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World Journal of Gastrointestinal Oncology 2021年第10期13卷 1412-1424页

作者： Shimpei Ogawa Michio Itabashi yuji inoue Takeshi Ohki Yoshiko Bamba Kurodo Koshino Ryosuke Nakagawa Kimitaka Tani Hisako Aihara Hiroka Kondo Shigeki Yamaguchi Masakazu Yamamoto Department of Surgery Institute of GastroenterologyTokyo Women's Medical UniversityTokyo 162-8666Japan

The current status and future prospects for diagnosis and treatment of lateral pelvic lymph node(LPLN)metastasis of rectal cancer are described in this *** resonance imaging(MRI)is recommended for the diagnosis of LPLN metastasis.A LPLN-positive status on MRI is a strong risk factor for metastasis,and evaluation by MRI is important for deciding treatment *** dissection(LPLD)has an advantage of reducing recurrence in the lateral pelvis but also has a disadvantage of complications;therefore,LPLD may not be appropriate for cases that are less likely to have LPLN *** therapy(RT)and chemoradiation therapy(CRT)have limited effects in cases with suspected LPLN metastasis,but a combination of preoperative CRT and LPLD may improve the treatment ***,RT and CRT plus selective LPLD may be a rational strategy to omit unnecessary LPLD and produce a favorable treatment outcome.

关键词： Diagnosis Treatment Rectal cancer Lateral pelvic lymph node metastasis Lateral pelvic lymph node dissection Radiotherapy

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磁头定位用的新型直线马达

电子计算机参考资料 1974年第10期 32-44页

作者： yuji inoue 陈思英

目前,磁盘装置的磁头定位时间一定要缩短。几年前,继在日本首次提出磁道伺服系统之后,作者又研制了FACOM 472L DPU,其中采用了所谓音圈马达。现在,作者又试制成性能更高的音圈马达以及它的控制系统,其静动态性能见表1。这些成果已应用... 详细信息

目前,磁盘装置的磁头定位时间一定要缩短。几年前,继在日本首次提出磁道伺服系统之后,作者又研制了FACOM 472L DPU,其中采用了所谓音圈马达。现在,作者又试制成性能更高的音圈马达以及它的控制系统,其静动态性能见表1。这些成果已应用于FACOM 477K磁盘装置(FACOM 477K与IBM 3330相容)。

关键词：磁头电感装置磁记录器电阻抗计算机外围设备磁盘存取时间磁轨磁道定位点跟随控制系统伺服系统马达动圈磁路定位精度

Spinal cord injury regenerative therapy development:integration of design of experiments

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Neural Regeneration Research 2025年第9期20卷 2571-2573页

作者： yuji Okano Hideyuki Okano Yoshitaka Kase Division of CNS Regeneration and Drug Discovery International Center for Brain Science(ICBS)Fujita Health UniversityKutsukake-ChoToyoake-ShiAichiJapan Department of Extended Intelligence for Medicine The Ishii-Ishibashi LaboratoryKeio University School of MedicineShinanomachiShinjuku-KuTokyoJapan Keio University Regenerative Medicine Research Center Kawasaki-kuKawasaki-shiJapan

Spinal cord injury(SCI)can cause motor and sensory paralysis,and autonomic nervous system disorders including malfunction of urination and defecation,thereby significantly impairing the quality of *** continue to explo re new stem cell strategies for the treatment of paralysis by transpla nting human induced pluripotent stem cell-derived neural ste m/progenitor cells(hiPSCNS/PCs)into spinal cord injured tissues.

关键词： Spinal paralysis injury

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Anti-breast cancer effect of quercetin nanoparticles based on MOFs for chemo-phototherapy and heat shock proteins inhibition

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Nano Research 2025年第1期18卷 545-558页

作者： Rongyue Zhu Shilang Liao Mengru Cai Dongge Yin Tingting Fu Jing Liu yuji Du Jiahui Kong Rongrong Chang Jian Ni Xingbin Yin Beijing University of Chinese Medicine Fangshan DistrictBeijing 102488China

Phototherapy, including photodynamic therapy(PDT) and photothermal therapy (PTT), is a promisingmethod of tumor treatment, which has the advantages ofstrong specificity and small side effects. However, PDT willaggravate the hypoxic environment in tumor cells, and PTTwill lead to heat-resistant reaction, both of which will make theorganism quickly produce heat shock proteins (HSPs) toprotect itself, thus seriously hindering the therapeuticefficiency of phototherapy. As a natural HSPs inhibitor,quercetin (QR) provides a feasible way to solve this ***, a kind of metal organic framework (MOF), Fe-TCPP(FT), was used as a delivery material and photosensitizer tobuild a chemo-phototherapy platform, and QR was used as achemotherapy drug and HSPs inhibitor. On this basis, the nanoparticles (NPs) were modified with PEG-CPP30 (a cellpenetratingpeptide that specifically recognizes human breast cancer MCF-7 cells), which showed excellent targetingcapacity and biocompatibility. The combination of chemotherapy and phototherapy significantly improved the anti-cancereffect. At the same time, NPs also showed prominent anti-HSPs effect. The effective connection of the two played acomplementary role in the process of tumor treatment, which provided a new strategy for the accurate and efficienttreatment of tumors in the future.

