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Advantage of autologous blood transfusion in surgery for hepatocellular carcinoma

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World Journal of Gastroenterology 2011年第32期17卷 3709-3715页

作者： Yoshito Tomimaru Hidetoshi Eguchi Shigeru Marubashi Hiroshi Wada Shogo Kobayashi Masahiro Tanemura Koji Umeshita yuichiro Doki Masaki Mori Hiroaki Nagano Department of Surgery Graduate School of Medicine Osaka University 2-2 Yamadaoka Suita 565-0871 Osaka Japan Division of Health Sciences Graduate School of Medicine Osaka University 2-2 Yamadaoka Suita 565-0871 Osaka Japan

AIM: To evaluate the significance of autologous blood transfusion (AT) in reducing homologous blood transfusion (HT) in surgery for hepatocellular carcinoma (HCC). METHODS: The proportion of patients who received HT was compared between two groups determined by the time of AT introduction; period A (1991-1994, n = 93) and period B (1995-2000, n = 201). Multivariate logistic regression analysis was performed in order to identify independent significant predictors of the need for HT. We also investigated the impact of AT and HT on long-term postoperative outcome after curative surgery for HCC. RESULTS: The proportion of patients with HT was significantly lower in period B than period A (18.9% vs 60.2%, P < 0.0001). Multivariate logistic regression analysis identified AT administration as a significant independent predictor of the need for HT (P < 0.0001). Disease-free survival in patients with AT was comparable to that without any transfusion. Multivariate analysis identified HT administration as an independent significant factor for poorer disease-free survival (P = 0.0380). CONCLUSION: AT administration significantly decreased the need for HT. Considering the postoperative survival disadvantage of HT, AT administration could improve the long-term outcome of HCC patients.

关键词： Hepatocellular carcinoma Surgery Autologous blood transfusion Homologous blood transfusion

Method of Searching for Earthquake Disaster Evacuation Routes Using Multi-Objective GA and GIS

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Journal of Geographic Information System 2014年第5期6卷 492-525页

作者： yuichiro Shimura Kayoko Yamamoto Graduate School of Information Systems University of Electro-Communications Tokyo Japan

This study treats the determination of routes for evacuation on foot in earthquake disasters as a multi-objective optimization problem, and aims to propose a method for quantitatively searching for evacuation routes using a multi-objective genetic algorithm (multi-objective GA) and GIS. The conclusions can be summarized in the following three points. 1) A GA was used to design and create an evacuation route search algorithm which solves the problem of the optimization of earthquake disaster evacuation routes by treating it as an optimization problem with multiple objectives, such as evacuation distance and evacuation time. 2) In this method, goodness of fit is set by using a Pareto ranking method to determine the ranking of individuals based on their relative superiorities and inferiorities. 3) In this method, searching for evacuation routes based on the information on present conditions allows evacuation routes to be derived based on present building and road locations.?Further, this method is based on publicly available information;therefore, obtaining geographic information similar to that of this study enables this method to be effective regardless of what region it is applied to, or whether the data regards the past or the future. Therefore, this method has high degree of spatial and temporal reproducibility.

关键词： Evacuation Route Evacuation Site Earthquake Disaster Multi-Objective Optimization Problem Multi-Objective GA (Multi-Objective Genetic Algorithm) Pareto Ranking Method GIS

Impact of Natural Forest Protection Program policies on forests in northeastern China

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Forestry Studies in China 2011年第3期13卷 231-238页

作者： ZHANG Kun Yasuto HORI ZHOU Shao-zhou Tetsuya MICHINAKA yuichiro HIRANO Satoshi TACHIBANA China National Forestry Economics and Development Research Center State Forestry Administration Beijing 100714 P. R. China Forestry and Forest Products Research Institute 1 Matsunosato Tsukuba Ibaraki 305-8687 Japan

This study analyzes the effects of the Natural Forest Protection Program （NFPP） on the restoration of forest resources in the northeastern forest region of China, an important region because of its ecological and geographical location and timber supply in China, by using panel data sets of 35 forest farms of state-owned forest enterprises. Panel data analysis results show that related policies under the NFPP have had positive effects on forest resources. Planting activity had a statistically significant effect on forest growth and could be reinforced continually by planting tree species suitable for a warming climate in temperate forests. Forest management and protection played a powerful role in increasing the growing stock of the forests. In NFPP areas timber harvests, after implementation of the NFPP, were a positive factor in increasing forest resources if the harvests combined effective tending and thinning under a carefully guided management plan.

