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Dual ligand-targeted Pluronic P123 polymeric micelles enhance the therapeutic effect of breast cancer with bone metastases

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Oncology Research 2024年第4期32卷 769-784页

作者： HUAN GAO JIE ZHANG TONY GKLEIJN ZHAOYONG wu BING LIU yujin MA BAOYUE DING DONGFENG YIN Jiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics Department of PharmaceuticsCollege of MedicineJiaxing UniversityJiaxing314001China Department of Pharmacy The General Hospital of Xinjiang Military RegionUrumqi830000China Department of Pathology and Medical Biology University Medical Center GroningenUniversity of GroningenGroningen9713 GZThe Netherlands Department of Pathology Laboratory of Experimental OncologyErasmus MCRotterdam3015 GDThe Netherlands Department of Pharmacy Jiaxing Maternal and Child Health Care HospitalAffiliated Hospital of Jiaxing UniversityJiaxing314001China Qinghai Enlu Biotechnology Co. Ltd.Haidong810700China

Bone metastasis secondary to breast cancer negatively impacts patient quality of life and survival.The treatment of bone metastases is challenging since many anticancer drugs are not effectively delivered to the bone to exert a therapeutic effect.To improve the treatment efficacy,we developed Pluronic P123(P123)-based polymeric micelles dually decorated with alendronate(ALN)and cancer-specific phage protein DMPGTVLP(DP-8)for targeted drug delivery to breast cancer bone metastases.Doxorubicin(DOX)was selected as the anticancer drug and was encapsulated into the hydrophobic core of the micelles with a high drug loading capacity(3.44%).The DOX-loaded polymeric micelles were spherical,123 nm in diameter on average,and exhibited a narrow size distribution.The in vitro experiments demonstrated that a pH decrease from 7.4 to 5.0 markedly accelerated DOX release.The micelles were well internalized by cultured breast cancer cells and the cell death rate of micelle-treated breast cancer cells was increased compared to that of free DOX-treated cells.Rapid binding of the micelles to hydroxyapatite(HA)microparticles indicated their high affinity for bone.P123-ALN/DP-8@DOX inhibited tumor growth and reduced bone resorption in a 3D cancer bone metastasis model.In vivo experiments using a breast cancer bone metastasis nude model demonstrated increased accumulation of the micelles in the tumor region and considerable antitumor activity with no organ-specific histological damage and minimal systemic toxicity.In conclusion,our study provided strong evidence that these pH-sensitive dual ligand-targeted polymeric micelles may be a successful treatment strategy for breast cancer bone metastasis.

关键词： Pluronic micelles Targeted nanotherapeutics Nanoparticulate drug delivery system Breast cancer with bone metastasis Therapeutic efficacy

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Finite-time path following control of a sailboat with actuator failure and unknown sideslip angle

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浙江大学学报(英文版)A辑:应用物理与工程 2023年第9期24卷 749-761页

作者： yujin wu Kangjian SHAO Ning WANG Zhongchao DENG Science and Technology on Underwater Vehicle Laboratory Harbin Engineering UniversityHarbin 150001China School of Marine Engineering Dalian Maritime UniversityDalian 116026China

Suffering from actuator failure and complex sideslip angle,the motion control of a sailboat becomes challenging.In this paper,an improved double finite-time observer-based line-of-sight guidance and finite-time control(IDFLOS-FC)scheme is presented for path following of sailboats.The salient features of the proposed IDFLOS-FC scheme are as follows:(1)Considering the problem of actuator failure,an actuator failure model is introduced into the dynamics model of a sailboat.(2)The time-varying sideslip angle of the sailboat is accurately observed by the double finite-time sideslip observers(DFSOs),which reduces the error in line-of-sight(LOS)guidance.(3)A radial basis function(RBF)neural network is used to fit the uncertainty of the model,and the upper bound of the sum of fault effects and external disturbances is estimated based on adaptive theory,so that the controller has accurate tracking and interference suppression.(4)According to the Lyapunov method,the system is finite-time stable.Finally,simulation was used to validate the effectiveness of the method.

