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Vaccine adjuvants:mechanisms and platforms

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Signal Transduction and Targeted Therapy 2023年第8期8卷 3681-3704页

作者： Tingmei Zhao Yulong Cai yujie jiang Xuemei He Yuquan Wei Yifan Yu Xiaohe Tian Laboratory of Aging Research and Cancer Drug Target State Key Laboratory of Biotherapy and Cancer CenterNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityNo.17Block 3Southern Renmin RoadChengdu 610041 SichuanPeople’s Republic of China Division of Biliary Tract Surgery Department of General SurgeryWest China HospitalSichuan UniversityChengduChina Department of Radiology and Huaxi MR Research Center(HMRRC) Functional and Molecular Imaging Key Laboratory of Sichuan ProvinceWest China HospitalSichuan UniversityChengduChina

Adjuvants are indispensable components of *** being widely used in vaccines,their action mechanisms are not yet *** a greater understanding of the mechanisms by which the innate immune response controls the antigen-specific response,the adjuvants’action mechanisms are beginning to be *** can be categorized as immunostimulants and delivery *** are danger signal molecules that lead to the maturation and activation of antigenpresenting cells(APCs)by targeting Toll-like receptors(TLRs)and other pattern recognition receptors(PRRs)to promote the production of antigen signals and co-stimulatory signals,which in turn enhance the adaptive immune *** the other hand,delivery systems are carrier materials that facilitate antigen presentation by prolonging the bioavailability of the loaded antigens,as well as targeting antigens to lymph nodes or *** adjuvants’action mechanisms are systematically summarized at the beginning of this *** is followed by an introduction of the mechanisms,properties,and progress of classical vaccine ***,since some of the adjuvants under investigation exhibit greater immune activation potency than classical adjuvants,which could compensate for the deficiencies of classical adjuvants,a summary of the adjuvant platforms under investigation is subsequently ***,we highlight the different action mechanisms and immunological properties of these adjuvant platforms,which will provide a wide range of options for the rational design of different *** this basis,this review points out the development prospects of vaccine adjuvants and the problems that should be paid attention to in the future.

关键词： activation rational summarized

Towards full-spectrum photocatalysis： Achieving a Z-scheme between Ag2S and TiO2 by engineering energy band alignment with interfacial Ag

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Nano Research 2015年第11期8卷 3621-3629页

作者： Yanrui Li Leilei Li Yunqi Gong Song Bai Huanxin Ju Chengming Wang Qian Xu Junfa Zhu Jun jiang yujie Xiong Hefei National Laboratory for Physical Sciences at the Microscale iChEM (Collaborative Innovation Center of Chemistry for Energy Materials) School of Chemistry and Materials Science and National Synchrotron Radiation Laboratory University of Science and Technology of China Hefei 230026 China

A Z-scheme is a promising approach to achieve broad-spectrum photocatalysis. Integration of TiO2 with another semiconductor with a band gap of -1.0 eV would be ideal to harvest both ultraviolet and visible-near infrared light for photocatalysis; however, most narrow-bandgap semiconductors have straddling band structure alignments with TiO2, constituting an obstacle to forming the Z-scheme for photocatalytic hydrogen production. In this communication, we demonstrate Ag2S as a model system where the energy band upshift of the narrow-bandgap semiconductor that shares an interface with a metal can overcome this limitation. To fabricate the design, we developed a unique approach to synthesize Ag2S-Ag-TiO2 hybrid structures. The obtained ternary hybrid structures exhibited dramatically enhanced performance in photocatalytic hydrogen pro- duction under full-spectrum light illumination. The activities were significantly higher than the sum of those of Ag2S-Ag-TiO2 structures under λ〈 400 nm and λ 〉 400 nm irradiation as well as those of their counterparts under any light illumination conditions.

关键词： photocatalysis Z-scheme semiconductor band structure water splitting

An all-silk-derived functional nanosphere matrix for sequential biomolecule delivery and in situ osteochondral regeneration

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Bioactive Materials 2020年第4期5卷 832-843页

作者： Wei Zhang Chen Ling Aini Zhang Haoyang Liu yujie jiang ,Xiaolong Li Renwang Sheng Qingqiang Yao Jialin Chen School of Medicine Southeast University210009NanjingChina Department of Orthopaedic Surgery Institute of Digital MedicineNanjing First HospitalNanjing Medical University210006NanjingChina jiangsu Key Laboratory for Biomaterials and Devices Southeast University210096NanjingChina China Orthopedic Regenerative Medicine Group(CORMed) China

