检索结果-南通市图书馆

Role of diffusion-weighted magnetic resonance imaging in the differential diagnosis of focal hepatic lesions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第46期15卷 5805-5812页

作者： Naoto Koike Akihiro Cho Katsuhiro Nasu Kazuhiko Seto Shigeyuki Nagaya yuji Ohshima Nobuhiro Ohkohchi Department of Surgery Seirei Sakura Citizen Hospital Department of Surgery Chiba Cancer Center Department of Radiology Institute of Clinical MedicineUniversity of Tsukuba Department of Radiology Seirei Sakura Citizen Hospital Department of Radiology Seirei Mikatabara Hospital Department of Surgery Institute of Clinical MedicineUniversity of Tsukuba

AIM： To evaluate the utility of diffusion-weighted imaging （DWl） in screening and differential diagnosis of benign and malignant focal hepatic lesions. METHODS： Magnetic resonance imaging （MRI） examinations were performed using the Signa Excite Xl Twin Speed 1.5T system （GE Healthcare, Milwaukee, Wl, USA）. Seventy patients who had undergone MRI of the liver [29 hepatocellular carcinomas （HCC）, four cholangiocarcinomas, 34 metastatic liver cancers, 10 hemangiomas, and eight cysts] between April 2004 and August 2008 were retrospectively evaluated. Visualization of lesions, relative contrast ratio （RCR）, and apparent diffusion coefficient （ADC） were compared between benign and malignant lesions on DWl. Su- perparamagnetic iron oxide （SPIO） was administered to 59 patients, and RCR was compared pre- and ***： DWI showed higher contrast between malignant lesions （especially in multiple small metastatic cancers） and surrounding liver parenchyma than did contrast-enhanced computed tomography. ADCs （mean±SD × 10^-3 mm2/s） were significantly lower （P 〈 0.05） in malignant lesions （HCC： 1.31 ± 0.28 and liver metastasis： 1.11 ± 0.22） and were significantly higher in benign lesions （hemangioma： 1.84 ± 0.37 and cyst： 2.61 ± 0.45） than in the surrounding hepatic tissues. RCR between malignant lesions and surrounding he- patic tissues significantly improved after SPIO administration, but RCRs in benign lesions were not ***： DWI is a simple and sensitive method for screening focal hepatic lesions and is useful for differential diagnosis.

关键词： Hepatic tumor Liver imaging Magneticresonance imaging Diffusion-weighted imaging Apparent diffusion coefficient

Overexpression of the bacterial tryptophan oxidase RebO affects auxin biosynthesis and Arabidopsis development

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science Bulletin 2016年第11期61卷 859-867页

作者： Yangbin Gao Xinhua Dai Zuyu Zheng Hiroyuki Kasahara yuji Kamiya Joanne Chory David Ballou Yunde Zhao Section of Cell and Developmental Biology University of California San Diego La Jolla CA 92093 USA Plant Biology Laboratory Salk Institute for Biological StudiesLa Jolla CA 92037 USA Plant Science Center RIKEN Yokohama Kanagawa 230-0045Japan The Global Innovation Research Organization Tokyo University of Agriculture and Technology Fuchu 183-8509 Japan Department of Biological Chemistry University of MichiganAnn Arbor MI 48109 USA

Both tryptophan （Trp） and auxin are essential for plant growth and Trp is a precursor for auxin biosynthesis. Concentrations of Trp and auxin need to be tightly con- trolled to ensure optimal growth and development. It has been very difficult to study the homeostasis of these two essential and inter-dependent compounds. Auxin is mainly synthesized from Trp via a two-step pathway using indole- 3-pyruvate （IPA） as the intermediate. Here we used a bacterial Trp oxidase RebO, which does not exist in Ara- bidopsis and which converts Trp to the imine form of IPA, to modulate IPA levels in Arabidopsis. Our results demonstrate that Arabidopsis plants use two strategies to ensure that no excess IPA is made from Trp. IPA is made from Trp by the TAA family of aminotransferases, which we show catalyzes the reverse reaction when IPA level is high. Moreover, excess IPA is converted back to Trp by the YAS1 aminotransferase. We show that the VASl-cat- alyzed reaction is very important for Trp homeostasis. This work not only elucidates the intricate biochemical mech- anisms that control the homeostasis of Trp, IPA, and auxin, but also provides novel tools for further biochemical studies on Tip metabolism and auxin biosynthesis in plants.

