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磷掺杂碳化硅的制备及其影响因素

武汉工程大学学报 2018年第5期40卷 538-542页

作者：袁密高峰竺昌海郑雨佳李梓烨薛俊曹宏武汉工程大学材料科学与工程学院湖北武汉430205 湖北省环境材料与膜技术工程技术研究中心湖北武汉430074

以葡萄糖粉剂为碳源,沉淀白炭黑为硅源,磷酸为掺杂源,通过碳热还原法制备了磷掺杂碳化硅(SiC)。并利用X射线衍射仪、紫外可见吸收光谱仪、扫描电子显微镜、比表面积测试仪等对不同合成温度、不同掺杂浓度下所制备样品物相组成、微观形... 详细信息

以葡萄糖粉剂为碳源,沉淀白炭黑为硅源,磷酸为掺杂源,通过碳热还原法制备了磷掺杂碳化硅(SiC)。并利用X射线衍射仪、紫外可见吸收光谱仪、扫描电子显微镜、比表面积测试仪等对不同合成温度、不同掺杂浓度下所制备样品物相组成、微观形貌以及性质进行了表征。结果表明,磷原子进入SiC晶格,形成了磷掺杂3C-SiC。所制备的SiC样品与白炭黑的微观结构相似,其一次粒子平均粒径约150 nm,最高比表面积84.4 m^2/g。当n(P)∶n(Si)≥0.01时,掺杂达到饱和。随着温度升高,SiC禁带宽度降低,1 350℃后变化微弱,1 400℃时,比表面积最大。合成磷掺杂SiC的原料廉价易得,工艺简单,有望实现工业化生产。

关键词：碳化硅磷掺杂碳热还原法禁带宽度比表面积影响因素

Dielectric metalens for miniaturized imaging systems:progress and challenges

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Light(Science & Applications) 2022年第8期11卷 1686-1717页

作者： Meiyan Pan Yifei Fu Mengjie zheng Hao Chen yujia Zang Huigao Duan Qiang Li Min Qiu Yueqiang Hu Jihua Laboratory Foshan528200China College of Mechanical and Vehicle Engineering Hunan UniversityChangsha410082China Greater Bay Area Institute for Innovation Hunan UniversityGuangzhou511300Guangdong ProvinceChina State Key Laboratory of Modern Optical Instrumentation College of Optical Science and EngineeringZhejiang UniversityHangzhou310027China Key Laboratory of 3D Micro/Nano Fabrication and Characterization of Zhejiang Province School of EngineeringWestlake University18 Shilongshan RoadHangzhou310024China Institute of Advanced Technology Westlake Institute for Advanced Study18 Shilongshan RoadHangzhou310024China

Lightweight, miniaturized optical imaging systems are vastly anticipated in these fields of aerospace exploration, industrial vision, consumer electronics, and medical imaging. However, conventional optical techniques are intricate to downscale as refractive lenses mostly rely on phase accumulation. Metalens, composed of subwavelength nanostructures that locally control light waves, offers a disruptive path for small-scale imaging systems. Recent advances in the design and nanofabrication of dielectric metalenses have led to some high-performance practical optical systems. This review outlines the exciting developments in the aforementioned area whilst highlighting the challenges of using dielectric metalenses to replace conventional optics in miniature optical systems. After a brief introduction to the fundamental physics of dielectric metalenses, the progress and challenges in terms of the typical performances are introduced. The supplementary discussion on the common challenges hindering further development is also presented, including the limitations of the conventional design methods, difficulties in scaling up, and device integration. Furthermore, the potential approaches to address the existing challenges are also deliberated.

