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Ferroptosis and its emerging roles in acute pancreatitis

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Chinese Medical Journal 2022年第17期135卷 2026-2034页

作者： Hongyao Li yujie lin ling Zhang Jing Zhao Peiwu Li Department of Emergency Lanzhou University Second HospitalLanzhou UniversityLanzhouGansu 730030China

Acute pancreatitis(AP)is a common and potentially life-threatening pancreatic inflammatory disease.Although it is usually self-limiting,up to 20%of patients will develop into severe AP.It may lead to systemic inflammatory response syndrome and multiple organ dysfunction,affecting the lungs,kidneys,liver,heart,etc.Surviving patients usually have sequelae of varying degrees,such as chronic hyperglycemia after AP(CHAP),pancreatic exocrine insufficiency,and chronic pancreatitis.Lacking specific target treatments is the main reason for high mortality and morbidity,which means that more research on the pathogenesis of AP is needed.Ferroptosis is a newly discovered regulated cell death(RCD),originally described in cancer cells,involving the accumulation of iron and the depletion of plasma membrane polyunsaturated fatty acids,and a caspase-independent RCD.It is closely related to neurological diseases,myocardial infarction,ischemia/reperfusion injury,cancer,etc.Research in the past years has also found the effects of ferroptosis in AP,pancreatic cancer,and AP complications,such as acute lung injury and acute kidney injury.This article reviews the research progress of ferroptosis and its association with the pathophysiological mechanisms of AP,trying to provide new insight into the pathogenesis and treatment of AP,facilitating the development of better-targeted drugs.

关键词： Acute pancreatitis Ferroptosis RCD Autophagy GPX4 PUFAs Regulated cell death

Luteolin suppresses oral carcinoma 3(OC3) cell growth and migration via modulating polo-like kinase 1(PLK1) expression and cellular energy metabolism

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第12期24卷 1151-1158页

作者： Pengfei GAO Wentao ZHANG yujie lin Ruijie LU Zijian LOU Gang LU Ruolang PAN Yunfang CHEN Center for Plastic&Reconstructive Surgery Department of StomatologyZhejiang Provincial People's Hospital(Affiliated People's Hospital)Hangzhou Medical CollegeHangzhou 310014China School of Stomatology Bengbu Medical CollegeBengbu 233030China The Second Clinical Medical College Wenzhou Medical UniversityWenzhou 325035China Key Laboratory of Cell-Based Drug and Applied Technology Development in Zhejiang Province Hangzhou 31122China

Oral squamous cell carcinoma(OSCC)is a prevalent malignant tumor affecting the head and neck region(Leemans et al.,2018).It is often diagnosed at a later stage,leading to a poor prognosis(Muzaffar et al.,2021;Li et al.,2023).Despite advances in OSCC treatment,the overall 5-year survival rate of OSCC patients remains alarmingly low,falling below 50%(Jehn et al.,2019;Johnson et al.,2020).According to statistics,only 50%of patients with oral cancer can be treated with surgery.Once discovered,it is more frequently at an advanced stage.In addition,owing to the aggressively invasive and metastatic characteristics of OSCC,most patients die within one year of diagnosis.Hence,the pursuit of novel therapeutic drugs and treatments to improve the response of oral cancer to medication,along with a deeper understanding of their effects.

关键词： PLK1 metabolism drugs

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基于激光表面织构提升钢材与木材间粘接强度

中国表面工程 2024年第1期37卷 216-224页

作者：林宇杰柏亚双徐国林李洪毅西南林业大学土木工程学院昆明650224

胶接钢-木组合构件中,受胶黏剂在钢材表面附着力弱的制约,钢材和木材的粘接强度不高。为改善胶黏剂在钢材上的粘附能力,提出采用激光在钢材表面形成微织构增加胶黏剂与钢材接触面积及嵌入深度。通过单搭接剪切试验,探究织构形状(方形凹... 详细信息

胶接钢-木组合构件中,受胶黏剂在钢材表面附着力弱的制约,钢材和木材的粘接强度不高。为改善胶黏剂在钢材上的粘附能力,提出采用激光在钢材表面形成微织构增加胶黏剂与钢材接触面积及嵌入深度。通过单搭接剪切试验,探究织构形状(方形凹坑、竖向沟槽、横向沟槽)对钢材和木材粘接强度的影响;借助激光共聚焦轮廓仪检测钢材表面粗糙度和织构深度,采用扫描电镜(SEM)观察激光处理后钢材表面形貌特征及断口特征,基于检测数据构建有限元模型,探究织构形状对钢材和木材间胶层应力分布影响;总结钢材表面织构对钢材和木材粘接强度影响规律和机制。结果表明:钢材表面织构能有效提升钢材和木材粘接强度;织构形状对钢材和木材粘接强度起决定性作用;在相同激光设置参数和相同织构设计参数(宽度和间距)下,沟槽织构比方形织构更有利于增加胶黏剂与钢材粘结强度;织构周围存在的激光熔融物有利于提高胶黏剂与钢材粘结强度。研究成果可为提高钢材和木材间粘接强度提供技术支撑,也为织构在胶接型钢-木组合构件中的应用与设计提供新思路。

