of local earthquakes and Pms, large angle differences are shown at most stations, implying different anisotropy properties between upper and mid-lower crust. However, in southwestern Yunnan, the fast polarization directions of Pms and Swave splitting are nearly parallel, and the stress and surface strain rate directions show strong correlation, which may indicate that the surface and deep crust deformations can be explained by the same mechanism and the surface deformation can represent the deformation of the whole crust. Therefore,the high correlation between surface strain and mantle deformation in this area suggests the mechanical coupling between crust and mantle in southwestern Yunnan. In the rest region of Yunnan, the crustmantle coupling mechanisms are supported by the lack of significant crustal anisotropy with Ne S fast polarization directions from Pms splitting. Therefore, we conclude that the crust and upper mantle are coupled in Yunnan, SE margin of Tibetan Plateau.

关键词： Shear wave splitting Stress Strain rate Yunnan area Crust-mantle coupling

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洗心汤对胰岛素抵抗的阿尔茨海默病小鼠PI3K/AKT/GSK-3β通路的影响

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中华中医药杂志 2024年第3期39卷 1488-1492页

作者：周源王郁金屈杰王楠陈连吉武姗姗张琪第五永长陕西中医药大学咸阳712046 陕西省中医体质与疾病防治研究重点实验室咸阳712046 陕西省中医脑病学重点实验室咸阳712046

目的:探究洗心汤对胰岛素抵抗(IR)的阿尔茨海默病(AD)小鼠模型中PI3K/AKT/GSK-3β通路的影响,阐明其缓解AD中IR及AD症状的分子机制。方法:通过高脂喂养APP/PS1小鼠并腹腔注射低浓度链脲佐菌素(STZ)构建AD-IR小鼠模型,然后给予洗心汤灌... 详细信息

目的:探究洗心汤对胰岛素抵抗(IR)的阿尔茨海默病(AD)小鼠模型中PI3K/AKT/GSK-3β通路的影响,阐明其缓解AD中IR及AD症状的分子机制。方法:通过高脂喂养APP/PS1小鼠并腹腔注射低浓度链脲佐菌素(STZ)构建AD-IR小鼠模型,然后给予洗心汤灌胃治疗。Morris水迷宫检测小鼠的学习记忆能力,血糖仪检测小鼠空腹血糖水平,ELISA检测小鼠空腹胰岛素水平,试剂盒检测ROS、MDA、GSH-Px、SOD,蛋白质印迹检测小鼠脑组织中相关蛋白的表达水平。结果:AD-IR组小鼠较对照组逃避潜伏期显著增加(P<0.05),目标平台象限滞留时间与穿越平台次数均显著减少(P<0.05),空腹血糖、血清空腹胰岛素、胰岛素抵抗值升高(P<0.05),脑组织中ROS和MDA升高(P<0.05),SOD和GSH-Px降低(P<0.05),GLUT4、p-PI3K、p-AKT、p-GSK-3β、Bcl-2蛋白降低(P<0.01),IRS1pS307、IRS1pS612、IRS1pS636、Aβ42、p-Tau、Bax、cleaved caspase-3蛋白升高(P<0.01)。经洗心汤治疗后,上述指标均显著改善(P<0.05,P<0.01)。结论:洗心汤能够激活AD-IR小鼠PI3K/AKT/GSK-3β通路,缓解小鼠脑组织中的IR,减轻AD症状及其诱导的损伤。

关键词：洗心汤阿尔茨海默病胰岛素抵抗 PI3K/AKT/GSK-3β通路

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Cost-reduction strategies in massive genomics experiments

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Marine Life Science & Technology 2019年第1期1卷 15-21页

作者： Haichao Li Kun wu Chenchen Ruan Jiao Pan yujin Wang Hongan Long Institute of Evolution and Marine Biodiversity KLMMEOcean University of ChinaQingdao 266003China

Many modern biology studies require deep, whole-genome sequencing of hundreds to thousands of samples. Although persamplecosts have dramatically decreased, the total budget for such massive genome sequencing constitutes a significantbarrier for poorly funded labs. The costly lab tools required for genomics experiments further hinder such studies. Here, weshare two strategies for extensively reducing the costs of massive genomics experiments, including miniaturization of theNEBNext Ultra II FS DNA Library Prep Kit for Illumina (reducing the per-sample total costs to ~ 1/6 of that charged byservice providers) and in-lab 3D model-designing of genomics tools. These strategies not only dramatically release fundingpressure for labs, but also provide students with additional training in hands-on genomics and 3D-model-designing skills,demonstrating the high potential for their application in genomics experiments and science education.

