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某铅蓄电池厂工人健康状况及其影响因素分析

职业卫生与应急救援 2018年第4期36卷 295-298页

作者：曹泽仁郭优程妤婕孙文亮崔守明张光辉新乡市职业病防治研究所河南新乡453003 新乡医学院公共卫生学院河南新乡453001

[目的]了解某铅蓄电池厂铅作业工人健康状况及其影响因素,为企业健康监护提供基础资料。[方法]以该铅蓄电池厂1 179名铅作业工人作为研究对象,进行问卷调查和健康体检。[结果]1 179名研究对象血铅值中位数和第25、75百分位数[M(P25,P75)... 详细信息

[目的]了解某铅蓄电池厂铅作业工人健康状况及其影响因素,为企业健康监护提供基础资料。[方法]以该铅蓄电池厂1 179名铅作业工人作为研究对象,进行问卷调查和健康体检。[结果]1 179名研究对象血铅值中位数和第25、75百分位数[M(P25,P75)]为152.2(65.4,356.7)μg/L,血铅超标(血铅值≥400μg/L)120人,超标率为10.2%。男性心电图异常率为14.3%,高于女性的2.2%,血常规异常率为7.1%,低于女性的18.1%,差异均有统计学意义(P<0.01)。多因素logistic回归分析结果显示:铅接触组发生血铅异常的危险性是不接触组的7.469倍(95%CI:2.817~19.804);男性发生心电图异常的危险性是女性的7.974倍(95%CI:4.099~15.511),血铅水平在300~μg/L组发生心电图异常的危险性是对照组(血铅水平<100μg/L)的3.450倍(95%CI:1.724~15.690);男性发生贫血的危险性是女性的34.2%(95%CI:0.235~0.499),血铅200~μg/L组、300~μg/L组发生贫血的危险性分别是对照组(<100μg/L)的3.020倍(95%CI:1.234~8.562)、3.870倍(95%CI:1.985~16.398)。[结论]心电图异常率男性高于女性,贫血发生率则是女性高于男性;血铅是铅作业工人健康状况的独立危险因素,应进一步加强监测,组织工人定期体检,保护工人健康。

关键词：铅蓄电池血铅血压心电图贫血血常规检测

Characteristics of atmospheric volatile organic compounds in urban area of Beijing: Variations, photochemical reactivity and source apportionment

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Journal of Environmental Sciences 2020年第9期32卷 190-200页

作者： Lihui Zhang Hong Li Zhenhai Wu Weiqi Zhang Kankan Liu Xi cheng yujie Zhang Bin Li Yizhen Chen State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China School of Environment and Safety Engineering North University of ChinaTaiyuan 030051China Collaborative Innovation Center on Atmospheric Environment and Equipment Technology Nanjing University of Information Science and TechnologyNanjing 210044China Shenhua Group Zhungeer Energy Co. LtdGangue Power CompanyOrdos 017100China

Atmospheric volatile organic compounds(VOCs)were observed by an on-line gas chromatography-flame ionization detector monitoring system from November 2016 to August 2017 in *** average concentrations were winter(40.27±25.25μg/m3)>autumn(34.25±19.90μg/m3)>summer(32.53±17.39μg/m3)>spring(24.72±17.22μg/m3).Although benzene(15.70%),propane(11.02%),ethane(9.32%)and n-butane(6.77%)were the most abundant species,ethylene(14.07%)and propene(11.20%)were the key reactive species to ozone formation potential(OFP),and benzene,toluene,ethylbenzene,mxylene+p-xylene and o-xylene(54.13%)were the most reactive species to secondary organic aerosol formation potential(SOAFP).The diurnal and seasonal variations indicated that diesel vehicle emission during early morning,gasoline vehicle emission at the traffic rush hours and coal burning during the heating period might be important *** major sources were further identified by positive matrix factorization(PMF).The vehicle exhaust(gasoline exhaust and diesel exhaust)was found to be contributed most to atmospheric VOCs,with 43.59%,41.91%,50.45%and 43.91%,respectively in spring,summer,autumn and winter;while solvent usage contributed least,with 11.10%,7.13%,14.00%and 19.87%,*** emission sources(13.11%)were only identified in ***,both vehicle exhaust and solvent usage were identified to be the key sources considering contributions to the OFP and ***,the contributions of combustion during heating period and gasoline evaporation source during warm seasons to OFP and SOAFP should not be overlooked.