Endogenous repair of osteochondral defect is usually limited by the insufficient number of cells in the early stage and incomplete cell differentiation in the later *** development of drug delivery systems for sequential release of pro-migratory and pro-chondrogenic molecules to induce endogenous bone marrow-derived mesenchymal stem cells(BMSCs)recruitment and chondrogenic differentiation is highly desirable for in situ osteochondral *** this study,a novel,all-silk-derived sequential delivery system was fabricated by incorporating the tunable drug-loaded silk fibroin(SF)nanospheres into a SF porous *** loading efficiency and release kinetics of biomolecules depended on the initial SF/polyvinyl alcohol(PVA)concentrations(0.2%,1%and 5%)of the nanospheres,as well as the hydrophobicity of the loaded molecules,resulting in controllable and programmed delivery *** findings indicated that the 5%nanosphere-incorporated matrix showed a rapid release of E7 peptide during the first 120 h,whereas the 0.2%nanosphere-incorporated matrix provided a slow and sustained release of Kartogenin(KGN)longer than 30 *** in vitro culture of BMSCs,this functional SF matrix incorporated with E7/KGN nanospheres showed good biocompatibility,as well as enhanced BMSCs migration and chondrogenic differentiation through the release of E7 and ***,when implanted into rabbit osteochondral defect,the SF nanosphere matrix with sequential E7/KGN release promoted the regeneration of both cartilage and subchondral *** work not only provided a novel all-silk-derived drug delivery system for sequential release of molecules,but also a functional tissueengineered scaffold for osteochondral regeneration.

关键词： Osteochondral regeneration Silk Sequential delivery BMSCs Nanospheres

Location Determination Of Optimal Emergency System For Hurricane Disaster Based On Mathematical Modeling

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Journal of Computer Science Research 2020年第1期2卷 12-15页

作者： Shizhong Ma Shilong Zhu yujie jiang College of Electrical Engineering North China University of Science and TechnologyTangshan063210China College of Science North China University of Science and TechnologyTangshan063210China School of Economics North China University of Science and TechnologyTangshan063210China

This article first introduces the current research status of space optical communication,and gives a brief overview of the development and application prospects of space optical communication,explaining its important research ***,the working principle of ATP in space optical communication system is studied,the mathematical model of ATP control system is established according to the actual needs,and the ATP control system design of space optical communication is *** selecting appropriate motors and gyroscopes as the actuators and detection elements of the system,substituting the actual parameters for simulation analysis,and correcting and verifying the results,some useful results are *** simulation results show the rationality and effectiveness of the ATP design scheme.

关键词： Emergency response system Reserve sites model Requirement analysis

Analysis of Drone Fleet Type and Quantity for Medical Package Distribution in Emergency System

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Modern Electronic Technology 2020年第1期4卷 12-15页

作者： yujie jiang Shizhong Ma Shilong Zhu School of Economics North China University of Science and TechnologyTangshanHebei063210China College of Electrical Engineering North China University of Science and TechnologyTangshanHebei063210China College of Science North China University of Science and TechnologyTangshanHebei063210China

In order to cope with the disasters caused by the worst hurricane in Puerto Rico in 2017,it is necessary to build an emergency system to reduce the *** emergency system should include the location of ISO standard dry cargo containers and the distribution of emergency medical *** paper discusses the distribution of emergency medical *** on the above location results of ISO standard dry cargo container,taking the demand of disaster areas not exceed its supply into consideration and considering the timeliness and weak economy,a multi-objective mixed integer programming model is constructed on the premise of minimum transportation time and *** is determined that the drone fleet consists of four B,one C and one F *** the optimization model,the distribution plan of emergency medical packages is formulated.

关键词： Emergency response system Multi-objective mixed integer programming Drone fleet

Impaired circulating CD56dim NK cells are closely related to decompensation of HBV-related cirrhosis

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Impaired circulating CD56dim NK cells are closely related to...

中国企业跨国并购后的整合模式——以吉利集团并购沃尔沃汽车为例

2019年浙江省检验医学学术大会

作者： yujie jiang Xiangyang Lin The First Affiliated Hospital of Wenzhou Medical University

Purpose:NK cells play an important role in immune regulation and defense of infection,but their characteristics in patients with decompensated cirrhosis and their relationship with liver function remain *** studied the functional properties of NK cells (including CD56 NK and CD56 NK cells) in patients with HBV-related decompensated liver cirrhosis (HBV-DLC) and analyzed their relationship with decompensation of liver ***:Thirty patients with HBV-DLC and 25 patients with HBV-related compensated liver cirrhosis(HBV-CLC) were recruited in this *** five age-and sex-matched healthy individuals were recruited as healthy controls (HCs).The phenotypical and functional characteristics of NK cell subsets were detected by flow cytometry,and the correlation between NK cells and decompensation of liver function was ***:The frequency of circulating CD56 NK cells was significantly increased while circulating CD56 NK cells was significantly decreased in HBV-DLC patients as compared with HCs and HBV-CLC *** activated-CD56 NK cells in HBV-DLC patients expressed higher levels of activating receptor NKG2D and lower levels of inhibitory receptor CD158b and the expression of perforin and granzyme(GrA,GrB) also increased significantly compared with HCs,suggesting a high cytotoxic status of peripheral CD56 NK cells in HBV-DLC *** circulating CD56 NK cells in HBV-DLC patients expressed higher levels of HLA-DR,their expression of CD107a and perforin was significantly decreased and positively correlated with cytolytic capacity of total NK ***,we found that the perforin expression of circulating CD56NK cells correlated negatively with child-pugh classification in HBV-DLC ***:The functional properties of circulating NK cell subsets in HBV-DLC patients have changed significantly,especially of CD56 NK cells which closely related to decompensation of liver *** findings may help provide new

