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Genomic insights into adaptation to bipedal saltation and desert-like habitats of jerboas

Science China(Life Sciences) 2024年第9期67卷 2003-2015页

作者： Simin Chai yujie chong Daiqing Yin Qiang Qiu Shixia Xu Guang Yang Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China Jiangsu Key Laboratory for Biodiversity and Biotechnology School of Life SciencesNanjing Normal UniversityNanjing 210023China School of Ecology and Environment Northwestern Polytechnical UniversityXi’an 710072China

Jerboas is a lineage of small rodents displaying atypical mouse-like morphology with elongated strong hindlimbs and short *** have evolved obligate bipedal saltation and acute senses,and been well-adapted to vast desert-like *** a newly sequenced chromosome-scale genome of the Mongolian five-toed jerboa(Orientallactaga sibirica),our comparative genomic analyses and in vitro functional assays showed that the genetic innovations in both protein-coding and non-coding regions played an important role in jerboa morphological and physiological ***-specific amino acid substitutions,and segment insertions/deletions(indels)in conserved non-coding elements(CNEs)were found in components of proteoglycan biosynthesis pathway(XYLT1 and CHSY1),which plays an important role in limb ***,we found specific evolutionary changes functionally associated with energy or water metabolism(e.g.,specific amino acid substitutions in ND5 and indels in CNEs physically near ROR2)and senses(e.g.,expansion of vomeronasal receptors and the FAM136A gene family)in *** dual-luciferase reporter assay verified that some of the CNEs with jerboa-specific segment indels exerted a significantly different influence on luciferase activity,suggesting changes in their regulatory function in *** results revealed the potential molecular mechanisms underlying jerboa adaptation since the divergence from the Eocene-Oligocene transition,and provided more resources and new insights to enhance our understanding of the molecular basis underlying the phenotypic diversity and the environmental adaptation of mammals.

关键词： jerboa adaptive evolution comparative genomics conserved non-coding elements bipedal saltation

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Adaptive changes in BMAL2 with enhanced awakening ability drive the evolution of unihemispheric slow–wave sleep in mammals

Adaptive changes in BMAL2 with enhanced awakening ability dr...

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第十六届全国野生动物生态与资源保护学术研讨会

作者： Daiqing Yin Biao Zhang yujie chong Wenhua Ren Shixia Xu Guang Yang Jiangsu Key Laboratory for Biodiversity and Biotechnology College of Life Sciences Nanjing Normal University

Marine mammals, especially cetaceans, have evolved a very special form of sleep characterized by unihemispheric slow–wave sleep(USWS) and a negligible amount or complete absence of rapid-eye-movement(REM) sleep;however, the underlying genetic mechanisms remain unclear. Here, we detected unique, significant selection signatures in basic helix-loop-helix ARNT like 2(BMAL2), a key circadian gene, in marine mammal lineages, and identified two nonsynonymous amino acid substitutions(K204E, K346Q) in the important PAS domain of cetacean BMAL2 by sequence comparison with other mammals. In vitro assays revealed that these cetacean-specific mutations specifically enhanced the response to E-boxlike enhancer and consequently promoted the transcriptional activation of PER2, which is closely linked to sleep regulation. The increased PER2 expression, which was further confirmed both in vitro and in vivo, is beneficial for allowing cetaceans to maintain continuous movement and alertness during sleep. Concordantly, the locomotor activities of zebrafish overexpressing cetacean-specific mutant bmal2 were significantly higher than zebrafish overexpressing the wild-type gene. Subsequently, transcriptome analyses revealed that cetacean-specific mutations caused the upregulation of arousal-related genes and the downregulation of several sleep-promoting genes, which is consistent with the need to suppress whole-brain sleep drive and maintain hemispheric arousal during USWS. Our findings suggest the potential close link between adaptive changes in BMAL2 and the remarkable adaptation of USWS, and may provide novel insights into the genetic basis for the evolution of animal sleep.

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黄土高原子午岭林区典型树种叶片N、P再吸收特征

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生态学报 2020年第11期40卷 3698-3705页

作者：邓健种玉洁贾小敏焦子怡任成杰韩新辉杨改河延安大学生命科学学院延安716000 陕西省红枣重点实验室(延安大学) 延安716000 西北农林科技大学农学院杨凌712100

为揭示黄土高原子午岭林区不同演替阶段和植被类型主要树种养分再吸收特征,研究选取4种次生植被树种(白桦、山杨、辽东栎和油松)和2种人工植被树种(刺槐和侧柏),测定其成熟叶、凋落叶和林下土壤碳(C)、氮(N)、磷(P)含量,研究了叶片N、P... 详细信息