关键词： volatile source winter

Mixed secondary chromatin structure revealed by modeling radiation-induced DNA fragment length distribution

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Science China(Life Sciences) 2020年第6期63卷 825-834页

作者： Wenzong Ma Chenyang Gu Lin Ma Caoqi Fan Chao Zhang yujie Sun cheng Li Gen Yang State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBejing 100871China Radiation Biology Center Graduate School of BiostudiesKyoto UniversityKyoto 606-8501Japan Medical Artificial Intelligence and Automation Department of Radiation OncologyUniversity of Texas Southwestern Medical CenterDallasTX 75390USA Center for Bioinformatics School of Life Sciences and Center for Statistical SciencePeking UniversityBejing 100871China State Key Laboratory of Membrane Biology School of Life Sciencesand Biomedical Pioneering Innovation Center(BIOPIC)Peking UniversityBejing 100871China

Spatial chromatin structure plays fundamental roles in many vital biological processes including DNA replication, transcription,damage and repair. However, the current understanding of the secondary structure of chromatin formed by local nucleosomenucleosome interactions remains controversial, especially for the existence and conformation of 30 nm structure. Since chromatin structure influences the fragment length distribution(FLD) of ionizing radiation-induced DNA strand breaks, a 3D chromatin model fitting FLD patterns can help to distinguish different models of chromatin structure. Here, we developed a novel "30-C" model combining 30 nm chromatin structure models with Hi-C data, which measured the spatial contact frequency between different loci in the genome. We first reconstructed the 3D coordinates of the 25 kb bins from Hi-C heatmaps. Within the25 kb bins, lower level chromatin structures supported by recent studies were filled. Simulated FLD patterns based on the 30-C model were compared to published FLD patterns induced by heavy ion radiation to validate the models. Importantly, the 30-C model predicted that the most probable chromatin fiber structure for human interphase fibroblasts in vivo was 45% zig-zag 30 nm fibers and 55% 10 nm fibers.

关键词： Hi-C DNA strand break ionizing radiation chromatin structure

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网络舆情语境中的高校治理结构转变

价值工程 2012年第7期31卷 177-177页

作者：李光昊程钰杰安徽大学管理学院合肥230039

本文首先介绍了我国高校治理结构现状,指出高校治理结构转变的重要性,进而论述了大学生网络信息行为特点和高校网络舆情的内涵及特征,随后通过简单分析展现了网络舆情影响下的实际高校治理和网络监督的作用。最后,依据国家教改试点方案... 详细信息

本文首先介绍了我国高校治理结构现状,指出高校治理结构转变的重要性,进而论述了大学生网络信息行为特点和高校网络舆情的内涵及特征,随后通过简单分析展现了网络舆情影响下的实际高校治理和网络监督的作用。最后,依据国家教改试点方案的高校改革要求,探讨了面向网络舆情的高校治理结构转变趋势。

关键词：网络舆情高校治理结构校务公开

SSR markers development and their application in genetic diversity evaluation of garlic(Allium sativum)germplasm

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Plant Diversity 2022年第5期44卷 481-491页

作者： Xiaxia Li Lijun Qiao Birong Chen yujie Zheng chengchen Zhi Siyu Zhang Yupeng Pan Zhihui cheng College of Horticulture Northwest A&F UniversityYangling712100Shaanxi ProvinceChina