关键词： NFPP policy impact forest growth panel data analysis

Didactic surgical experience of thyroid metastasis from renal cell carcinoma: A case report

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World Journal of Clinical Cases 2018年第15期6卷 1018-1023页

作者： Moriyasu Yamauchi Keita Kai Natsuko Shibamiya Rintaro Shimazu Mikio Monji Kumiko Suzuki Hiroaki Kakinoki Shohei Tobu yuichiro Kuratomi Department of Otolaryngology Head and Neck Surgery Saga University Faculty of Medicine Department of Pathology Saga University Hospital Department of Urology Saga University Faculty of Medicine

BACKGROUND The optimal therapeutic strategy in treating thyroid metastasis from renal cell carcinoma(RCC) has not been clearly established. Here we describe a case of didactic surgical experience of the disease which caused massive intraoperative *** SUMMARY A 59-year-old male patient presented with a thyroid left lobe soft mass detected by chest computed tomography scans prior to the surgical treatment of RCC of the left kidney. The thyroid mass was initially considered to be benign, then he underwent left radical nephrectomy. One year after the nephrectomy, stereotactic radiosurgery was performed for brain metastasis. During follow-up, the thyroid nodule gradually grew, and the patient manifested swallowing discomfort. Under a clinical diagnosis of thyroid follicular neoplasm, left hemithyroidectomy was performed. Although hemithyroidectomy is usually a safe and straightforward procedure, massive bleeding from markedly developed tumor vessels made the operation very difficult. The thyroid tumor was finally diagnosed as metastasis from clear cell RCC. CONCLUSION For proper timing of the surgery, a clinician should take into consideration the possibility of thyroid metastasis of RCC when a thyroid lesion is found in patients with RCC or in patients with a previous history of RCC. We recommend that thyroid metastasis of RCC should be resected as early as possible even if a patient has other metastatic sites.

关键词： Renal cell carcinoma Thyroid metastasis Hemorrhage Thyroidectomy Case report

Identification of the Bacterial Gene in Patients Who Repeatedly Develop Streptococcal Pharyngitis

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International Journal of Clinical Medicine 2012年第7期3卷 680-684页

作者： yuichiro Tsuji Ichihashi Izumi Department of Pediatrics Sempos Tokyo Takanawa Hospital Tokyo Japan

Background: We aimed at determining whether the pathogenic bacteria at the onset of disease are genetically different and whether this affects future choice of the therapeutic methods against group A β-hemolytic streptococcal acute pharyngitis/tonsillitis. Methods: A pharynx swab was collected from pediatric patients who visited our hospital. The swab was cultured, and hemolytic streptococcus was detected 230 times. We isolated pathogenic bacteria of patients infected more than once and examined the bacteria using pulse-field gel electrophoresis. Results: Based on gene search results, we found that if the period of developing relapse was within 1 month from the first infection, all patients had the same gene. However, all patients in whom reinfection occurred after 6 months or later had different pertinent genes. Conclusions: The number of relapse/reinfection is significant for this disease, and considerably caution is essential for its treatment. No changes to antibacterial drug administration may be necessary for the second administration unless more than 6 months have passed since the first infection.

关键词： Bacterial Gene Cefcapene Pivoxil PFGE (Pulse-Field Gel Electrophoresis) Reinfection Streptococcal Pharyngitis

Application of povacoat as dispersion stabilizer of nanocrystal formulation

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 48-49页

作者： Kayo Yuminoki Fuko Seko Shota Horii Haruka Takeuchi Katsuya Teramoto yuichiro Nakada Naofumi Hashimoto Setsunan University 45-1Nagaotoge-choHirakataOsaka 573-0101Japan Santen Pharmaceutical Company Ltd. 40-20OfukachoKita-kuOsaka 530-8552Japan

Nanosizing by wet beads milling is one of the methods to improve the solubility of poorlywater soluble compounds[1,2].Hydrophilic polymers,such as Hydroxypropylcellulose-SSL(HPC),Polyvinylalcohol(PVA),and Polyvinylpyrrolidone-K30(PVP)*** used as dispersion stabilizer to prevent aggregation of ***,there are many compounds that cannot be dispersed by ordinary dispersion *** this study,we used Povacoat?as a dispersion stabilizer for several poorly water soluble compounds milled to *** influences of aggregation of the nanoparticles on the dissolution behavior and the oral absorption of the compoundswere studied using formulations with high and low dispersion characters.

关键词： Nanocrystal Wet beads milling Poorly water soluble compounds

Use of transabdominal (external) ultrasound during balloon dilatation to diagnose tracheobronchial remnant in congenital esophageal stenosis

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World Journal of Pediatric Surgery 2018年第1期1卷 9-11页

作者： Kengo Hattori Shigeru Takamizawa yuichiro Miyake Tomoko Hatata Katsumi Yoshizawa Tomoko Furukawa Yoshiaki Kondo Department of Surgery Nagano Children's HospitalNaganoJapan Department of Radiology Nagano Children's HospitalNaganoJapan

Preoperativedifferential diagnosis between tracheobronchial remnant(TBR)and other typesof congenital esophageal stenosis(CES)is challenging,even when usingendoscopic ultrasonography(EUS).This report is the first to demonstrate theuse of transabdominal(external)ultrasound during balloon dilatation todiagnose TBR in *** simple technique is a promising diagnostic tool forTBR as an alternative to EUS.