关键词： quercetin Fe-metal organic frameworks(MOFs) phototherapy anti-cancer heat shock proteins inhibition

Efficient hemostatic method for endoscopic submucosal dissection of colorectal tumors

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World Journal of Gastroenterology 2010年第33期16卷 4180-4186页

作者： Naohisa Yoshida yuji Naito Munehiro Kugai Ken inoue Naoki Wakabayashi Nobuaki Yagi Akio Yanagisawa Toshikazu Yoshikawa Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of MedicineGraduate School of Medical Science Department of Surgical Pathology Kyoto Prefectural University of MedicineGraduate School of Medical Science

AIM:To evaluate a new hemostatic method using hemostatic forceps to prevent perforation and perioperative hemorrhage during colonic endoscopic submucosal dissection(ESD).METHODS:We studied 250 cases,in which ESD for colorectal tumors was performed at the Kyoto Prefectural University of Medicine or Nara City Hospital between 2005 and *** developed a new hemostatic method using hemostatic forceps in December 2008 for the efficient treatment of submucosal thick *** was performed on 126 cases after adoption of the new method(the adopted group)and the new method was performed on 102 of these *** was performed on 124 cases before the adoption of the new method (the unadopted group).The details of the new method are as follows:firstly,a vessel was coagulated using the hemostatic forceps in the soft coagulation mode according to the standard procedure,and the coagulated vessel was removed using the forceps in the"endocut" mode without perioperative ***,the partial surrounding submucosa was dissected using the forceps in the endocut *** the current study,we evaluated the efficacy of this ***:Coagulated vessels were successfully removed using the hemostatic forceps in all 102 cases without severe perioperative *** perioperative hemorrhage occurred in five cases(4.9%);however,it was stopped by immediately reuse of the hemostatic *** partial surrounding submucosa was dissected using the forceps in all 102 *** the adopted group,the median operation time was 105 *** proportion of endoscopic en bloc resection was 92.8%(P<0.01)compared to 80.6%in the unadopted *** postoperative hemorrhage and perforation rates were 2.3%and 2.3%.The rate of perforation was significantly lower than that in the unadopted group (9.6%,P<0.01).We evaluated the ease of use of this method by allowing our three trainees to performed ESD on 46 cases,which were accomplished without any severe ***:The new

关键词： Endoscopic submucosal dissection Colorectal tumor Hemostatic forceps Perforation Perioperative hemorrhage

TTYH2,a human homologue of the Drosophila melanogaster gene tweety,is up-regulated in colon carcinoma and involved in cell proliferation and cell aggregation

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World Journal of Gastroenterology 2007年第19期13卷 2717-2721页

作者： yuji Toiyama Akira Mizoguchi Kazushi Kimura Junichirou Hiro Yasuhiro inoue Tomonari Tutumi Chikao Miki Masato Kusunoki Department of Gastrointestinal and Pediatric Surgery Division of Reparative Medicine Institute of Life Sciences Mie University Graduate School of Medicine Japan Department of Anatomy Faculty of Medicine Mie University 2-174 EdobashiTsu Mie 514-8507 Japan

AIM: To investigate the expression patterns of TTYH2 in the human colon cancer and colon cancer cell lines and to evaluate the inhibitory effect of small interfering RNA (siRNA) on the expression of TTYH2 in colon cancer cell ***: We investigated the expression patterns of TTYH2 in colon cancer, adjacent non-tumorous colon mucosa, and cancer cell lines (DLD-1, caco-2, and Lovo) by RT-PCR. Furthermore, a siRNA plasmid expression vector against TTYH2 was constructed and transfected into DLD-1 and Caco-2 with LipofectamineTM 2000. The down regulation of TTYH2 expression was detected by RT-PCR and the role of siRNA in inducing cell proliferation and cell aggregation was evaluated by MTT and aggregation ***: TTYH2 gene expression in colon cancer tissue was significantly up-regulated compared with normal colonic mucosa (1.23 ± 0.404 vs 0.655 ± 0.373, P = 0.0103). Colon cancer derived cell lines including DLD-1, Caco-2, and Lovo also expressed high levels of TTYH2. In contrast, transfection with siRNA-TTYH2 signifi cantly inhibited both proliferation and scattering of these cancer cell ***: The present work demonstrates, for the fi rst time, that the TTYH2 gene expression is signifi cantly up-regulated in colon cancer. The TTYH2 gene may play an important role in regulating both proliferating andmetastatic potentials of colorectal cancer.