关键词： 3D model designing and printing Genome sequencing Lab-made tools Library construction Miniaturization

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Preparation and evaluation of controllable drug delivery system:A light responsive nanosphere based on β-cyclodextrin/mesoporous silica

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Chinese Journal of Chemical Engineering 2023年第10期62卷 159-167页

作者： Yi wu Hongzhou Shang Shisheng Lai Yali Di Xiaoran Sun Ning Qiao Lihua Han Zheng Zhao yujin Lu College of Chemical Engineering North China University of Science and TechnologyTangshan 063210China College of Materials Science and Engineering North China University of Science and TechnologyTangshan 063210China College of Pharmacy North China University of Science and TechnologyTangshan 063210China Department of Cardiology Tangshan Central HospitalTangshan 063000China

A novel light responsive nanosphere was constructed,and it was used as a drug carrier to investigate the loading and release properties of the Quercetin(QU).In this paper,mesoporous silica nanoparticles(MSN)were used as a substrate,and 3-aminopropyl triethyoxysilane was used as a surface modification agent to introduce—NH_(2),and the azobenzene-4,4’-dicarboxylic acid(AZO)was used as light responsive agent to introduce the group of—N=N—,and thenβ-cyclodextrin(β-CD)was combined with AZO through host-guest interaction to construct light responsive nanoparticles(MSN@β-CD).The structure and properties of the carrier were analyzed by FTIR,BET,XPS,TGA,XRD,SEM and *** vitro drug release studies showed the release rate of QU@MSN@β-CD(dark)was 12.19%within 72 h,but the release rate of QU@MSN@β-CD(light 10 min)was 26.09%,exhibiting a light-responsive *** CCK8 tests demonstrated that MSN@β-CD could significantly decrease the toxicity of ***,the controllable light-responsive drug delivery system has great application prospects.

关键词： Silica Drug delivery system Light-responsive b-CD Nanomaterials Support

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The prior rules of designing Ti_(3)C_(2)T_(x) MXene-based gas sensors

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Frontiers of Chemical Science and Engineering 2021年第3期15卷 505-517页

作者： Yingying Jian Danyao Qu Lihao Guo yujin Zhu Chen Su Huanran Feng Guangjian Zhang Jia Zhang Weiwei wu Ming-Shui Yao School of Advanced Materials and Nanotechnology Interdisciplinary Research Center of Smart SensorsXidian UniversityXi’an 710126China Institute for Integrated Cell-Material Sciences Kyoto University Institute for Advanced StudyKyoto UniversityKyoto 606-8501Japan Department of Thoracic Surgery The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China

Working temperature,sensitivity,and selectivity are some of the characteristics of the applied gas *** to design and fabricate an ideal gas sensor working at room temperature is still challenging and attracting lots of ***-dimensional(2D)materials with ultra-thin structure have been demonstrated as a family of ideal candidates to achieve this *** them,Ti_(3)C_(2)T_(x) MXene,a kind of layered sheet synthesized by selectively etching MAX phases materials,shows remarkable potential to be the sensitive materials solely or in a ***,their designing rules are still lacking critical thinking from the viewpoint of the intrinsic property of Ti_(3)C_(2)T_(x) MXene based *** this article,two critical features,i.e.,the thickness of the sensitive materials,and the scope of the analytes,are elaborated towards Ti_(3)C_(2)T_(x) MXene based gas sensors after characterizing the performance of sensing reducing gases(NH3 and CO)and oxidizing gas(NO2).First,the thinner the Ti_(3)C_(2)T_(x) MXene sensitive layer,the better the ***,the Ti_(3)C_(2)T_(x) MXene based gas sensor is not suitable for strong and moderate oxidation gas due to its ease of *** two rules are demonstrated,and could be considered with priority both in the future researches and practical applications.

关键词： MXene based sensor prior reducing gases oxidizing gases

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肠炎清对溃疡性结肠炎大鼠TGF-β_(1)/Smad3/ERK通路的影响

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世界中医药 2022年第14期17卷 1990-1994,2001页

作者：詹原泉丛龙玲吕永慧黄雅静谢英杰周婉妃吴宇金广州医科大学附属中医医院脾胃科广州510130 广东省人民医院广州510000 广州中医药大学广州510405

目的:观察肠炎清对溃疡性结肠炎(UC)大鼠的保护作用及对TGF-β_(1)/Smad3/ERK信号通路的调控作用。方法:将25只雌性SD大鼠随机分为5组:空白对照组、模型组、美沙拉嗪组、肠炎清低剂量组和肠炎清高剂量组,除空白对照组外,其余大鼠均采用2... 详细信息