关键词： dielectric replace mentioned

Response of the sensorimotor cortex of cerebral palsy rats receiving transplantation of vascular endothelial growth factor 165-transfected neural stem cells

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Neural Regeneration Research 2014年第19期9卷 1763-1769页

作者： Jielu Tan Xiangrong zheng Shanshan Zhang yujia Yang Xia Wang Xiaohe Yu Le Zhong Department of Pediatrics Xiangya HospitalCentral South University

Neural stem cells are characterized by the ability to differentiate and stably express exogenous ge- nes. Vascular endothelial growth factor plays a role in protecting local blood vessels and neurons of newborn rats with hypoxic-ischemic encephalopathy. Transplantation of vascular endothelial growth factor-transfected neural stem cells may be neuroprotective in rats with cerebral palsy. In this study, 7-day-old Sprague-Dawley rats were divided into five groups：（1） sham operation （control）, （2） cerebral palsy model alone or with （3） phosphate-buffered saline, （4） vascular en- dothelial growth factor 165 ＋ neural stem cells, or （5） neural stem cells alone. The cerebral palsy model was established by ligating the left common carotid artery followed by exposure to hypox- ia. Phosphate-buffered saline, vascular endothelial growth factor ＋ neural stem cells, and neural stem cells alone were administered into the sensorimotor cortex using the stereotaxic instrument and microsyringe. After transplantation, the radial-arm water maze test and holding test were performed. Immunohistochemistry for vascular endothelial growth factor and histology using hematoxylin-eosin were performed on cerebral cortex. Results revealed that the number of vas- cular endothelial growth factor-positive cells in cerebral palsy rats transplanted with vascular endothelial growth factor-transfected neural stem cells was increased, the time for finding water and the finding repetitions were reduced, the holding time was prolonged, and the degree of cell degeneration or necrosis was reduced. These findings indicate that the transplantation of vascu- lar endothelial growth factor-transfected neural stem cells alleviates brain damage and cognitive deficits, and is neuroprotective in neonatal rats with hypoxia ischemic-mediated cerebral palsy.

关键词： nerve regeneration vascular endothelial growth factor neural stem cells cerebral palsy animal model transplantation neuroprotection NSFC grant neural regeneration

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口腔硬组织修复材料仿生设计制备和临床转化

Metal-Organic Framework Nanocarriers for Drug Delivery in Biomedical Applications

北京大学学报（医学版） 2024年第1期56卷 4-8页

作者：赵菡卫彦张学慧杨小平蔡晴宁成云徐明明刘雯雯黄颖何颖郭亚茹江圣杰白云洋吴宇佳郭雨思郑晓娜李文静邓旭亮北京大学口腔医学院·口腔医院综合科国家口腔医学中心国家口腔疾病临床医学研究中心口腔生物材料和数字诊疗装备国家工程研究中心国家药品监督管理局口腔材料重点实验室北京 100081 北京大学口腔医学院·口腔医院特诊科国家口腔医学中心国家口腔疾病临床医学研究中心口腔生物材料和数字诊疗装备国家工程研究中心国家药品监督管理局口腔材料重点实验室北京 100081 北京大学口腔医学院·口腔医院材料研究室国家口腔医学中心国家口腔疾病临床医学研究中心口腔生物材料和数字诊疗装备国家工程研究中心国家药品监督管理局口腔材料重点实验室北京 100081 北京化工大学材料科学与工程学院生物材料系有机无机复合材料国家重点实验室生物医用材料北京实验室北京100029 华南理工大学材料科学与工程学院生物材料系国家人体组织功能重建工程技术研究中心广东省生物医学工程重点实验室广州 510641

Oral diseases concern almost every individual and are a serious health risk to the *** restorative treatment of tooth and jaw defects is an important means to achieve oral function and support the appearance of the *** on the principle of"learning from the nature",Deng Xu-liang's group of Peking University School and Hospital of Stomatology has proposed a new concept of"microstructural biomimetic design and tissue adaptation of tooth/jaw materials"to address the worldwide problems of difficulty in treating dentine hypersensitivity,poor prognosis of restoration of tooth defects,and vertical bone augmentation of alveolar bone after tooth *** group has broken through the bottle-neck of multi-stage biomimetic technology from the design of microscopic features to the enhancement of macroscopic effects,and invented key technologies such as crystalline/amorphous multi-level assembly,ion-transportation blocking,and multi-physical properties of the micro-environment reconstruction,*** group also pioneered the cationic-hydrogel desensitizer,digital stump and core integrated restora-tions,and developed new crown and bridge restorative materials,gradient functionalisation guided tissue regeneration membrane,and electrically responsive alveolar bone augmentation restorative membranes,*** products have established new clinical strategies for tooth/jaw defect repair and achieved inno-vative *** conclusion,the research results of our group have strongly supported the theoretical im-provement of stomatology,developed the technical system of oral hard tissue restoration,innovated the clinical treatment strategy,and led the progress of the stomatology industry.

