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Body mass index is associated with age-at-onset of HCV-infected hepatocellular carcinoma patients

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World Journal of Gastroenterology 2011年第7期17卷 914-921页

作者： Takumi Akiyama Toshihiko Mizuta Seiji Kawazoe yuichiro eguchi Yasunori Kawaguchi Hirokazu Takahashi Iwata Ozaki Kazuma Fujimoto Department of Internal Medicine Saga Medical School Department of Hepatology Saga Prefectural Hospital Department of Hepatology Saga Prefectural Hospital Saga 8408571 Japan

AIM: To identify factors associated with the age at onset of hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC). METHODS: Five hundred and fifty-six consecutive patients positive for HCV antibody and treatment-nafive HCC diagnosed between 1995 and 2004 were analyzed. Patients were classified into three groups according to age at HCC onset: 60 years old were lower and mean BMI values of female patients 25 kg/m2 [hazard ratio (HR), 1.8, P = 0.045], excessive alcohol consumption (HR, 2.5, P = 0.024), male sex (HR, 3.6, P = 0.002), and GGT levels > 50 IU/L (HR, 2.4, P = 0.014) were independently associated with HCC onset in patients < 60 years. Low ALT level was the only factor associated with HCC onset in patients aged ≥ 80 years. CONCLUSION: Increased BMI is associated with increased risk for early HCC development in HCV-infected patients. Achieving recommended BMI and reducing alcohol intake could help prevent hepatic carcinogenesis.

关键词： Age-at-onset Hepatocellular carcinoma Hepatitis C virus Body mass index Alcohol consumption Sex difference

Simple scoring system for predicting cirrhosis in nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2014年第29期20卷 10108-10114页

作者： Takaomi Kessoku Yuji Ogawa Masato Yoneda Kento Imajo Yoshio Sumida yuichiro eguchi Hideki Fujii Hideyuki Hyogo Masafumi Ono Yasuaki Suzuki Takumi Kawaguchi Kazuaki Chayama Saiyu Tanaka Kazuma Fujimoto Keizo Anzai Toshiji Saibara Michio Sata Yoshito Itoh Atsushi Nakajima Takeshi Okanoue Japan Study Group of NAFLD(JSG-NAFLD)[] Department of Gastroenterology Hepatology Yokohama City University Graduate School of MedicineYokohama 236-0004Japan Department of Molecular Gastroenterology Hepatology Kyoto Prefectural University of Medicine Kyoto 602-0841Japan Department of General Medicine Saga Medical School Saga 849-8501Japan Department of Hepatology Osaka City University Osaka 558-8585Japan Department of Medicine Molecular Science Graduate School of Biomedical Sciences Hiroshima University Hiroshima 730-0053 Japan Department of Gastroenterology and Hepatology Kochi Medical School Kochi 783-8505 Japan Department of Gastroenterology Nayoro City General Hospital Hokkaido 096-8511 Japan Department of Gastroenterology Kurume University School of Medicine Kurume 830-0011 Japan Department of Internal Medicine University Hospital Saga 849-8577 Japan Department of Gastroenterology Hepatology Saiseikai Suita Hospital Osaka 565-0862 Japan

AIM: To investigate a simple noninvasive scoring system for predicting liver cirrhosis in nonalcoholic fatty liver disease (NAFLD) patients.

关键词： Nonalcoholic fatty liver disease Cirrhosis Fibrosis Platelet Albumin Alanine aminotransferase ratio

Advantage of autologous blood transfusion in surgery for hepatocellular carcinoma

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World Journal of Gastroenterology 2011年第32期17卷 3709-3715页

作者： Yoshito Tomimaru Hidetoshi eguchi Shigeru Marubashi Hiroshi Wada Shogo Kobayashi Masahiro Tanemura Koji Umeshita yuichiro Doki Masaki Mori Hiroaki Nagano Department of Surgery Graduate School of Medicine Osaka University 2-2 Yamadaoka Suita 565-0871 Osaka Japan Division of Health Sciences Graduate School of Medicine Osaka University 2-2 Yamadaoka Suita 565-0871 Osaka Japan

AIM: To evaluate the significance of autologous blood transfusion (AT) in reducing homologous blood transfusion (HT) in surgery for hepatocellular carcinoma (HCC). METHODS: The proportion of patients who received HT was compared between two groups determined by the time of AT introduction; period A (1991-1994, n = 93) and period B (1995-2000, n = 201). Multivariate logistic regression analysis was performed in order to identify independent significant predictors of the need for HT. We also investigated the impact of AT and HT on long-term postoperative outcome after curative surgery for HCC. RESULTS: The proportion of patients with HT was significantly lower in period B than period A (18.9% vs 60.2%, P < 0.0001). Multivariate logistic regression analysis identified AT administration as a significant independent predictor of the need for HT (P < 0.0001). Disease-free survival in patients with AT was comparable to that without any transfusion. Multivariate analysis identified HT administration as an independent significant factor for poorer disease-free survival (P = 0.0380). CONCLUSION: AT administration significantly decreased the need for HT. Considering the postoperative survival disadvantage of HT, AT administration could improve the long-term outcome of HCC patients.