Garlic(Allium sativum),an asexually propagated vegetable and medicinal crop,has abundant genetic *** diversity evaluation based on molecular markers has apparent advantages since their genomic abundance,environment insensitivity,and non-tissue specific ***,the limited number of available DNA markers,especially SSR markers,are insufficient to conduct related genetic diversity assessment studies in *** this study,4372 EST-SSR markers were newly developed,and 12 polymorphic markers together with other 17 garlic SSR markers were used to assess the genetic diversity and population structure of 127 garlic *** averaged polymorphism information content(PIC)of these 29 SSR markers was 0.36,ranging from 0.22 to ***-nine polymorphic loci were detected among these accessions,with an average of 3.48 polymorphic loci per *** the clustering analyses based on either the genotype data of SSR markers or the phenotypic data of morphological traits obtained genetic distance divided the 127 garlic accessions into three ***,the Mantel test showed that genetic distance had no significant correlations with geographic distance,and weak correlations were found between genetic distance and the phenotypic *** analysis showed that the main genetic variation of this garlic germplasm collection existed in the within-population or *** of this study will be of great value for the genetic/breeding studies in garlic and enhance the utilization of these garlic germplasms.

关键词： Garlic SSR markers Genetic diversity Population structure

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面向合肥市房地产行业竞争情报分析

价值工程 2011年第34期30卷 57-57页

作者：程钰杰李光昊安徽大学管理学院合肥230039

竞争情报在地产企业中已经发挥越来越重要的作用,地产行业的情报来源主要有出版物、电脑人际网络、相关的会议与招聘信息等,利用信息检索、竞争对手跟踪、市场调查、SWOT分析、定标比超等方法搜集,分析处理后形成对企业本身有作用的情... 详细信息

竞争情报在地产企业中已经发挥越来越重要的作用,地产行业的情报来源主要有出版物、电脑人际网络、相关的会议与招聘信息等,利用信息检索、竞争对手跟踪、市场调查、SWOT分析、定标比超等方法搜集,分析处理后形成对企业本身有作用的情报和策略。

关键词：情报来源竞争情报情报分析

High-conductivity graphene nanocomposite via facile,covalent linkage of gold nanoparticles to graphene oxide

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Chinese Science Bulletin 2012年第23期57卷 3086-3092页

作者： ZHANG yujie GENG MaKe ZHANG Huan HE Yao PENG cheng HUANG Qing FAN ChunHai Laboratory of Physical Biology Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201800 China Functional Nano & Soft Materials Laboratory Soochow University Suzhou 215123 China

Graphene and its derivative,graphene oxide (GO) have been substantively used as the main framework for dispersing or building nanoarchitectures because of their excellent properties in electronics and *** requirement to obtain superior graphene-metal hybrid nanomaterials has led us to explore a facile way to design 4-aminobenzenethiol/1-hexanethiolate-protected gold nanoparticles (aAuNPs)-functionalized graphene oxide composite (aAuNPs-GO) in *** demonstrate that when aAuNPs with amino groups are exposed to GO,well-dispersed coverage of Au nanoparticles are mainly observed on the edge of GO *** contrast,when 1-hexanethiolate-protected gold nanoparticles (hAuNPs) without amino groups are exposed to GO,hAuNPs simply aggregate on the surface of *** indicates that amino groups located on the surface of Au nanoparticles are an essential prerequisite for attachment of nearly monodispersed *** strategy described here for the fabrication of aAuNPs-GO provides a straightforward approach to develop graphene-based nanocomposites with undamaged sheets structure and good solubility and also improve the conductivity of GO sheets evidently.