关键词：牙齿修复材料骨组织引导再生膜电学微环境骨充填材料生物力学

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Nano-Micro Letters 2020年第8期12卷 184-212页

作者： yujia Sun Liwei zheng Yu Yang Xu Qian Ting Fu Xiaowei Li Zunyi Yang He Yan Cheng Cui Weihong Tan Molecular Science and Biomedicine Laboratory(MBL) State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringCollege of BiologyAptamer Engineering Center of Hunan ProvinceHunan UniversityChangsha 410082People’s Republic of China Center for Research at Bio/Nano Interface Department of Chemistry and Department of Physiology and Functional GenomicsUF Health Cancer CenterUF Genetics Institute and McKnight Brain InstituteUniversity of FloridaGainesvilleFL 32611USA Department of Electrical Engineering Stanford UniversityStanfordCA 94305USA Institute of Molecular Medicine(IMM) Renji HospitalState Key Laboratory of Oncogenes and Related GenesShanghai Jiao Tong University School of Medicine and College of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Institute of Cancer and Basic Medicine(IBMC) Chinese Academy of SciencesThe Cancer Hospital of the University of Chinese Academy of SciencesHangzhou 310022People’s Republic of China Foundation for Applied Molecular Evolution 13709 Progress BoulevardAlachuaFL 32615USA

Investigation of metal–organic frameworks(MOFs)for biomedical applications has attracted much attention in recent *** are regarded as a promising class of nanocarriers for drug delivery owing to well-defined structure,ultrahigh surface area and porosity,tunable pore size,and easy chemical *** this review,the unique properties of MOFs and their advantages as nanocarriers for drug delivery in biomedical applications were discussed in the first ***,state-ofthe-art strategies to functionalize MOFs with therapeutic agents were summarized,including surface adsorption,pore encapsulation,covalent binding,and functional molecules as building *** the third section,the most recent biological applications of MOFs for intracellular delivery of drugs,proteins,and nucleic acids,especially aptamers,were ***,challenges and prospects were comprehensively discussed to provide context for future development of MOFs as efficient drug delivery systems.

关键词： Metal-organic frameworks Drugs Biomolecules Drug delivery Biomedical applications

Berberine mediates root remodeling in an immature tooth with apical periodontitis by regulating stem cells from apical papilla differentiation

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International Journal of Oral Science 2020年第2期12卷 172-181页

作者： yujia Cui Jing Xie Yujie Fu Chuwen Li Liwei zheng Dingming Huang Changchun Zhou Jianxun Sun Xuedong Zhou State Key Laboratory of Oral Diseases&National Clinical Center for Oral Diseases&Department of Cariology and Endodontics West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Clinical Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology&National Clinical Research Center for Oral Diseases&Department of Oral and Maxillofacial-Head Neck Oncology Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghaiChina State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Pediatric Dentistry West China Hospital of StomatologySichuan UniversityChengduChina and 5National Engineering Research Center for BiomaterialsSichuan UniversityChengduChina