关键词： Hepatocellular carcinoma Surgery Autologous blood transfusion Homologous blood transfusion

Cancer immunotherapy for pancreatic cancer utilizing α-gal epitope/natural anti-Gal antibody reaction

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World Journal of Gastroenterology 2015年第40期21卷 11396-11410页

作者： Masahiro Tanemura Eiji Miyoshi Hiroaki Nagano Hidetoshi eguchi Katsuyoshi Matsunami Kiyomi Taniyama Nobutaka Hatanaka Hiroki Akamatsu Masaki Mori yuichiro Doki Department of Surgery Osaka Police Hospital10-31 Kitayamacho Tennoujiku Department of Molecular Biochemistry and Clinical Investigation Osaka University Graduate School of Medicine Department of Digestive Surgery and Surgical Oncology Yamaguchi University Graduate School of Medicine Department of Gastroenterological Surgery Osaka University Graduate School of Medicine Department of Pharmacognosy Graduate School of Biomedical and Health SciencesHiroshima University Department of Surgery and Institute for Clinical Research National Hospital Organization Kure Medical Center and Chugoku Cancer Center

Pancreatic ductal adenocarcinoma(PDAC) has the poorest prognosis of all malignancies and is largely resistant to standard therapy. Novel treatments against PDAC are desperately needed. Anti-Gal is the most abundant natural antibody in humans,comprising about 1% of immunoglobulins and is also naturally produced in apes and Old World monkeys. The anti-Gal ligand is a carbohydrate antigen called "α-gal epitopes" with the structure Galα1-3Galβ1-4Glc NAc-R. These epitopes are expressed as major carbohydrate antigens in non-primate mammals,prosimians,and New World monkeys. Anti-Gal is exploited in cancer vaccines to increase the immunogenicity of antigen-presenting cells(APCs). Cancer cells or PDAC tumor lysates are processed to express α-gal epitopes. Vaccination with these components results in in vivo opsonization by anti-Gal Ig G in PDAC patients. The Fc portion of the vaccine-bound anti-Gal interacts with Fcγ receptors of APCs,inducing uptake of the vaccine components,transport of the vaccine tumor membranes to draining lymph nodes,and processing and presentation of tumor-associated antigens(TAAs). Cancer vaccines expressing α-gal epitopes elicit strong antibody production against multiple TAAs contained in PDAC cells and induce activation of multiple tumor-specific T cells. Here,we review new areas of clinical importance related to the α-gal epitope/anti-Gal antibody reaction and the advantages in immunotherapy against PDAC.

关键词： Pancreatic cancer Immunotherapy Cancer antigen MUC

Fresh frozen plasma transfusion does not affect outcomes following hepatic resection for hepatocellular carcinoma

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World Journal of Gastroenterology 2010年第44期16卷 5603-5610页

作者： Yoshito Tomimaru Hiroshi Wada Shigeru Marubashi Shogo Kobayashi Hidetoshi eguchi Yutaka Takeda Masahiro Tanemura Takehiro Noda Koji Umeshita yuichiro Doki Masaki Mori Hiroak Nagano Department of Surgery Graduate School of Medicine Osaka University Division of Health Sciences Graduate School of MedicineOsaka University

AIM:To investigate whether fresh frozen plasma (FFP) transfusion affects outcomes following hepatic resection for hepatocellular carcinoma (HCC) in terms of liver function,postoperative complications and cancer ***:We retrospectively compared the incidence of postoperative complications between 204 patients who underwent hepatectomy for HCC with routine FFP transfusion in an early period (1983-1993,Group A) and 293 with necessity for FFP transfusion during a later period (1998-2006,Group B),and also between two subgroups of Group B [22 patients with FFP transfusion (Group B1) and 275 patients without FFP transfusion (Group B2)].Additionally,only in limited patients in Group B1 and Group B2 with intraoperative blood loss≥ 2000 mL (Group B1 ≥ 2000 mL and Group B2 ≥ 2000 mL),postoperative complications,liver function tests,and cancer prognosis were ***:No mortality was registered in Group B,compared to 8 patients (3.9%) of Group *** incidence of morbidity in Group B2 [23.2% (64/275)] was not significantly different from Group B1 [40.9% (9/22)] and Group A [27.0% (55/204)].The incidence of complications and postoperative liver function tests were comparable between Group B1 ≥ 2000 mL vs Group B2 ≥ 2000 *** prognosis did not correlate with administration of FFP,but with tumor-related ***:The outcome of hepatectomy for HCC is not influenced by FFP *** suggest FFP transfusion be abandoned in patients who undergo hepatectomy for HCC.