为揭示黄土高原子午岭林区不同演替阶段和植被类型主要树种养分再吸收特征,研究选取4种次生植被树种(白桦、山杨、辽东栎和油松)和2种人工植被树种(刺槐和侧柏),测定其成熟叶、凋落叶和林下土壤碳(C)、氮(N)、磷(P)含量,研究了叶片N、P再吸收率及其与养分指标的关系。结果表明:(1)不同树种叶片养分和林下土壤养分含量存在显著差异,土壤C、N含量和C∶N∶P计量比均表现为演替后期林地(辽东栎和油松)>演替前期林地(山杨和白桦)>人工林(侧柏和刺槐);(2)不同树种叶片N、P再吸收率分别为17.18%-43.34%和27.13%-58.12%,均表现为演替后期林地>人工林>演替前期林地,且P的再吸收率总体高于N的再吸收率;(3)不同树种叶片N、P再吸收率与叶片养分指标的关系强于土壤,与养分计量比的相关性大于养分含量的相关性。说明子午岭典型植被会通过叶片N、P再吸收来适应养分限制环境,尤其是演替后期植被再吸收能力更强,研究可为黄土高原植被恢复提供理论依据。

关键词：养分再吸收率生态化学计量学土壤养分凋落叶黄土高原

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亚热带退化森林不同恢复方式对土壤团聚体胶结物质及稳定性的影响

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生态学报 2023年第9期43卷 3689-3698页

作者：蔡琳杨予静种玉洁袁义平曾翔宇姚和风陈初明李中强魏立飞余海燕湖北大学资源环境学院区域开发与环境响应湖北省重点实验室武汉430062 湖北省黄冈市罗田县大别山薄刀峰国有林场黄冈438600

退化森林的恢复一直是林业和生态学研究的热点。良好的森林土壤结构有助于林木生长发育,作为土壤最基本的结构单元,土壤团聚体组成和稳定性是衡量土壤肥力和质量的重要指标,其团聚结构的形成依靠土壤胶结物质。然而,土壤胶结物质与团聚... 详细信息

退化森林的恢复一直是林业和生态学研究的热点。良好的森林土壤结构有助于林木生长发育,作为土壤最基本的结构单元,土壤团聚体组成和稳定性是衡量土壤肥力和质量的重要指标,其团聚结构的形成依靠土壤胶结物质。然而,土壤胶结物质与团聚体稳定性之间的关系尚不确定。为探明亚热带退化森林的不同恢复方式对团聚体稳定性的影响及其潜在机制,以自然恢复的次生林为对照(CK),选取了亚热带三种常见的人工林:一代杉木林(P1)、二代杉木林(P2)和黄山松林(P3),测定土壤团聚体稳定性及其胶结物质的含量,并分析了各胶结物质对团聚体稳定性的影响。研究发现:不同森林恢复方式显著影响了土壤pH值、碳氮比、速效磷含量、团聚体的组成和稳定性。所有森林类型中,三种人工林的团聚体稳定性显著高于CK,P2的大团聚体所占比例最大,团聚体稳定性最高。恢复方式显著影响了土壤游离氧化铁含量、菌根密度和易提取球囊霉素相关土壤蛋白(EEG)含量。团聚体稳定性与游离氧化铁含量、菌根密度呈正相关,但与EEG含量呈负相关。研究结果表明,亚热带退化森林的人工恢复比自然恢复更有助于增强土壤团聚体稳定性,土壤游离氧化铁、菌根密度和EEG是显著影响团聚体稳定性的胶结物质。

关键词：土壤团聚体稳定性土壤游离氧化铁、铝球囊霉素相关土壤蛋白森林恢复方式亚热带森林

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Novel Private Data Access Control Scheme Suitable for Mobile Edge Computing

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China Communications 2021年第11期18卷 92-103页

作者： Wei Liang Songyou Xie Jiahong Cai chong Wang yujie Hong Xiaoyan Kui College of Computer Science and Electronic Engineering Hunan UniversityChangsha 410082China School of Computer Science and Engineering Hunan University of Science and TechnologyXiangtan 411201China School of Computer Science and Engineering Central South UniversityChangsha 410083China

Efficient response speed and information processing speed are among the characteristics of mobile edge computing(MEC).However,MEC easily causes information leakage and loss problems because it requires frequent data *** work proposes an anonymous privacy data protection and access control scheme based on elliptic curve cryptography(ECC)and bilinear pairing to protect the communication security of the *** the proposed scheme,the information sender encrypts private information through the ECC algorithm,and the information receiver uses its own key information and bilinear pairing to extract and verify the identity of the information *** each round of communication,the proposed scheme uses timestamps and random numbers to ensure the freshness of each round of *** results show that the proposed scheme has good security performance and can provide data privacy protection,integrity verification,and traceability for the communication process of *** proposed scheme has a lower cost than other related *** communication and computational cost of the proposed scheme are reduced by 31.08% and 22.31% on average compared with those of the other related schemes.