关键词： Auxin RebO Trp Arabidopsis Metabolism

A scientometric review of research on built environment influence on public transportation demand

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Traffic and Transportation Engineering(English Edition) 2024年

作者： yuji Shi Zan Zhang Zhuofan Yan Department of Traffic Engineering， Jiangsu University

There is a rich amount of reviews offer valuable references on the topic of exploring relationship between built environment and public transportation demand， but they often focus on certain perspectives and none of them provide a comprehensive and quantitative overview on available publications. To fill this gap， this study employed bibliometric analysis to develop a comprehensive review of relevant literature retrieved from the WOS core collection database from 2001 to 2022， aiming to identify the evolutionary trends and hot topics at global level， including historical and geographical trends， leading journals and institutions， keyword characteristics， citation network analysis and content analysis. The output results show that there is an increasing geographic spread along with the growth spurt of research publications on the topic of built environment influence on public transportation demand. According to results output from the keywords’ distribution and citation network analysis， hot topics of available studies as well as future research directions were identified based on their research objects， built environment measurement， and applied models. It is hoped that the output results will help researchers gain a deeper understanding of the development of research in this area， and help urban planning decision makers determine the most effective decisions and the most appropriate practices.

关键词：

Can control of gut microbiota be a future therapeutic option for inflammatory bowel disease?

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2021年第23期27卷 3317-3326页

作者： Atsushi Nishida Kyohei Nishino Keitaro Sakai yuji Owaki Yoshika Noda Hirotsugu Imaeda Department of Gastroenterology and Hepatology Nagahama City HospitalNagahama 5268580ShigaJapan

Inflammatory bowel disease(IBD)is a chronic inflammatory condition of the gastrointestinal tract encompassing two main clinical entities,Crohn’s disease and ulcerative *** evidence indicates that an aberrant immune activation caused by the interplay of genetic susceptibility and environmental impact on the gut microbiota may be involved in the pathogenesis of *** advances in next-generation sequencing technology have enabled a number of studies to identify the alteration of the gut microbiota,termed dysbiosis,in ***,the alteration in the metabolites derived from the gut microbiota in IBD has also been described in many ***,microbiota-based interventions such as fecal microbiota transplantation(FMT)have attracted attention as a novel therapeutic option in ***,in clinical trials,the efficacy of FMT for IBD remains *** basic and clinical studies are required to validate whether FMT can assume a complementary role in the treatment of *** present review provides a synopsis on dysbiosis in IBD and on the association between the gut microbiota and the pathogenesis of *** addition,we summarize the use of probiotics in IBD and the results of current clinical trials of FMT for IBD.

关键词： Inflammatory bowel disease Dysbiosis Fecal microbiota transplantation Short chain fatty acid Probiotics

AlGaN/GaN heterostructure field transistor for label-free detection of DNA hybridization

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2013年第21期58卷 2601-2605页

作者： WEN XueJin WANG ShengNian WANG yuji LEE Ly James LU Wu Department of Electrical and Computer Engineering The Ohio State University Department of Chemical and Biomedical Engineering The Ohio State University Department of Nanobio Materials and Electronics Gwangju Institute of Science and Technology

This paper demonstrates electrical detection of single strand deoxyribonucleic acid (ssDNA) conjugation by AlGaN/GaN hetero-structure field effect transistor (HFET) biological sensors. The probe ssDNA molecules are modified by thiol groups. The immobilization of probe molecules is achieved by S-Au bonding on a thin layer of gold film in the sensing area. The immobilization and hybridization process are firstly implemented on Si surfaces and checked by fluorescent and atomic force microscopy (AFM) imaging. The hybridization process is monitored on AlGaN/GaN HFETs. Time-dependent current change is observed when a matched ssDNA solution is applied, while no response is observed for a mismatched ssDNA sequence. The DNA hybridization process is dominated by the conjugation between matched ssDNA sequences in the first few tens of seconds. After that, the hybridization process is dominated by mass transfer processes and saturation of the immobilized probe ssDNA molecules.