关键词：激光表面处理微织构粘接强度胶接钢-木组合构件

Impact of Phase Noise on TDMS Based Calibration for Spaceborne Multi-Beam Antennas

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China Communications 2018年第3期15卷 128-136页

作者： yujie lin Xiangyuan Bu Shuai Wang Yuan Chai Jianping An School of Information and Electronics Beijing Institute of Technology Institute of Telecommunication Satellite China Academy of Space Technology

For spaceborne multi-beam antennas(MBAs), time division multiplexed switching(TDMS) based calibration receiver can reduce implementation costs effectively and is very suitable for large-scale applications. However, in practice, random phase noise imposed by noisy local oscillators can cause significant performance degradation in TDMS-based calibration systems. Characterization of phase noise effects is therefore crucial for practical applications. In this paper, we analyze the impact of phase noise on the calibration performance for a MBA system. Specifically, we derive the relationship between the probability of correct amplitude/phase estimation and various practical factors involving the signal-to-noise ratio(SNR), the standard deviation of phase noise, the given tolerance region, and the length of the spreading code. The results provide high efficiency for evaluating the calibration performance of the MBAs based on TDMS, especially for precisely anticipating the impact of phase noise. Finally, the accuracy of the derived results is assessed by simulations in different scenarios.

关键词： TDMS 刻度噪音天线横梁卫星本地振荡器接收装置

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计及复合碳泄漏效应的电力系统双层规划

电力系统自动化 2024年第12期48卷 1-13页

作者：林雨洁张笑演熊厚博乔艺林石浩杰郭创新浙江大学电气工程学院浙江省杭州市310027 国网浙江省电力有限公司嘉兴供电公司浙江省嘉兴市314000

“双碳”目标下,不对称碳监管政策在电力行业低碳转型路径中引发的强、弱复合碳泄漏效应需要引起关注。针对单边碳减排政策在电力系统中的影响,结合边际电价理论构建了考虑输电网级能源网架扩展与配电网级能源枢纽负荷行为的电力系统双... 详细信息

“双碳”目标下,不对称碳监管政策在电力行业低碳转型路径中引发的强、弱复合碳泄漏效应需要引起关注。针对单边碳减排政策在电力系统中的影响,结合边际电价理论构建了考虑输电网级能源网架扩展与配电网级能源枢纽负荷行为的电力系统双层规划模型。首先,在上层能源网架规划中分析线路扩展带来的弱碳泄漏效应,通过拉格朗日乘子求解电网边际电价,在此基础上计及强碳泄漏效应影响下的负荷转移行为,建立下层能源枢纽经济规划模型;其次,分析碳泄漏的成因并提出缓和手段,建立对应模型;然后,提出电力系统双层低碳规划的求解流程,并设计提升双层规划收敛性的二分启发式方法;最后,在改进的IEEE 12节点系统与改进的IEEE 236节点系统中进行仿真,分析碳价格与碳泄漏缓和手段对碳泄漏效应的影响,算例结果验证了碳泄漏的形成渠道与影响。分析免费碳配额或碳排放关税对碳泄漏效应的缓和作用与风险,同时,研究双层规划模型收敛性,可为电力系统低碳转型路径中开展合理碳监管提供参考。

关键词：碳泄漏双碳低碳政策边际电价负荷转移电力系统规划

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浅析解构主义形式图形设计中的应用

鞋类工艺与设计 2024年第6期4卷 115-117页

作者：林雨婕卢欣然湖北民族大学湖北恩施445000 四川农业大学四川成都611134

随着时代的发展,图形设计开始从各个风格形式汲取营养,本文就如何将解构主义形式语言与图形设计更好地结合展开叙述。通过对论文文献、目前为止解构主义在图形设计、海报设计和建筑设计各领域的优秀作品分析研究。希望为设计师提供一种... 详细信息

随着时代的发展,图形设计开始从各个风格形式汲取营养,本文就如何将解构主义形式语言与图形设计更好地结合展开叙述。通过对论文文献、目前为止解构主义在图形设计、海报设计和建筑设计各领域的优秀作品分析研究。希望为设计师提供一种解构主义形式语言与图形设计结合的可行思路。