目的:观察肠炎清对溃疡性结肠炎(UC)大鼠的保护作用及对TGF-β_(1)/Smad3/ERK信号通路的调控作用。方法:将25只雌性SD大鼠随机分为5组:空白对照组、模型组、美沙拉嗪组、肠炎清低剂量组和肠炎清高剂量组,除空白对照组外,其余大鼠均采用2,4,6三硝基苯磺酸(TNBS)诱导,建立UC模型。造模24 h后,模型组、空白对照组分别用0.9%生理盐水灌胃;美沙拉嗪对照组以30 mg/kg艾迪莎混悬液灌胃;肠炎清高剂量组以147.2 g/kg肠炎清灌胃;肠炎清低剂量组以36.8 g/kg肠炎清灌胃;1次/d,时间固定,持续7 d。检测结肠黏膜组织中转化生长因子(TGF)-β_(1)、Smad3、胞外信号调节激酶(ERK)磷酸化的水平及TGF-β_(1)信号通路活化的程度。结果:模型组ERK表达水平最低,低于溶媒对照组、美沙拉嗪组、肠炎清高剂量组和低剂量组,肠炎清剂量组该指标水平随剂量升高而上升,且高剂量肠炎清组ERK表达水平显著高于模型组。模型组TGF-β_(1)和Smad3高于美沙拉嗪组组、空白对照组和肠炎清低剂量组及高剂量组。结论:肠炎清对UC大鼠肠黏膜具有保护作用,其机制可能与通过下调TGF-β_(1)-Smad3通路,提高ERK表达有关。

关键词：肠炎清大鼠转化生长因子-β_(1) 信号传导蛋白-3 细胞外信号调节激酶作用机制溃疡性结肠炎信号通路

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Safety Evaluation Method for Long-Term Operation of Metro Based on Combination Weighting Method

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Journal of Shanghai Jiaotong university(Science) 2020年第6期25卷 700-705页

作者： CAO Weiwei LI Mingguang wu Wei XIA Xiaohe SHI yujin State Key Laboratory of Ocean Engineering Department of Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China Shanghai Institute of Geological Survey Shanghai 200072China

Metros are critical infrastructure in big cities and evaluation of their safe operation is of increasing *** make a reasonable safety evaluation for the metro during operation,this paper establishes a rational safety evaluation model based on long-term monitoring data of Shanghai Metro Line *** evaluation indicators,ie.,absolute settlement,relative curvature,deformation rate and curvature radius,are *** hierar-chy process(AHP)and entropy method are combined to determine the weights of the *** risk level values at different mileage are calculated and five danger levels are defined accordingly to determine the safety state of Shanghai Metro Line 2,ie.,safe,relatively safe,critical,relatively dangerous,and *** evaluation of Shanghai Metro Line 2 shows that:83.81%areas of Shanghai Metro Line 2 are in safe,relatively safe and critical states,while 15.63%and 0.57%areas are in relatively dangerous and dangerous states,respectively;the parts of Shanghai Metro Line 2 where the risk level values exceed the critical value are mainly distributed around the mileage at 6.0-7.5km and 8.5-11.0 km,and the risk level value peaks around the mileage at 7.3km,to which much attention should be attached and relevant protective measures be taken;the sections with the high risk level values coincide with the distinctly deforming arcas of the metro,indicating that this evaluation method is valid.

关键词： long-term deformation safety evaluation combination weighting method Shanghai Metro

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Neoarchean Magmatic Events in the Western Songnen Massif,Central Asian Orogenic Belt:Timing and Tectonic Significance

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Acta Geologica Sinica(English Edition) 2023年第2期97卷 436-448页

作者： wu Xinwei LIU Zhenghong LIU Yongjiang ZHANG Chao SHAO Jun ZHANG Chao ZHANG yujin GUO Wei LIU Baoshan ZHANG Guangyu Shenyang Center of China Geological Survey Shenyang 110034China Key Laboratory of Deep Mineral Resources Exploration and Evaluation Department of Natural Resource of Liaoning ProvinceShenyang 110034China College of Earth Sciences Jilin UniversityChangchun 130061China Frontiers Science Center for Deep Ocean Multispheres and Earth System Key Laboratory of Submarine Geosciences and Prospecting TechniquesMOE and College of Marine GeosciencesOcean University of ChinaQingdaoShandong 266100China Laboratory for Marine Mineral Resources Qingdao National Laboratory for Marine Science and TechnologyQingdao Shandong 266100China School of Resources and Environmental Engineering Shandong University of TechnologyZiboShandong 255049China

