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Probiotics for gastrointestinal disorders: Proposed recommendations for children of the Asia-Pacific region

World Journal of Gastroenterology 2017年第45期23卷 7952-7964页

作者： Donald Cameron Quak Seng Hock Musal Kadim Neelam Mohan Eell Ryoo Bhupinder Sandhu yuichiro yamashiro Chen Jie Hans Hoekstra Alfredo Guarino Department of Gastroenterology and Clinical Nutrition Royal Children’s Hospital Yong Loo Lin School of Medicine National University of Singapore Child Health Department Cipto Mangunkusumo HospitalUniversity of Indonesia Department of Pediatric Gastroenterology Hepatology And Liver Transplantation Department of Pediatrics Gachon UniversityGil Gachon Children’s Hosptial Department of Paediatric Gastroenterology Royal Hospital for Children Probiotics Research Laboratory Juntendo University Graduate School of Medicine The Children’s Hospital Zhejiang University School of Medicine Department of Pediatrics Hieronymus Bosch Hospital Unit of Pediatrics Infectious Diseases and Clinical Nutrition of the Department of Translational Medical Science-Section of Pediatrics University of Naples Federico II

Recommendations for probiotics are available in several regions. This paper proposes recommendations for probiotics in pediatric gastrointestinal diseases in the Asia-Pacific region. Epidemiology and clinical patterns of intestinal diseases in Asia-Pacific countries were discussed. Evidence-based recommendations and randomized controlled trials in the region were revised. Cultural aspects,health management issues and economic factors were also considered. Final recommendations were approved by applying the Likert scale and rated using the GRADE system. Saccharomyces boulardii CNCM I-745(Sb) and Lactobacillus rhamnosus GG(LGG) were strongly recommended as adjunct treatment to oral rehydration therapy for gastroenteritis. Lactobacillus reuteri could also be considered. Probiotics may be considered for prevention of(with the indicated strains): antibiotic-associated diarrhea(LGG or Sb); Clostridium difficile-induced diarrhea(Sb); nosocomial diarrhea(LGG); infantile colic(L reuteri) and as adjunct treatment of Helicobacter pylori(Sb and others). Specific probiotics with a history of safe use in preterm and term infants may be considered in infants for prevention of necrotizing enterocolitis. There is insufficient evidence for recommendations in other conditions. Despite a diversity of epidemiological,socioeconomical and health system conditions,similar recommendations apply well to Asia pacific countries. These need to be validated with local randomized-controlled trials.

关键词：乳杆菌 rhamnosus 肠胃炎指南 Probiotics 孩子建议亚太 Saccharomyces boulardii

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Antimicrobial therapy using sulfamethoxazole trimethoprim for Kawasaki disease patients unresponsive to intravenous immunoglobulin

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Open Journal of Pediatrics 2011年第3期1卷 27-29页

作者： Satoru Nagata yuichiro yamashiro Makoto Fujimori Yukihide Chiba Yoshikazu Ohtsuka Toshiaki Shimizu 不详

Our previous study suggested that the production of superantigens and heat-shock protein 60 by small intestinal bacteria might play a role in Kawasaki disease (KD). We demonstrated that they were all resistant to commonly used antibiotics, except for sulamethoxazole trimethoprim (SMX-TMP). We used SMX-TMP for 7 cases of KD that were unresponsive to intravenous immunoglobulin (IVIG) and studied the antipyretic potency of this treatment. In 6 out of the 7 cases, we demonstrated that antipyretic potency was observed without side effects within 2 days of the initial administration. Antimicrobial therapy using SMX-TMP might represent a novel strategy for cases of KD that are unresponsive to IVIG.

关键词： Antimicrobial Therapy Intravenous Immunoglobulin Resistance Kawasaki Disease Sulfamethoxazole Trimethoprim

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婴儿配方粉成分的全球标准:欧洲儿科胃肠病、肝病和营养学会牵头的国际专家组建议

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中国循证儿科杂志 2006年第4期1卷 307-319页

作者： Berthold Koletzko Susan Baker Geoff Cleghorn Ulysses Fagundes Neto Sarath Gopalan Olle Hernell Quak Seng Hock Pipop Jirapinyo Bo Lonnerdal Paul Pencharz Hildegard Pzyrembel Jaime Ramirez-Mayans Raanan Shamir Dominique Turck yuichiro yamashiro 丁宗一(译) 无德国慕尼黑大学冯豪内儿童医院国际专家组美国纽约州布法罗大学儿科系澳大利亚布里斯班昆士兰大学儿科与儿童健康系巴西圣保罗联邦大学儿科系印度新德里营养支持系统研究中心瑞典Umea大学儿科系临床科学部新加坡国立大学儿科系泰国曼谷大学儿科系美国加州大学营养与内科系加拿大多伦多儿童医院胃肠病与营养系德国柏林联邦风险评估研究所墨西哥国家儿科研究所胃肠病与营养系以色列海法Meyer儿童医院儿科胃肠病与营养系法国里尔胃肠病肝病与营养系日本东京顺天堂大学儿科系中国北京市儿童医院欧洲儿科胃肠病肝病和营养学会牵头的国际专家组

联合国粮食及农业组织(FAO)和WHO的食品法典委员会提出的食品标准、指南和其他相关文件旨在保护消费者健康以及全球的公平贸易.

关键词：全球标准婴儿配方营养学会胃肠病专家组食品法典委员会儿科欧洲

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