关键词： balloon esophageal congenital

Probiotics for gastrointestinal disorders: Proposed recommendations for children of the Asia-Pacific region

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World Journal of Gastroenterology 2017年第45期23卷 7952-7964页

作者： Donald Cameron Quak Seng Hock Musal Kadim Neelam Mohan Eell Ryoo Bhupinder Sandhu yuichiro Yamashiro Chen Jie Hans Hoekstra Alfredo Guarino Department of Gastroenterology and Clinical Nutrition Royal Children’s Hospital Yong Loo Lin School of Medicine National University of Singapore Child Health Department Cipto Mangunkusumo HospitalUniversity of Indonesia Department of Pediatric Gastroenterology Hepatology And Liver Transplantation Department of Pediatrics Gachon UniversityGil Gachon Children’s Hosptial Department of Paediatric Gastroenterology Royal Hospital for Children Probiotics Research Laboratory Juntendo University Graduate School of Medicine The Children’s Hospital Zhejiang University School of Medicine Department of Pediatrics Hieronymus Bosch Hospital Unit of Pediatrics Infectious Diseases and Clinical Nutrition of the Department of Translational Medical Science-Section of Pediatrics University of Naples Federico II

Recommendations for probiotics are available in several regions. This paper proposes recommendations for probiotics in pediatric gastrointestinal diseases in the Asia-Pacific region. Epidemiology and clinical patterns of intestinal diseases in Asia-Pacific countries were discussed. Evidence-based recommendations and randomized controlled trials in the region were revised. Cultural aspects,health management issues and economic factors were also considered. Final recommendations were approved by applying the Likert scale and rated using the GRADE system. Saccharomyces boulardii CNCM I-745(Sb) and Lactobacillus rhamnosus GG(LGG) were strongly recommended as adjunct treatment to oral rehydration therapy for gastroenteritis. Lactobacillus reuteri could also be considered. Probiotics may be considered for prevention of(with the indicated strains): antibiotic-associated diarrhea(LGG or Sb); Clostridium difficile-induced diarrhea(Sb); nosocomial diarrhea(LGG); infantile colic(L reuteri) and as adjunct treatment of Helicobacter pylori(Sb and others). Specific probiotics with a history of safe use in preterm and term infants may be considered in infants for prevention of necrotizing enterocolitis. There is insufficient evidence for recommendations in other conditions. Despite a diversity of epidemiological,socioeconomical and health system conditions,similar recommendations apply well to Asia pacific countries. These need to be validated with local randomized-controlled trials.

关键词： Lactobacillus rhamnosus Gastroenteritis Guidelines Probiotics Children Recommendations Asia-Pacific Saccharomyces boulardii

Outcomes of endoscopic endonasal dacryocysto-rhinostomy for intractable lacrimal dacryostenosis and associated factors

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International Journal of Ophthalmology(English edition) 2016年第10期9卷 1471-1475页

作者： Tohru Tanigawa Hirokazu Sasaki Hiroshi Nonoyama yuichiro Horibe Kunihiro Nishimura Tetsuro Hoshino Tetsuya Ogawa Kenta Murotani Hiromi Ueda Masahiro Kaneda Department of Otolaryngology Aichi Medical University Department of Otolaryngology Tono Kosei Hospital Division of Biostatistics Clinical Research CenterAichi Medical University Department of Ophthalmology Tono Kosei Hospital

AIM：To examine the effects of patient age,canalicular obstruction,mode of anesthesia,and duration of nasolacrimal intubation on the outcomes of endoscopic endonasal dacryocystorhinostomy（DCR）. METHODS： Totally 56 eyes of 46 patients with prolonged epiphora underwent minimally invasive endoscopic endonasal DCR.A successful surgical outcome was defined as a significant improvement in symptoms,adequate water passage from the puncta to the nasal cavity,and patency of the DCR *** outcomes were assessed at least 6mo after ***＇s exact test was used to discuss the factors,and then the logistic regression analysis was made by SAS9.4 ***： The overall success rate was 75.0%,and complete resolution was observed in 27 *** success rate was higher for patients with ≥6mo intubation than for those with 〈6mo ***,there were no significant differences in outcomes between groups stratified by age（〈65 or ≥65y）,presence or absence of canalicular obstruction,mode of anesthesia（local or general）,and use or nonuse of a radiowave *** patient developed subcutaneous emphysema around the eye and nose and one developed subcutaneous hemorrhage after surgery. CONCLUSION： Endoscopic endonasal DCR can be considered safe and minimally invasive with reasonable success rates,particularly when the duration of nasolacrimal intubation is ≥6mo.

关键词： dacryocystorhinostomy endoscopy,, intubation epiphora