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Collagen fiber membrane-derived chemically and mechanically durable superhydrophobic membrane for high- performance emulsion separation

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Journal of Leather Science and Engineering 2021年第1期3卷 214-223页

作者： Huifang Li Wan zheng Hanzhong Xiao Baicun Hao yujia Wang Xin Huang Bi Shi National Engineering Research Center of Clean Technology in Leather Industry Sichuan University610065 ChengduP.R.China

Developing high-performance separation membrane with good durability is a highly desired while challenging ***,we reported the successful fabrication of chemically and mechanically durable superhydrophobic membrane that was prepared by embedding UiO-66 as size-sieving sites within the supramolecular fiber structure of collagen fiber membrane(CFM),followed by the polydimethylsiloxane(PDMS)*** as-prepared CFM/UiO-66(12)/PDMS membrane featured capillary effect-enhanced separation flux and homogeneous porous channels guaranteed high separation *** utilized as double-layer separation membranes,this new type of composite membranes separated various surfactant stabilized water-in-oil microemulsions and nanoemulsions,with the separation efficiency high up to 99.993%and the flux as high as 973.3 L m−2 h−*** with commercial polytetrafluoro ethylene(PTFE)membrane,the advantage of the double-layer CFM/UiO-66(12)/PDMS membranes in separation flux was evident,which exhibited one order of magnitude higher than that of commercial PTFE *** CFM/UiO-66(12)/PDMS membrane was acid-alkali tolerant,UV-aging resistant and reusable for emulsion ***,the CFM/UiO-66(12)/PDMS membrane was mechanically durable against strong mechanical abrasion,which was still capable of separating diverse water-in-oil emulsions after the abrasion with sandpaper and assembled as double-layer separation *** anticipate that the combination of CFM and metal organic frameworks(MOFs)is an effective strategy for fabricating high-performance separation membrane with high mechanical and chemical durability.

关键词： collagen fiber membrane metal organic frameworks superhydrophobic composite membrane emulsion separation mechanical and chemical durability

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Peri-procedural myocardial injury predicts poor short-term prognosis after TAVR:A single-center retrospective analysis from China

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Chinese Medical Journal 2023年第24期136卷 3013-3015页

作者： Qi Liu Kaiyu Jia Yijun Yao Yijian Li Tianyuan Xiong Fei Chen Yuanweixiang Ou Xi Wang yujia Liang Xi Li Yong Peng Jiafu Wei Sen He Qiao Li Wei Meng Guo Chen Wenxia Zhou Mingxia zheng Xuan Zhou Yuan Feng Mao Chen Department of Cardiology West China HospitalSichuan UniversityChengduSichuan 610041China Department of Cardiovascular Surgery West China HospitalSichuan UniversityChengduSichuan 610041China Department of Anaesthesiology West China HospitalSichuan UniversityChengduSichuan 610041China Department of Radiology West China HospitalSichuan UniversityChengduSichuan 610041China

To the Editor:Approximately 2%of people>65 years old have aortic stenosis(AS).[1]Without intervention,AS is a rapidly progressive valvular heart disease with a 2-year mortality of 50%.[1]Since the first transcatheter aortic valve replacement(TAVR)was performed by Cribier et al[2]in 2002,TAVR has been suggested to be non-inferior in AS patients of various risk ***-TAVR complications are essential in predicting patient survival and improving quality of life,especially with the procedure being performed in an increasing population of low-risk patients.[3]Among them,myocardial infarction(MI)is a rare but life-threatening complication usually caused by the obstruction of coronary ostia.[1]In comparison,peri-procedural myocardial injury,primarily characterized by the elevation of cardiac markers,is a relatively common complication of *** recent studies have demonstrated promising results of cardiac markers in predicting cardiovascular adverse events,the impact of peri-procedural myocardial injury on short-term and long-term mortality has yet to be established.

关键词： TAVR mortality injury

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基于双热电偶测温和自动图像采集功能的自燃点试验仪

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上海计量测试 2018年第6期45卷 22-26页

作者：薛民杰朱惠臣郑雨佳孙晓光陈黎明朱力敏白广宇朱伟上海市计量测试技术研究院杭州研一智控科技有限公司上海民航职业技术学院

综合国家标准GB/T 21860-2008《液体化学品自燃温度的试验方法》和GB/T 5332-2007《可燃液体和气体引燃温度试验方法》上的仪器设计方案,通过优化双热电偶测温方式,建立自动化的图像采集功能来提升危险化学品自燃点的检测技术,以实现样... 详细信息