Once pulp necrosis or apical periodontitis occurs on immature teeth,the weak root and open root apex are challenging to ***(BBR)is a potential medicine for bone disorders,therefore,we proposed to apply BBR in root canals to enhance root repair in immature *** in vivo model of immature teeth with apical periodontitis was established in rats,and root canals were filled with BBR,calcium hydroxide or sterilized saline for 3 *** shape of the roots was analyzed by micro-computed tomography and histological *** vitro,BBR was introduced into stem cells from apical papilla(SCAPs).Osteogenic differentiation of stem cells from apical papilla was investigated by alkaline phosphatase activity,mineralization ability,and gene expression of osteogenic *** signaling pathway,which regulated the osteogenesis of SCAPs was evaluated by quantitative real time PCR,Western blot analysis,and *** rats treated with BBR,more tissue was formed,with longer roots,thicker root walls,and smaller apex *** addition,we found that BBR promoted SCAPs osteogenesis in a time-dependent and concentration-dependent *** induced the expression ofβ-catenin and enhancedβ-catenin entering into the nucleus,to up-regulate more runt-related nuclear factor 2 *** enhanced root repair in immature teeth with apical periodontitis by activating the canonical Wnt/β-catenin pathway in SCAPs.

关键词： roots walls filled

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食管癌肿瘤出芽的研究进展

中华胸部外科电子杂志 2021年第1期8卷 51-55页

作者：郑羽佳陈东来王文佳王伟桑永华张永胜陈勇兵苏州大学附属第二医院胸心外科苏州215004 同济大学附属上海市肺科医院胸外科上海200433 苏州大学附属第二医院病理科苏州215004

肿瘤出芽作为一种特殊的病理学表现,可以出现在食道、胃、结直肠、肺、口腔等部位,是反映肿瘤侵袭性和预后的独立因素。近年来随着学者对肿瘤出芽的关注和深入研究,肿瘤出芽可以作为食管癌的预后指标,并对食管癌的临床治疗决策有所帮助。

关键词：食管癌肿瘤出芽预后

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无人外卖终端设计研究

物流技术 2019年第12期38卷 119-121,142页

作者：钱润马成林李王欣杨若怡陈怡冰郑宇佳王婧婷东北林业大学工程技术学院

为了适应外卖行业的飞速发展,解决外卖员配送等待时间过长,外卖易被盗,与非法外卖员接触存在安全隐患等问题,设计了一种成本低、使用便捷的无人外卖终端设备,设备主要分为底盘和杆体两部分,杆体顶部设有摄像头用于监控防盗;杆体上分布... 详细信息

为了适应外卖行业的飞速发展,解决外卖员配送等待时间过长,外卖易被盗,与非法外卖员接触存在安全隐患等问题,设计了一种成本低、使用便捷的无人外卖终端设备,设备主要分为底盘和杆体两部分,杆体顶部设有摄像头用于监控防盗;杆体上分布着15个电控锁与锁环,可用于悬挂外卖以及上锁;底盘内设有以ESP8266EX为核心处理器的嵌入式控制器、控制电控锁的继电器等。本设备通过手持设备APP客户端、云服务器、设备嵌入式控制器,以现行标准网络形式进行无线信息传输,实现从手机终端进行对无人外卖终端锁的开关控制,使整个取送外卖过程更加便捷、安全。

关键词：外卖无人终端设备机构设计

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医用二氧化碳中杂质含量的不同测定方法比较

上海计量测试 2021年第5期48卷 23-27页

作者：魏王慧董翊于瑞祥高艳秋郑雨佳姜阳任逸尘陈鹰上海市计量测试技术研究院

文章以医用二氧化碳中一氧化碳、总硫化物两种杂质为例,使用欧洲药典中提供的两种不同的检测方法对杂质进行测定。对比结果表明,色谱、光谱等仪器类方法的杂质检出限更低,重复性和中间精密度也更好。气体检测管系统操作简单、用气量少,... 详细信息

文章以医用二氧化碳中一氧化碳、总硫化物两种杂质为例,使用欧洲药典中提供的两种不同的检测方法对杂质进行测定。对比结果表明,色谱、光谱等仪器类方法的杂质检出限更低,重复性和中间精密度也更好。气体检测管系统操作简单、用气量少,适用于对检测限等要求不高的检测需求。仪器法和检测管法都是实用的医用二氧化碳中杂质的检测手段,可根据需求选用不同的方法实施检测。

关键词：二氧化碳一氧化碳总硫检测管