Whether a Neoarchean basement existing in the Songnen massif is currently *** of Archean magmatism from the Songnen Massif is helpful to resolve this ***,we report newly discovered Neoarchean Shanquan pluton in the Western Songnen *** Neoarchean Shanquan pluton are mainly composed of granites that are exposed near the town of Shanquan in Heilongjiang ***-ICP-MS zircon U-Pb dating reveals that the sample 2015TW1 has an upper intercept age of 2801±69 Ma and a weighted mean age of 2708±18 Ma,while samples LJ27QY1 and LJ27QY2 have upper intercept ages of 2677±57 Ma and 2653±18 Ma,and weighted mean ages of 2649±10 Ma and 2653±15 Ma,*** indicates that these granites were formed at~2.7 *** of the~2.7 Ga zircons have older TDM2 ages of 2762–3326 Ma with positiveεHf(t)values ranging from 0 to 6.4,while a few of the zircons have negativeεHf(t)values ranging from-8.1 to-11.5 and older TDM2 ages varying from 3158 to 3264 *** zircon Hf isotopes indicate that Paleo-Mesoarchean crusts might once existed in the Songnen Massif,and the studied Neoarchean magmas were principally derived from partial melting of these Paleo-Mesoarchean ancient *** on the geochronological spectrum of magmatic and detrital zircons,the Songnen,Erguna,Jiamusi,Bureya massifs may have a common basement prior to the Neoproterozoic and may even be linked with the Triam Craton.

关键词： tectonic attribute Neoarchean magmatism Precambrian basement Longjiang area Songnen Massif

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Highly crystalline and water-wettable benzobisthiazole-based covalent organic frameworks for enhanced photocatalytic hydrogen production

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National Science Review 2023年第1期10卷 268-276页

作者： Wei Huang Yongpan Hu Zhengyuan Qin yujin Ji Xuan Zhao Yunling wu Qing He Youyong Li Chunfeng Zhang Jun Lu Yanguang Li Institute of Functional Nano and Soft Materials(FUNSOM) Soochow University Jiangsu Key Laboratory for Advanced Negative Carbon Technologies Soochow University National Laboratory of Solid State Microstructures School of Physics and Collaborative Innovation Center for Advanced MicrostructuresNanjing University Macao Institute of Materials Science and Engineering (MIMSE) MUST-SUDA Joint Research Center for Advanced Functional Materials Macau University of Science and Technology College of Chemical and Biological Engineering Zhejiang University

Two-dimensional covalent organic frameworks are promising for photocatalysis by virtue of their structural and functional diversity,but generally suffer from low activities relative to their inorganic *** fulfill their full potential re quires a rational tailoring of their structures at different scales as well as their surface ***,we demonstrate benzobisthiazole-based covalent organic frameworks as a superior photocatalyst for hydrogen *** product features high crystallinity with ordered 2.5-nm-wide cylindrical mesopores and great water *** structural advantages afford our polymeric photo catalyst with fast charge carrier dynamics as evidenced by a range of spectroscopic characterizations and excellent catalytic performances when suspended in solution or supported on melamine *** visible-light irradiation,it enables efficient and stable hydrogen evolution with a production rate of 487 μmol h-1(or a mass-specific rate of 48.7 mmol g-1h-1)—far superior to the previous state of the *** also demonstrate that hydrogen production can be stoichiometrically coupled with the oxidation conversion of biomass as exemplified by the conversion of furfuryl alcohol to 2-furaldehyde.

关键词： covalent organic frameworks photocatalysis hydrogen evolution benzobisthiazole water-wettable

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Two New Species of Protocedroxylon Gothan(Pinaceae) from the Middle Jurassic of Eastern Inner Mongolia, NE China

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Acta Geologica Sinica(English Edition) 2018年第5期92卷 1685-1699页

作者： ZHANG yujin TIAN Ning ZHU Zhipeng WANG Yongdong wu Xinwei ZHANG Zhibin ZHANG Chao SI Qiuliang MA Yongfei Shenyang Center of the Geological Survey CGS College of Earth Sciences Jilin University College of Palaeontology Shenyang Normal University State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyCAS Center for Excellence in Life and Palaeoenvironment Chinese Academy of Sciences

Two new coniferous wood taxa, Protocedroxylon zhangii sp. nov. and P. zhalantunense sp. nov., are described from the Middle Jurassic Wanbao Formation in Zhalantun City, Inner Mongolia, NE China. The new discovery represents the first record of petrified wood in the Wanbao Formation, and contributes to further understanding the floral composition, especially that of the forest, of the Wanbao Formation. Anatomically, the two new species are characterized by having a mixed type of radial pitting and Abietineentüpfelung. In extant conifers, Abietineentüpfelung is considered to be characteristic of the wood of Pinaceae. The new discovery further indicates that the first occurrence of Abietineentüpfelung in conifer-like wood should be earlier than the Kimmeridgian. The palaeolatitudinal distribution pattern of Protocedroxylon indicates that the genus is a palaeobiogeographically consistent group, which was probably restricted to wetter and cooler temperate climates. In combination with distinct growth rings, the occurrence of Protocedroxylon suggests that a cool temperate and seasonal climate might have prevailed during the sedimentation period of the Wanbao Formation in eastern Inner Mongolia, NE China. Such a view is also in agreement with the palaeoclimatic conditions indicated by the plant megafossils of the Wanbao Formation.

关键词： Protocedroxylon Pinaceae Wanbao Formation Middle Jurassic Inner Mongolia

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