综合国家标准GB/T 21860-2008《液体化学品自燃温度的试验方法》和GB/T 5332-2007《可燃液体和气体引燃温度试验方法》上的仪器设计方案,通过优化双热电偶测温方式,建立自动化的图像采集功能来提升危险化学品自燃点的检测技术,以实现样品自燃点的自动化准确测定。

关键词：自燃点试验仪双热电偶测温

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Proanthocyanidins extracted from grape seeds inhibit the growth of hepatocellular carcinoma cells and induce apoptosis through the MAPK/AKT pathway

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Food Bioscience 2022年第1期45卷 361-369页

作者： Wancai zheng a Yujing Feng yujia Bai Zuoshan Feng Xijuan Yang Bin Dang Ming Xiao Jianmei Zhang Sheng-Qiang Han Qinghai Academy of Agricultural and Forestry Sciences Qinghai UniversityXining810016China College of Food Science and Pharmacology Xinjiang Agricultural UniversityUrumqi830052China Xinjiang Key Laboratory for Postharvest Science and Technology of Fruits Xinjiang Agricultural UniversityUrumqi830052China Shanghai Punan Hospital of Pudong New District Shanghai200120China

Proanthocyanidins naturally occur in various fruits,some vegetables and *** evidence has shown that dietary intake of proanthocyanidins is a promising alternative to tumor chemoprevention or *** seeds are the most abundant source of proanthocyanidins,and grape seed proanthocyanidins(GSPs)show an anticancer effect on hepatocellular carcinoma(HCC),which accounts for approximately 85-90%of all primary liver *** an increasing number of studies have investigated the effects of GSPs on HCC and the associated mechanisms,the precise mechanism of GSP therapy in HCC remains *** study aimed to understand the cytotoxic effect of GSPs on HepG2 cells by investigating morphology and growth *** proliferation and apoptosis were estimated by an MTT assay and flow cytometry,and the protein expression of HepG2 cells was determined through Western *** results indicated that GSPs could markedly inhibit HepG2 liver cancer cells and induce apoptosis,with the effects varying by dose and treatment ***,GSPs inhibited the phosphorylation of extracellular regulated protein kinases(ERK),c-Jun NH2-terminal kinase(JNK),p38 mitogen-activated protein kinase(p38 MAPK),IκBα,pyruvate dehydrogenase kinase 1(PDK1),glycogen synthase kinase-3 beta(GSK3β)and protein kinase B(AKT),which accounted for the inactivation of mitogen-activated protein kinase/AKT(MAPK/AKT)*** results indicate that GSPs are a potential source of natural chemopreventive agents for the treatment of HCC.

关键词： Grape seed proanthocyanidins Hepatocellular carcinoma Proliferation Apoptosis

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Enhancing both selectivity and coking-resistance of a single-atom Pd1/C3N4 catalyst for acetylene hydrogenation

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Nano Research 2017年第4期10卷 1302-1312页

作者： Xiaohui Huang yujia Xia Yuanjie Cao Xusheng zheng Haibin Pan Junfa Zhu Chao Ma Hengwei Wang Junjie Li Rui You Shiqiang Wei Weixin Huang Junling Lu Department of Chemical Physics iChEM CAS Key Laboratory of Materials for Energy Conversion University of Science and Technology of China Hefei 230026 China National Synchrotron Radiation Laboratory University of Science and Technology of China Hefei 230029 China Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of China Hefei 230026 China

Selective hydrogenation is an important industrial catalytic process in chemical upgrading, where Pd-based catalysts are widely used because of their high hydrogenation activities. However, poor selectivity and short catalyst lifetime because of heavy coke formation have been major concerns. In this work, atomically dispersed Pd atoms were successfully synthesized on graphitic carbon nitride （g-C3N4） using atomic layer deposition. Aberration-corrected high-angle annular dark-field scanning transmission electron microscopy （HAADF-STEM） confirmed the dominant presence of isolated Pd atoms without Pd nanoparticle （NP） formation. During selective hydrogenation of acetylene in excess ethylene, the g-C3N4-supported Pd NP catalysts had strikingly higher ethylene selectivities than the conventional Pd/Al2O3 and Pd/SiO2 catalysts. In-situ X-ray photoemission spectroscopy revealed that the considerable charge transfer from the Pd NPs to g-C3N4 likely plays an important role in the catalytic performance enhancement. More impressively, the single-atom Pd1/C3N4 catalyst exhibited both higher ethylene selectivity and higher coking resistance. Our work demonstrates that the single-atom Pd catalyst is a promising candidate for improving both selectivity and coking-resistance in hydrogenation reactions.