关键词： TTYH2 Colorectal carcinoma Cell proliferation Cell aggregation

Efficacy and safety of rabeprazole in non-steroidal anti-inflammatory drug-induced ulcer in Japan

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World Journal of Gastroenterology 2009年第40期15卷 5097-5102页

作者： yuji Mizokami Gamagori City Hospital

AIM: To investigate the effi cacy and safety of rabepra-zole under continuous non-steroidal anti-inflammatory drug (NSAID) administration for NSAID-induced ulcer in Japan. METHODS: Subjects comprised patients undergoing NSAID treatment in whom upper gastrointestinal en-doscopy revealed an ulcerous lesion (open ulcer) with diameter ≥ 3 mm, who required continuous NSAID treatment. Endoscopies were performed at the start of treatment, during the treatment period, and at the conclusion (or discontinuation) of treatment. Findings were evaluated as size (maximum diameter) and stage based on the Sakita-Miwa classifi cation. An ulcer was regarded as cured when the "white coating" was seen to have disappeared under endoscopy. As criteria for evaluating safety, all medically untoward symptoms and signs (adverse events, laboratory abnormalities, accidental symptoms, etc.) occurring after the start of rabeprazole treatment were handled as adverse ***: Endoscopic cure rate in 38 patients in the efficacy analysis (endoscopic evaluation) was 71.1% (27/38). Among those 38 patients, 35 had gastric ulcer with a cure rate of 71.4% (25/35), and 3 had duodenal ulcer with a cure rate of 66.7% (2/3). Three adverse drug reactions were reported from 64 patients in the safety analysis (interstitial pneumonia, low white blood cell count and pruritus); thus, the incidence rate for adverse drug reactions was 4.7% (3/64).CONCLUSION: The treatment efficacy of rabeprazole for NSAID-induced ulcer under continuous NSAID ad-ministration was confi rmed.

关键词： Rabeprazole Non-steroidal anti-inflammatory drug Non-steroidal anti-inflammatory drug-induced ulcer Endoscopic findings Continuous non-steroidal anti-inflammatory drug administration

Pummerer-type Functionalization of Aryl and Alkenyl Selenoxides

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复旦学报(自然科学版) 2005年第5期44卷 881-882页

作者： Kazuaki Shimada Yutaka Kikuta Ken-ichi Satake Takahiro Suzuki Yukiko inoue Shigenobu Aoyagi yuji Takikawa Department of Chemical Engineering Faculty of EngineeringIwate University MoriokaIwate 020-8551Japan

1 Introduction Heteroatom-stabilized carbenium ions have been widely recognized as potential electrophilic ***,in contrast with the extensive works on thionium ion series,the highly labile character of selenoxide functionalities has caused serious limitation in the synthetic use in spite of their wide potentiality as synthetic equivalents of electrophilic selonium *** this paper,novel generation of selonium ions and the synthetic uses of the species for Pummerer-typeα-functionalization and for cycloaddition by using the novel dienophilic behavior ofπ-conjugated selonium cations.

关键词： selenoxide alkenyl selenoxide Pummerer reaction a-allylation a-azidation Diels-Alder reaction seloniumion

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Deep carbon recycling viewed from global plate tectonics

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National Science Review 2024年第6期11卷 37-55页

作者： Maoliang Zhang Sheng Xu yuji Sano School of Earth System Science Tianjin University Marine Core Research Institute Kochi University Atmosphere and Ocean Research Institute The University of Tokyo

Plate tectonics plays an essential role in the redistribution of life-essential volatile elements between Earth's interior and surface, whereby our planet has been well tuned to maintain enduring habitability over much of its history. Here we present an overview of deep carbon recycling in the regime of modern plate tectonics,with a special focus on convergent plate margins for assessing global carbon mass balance. The up-to-date flux compilation implies an approximate balance between deep carbon outflux and subduction carbon influx within uncertainty but remarkably limited return of carbon to convecting mantle. If correct, carbon would gradually accumulate in the lithosphere over time by（i） massive subsurface carbon storage occurring primarily in continental lithosphere from convergent margins to continental interior and（ii） persistent surface carbon sinks to seafloors sustained by high-flux deep CO2emissions to the atmosphere. Further assessment of global carbon mass balance requires updates on fluxes of subduction-driven carbon recycling paths and reduction in uncertainty of deep carbon outflux. From a global plate tectonics point of view, we particularly emphasize that continental reworking is an important mechanism for remobilizing geologically sequestered carbon in continental crust and sub-continental lithospheric mantle. In light of recent advances,future research is suggested to focus on a better understanding of the reservoirs, fluxes, mechanisms, and climatic effects of deep carbon recycling following an integrated methodology of observation, experiment,and numerical modeling, with the aim of decoding the self-regulating Earth system and its habitability from the deep carbon recycling perspective.

关键词： deep carbon recycling convergent plate margins subduction continental reworking global carbon mass balance