关键词： Sailboat Sideslip angle Sideslip angle observer Finite-time control(FC) Path following

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MINIMIZERS OF L^(2)-SUBCRITICAL VARIATIONAL PROBLEMS WITH SPATIALLY DECAYING NONLINEARITIES IN BOUNDED DOMAINS

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Acta Mathematica Scientia 2024年第3期44卷 984-996页

作者：陈彬高永帅郭玉劲吴越 School of Mathematics and Statistics Hubei key Laboratory of Mathematical SciencesCentral China Normal UniversityWuhan430079China

This paper is concerned with the minimizers of L^(2)-subcritical constraint variar tional problems with spatially decaying nonlinearities in a bounded domain Ω of R~N(N≥1).We prove that the problem admits minimizers... 详细信息

关键词： decaying nonlinearity L~2-subcritical minimizers bounded domains mass concentration

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北京月季叶际表生真菌多样性及群落结构

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菌物学报 2024年第1期43卷 1-18页

作者：崔玉进吴芳北京林业大学生态与自然保护学院微生物研究所北京100083

叶际微生物在维持植物健康,促进植物的生长和生物地球化学循环等生态功能中发挥着重要作用,近年来叶际微生物的作用以及多样性变化受到广泛关注,其重要性日益突出。本研究以北京常见的绿化植物月季为研究对象,对市中心向北、由近到远的... 详细信息

叶际微生物在维持植物健康,促进植物的生长和生物地球化学循环等生态功能中发挥着重要作用,近年来叶际微生物的作用以及多样性变化受到广泛关注,其重要性日益突出。本研究以北京常见的绿化植物月季为研究对象,对市中心向北、由近到远的4个采样点,安定门地区(ADM)、和平街地区(HPJ)、亚运村地区(YYC)和北七家地区(BQJ);3个月份(四月、七月和十一月)和道路2个不同位置(道路中央和两侧)的月季叶际表生真菌多样性及群落结构进行了研究。结果表明:在月季叶际表生真菌系统中,共获得3425条扩增子系列变异特征序列(ASVs),其中座囊菌纲Dothideomycetes是优势类群,不同采样点间的月季叶际表生真菌Shannon指数由高到低依次为ADM>BQJ>HEJ>YYC,其中ADM显著高于YYC,多样性由市中心向北、由近到远呈现先降低后升高的变化趋势;月份间的Shannon指数由高到低依次为四月份>七月份>十一月份,其中四月份显著高于七月份和十一月份;道路中央样品与道路两侧样品无显著性差异。LEfSe分析判定了不同地区和季节的差异指示菌属,其中ADM的差异指示属为新刺毛茎点霉属Neosetophoma、新齿裂菌属Neophaeococcomyces及假赤壳属Pseudocosmospora,HPJ的差异指示属为光黑壳属Preussia,YYC的差异指示属为圆盘菌属Orbilia,BQJ的差异指示属为假小垫革菌属Pseudotomentella。通过网络分析发现,空泡茎点霉属Vacuiphoma、担孢酵母属Erythrobasidium、枝孢属Cladosporium、木拉克属Mrakia和亚球壳属Sphaerulina平均度最大,确定为核心节点菌属。真菌群落功能预测得出腐生功能类群和病理功能类群是月季叶际表生真菌的主要类群,且腐生功能类群在不同季节条件下和不同样点间丰度均存在显著变化。研究结果为城市叶际微生物群落结构变化和城市绿化科学管理提供了参考。

关键词：叶际真菌月季 Illumina MiSeq测序真菌多样性群落组成指示物种

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Changes of auditory evoked magnetic fields in patients after acute cerebral infarction using magnetoencephalography

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Neural Regeneration Research 2012年第24期7卷 1906-1913页

作者： Zhanyong Sun Chunfeng Song Jilin Sun Ling Li Yanhong Dong Jianhua Wang Jie wu Wenzhu Cui yujin wu Peiyuan Lv Department of Neurology Hebei Medical UniversityShijiazhuang 050017Hebei ProvinceChina Institute of Basic Medicine Hebei Medical UniversityShijiazhuang 050017Hebei ProvinceChina Department of Magnetoencephalography Hebei General HospitalShijiazhuang 050051Hebei ProvinceChina Department of Neurology Hebei General HospitalShijiazhuang 050051Hebei ProvinceChina

Auditory evoked magnetic fields were recorded from 15 patients with acute cerebral infarction and 11 healthy volunteers using magnetoencephalography.The auditory stimuli of 2 kHz pure tone were binaurally presented with an interstimulus interval of 1 second.The intensity of stimuli was 90 dB and the stimulus duration was 8 ms.The results showed that the M100 was the prominent response, peaking approximately 100 ms after stimulus onset in all subjects.It originated from the area close to Heschl’s gyrus.In the patient group,the peak latency of M100 responses was significantly prolonged,and the mean strength of equivalent current dipole was significantly smaller in the affected hemisphere.The three-dimensional inter-hemispheric difference of the M100 positions was increased in the patient group.Our experimental findings suggested that impairment of cerebral function in patients with acute ischemic stroke can be detected using magnetoencephalography with the higher spatial resolution and temporal resolution.Magnetoencephalography could provide objective and sensitive indices to estimate auditory cortex function in patients with acute cerebral infarction.