关键词： mobile edge computing(MEC) privacy protection access control anonymous authentication

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High-performance and multifunctional organic field-effect transistors

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Chinese Chemical Letters 2023年第9期34卷 100-118页

作者： yujie Zhao Wei Wang Zihan He Boyu Peng chong-An Di Hanying Li MOE Key Laboratory of Macromolecular Synthesis and Functionalization International Research Center for X PolymersDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049China

Organic field-effect transistors(OFETs)refer to field-effect transistors that use organic semiconductors as channel *** to the advantages of organic materials such as solution processability and intrinsic flexibility,OFETs are expected to be applicable in emergent technologies including wearable electronics and sensors,flexible displays,internet-of-things,neuromorphic computing,*** the electrical performance and developing multifunctionalities of OFETs are two major and closely relevant aspects for OFETs-related *** former one aims for investigating the device physics and expanding the horizons of OFETs,while the later one is critical for leading OFETs into practical and emergent *** development in each of the two aspects would undoubtfully promote the other and bring more confidence for future development of ***,this review is divided into two parts that respectively summarize the recent progress in high-performance OFETs and multifunctional OFETs.

关键词： Organic filed-effect transistors Organic semiconductors High-performance Multifunctionality Organic electronics

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Baeyer-Villiger Oxidation of Cyclic Ketones Catalyzed by Amino Acid Ionic Liquids

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Chemical Research in Chinese Universities 2020年第5期36卷 865-869页

作者： YU Fengli CHI yujie GAO chong CHEN Ruirui XIE Congxia YU Shitao State Key Laboratory Base of Eco-chemical Engineehng College of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266042P.R.China College of Chemical Engineering Qingdao University of Science and TechnologyQingdao 266042P.R.China

A series of amino-acid-based ionic liquids was synthesized via one-step protonation of the corresponding L-amiiio acid by utilizing an array of proton *** catalytic activity of the amino-acid-based ionic liquids for the Baeyer-Villiger oxidation of cyclic ketones was investigated using cyclopentanone as a model ***-based ionic liquid[ProH]CF3SO3 was shown to exliibit thebest catalytic *** reaction condition was optimized to give the following reagent ratio of h(cyclopentanone):n(catalyst):w(H2O2)=1:0.06:4,60℃and 6 *** the optimum conditions,the conversion of cyclopentanone was 96.57%and the selectivity forδ-valerolactone was 73.01%.The catalytic activity was shown to be constant after 4 cycles.A simple treatment was allowed for the recover and the reuse of[ProH]*** successful utilization of[ProH]CF3SO3 to catalyze a host of cyclic ketones via Baeyer-Villiger oxidation clearly demonstrated the capacity of[ProH]CF3S03 to tolerate variation in the substrate.

关键词： Amino acid ionic liquid Baeyer-Villiger oxidation Cyclic ketone Lactone

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TRANSITION TOWARDS GREEN FACILITY MANAGEMENT: BRIDGING THE KNOWLEDGE GAPS OF FACILITIES MANAGERS

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Journal of Green Building 2018年第3期13卷 122-143页

作者： yujie Lu Ruidong Chang Dan chong Min Li Joyce Ngiam Department of Building School of Design and EnvironmentNational University of SingaporeSingapore Centre for Comparative Construction Research Faculty of Society and DesignBond UniversityGold CoastAustralia Department of Management Science and Engineering School of ManagementShanghai UniversityShanghaiChina

The building industry has experienced a widespread transition towards green buildings and consequently a growing need for green facilities professionals to maximize green building potential in terms of energy efficiency,water conservation and waste reduc-tion in their operational *** buildings have unique technological systems that require facility managers to have relevant knowledge and skills to conduct proper facilities management and maintenance planning to maximize the potential of green *** is important,then,to investigate whether knowledge gaps for facil-ity managers exist with respect to green buildings,and if so,how these knowledge gaps could be *** several studies have investigated the operation and maintenance processes of green buildings,few studies considered facility managers’knowledge and skills regarding green facility management(GFM).Set in the context of Singapore,this study aims to holistically investigate the knowledge and skills of managing green buildings in the community of facility managers,including their per-ceived differences between green and conventional buildings,the difficulty of GFM,the knowledge gaps of GFM and the underlying reasons,as well as how the gaps could be bridged.A total of 90 survey responses were collected and eight interviews with key stakeholders were conducted,which indicate facility managers believe green build-ings do have special features that require unique knowledge and skills,and currently knowledge gaps do exist hindering the transition towards ***,this paper derives plausible solutions to bridge the knowledge gaps,such as establishing holistic subsidies for those facility managers participating in training programs of *** study provides references for researchers and relevant governmental departments to better understand industry professionals’knowledge gaps in the transitioning process towards a green built environment,and to make better policy decisions bridging the