关键词： graphene oxide gold nanoparticles nanocomposite Michael addition reaction

p53 exerts anticancer effects by regulating enhancer formation and activity

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Journal of Biomedical Research 2024年第4期38卷 334-347页

作者： Shuhan Chen Xuchun Wang Nan Yang Yuechi Song He cheng yujie Sun Key Laboratory of Human Functional Genomics of Jiangsu Province School of Basic Medical SciencesNanjing Medical UniversityNanjingJiangsu 211166China Department of Cell Biology School of Basic Medical SciencesNanjing Medical UniversityNanjingJiangsu 211166China Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Personalized Cancer MedicineNanjing Medical UniversityNanjingJiangsu 211166China

The abnormality of the p53 tumor suppressor is crucial in lung cancer development,because p53 regulates target gene promoters to combat *** studies have shown extensive p53 binding to enhancer ***,whether p53 exerts a tumor suppressor role by shaping the enhancer landscape remains poorly *** the current study,we employed several functional genomics approaches to assess the enhancer activity at p53 binding sites throughout the genome based on our established TP53 knockout(KO)human bronchial epithelial cells(BEAS-2B).A total of 943 active regular enhancers and 370 super-enhancers(SEs)disappeared upon the deletion of p53,indicating that p53 modulates the activity of hundreds of enhancer *** found that one p53-dependent SE,located on chromosome 9 and designated as KLF4-SE,regulated the expression of the Krüppel-like factor 4(KLF4)***,the deletion of p53 significantly decreased the KLF4-SE enhancer activity and the KLF4 expression,but increased colony formation ability in the nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced cell transformation ***,in TP53 KO cells,the overexpression of KLF4 partially reversed the increased clonogenic capacity caused by p53 ***,KLF4 expression also decreased in lung cancer tissues and cell *** appeared that overexpression of KLF4 significantly suppressed the proliferation and migration of lung cancer ***,our results suggest that the regulation of enhancer formation and activity by p53 is an integral component of the p53 tumor suppressor ***,our findings offer some novel insights into the regulation mechanism of p53 in lung oncogenesis and introduce a new strategy for screening therapeutic targets.

关键词： p53 enhancer tumor malignant transformation

Stretchable organic electrochemical transistors via threedimensional porous elastic semiconducting films for artificial synaptic applications

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Nano Research 2023年第7期16卷 10206-10214页

作者： yujie Peng Lin Gao Changjian Liu Jinyi Deng Miao Xie Libing Bai Gang Wang Yuhua cheng Wei Huang Junsheng Yu State Key Laboratory of Electronic Thin Films and Integrated Devices School of Optoelectronic Science and EngineeringUniversity of Electronic Science and Technology of ChinaChengdu 610054China School of Automation Engineering University of Electronic Science and Technology of ChinaChengdu 611731China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringShanghai Key Laboratory of Lightweight Structural CompositesKey Laboratory of High Performance fibers&productsMinistry of EducationDonghua UniversityShanghai 201620China

Neuromorphic computing targets realizing biomimetic or intelligence systems capable of processing abundant tasks in parallel analogously to our brain,and organic electrochemical transistors(OECTs)that rely on the mixed ionic-electronic synergistic couple possess significant similarity to biological systems for implementing synaptic ***,the lack of reliable stretchability for synaptic OECTs,where mechanical deformation occurs,leads to consequent degradation of electrical ***,we demonstrate stretchable synaptic OECTs by adopting a three-dimensional poly(3-hexylthiophene)(P3HT)/styrene-ethylene-butylene-styrene(SEBS)blend porous elastic film for neuromorphic *** architecture shows the full capability to emulate biological synaptic *** the accumulated layer numbers of porous film enables tunable OECT output and hysteresis,resulting in transition in ***,with a trilayer porous film,large-scale conductance and hysteresis are endorsed for efficient mimicking of memory-dependent synapse *** from the interconnected three-dimensional porous structures,corresponding stretchable synaptic OECTs exhibit excellent mechanical robustness when stretched at a 30%strain,and maintain reliable electrical characteristics after 500 stretching ***,near-ideal weight updates with near-zero nonlinearities,symmetricity in long-term potentiation(LTP)and depression,and applications for image simulation are *** work paves a universal design strategy toward highperformance stretchable neuromorphic computing architecture and could be extended to other flexible/stretchable electronics.

关键词： organic electrochemical transistors(OECTs) artificial synapses porous films flexible electronics neuromorphic computing