关键词： Fresh frozen plasma Hepatocellular carcinoma Surgery Transfusion

Femtosecond pulses cleaning by transient-grating process in Kerr-optical media

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Chinese Optics Letters 2011年第5期9卷 63-65页

作者： Kotaro Okamura yuichiro Kida Takayoshi Kobayashi Advanced Ultrafast Laser Research Center and Department of Engineering ScienceFaculty of Informatics and EngineeringDepartment of Engineering ScienceThe University of Electro-Communications International Cooperative Research Project (ICORP) Japan Science and Technology Agency Department of Electrophysics National Chiao Tung University Institute of Laser Engineering Osaka University

We use a transient-grating （TG） process in a Kerr bulk medium to clean a femtosecond laser pulse. Using the technique, the temporal contrast of the generated TG signal is improved by more than two orders of magnitude in comparison with the incident pulse in a 0.5-mm-thick fused silica plate. The laser spectrum is smoothed and broadened, and the pulse duration is shortened simultaneously. We expect to extend this technique to a clean pulse with broadband spectral bandwidth at a wide spectral range because it is a phase-matched process.

关键词： Electromagnetic pulse Fused silica Ultrafast lasers

Quality assessment of volunteered geographic information for outdoor activities:an analysis of OpenStreetMap data for names of peaks in Japan

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Geo-Spatial Information Science 2023年第3期26卷 333-345页

作者： Jun Yamashita Toshikazu Seto Nobusuke Iwasaki yuichiro Nishimura Faculty of Social and Cultural Studies Kyushu UniversityFukuokaJapan Faculty of Letters Komazawa UniversityTokyoJapan Sciences NAROInstitute for Agro-EnvironmentalTsukubaJapan Faculty of Letters Nara Women’s UniversityNaraJapan

Geographical studies of outdoor activities have increased in recent years with the rise in popularity of these activities worldwide,including in *** geographic information(VGI)is a key tool for organizing outdoor activities as it offers a means to determine the locational information and names of *** evaluate the quality of VGI,geospatial data generated by land survey agencies and other VGI are often utilized as reference ***,since these reference data may not be available,other methods are necessary to assure the quality of *** this study,we examined five trust indicators based on the inherent characteristics of VGI through an empirical case *** used mountain names extracted from OpenStreetMap in Japan as data because there were almost no other VGI in the *** a result,we isolated three trust indicators,namely versions,users,and tag corrections,to examine the thematic accuracy of VGI because these were the only statistically significant ***,we found that the prediction rate of thematic accuracy was very *** improve thematic accuracy,this study recommends using the most accurate versions,applying correctly given tags,and considering the motivations and characteristics of the VGI contributors.

关键词： Outdoor activities volunteered geographic information(VGI) OpenStreetMap(OSM) data quality assessment trust integrated usage

Sclerosing epithelioid fibrosarcoma of the liver infiltrating the inferior vena cava

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World Journal of Gastroenterology 2009年第33期15卷 4204-4208页

作者： Yoshito Tomimaru Hiroaki Nagano Shigeru Marubashi Shogo Kobayashi Hidetoshi eguchi Yutaka Takeda Masahiro Tanemura Toru Kitagawa Koji Umeshita Nobuyuki Hashimoto Hideki Yoshikawa Kenichi Wakasa yuichiro Doki Masaki Mori Department of Surgery Graduate School of MedicineOsaka University Division of Health Sciences Graduate School of MedicineOsaka University Department of Orthopaedics Graduate School of MedicineOsaka University Department of Pathology Osaka City University Hospital

Sclerosing epithelioid fibrosarcoma （SEF） is a rare and distinct variant of fibrosarcoma, composed of epithelioid tumor cells arranged in strands, nests, cords, or sheets embedded within a sclerotic collagenous matrix. We report a 39-year-old man with SEF of the liver, which infiltrated the inferior vena cava （IVC）. The SEF of the liver was successfully resected, and the infiltrated IVC was also removed together with the liver tumor. Histopathological examination of the tumor showed typical histopathology of SEE Immunohistochemically, the tumor was positive for vimentin. Recurrence was noted 7 mo after surgery. After chemotherapy, the recurrent tumor was resected surgically, and histopathological examination showed similar findings to those of the primary tumor. To our knowledge, this is the first report of SEF of the liver with tumor invasion of the IVC.

关键词： Sclerosing epithelioid fibrosarcoma Liver tumor Surgery Inferior vena cava invasion Vimentin

IDENTIFICATION OF STIFFNESS COEFFICIENTS OF LAMINATED COMPOSITE PLATES

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中国有色金属学会会刊：英文版 1997年第3期7卷 46-50页

作者： Wang, XC Shen, XP yuichiro, M Xu, BY N CHINA UNIV TECHNOL BEIJING 100041PEOPLES R CHINA TSING HUA UNIV DEPT MECH ENGNBEIJING 100084PEOPLES R CHINA IBARAKI UNIV DEPT ENGNHITACHIIBARAKI 316JAPAN

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关键词： inverse analysis composite laminated plate stiffness coefficient