关键词： acute cerebral infarction cerebral ischemia magnetoencephalography auditory evoked magnetic fields equivalent current dipole Heschl’s gyrus brain functional impairment nerve injury regeneration neural regeneration

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改性氮化硼/水性聚氨酯导热复合材料的制备与表征

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化工新型材料 2024年第5期52卷 120-124,132页

作者：薛耀宗赵玉金吴淑英吴志民湘潭大学机械工程与力学学院湘潭411105 湘潭大学化工学院湘潭411105

以氮化硼为原料,用γ-氨丙基三乙氧基硅烷对其进行氨基化改性,利用水解产生的硅羟基和氮化硼烯表面的含氧官能团进行缩合反应后,得到改性导热填料。将其与水性聚氨酯乳液原位聚合,制备改性氮化硼/水性聚氨酯复合乳液,室温干燥成膜后得... 详细信息

以氮化硼为原料,用γ-氨丙基三乙氧基硅烷对其进行氨基化改性,利用水解产生的硅羟基和氮化硼烯表面的含氧官能团进行缩合反应后,得到改性导热填料。将其与水性聚氨酯乳液原位聚合,制备改性氮化硼/水性聚氨酯复合乳液,室温干燥成膜后得到胶膜样品。分析了填料含量对复合胶膜结构、机械性能、导热性能和热稳定性等性能的影响,并分析其作为热界面材料的散热效果。结果表明:改性后的胶膜拉伸强度、断裂伸长率、导热性能和热稳定性都能得到明显的提升。当填料质量分数为15%时,复合胶膜较纯胶膜热源温度降低了2.2℃,界面间传热效率得到提高。

关键词：氮化硼水性聚氨酯导热性能机械性能散热

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Effects of water on CO catalytic oxidation over Pd/CeO2

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Journal of Rare Earths 2020年第8期38卷 891-898,I0003页

作者： Shaofei Song Cheng Zhang Yake Lou yujin wu Li Wang Yanglong Guo Wangcheng Zhan Yun Guo Key Lab for Advanced Material Laboratory for Research Institute of Industrial CatalysisSchool of Chemistry&Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China

The role of water in CO oxidation was investigated on Pd/CeO2 with different morphologies(rods(R),cubes(C)and octahedrons(O)).Compared with the absence of water,CO oxidation activity increases 2 times in the presence of water on Pd/CeO2-C;but a decrease is found on Pd/CeO2-R.Catalyst characterization reveals that Pd is mainly in the form of solid solution(PdxCe1-xO2-σ)on Pd/CeO2-R and a mixture of metal and PdxCe1-xO2-σsolid solution on Pd/CeO2-C.The strong interaction between Pd and CeO2-R results in the form of stable bidentate carbonates species;while the relatively weak interaction between Pd and CeO2-C leads to the produce of unstable monodentate carbonates species.The effects of water on CO oxidation activity closely relate with the Pd chemical state and the types of carbonates species.Water restrains CO adsorption on PdxCe1-xO2-σsolid solution,but it has negligent effects on metallic Pd species.In the presence of water,bidentate carbonates species remains stable but the decrease in the amount of monodentate carbonates species is observed.

关键词： CO oxidation Pd catalyst Support morphology Water Rare earths

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QTL analysis of ear leaf traits in maize(Zea mays L.)under different planting densities

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The Crop Journal 2017年第5期5卷 387-395页

作者： Hongwu Wang Qianjin Liang Kun Li Xiaojiao Hu yujin wu Hui Wang Zhifang Liu Changling Huang Institute of Crop Science Chinese Academy of Agricultural Sciences

Modem maize varieties have become more productive than ever, owing largely to increased tolerance of high plant density. However, the genetics of ear leaf traits under different densities remains poorly understood. In this study, Zhongdan 909 recombinant inbred lines(RILs) derived from a cross between Z58 and HD568 were genotyped for 3072 single-nucleotide polymorphisms(SNPs), and phenotyped for leaf length(LL), leaf width(LW), and leaf angle(LA) of the uppermost ear leaf under three planting densities(52,500,67,500, and 82,500 plants ha-1, respectively). A genetic map was then constructed using1358 high-quality SNPs. The total length of the linkage map was 1985.2 cM and the average interval between adjacent markers 1.46 cM. With increasing density, LL and LW decreased from 63.68 to 63.02 cm and from 8.56 to 8.21 cm, respectively, while LA increased from19.42° to 19.66°. All three traits had high heritabilities, of 0.75, 0.78, and 0.84, respectively.Using inclusive composite interval mapping, 23, 25, and 17 quantitative trait loci(QTL) were detected for LL, LW, and LA, respectively. Of these, 35 were simultaneously detected under two or three plant densities, while 30 were detected under only one. Sixty-five individual QTL explained 2.41% to 16.53% of phenotypic variation, while eight accounted for >10%.These findings will help us understand the genetic basis of leaf traits in maize as well as the response of maize to increased plant density.