关键词： facilities management green buildings Green Mark knowledge gap transition

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Severe Henoch-Schonlein purpura with infliximab forulcerative colitis

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World Journal of Gastroenterology 2015年第19期21卷 6082-6087页

作者： Yang Song YanHong Shi chong He ChangQin Liu JunShan Wang yujie Zhao YanMin Guo RuiJin Wu XiaoYue Feng ZhanJu Liu Yang Song Yan-Hong Shi Chong He Chang-Qin Liu Jun-Shan Wang Yu-Jie Zhao Yan-Min Guo Rui-Jin Wu Xiao-Yue Feng Zhan-Ju Liu Department of Gastroenterology Shanghai Tenth People's Hospital Tongji University Shanghai 200072 China.

Infliximab （IFX） is an anti-tumor necrosis factorchimeric antibody that is effective for treatment ofautoimmune disorders such as Crohn＇s disease andulcerative colitis （UC）. IFX is well tolerated with alow incidence of adverse effects such as infections,skin reactions, autoimmunity, and *** manifestations can appear as infusionreaction, vasculitis, cutaneous infections, psoriasis,eczema, and skin cancer. Here, we present anunusual case of extensive and sporadic subcutaneousecchymosis in a 69-year-old woman with severe UC,partial colectomy and cecostomy, following her initialdose of IFX. The reaction occurred during infliximabinfusion, and withdrawal of IFX led to gradual alleviationof her symptoms. We concluded that Henoch-Sch？nleinpurpura, a kind of leukocytoclastic vasculitis, mighthave contributed to the development of the *** the precise mechanisms of the vasculitis arestill controversial, such a case highlights the importanceof subcutaneous adverse effects in the management ofUC with IFX.

关键词： Henoch-Sch?nlein purpura Infliximab Vasculitis Subcutaneous ecchymosis Ulcerative colitis

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The ORF3a protein of SARS-CoV-2 induces apoptosis in cells

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Cellular & Molecular Immunology 2020年第8期17卷 881-883页

作者： yujie Ren Ting Shu Di Wu Jingfang Mu chong Wang Muhan Huang Yang Han Xue-Yi Zhang Wei Zhou Yang Qiu Xi Zhou Center for Precision Translational Medicine of Wuhan Institute of Virology&Guangzhou Women and Children’s Medical Center Guangzhou Women and Children’s Medical CenterGuangzhouGuangdong510120China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of Sciences(CAS)WuhanHubei430071China Center for Precision Translational Medicine of Wuhan Institute of Virology&Guangzhou Women and Children’s Medical Center Wuhan Institute of VirologyCASWuhanHubei430071China Joint Laboratory of Infectious Diseases and Health Wuhan Institute of Virology&Wuhan Jinyintan HospitalCASWuhanHubei430023China Center for Translational Medicine Wuhan Jinyintan HospitalWuhanHubei430023China State Key Laboratory of Virology College of Life SciencesWuhan UniversityWuhanHubei430072China University of Chinese Academy of Sciences Beijing100049China

Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)has caused the ongoing pandemic of Coronavirus Disease ***-CoV-2 belongs to the genus Betacoronavirus of the Coronaviridae family,which includes SARS-CoV and Middle East respiratory syndrome coronavirus.1,2 Coronavirus-encoded accessory proteins play critical roles in virus–host interactions and the modulation of host immune responses,thereby contributing to coronaviral pathogenicity via different strategies.3 However,the functions of SARS-CoV-2-encoded accessory proteins are not well *** is a predominant type of programmed cell death,and has been recognized as an important host antiviral defense mechanism that controls viral infection and regulates the inflammatory response.4,5 Previous studies have reported that the SARS-CoV-encoded accessory protein ORF3a can induce apoptosis in cells,6,7 leading to the question of whether SARS-CoV-2 ORF3a also has pro-apoptotic ***,we investigated the potential apoptosis-inducing activity of SARS-CoV-2 ORF3a in different cell lines and compared the pro-apoptotic activities of SARS-CoV-2 ORF3a with those of SARS-CoV ORF3a using the same system.

关键词： respiratory acute thereby

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