关键词： single-atom catalyst Pd catalyst atomic layer deposition acetylene hydrogenation C3N4 selectivity coke formation support effect

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松果菊苷对高糖诱导的人视网膜毛细血管内皮细胞增殖、迁移及新生血管形成的影响

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眼科新进展 2022年第4期42卷 272-277页

作者：毛羽佳殷俏郑琳璐曾军江西医学高等专科学校第一附属医院眼科江西省上饶市334000 中南大学湘雅二医院眼科湖南省长沙市410012

目的探讨松果菊苷(ECH)对高糖诱导的人视网膜毛细血管内皮细胞(HRCECs)增殖、迁移及新生血管形成的影响及其作用机制。方法将HRCECs分为5组正常对照(Con)组、高糖组(HG,25 mmol·L^(-1) D-葡萄糖)、HG+1μmol·L^(-1) ECH组、HG+5μmol... 详细信息

目的探讨松果菊苷(ECH)对高糖诱导的人视网膜毛细血管内皮细胞(HRCECs)增殖、迁移及新生血管形成的影响及其作用机制。方法将HRCECs分为5组正常对照(Con)组、高糖组(HG,25 mmol·L^(-1) D-葡萄糖)、HG+1μmol·L^(-1) ECH组、HG+5μmol·L^(-1) ECH组和HG+25μmol·L^(-1) ECH组。利用细胞管腔形成实验检测各组HRCECs血管新生能力,用MTT法检测各组HRCECs的细胞活性;用细胞集落形成实验检测各组HRCECs集落形成能力;用Transwell法检测各组HRCECs的迁移能力;用Ki67抗原(Ki67)免疫荧光染色评估各组HRCECs增殖情况;用免疫荧光染色观察各组HRCECs中细胞间黏附分子-1(ICAM-1)阳性表达;采用Western blot法检测各组HRCECs中缺氧诱导因子-1α(HIF-1α)蛋白和血管内皮生长因子(VEGF)蛋白的表达。结果与Con组比较,HG组HRCECs的血管新生能力、细胞活性、集落形成能力、Ki67阳性细胞比例、迁移能力以及细胞中ICAM-1、HIF-1α蛋白和VEGF蛋白表达均明显升高(均为P<0.001);与HG组比较,HG+1μmol·L^(-1) ECH组、HG+5μmol·L^(-1) ECH组和HG+25μmol·L^(-1) ECH组HRCECs的上述指标随ECH剂量的增加而递减(P<0.05、P<0.01、P<0.001)。结论ECH具有抑制HG诱导的HRCECs增殖、迁移及血管新生的作用,这些作用可能与其抑制HIF-1α/VEGF信号通路有关。

关键词：松果菊苷糖尿病视网膜病变视网膜毛细血管内皮细胞增殖迁移血管新生 HIF-1α/VEGF信号通路

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The targeting expression of the vascular endothelial growth factor gene in endothelial cells regulated by ***-1

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Science China(Life Sciences) 2008年第11期51卷 959-965页

作者： zheng XiangRong, ZHANG ShangShang, YANG yujia, WANG Xia, ZHONG Le & YU XiaoHe Department of Pediatrics, Xiangya Hospital, Central South University, Changsha 410008, China Department of Pediatrics Xiangya Hospital Central South University Changsha China

The success of gene therapy depends largely on the efficacy of gene delivery vector systems that can deliver genes to target organs or cells selectively and efficiently with minimal toxicity. Here, we show that by using the ***-1 regulatory element, we were able to restrict expression of the transgene of vascular endothelial growth factor (VEGF) to endothelial cells exclusively in hypoxic conditions. Eukaryotic expression vectors such as ***-1, pcDNA3.1-VEGF+Pa, pcDNA3.1-ppET-1+ EGF+Pa, and ***-1+VEGF+Pa were constructed by using a series of nuclear molecule handling methods like PCR, enzyme digestion. The recombinant vectors were transfected into HUVEC cells and HL7702 cells by the lipofectin method. GFP expression was observed with a fluorescence microscope to validate the specificity of expression in endothelial cells under the regulation of ***-1 element. Cobalt chloride (final concentration 100 μmol/L) was added to the medium to mimic hypoxia in vitro. After transfection of vectors, the expression of VEGF mRNA was detected by RT-PCR, and the expression of VEGF was detected by Western blotting and ELISA methods under normoxia and hypoxia, respectively. The cell proliferation rate was detected by the MTT test. The ex- pression of GFP revealed that the exterior gene was transcripted effectively in endothelial cells regu- lated by the ***-1 element, while the expression of GFP was very weak in nonendothelial cells. The results of RT-PCR, Western blotting and ELISA showed that VEGF gene expression in the ***-1+VEGF+Pa group and in the pcDNA3.1-ppET-1+VEGF+Pa group was higher in hypoxia than it was in normoxia (P<0.05). The MTT test showed that the proliferation rate of HUVEC transfected with HPVA under hypoxia exceeded that of the control group. We conclude that the ***-1 element was expressed specifically in endothelial cells, and can increase the expression of VEGF in hypoxia and stimulate proliferation of

