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Short Hydration in Chemotherapy with Cisplatin plus S-1 for Advanced or Recurrent Gastric Cancer: A Retrospective Study

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Journal of Cancer Therapy 2015年第15期6卷 1254-1261页

作者： Akihito Tsuji yuji negoro Yoshihiro Okita Masahito Kotaka Takamasa Nishiuchi Takeshi Kotake Hironaga Satake Yukimasa Hatachi Department of Medical Oncology Kobe City Medical Center General Hospital Hyogo Japan Department of Clinical Oncology Faculty of Medicine Kagawa University Kagawa Japan Department of Medical Oncology Kochi Health Sciences Center Kochi Japan Gastrointestinal Cancer Center Sano Hospital Hyogo Japan

Background: Despite there are a few reports that assessed the S-1 + CDDP regimen with short hydration regimen for unresectable or metastatic gastric cancer, there is no consensus on the best regimen for short hydration. The aim of study was to evaluate the safety and the efficacy of S-1 plus cisplatin doublet chemotherapy with short hydration. Methods: S-1 was administered orally (p.o.) twice daily for the first 3 weeks of a 5-week cycle. Dose of S-1 administered was calculated according to the body surface area. CDDP was given as an intravenous (i.v.) infusion of 60 mg/m2 on day 8 of each cycle. Patients received the total of 1900 ml infusion containing 1000 ml of acetate Ringer’s solution as pre- and post-hydraion. 300 ml of 20% mannitol was administered as a diuretic. Results: 35 patients with unresectable or recurrent gastric cancer were enrolled. The reasons for termination of S-1 + CDDP were as follows: 21 (63.6%) by progressive disease;12 (31.4%) by toxicity. Even though 12 of 35 patients (34.2%) were discontinued S-1 + CDDP chemotherapy, only one patient was discontinued by Grade 2 of increased creatinine. TTF (time to progression) was 174 days (3 - 586 days), and the median of the total number of treatment cycles of S-1 + CDDP was 3.31. Median overall survival, as secondary endpoint, was 518 days. Conclusions: Our study suggested that the short hydration regimen is as safe and efficient as the continuous hydration regimen.

关键词： Short Hydration Cisplatin Plus S-1 Gastric Cancer

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