关键词：解构主义形式语言图形设计

Optical and electrical properties of a spiral LED filament

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Journal of Semiconductors 2018年第2期39卷 39-44页

作者： Liping Wang Jun Zou Bobo Yang Wenbo Li Yang Li Mingming Shi Wei Zhu Canyun Zhang Fengchao Wang yujie lin School of Materials Science and Engineering Shanghai Institute of Technology Shanghai 201418 China School of Science Shanghai Institute of Technology Shanghai 201418 China Zhejiang Emitting Optoelectronic Technology Company Hangzhou 310000 China Shanghai Pn-stone Optoelectronics Co. Ltd. Shanghai 201108 China

This paper introduces a new type of spiral white light-emitting diodes（WLED） filament with high luminous efficiency and uniform optical performance. The optical and thermal properties of the flexible filament were investigated at different stretching heights, namely 0, 1, 2, and 3 cm. The results indicated that the filament showed the best optical characteristics at the stretching height of 2 cm, because of good heat dissipation. In addition, the radiation temperature of the filament was inversely proportional to the output luminous flux. The reliability of the filament at a stretching height of 2 cm was also evaluated after 1000 h of use. The result demonstrated that the luminous flux decay of the bulb was only 0.85%. The flexible spiral WLED filament exhibiting high luminous flux and good reliability could be adapted to promote industrial development in the near future.

关键词： white light-emitting diode spiral substrate flip chip stretching height

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单光子激光通信测距一体化系统设计

国外电子测量技术 2024年第6期43卷 119-126页

作者：胡春源林玉洁朱简尊吴梓豪北京理工大学信息与电子学院北京100081

超导单光子探测技术能够实现光子量级极微弱光接收,是深空探测的关键技术之一,然而光子概率分布产生的脉冲抖动效应造成通信、测距性能恶化。对此,设计了基于脉冲位置调制(pulse position modulation,PPM)调制的单光子激光通信测距一体... 详细信息

超导单光子探测技术能够实现光子量级极微弱光接收,是深空探测的关键技术之一,然而光子概率分布产生的脉冲抖动效应造成通信、测距性能恶化。对此,设计了基于脉冲位置调制(pulse position modulation,PPM)调制的单光子激光通信测距一体化系统。根据光子分布特性,提出了脉冲宽度压缩的PPM新波形,降低了脉冲抖动效应对通信可靠性、测距精度的影响。同时,研制了星载端与地面端原理样机,搭建了双向通信与同步转发测距试验验证平台。试验验证结果表明,同等接收功率(-53.2 dBm)条件下,采用1/4脉宽压缩比时,通信接收误码率从4.7×10^(-4)降至5×10^(-10),测距精度从23.61 cm提高至0.91 cm,实现了高可靠通信传输与高精度距离测量。

关键词：激光通信测距一体化单光子探测脉冲位置调制

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温胆汤加减治疗失眠的效果分析

中外医药研究 2024年第12期3卷 67-69页

作者：江健俐李建军吴贵云林玉洁中山大学孙逸仙纪念医院中医科广东广州510120 中山大学孙逸仙纪念医院麻醉科广东广州510120

目的:探讨温胆汤加减治疗失眠的临床效果。方法:选取2021年1月—2022年12月中山大学孙逸仙纪念医院收治的失眠患者82例,按照随机数字表法分为两组,各41例。对照组口服艾司唑仑治疗,观察组在对照组基础上加用温胆汤加减治疗,两组持续治疗... 详细信息

目的:探讨温胆汤加减治疗失眠的临床效果。方法:选取2021年1月—2022年12月中山大学孙逸仙纪念医院收治的失眠患者82例,按照随机数字表法分为两组,各41例。对照组口服艾司唑仑治疗,观察组在对照组基础上加用温胆汤加减治疗,两组持续治疗4周。比较两组患者临床疗效、睡眠质量、睡眠状态、心理状态及不良反应情况。结果:观察组总有效率高于对照组,差异有统计学意义(P=0.043)。治疗后,观察组匹兹堡睡眠质量评定量表评分低于对照组,睡眠潜伏期、觉醒时间短于对照组,睡眠总时间长于对照组,差异有统计学意义(P<0.05)。观察组治疗后焦虑、抑郁评分低于对照组,差异有统计学意义(P<0.05)。两组不良反应比较,差异无统计学意义(P=0.710)。结论:应用温胆汤加减治疗失眠,效果显著,可纠正睡眠状态异常,减轻心理负担,安全可靠。

关键词：失眠温胆汤艾司唑仑睡眠质量不良反应