关键词： Maize Quantitative trait loci Leaf traits Density treatment

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利用双差走时成像研究青藏高原东缘地壳速度结构

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地球物理学报 2024年第3期67卷 871-888页

作者：武振波邹昆苏金蓉滑玉琎李萍萍徐涛成都理工大学地球物理学院成都610059 成都理工大学地球勘探与信息技术教育部重点实验室成都610059 四川省地震局成都610041 太原理工大学矿业工程学院太原030024 中国科学院地质与地球物理研究所中国科学院矿产资源研究重点实验室北京100029 中国科学院地球科学研究院北京100029

青藏高原东缘断裂密布,强震频发,是研究高原侧向挤出及深部孕震环境的理想实验室.为了解龙门山次级块体及其西界龙日坝断裂带在青藏高原东缘隆升过程中的作用,我们基于四川地震台网64个宽频带地震台在2008年1月至2015年12月期间记录的... 详细信息

青藏高原东缘断裂密布,强震频发,是研究高原侧向挤出及深部孕震环境的理想实验室.为了解龙门山次级块体及其西界龙日坝断裂带在青藏高原东缘隆升过程中的作用,我们基于四川地震台网64个宽频带地震台在2008年1月至2015年12月期间记录的震级≥3.0地震事件波形,利用双差层析成像方法揭示了四川盆地及青藏高原东缘的地壳速度结构.结果表明:夹持于龙门山断裂带(LMSF)与龙日坝断裂带(LRBF)之间的龙门山次级块体,相对东侧龙门山断裂带和四川盆地呈现明显的低速特征.结合该区域的低阻、低密度结构特征,以及块体内部、特别是龙日坝断裂带现今地震活动缺乏,我们推测这是因为该块体“相对较软”,不易脆性破裂产生地震,在青藏高原东缘与扬子块体西缘强烈相互作用过程中,该块体主要通过地壳缩短增厚和地表隆升吸收板块挤压造成的累积应变能.依据本文获得的速度等值线变化特征及已有地球物理剖面探测结果,推测龙日坝断裂带为深部向南东倾斜且向下切入基底,该断裂倾角较陡,主要以走滑运动调节应变能,而东侧龙门山断裂带倾角较缓,表现为逆冲运动导致的地壳缩短是其调节应变能的主要形式.此外,据本文多条速度剖面及已有电性剖面、重力异常的联合约束,我们推测鲜水河、安宁河断裂带均以较大倾角向南东倾斜,至少延伸至中下地壳.

关键词：青藏高原东缘双差层析成像龙门山次级块体龙日坝断裂带

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Genome-wide alternative splicing variation and its potential contribution to maize immature-ear heterosis

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The Crop Journal 2021年第2期9卷 476-486页

作者： Xiaojiao Hu Hongwu Wang Kun Li Xiaogang Liu Zhifang Liu yujin wu Shuqiang Li Changling Huang National Engineer Laboratory of Crop Molecular Breeding Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China

Heterosis is a well-known phenomenon widely applied in agriculture.Recent studies have suggested that differential gene and protein expression between hybrids and their parents play important roles in heterosis.Alternative splicing(AS)is an essential posttranscriptional mechanism that can greatly affect the transcriptome and proteome diversity in plants.However,genome-wide AS divergence in hybrids compared to their parents and its potential contribution to heterosis have not been comprehensively investigated.We report the direct profiling of the AS landscape using RNA sequencing data from immature ears of the maize hybrid ZD808 and its parents NG5 and CL11.Our results revealed a large number of significant differential AS(DAS)events in ZD808 relative to its parents,which can be further classified into parental-dominant and novel DAS patterns.Parental-dominant,especially NG5-dominant,events were prevalent in the hybrid,accounting for 42%of all analyzed DAS events.Functional enrichment analysis revealed that the NG5-dominant AS events were involved mainly in regulating the expression of genes associated with carbon/nitrogen metabolism and cell division processes and contributed greatly to maize ear heterosis.Among ZD808,CL11,and NG5,32.5%of DAS contained or lacked binding sites of at least one annotated maize microRNA(miRNA)and may be involved in miRNA-mediated posttranscriptional regulation.Cis regulation was the predominant contributor to AS variation and participates in many important biological processes associated with immature ear development.This study provides a comprehensive view of genome-wide alternative splicing variation in a maize hybrid.

关键词： Maize Heterosis Dominant alternative splicing Cis-regulation

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