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经济与管理研究 2017年第7期38卷 126-132页

作者：蒋瑜洁重庆大学公共管理学院

本文通过对中国吉利集团跨国并购瑞典沃尔沃汽车后整合过程的案例研究,揭示出中国企业在并购全球领先企业时的一种有效整合方式:并购双方应维持企业文化、运营模式、企业内部管理系统的独立性,以保护被并购全球领先企业的品牌价值,降低... 详细信息

本文通过对中国吉利集团跨国并购瑞典沃尔沃汽车后整合过程的案例研究,揭示出中国企业在并购全球领先企业时的一种有效整合方式:并购双方应维持企业文化、运营模式、企业内部管理系统的独立性,以保护被并购全球领先企业的品牌价值,降低文化冲突,减少企业间调和成本;并积极地融合技术创新能力、促进全球规模化生产以及基础资源共享,追求整合的协同效应,增强核心竞争力。本文提出,并购交易完成后迅速、简洁、明确的战略定位及组织间交流机制的确立是中国企业跨国并购整合成功的关键影响因素之一。

关键词：跨国并购整合模式案例研究

中国民营制造企业如何构建动态能力——基于吉利汽车的案例研究

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外国经济与管理 2019年第6期41卷 17-28,42页

作者：蒋瑜洁重庆大学公共管理学院

动态能力对于中国民营制造企业适应环境变化,持续保持竞争优势至关重要。然而中国民营制造企业如何构建动态能力,尚未得到学界的充分认识。本研究在引入日本制造企业动态能力构建机制研究框架的基础上,通过中国吉利汽车的单案例分析研究... 详细信息

动态能力对于中国民营制造企业适应环境变化,持续保持竞争优势至关重要。然而中国民营制造企业如何构建动态能力,尚未得到学界的充分认识。本研究在引入日本制造企业动态能力构建机制研究框架的基础上,通过中国吉利汽车的单案例分析研究,探索并尝试阐释了中国民营制造企业动态能力的构建机制:由于企业先期经验、资金、技术等资源积累不足,组织内外环境变化加剧,组织计划的不确定性增加,非计划突发应对式动态能力发展路径成为主导;由于企业'感知、补足、重构'过程时间缩短和员工离职率偏高,动态能力主体范围缩小并集中于组织忠诚度较高的多样职能背景出身的高层管理者;同时需要强化组织外部支持,建立全职能对接式产学联盟,在员工入职前培养中层和基层员工的组织常规能力,从而支持组织基本职能的运行。本研究有助于深入理解中国民营制造企业的组织特征,构建东方特色企业治理理论,对于中国民营制造企业动态能力的提升具有一定的指导意义。

关键词：动态能力构建机制吉利汽车案例研究

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日本分享经济的发展现状研究

日本学刊 2018年第4期 63-84页

作者：蒋瑜洁重庆大学公共管理学院

近年来全球分享经济迅速崛起,其发展速度已远超各国现有政策法规和社会基础设施保障的预期,急需政府创新监管理念,制定完善相应的政策法规和服务标准,促进多方协作加快企业转型。日本分享经济发展缓慢,主要原因包括互联网信任和安全保... 详细信息

近年来全球分享经济迅速崛起,其发展速度已远超各国现有政策法规和社会基础设施保障的预期,急需政府创新监管理念,制定完善相应的政策法规和服务标准,促进多方协作加快企业转型。日本分享经济发展缓慢,主要原因包括互联网信任和安全保障机制的欠缺、现有法律法规的制约和创业精神的不足。为了促进分享经济的发展,日本政府设立专门机构,通过推行个人和法人数字化身份认证制度,促进分享经济诚信体系的信息化;实施"灰色地带解除制度"和"企业实证特例制度",为分享经济发展所需相关配套政策措施的完善和调整提供路径保障;推选分享经济发展标杆,派遣专家加强多方协作,促进传统企业抓住分享经济发展机会。日本分享经济发展的经验教训可为中国提供一些有益的启示和借鉴。

关键词：分享经济发展现状政府治理中日比较诚信体系