关键词： hypoxia-responsive element human preproendothelin-1 promoter vascular endothelial growth factor endothelial cells

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Gender differences in mortality following tanscatheter aortic valve replacement(TAVR):a single-centre retrospective analysis from China

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Chinese Medical Journal 2023年第20期136卷 2511-2513页

作者： Qi Liu Yali Wang Yijian Li Tianyuan Xiong Fei Chen Yuanweixiang Ou Xi Wang Yijun Yao Kaiyu Jia yujia Liang Xin Wei Xi Li Yong Peng Jiafu Wei Sen He Qiao Li Wei Meng Guo Chen Wenxia Zhou Mingxia zheng Xuan Zhou zhengang Zhao Chen Mao Feng Yuan Department of Cardiology West China HospitalSichuan UniversityChengduSichuan 610041China Department of Cardiovascular Surgery West China HospitalSichuan UniversityChengduSichuan 610041China Department of Anaesthesiology West China HospitalSichuan UniversityChengduSichuan 610041China Department of Radiology West China HospitalSichuan UniversityChengduSichuan 610041China

To the Editor:Transcatheter aortic valve replacement(TAVR)has become an established treatment for patients with severe aortic stenosis(AS)at all levels of surgical risk.^([1,2])With the exploration of TAVR and technological developments,TAVR is an alternative for patients with intermediate or low surgical risk.^([3])There are some studies regarding gender differences in TAVR,but there are few studies on it in Asia.^([4])However,the studies of outcomes based on gender differences in TVAR are still lacking,especially in China and other Asian countries.

关键词： TAVR aortic stenosis

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NLRP3炎症小体与缺血性卒中的关系及中医药的干预作用

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中国实验方剂学杂志 2022年第18期28卷 225-236页

作者：刘迅李钰佳罗政周月邓奕辉湖南中医药大学长沙410208

缺血性卒中又称脑梗死,是脑卒中最常见的类型。缺血性卒中危害极大,其患病率、发病率、致残率和死亡率均位居前列,给社会和家庭造成巨大负担。因此,寻找新的、有效的防治方法极为迫切。缺血性卒中的病理机制十分复杂且相互叠加,其中炎... 详细信息

缺血性卒中又称脑梗死,是脑卒中最常见的类型。缺血性卒中危害极大,其患病率、发病率、致残率和死亡率均位居前列,给社会和家庭造成巨大负担。因此,寻找新的、有效的防治方法极为迫切。缺血性卒中的病理机制十分复杂且相互叠加,其中炎症反应是缺血性卒中级联损伤过程中的关键病理环节。NOD样受体蛋白3(NLRP3)是一种细胞内传感器,活化的NLRP3炎症小体介导的炎症级联反应通过释放炎症因子等能加剧缺血性卒中损伤。中医药领域以NLRP3炎症小体为切入点,开展了大量中医药干预NLRP3炎症小体的组装和激活的实验研究,证明了以补虚、清热解毒、祛痰、活血化瘀等为主要功效的中药单体或组方制剂能干预NLRP3炎症小体的组装和激活,降低炎症反应,从而缓解缺血性卒中。本研究从NLRP3炎症小体的组装和激活,NLRP3炎症小体在缺血性卒中的作用和中医药通过调控NLRP3炎症小体防治缺血性卒中方面进行综述,旨在为缺血性卒中的病理机制提供新的切入点,为开发缺血性卒中新的治疗手段提供方向。

关键词： NOD样受体3 炎症小体缺血性卒中中医药

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A New Algorithm for Black-start Zone Partitioning Based on Fuzzy Clustering Analysis

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Energy and Power Engineering 2013年第4期5卷 763-768页

作者： yujia Li Yu Zou Yupei Jia Yunxia zheng China Electric Power Research Institute Beijing China Jibei Qinhuangdao Electric Power Company Hebei China

On the process of power system black start after an accident, it can help to optimize the resources allocation and accelerate the recovery process that decomposing the power system into several independent partitions for parallel recovery. On the basis of adequate consideration of fuzziness of black-start zone partitioning, a new algorithm based on fuzzy clustering analysis is presented. Characteristic indexes are extracted fully and accurately. The raw data matrix is made up of the electrical distance between every nodes and blackstart resources. Closure transfer method is utilized to get the dynamic clustering. The availability and feasibility of the proposed algorithm are verified on the New-England 39 bus system at last.

关键词： Black-start Zone Partitioning Fuzzy Clustering Analysis Electrical Distance Closure Transfer Method

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