关键词：异质结场效应晶体管 DNA杂交检测无标记 GaN 单链DNA DNA分子 DNA序列

Unsedated transnasal small-caliber esophagogastroduoden oscopy in elderly and bedridden patients

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第44期15卷 5586-5591页

作者： Mika Yuki yuji Amano Yoshinori Komazawa Hiroyuki Fukuhara Toshihiro Shizuku Shun Yamamoto Yoshikazu Kinoshita Division of Internal Medicine Izumo-City General Medical Center613 Nadabunn-choIzumo-shi Shimane 693-0003Japan Division of Endoscopy Shimane University Hospital89-1 Enya-choIzumo-shiShimane 693-8501Japan Division of Internal Medicine Unnan Municipal General Hospital96-1 Iida-choUnnan-shiShimane 699-1221Japan Second Department of Internal Medicine Shimane UniversitySchool of Medicine89-1 Enya-choIzumo-shiShimane 693-8501Japan

AIM： To evaluate the safety of unsedated transnasal small-caliber esophagogastroduodenoscopy （EGD） for elderly and critically ill bedridden patients. METHODS： One prospective randomized comparative study and one crossover comparative study between transnasal small-caliber EGD and transoral conventional EGD was done （Study 1）. For the comparative study, we enrolled 240 elderly patients aged 〉 65 years old. For the crossover analysis, we enrolled 30 bedridden patients with percutaneous endoscopic gastrostomy （PEG）（Study 2）, We evaluated cardiopulmonary effects by measuring arterial oxygen saturation （SpO2） and calculating the rate-pressure product （RPP）（pulse rate x systolic blood pressure/100） at baseline, 2 and 5 min after endoscopic intubation in Study 1. To assess the risk for endoscopy-related aspiration pneumonia during EGD, we also measured blood leukocyte counts and serum C-reactive protein （CRP） levels before and 3 d after EGD in Study 2. RESULTS： In Study 1, we observed significant decreases in SpO2 during conventional transoral EGD, but not during transnasal small-caliber EGD （0.24% vs -0.24% after 2 min, and 0.18% vs -0.29% after 5 min, P = 0.034, P = 0.044）. Significant differences of the RPP were not found between conventional transoral and transnasal small-caliber EGD. In Study 2, crossover analysis showed statistically significant increases of the RPP at 2 min after intubation and the end of endoscopy （26.8 and 34.6 vs 3.1 and 15.2, P = 0.044, P = 0.046）, and decreases of SpO2 （-0.8% vs -0.1%, P = 0.042） during EGD with transoral conventional in comparison with transnasal small-caliber endoscopy. Thus, for bedridden patients with PEG feeding, who were examined in the supine position, transoral conventional EGD more severely suppressed cardiopulmonary function than transnasal small-caliber EGD. There were also significant increases in the markers of inflammation, blood leukocyte counts and serum CRP values, in bedridden patients after transoral co

关键词： Aged Aspiration pneumonia Gastrointestina endoscopy Critical illness

Defensive medicine practices among gastroenterologists in Japan

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第47期12卷 7671-7675页

作者： Toru Hiyama Masaharu Yoshihara Shinji Tanaka yuji Urabe Yoshihiko Ikegami Tatsuma Fukuhara Kazuaki Chayama Health Service Center Hiroshima University Higashihiroshima Japan Department of Endoscopy Hiroshima University Hospital Hiroshima Japan Department of Medicine and Molecular Science Division of Frontier Medical Science Programs for Biomedical Research Graduate School of Biomedical Sciences Hiroshima University Hiroshima Japan

AIM： To clarify the prevalence of defensive medicine and the specific defensive medicine practices among gastroenterologists in Japan. METHODS： A survey of gastroenterologists in Hiroshima, Japan, was conducted by mail in March 2006. The number of gastroenterologists reporting defensive medicine behaviors or changes in their scope of practice and the reported defensive medicine practices, i.e., assurance and avoidance behaviors, were examined. RESULTS： A total of 131 （77%） out of 171 gastroenterologists completed the survey. Three （2%） respondents were sued, and most respondents （96%） had liability insurance. Nearly all respondents （98%） reported practicing defensive medicine. Avoidance behaviors, such as avoiding certain procedures or interventions and avoiding caring for high-risk patients, were very common （96%）. Seventy-five percent of respondents reported often avoiding certain procedures or interventions. However, seasoned gastroenterologists （those in practice for more than 20 years） adopted avoidance behaviors significantly less often than those in practice for less than 10 years. Assurance behaviors, i.e., supplying additional services of marginal or no medical value, were also widespread （91%）. Sixty-eight percent of respondents reported that they sometimes or often referred patients to other specialists unnecessarily. CONCLUSION： Defensive medicine may be highly prevalent among gastroenterologists throughout 3apan, with potentially serious implications regarding costs, access, and both technical and interpersonal quality of care.

关键词： Defensive medicine Gastroenterologist Japan Survey Clinical practice

Carcinosarcoma of the liver with mesenchymal differentiation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2007年第5期13卷 809-812页

作者： Shinichi Sumiyoshi Masataka Kikuyama yuji Matsubayashi Fujito Kageyama Yoshihiro Ide Yoshimasa Kobayashi Hirotoshi Nakamura Department of Gastroenterology Hamamatsu Rosai Hospital Hamamatsu Japan Department of Pathology Hamamatsu Rosai Hos-pital Hamamatsu Japan Second Division Department of Internal Medicine Hamamatsu University School of Medicine Hamamatsu Japan

We report an extremely rare case where a mesenchymal differentiation, especially embryonal sarcoma, was demonstrated in cholangiocarcinoma. At autopsy, a yellowish-white tumor （15 cm× 12 cm） was found in the right hepatic lobe, and there were several daughter nodules in both hepatic lobes. Histologically, most of the main tumor and all of the daughter nodules examined showed sarcomatous changes （spindle cells, pleomorphic ceils and hyalization）. Histologic examination of a part of the main tumor disclosed a focus of adenocarcinoma within the tumor. The frequent transitions between the adenocarcinomatous areas and the sarcomatous areas suggested that sarcomatous transformation occurred in the cholangiocarcinoma and then spread rapidly. Immunohistochemically, the adenocarcinomatous elements were positive for cytokeratin, carcinoembryonic antigen （CEA） and epithelial membrane antigen, and negative in the sarcomatous cells. Vimentin was positive only in the sarcomatous elements. The findings of the present case support the view that carcinosarcomas represent carcinomas that develop sarcomatous elements via metaplasia of the epithelial element.

关键词： Cholangiocarcinoma Carcinosarcoma Mesenchymal differentiation

Wild Gibbon Optimization Algorithm

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2024年第7期80卷 1203-1233页

作者： Jia Guo JinWang Ke Yan Qiankun Zuo Ruiheng Li Zhou He Dong Wang yuji Sato Hubei Key Laboratory of Digital Finance Innovation Hubei University of EconomicsWuhan430205China School of Information Engineering Hubei University of EconomicsWuhan430205China China Construction Third Engineering Bureau Installation Engineering Co. Ltd.Wuhan430074China Hubei Internet Finance Information Engineering Technology Research Center Hubei University of EconomicsWuhan430205China College of Informatics Huazhong Agricultural UniversityWuhan430070China Faculty of Computer and Information Sciences Hosei UniversityTokyo184-8584Japan

Complex optimization problems hold broad significance across numerous fields and ***,as the dimensionality of such problems increases,issues like the curse of dimensionality and local optima trapping also *** address these challenges,this paper proposes a novel Wild Gibbon Optimization Algorithm(WGOA)based on an analysis of wild gibbon population *** two strategies:community search and community *** community search strategy facilitates information exchange between two gibbon families,generating multiple candidate solutions to enhance algorithm ***,the community competition strategy reselects leaders for the population after each iteration,thus enhancing algorithm *** assess the algorithm’s performance,CEC2017 and CEC2022 are chosen as test *** the CEC2017 test suite,WGOA secures first place in 10 *** the CEC2022 benchmark functions,WGOA obtained the first rank in 5 *** ultimate experimental findings demonstrate that theWildGibbonOptimization Algorithm outperforms others in tested *** underscores the strong robustness and stability of the gibbonalgorithm in tackling complex single-objective optimization problems.

关键词： Complex optimization wild gibbon optimization algorithm community search community competition