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Frontiers in Energy 2021年第3期15卷 568-576页

作者： yuichi yamaguchi Akihiko KUDO Department of Applied Chemistry Faculty of ScienceTokyo University of ScienceTokyo 162-8601Japan

To solve resource,energy,and environmental issues,development of sustainable clean energy system is strongly *** recent years,hydrogen has been paid much attention to as a clean *** hydrogen production by water splitting using a photocatalyst as artificial photosynthesis is a promising method to solve these *** utilization of visible light comprised of solar light is essential for practical *** strategies,i.e.,doping,control of valence band,and formation of solid solution are often utilized as the useful methods to develop visible light responsive *** minireview introduces the recent work on visible-light-driven photocatalysts developed by substitution with metal cations of those strategies.

关键词： visible light responsive photocatalyst water splitting artificial photosynthesis:metal ion substitution

Photocatalysis:from solar light to hydrogen energy

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Frontiers in Energy 2021年第3期15卷 565-567页

作者： Wenfeng SHANGGUAN Akihiko KUDO Zhi JIANG yuichi yamaguchi Research Center for Combustion and Environment Technology Shanghai Jiao Tong UniversityShanghai 200240China Department of Applied Chemistry Faculty of ScienceTokyo University of ScienceTokyo 162-8601Japan

The exploitation and utilization of fossil energy has caused serious problems such as environmental pollution and climate *** is imperative to develop renewable and clean energy *** energy is recognized as one of the most superior energy carriers in the world because of its characteristics of high energy density,convenient storage and transportation,and pollution-free energy conversion *** energy sources could be converted to hydrogen energy,of which,solar energy is abundant and ***,nowadays,the efficient conversion of solar energy to hydrogen energy has become one of the hot topics in the renewable energy *** based on the principles of Honda-Fujishima effect provides an opportunity to address the above *** recent years have witnessed the rapid growth of photocatalytic hydrogen production from photocatalysis and photoelectrocatalysis via solar light.

关键词： catalysis pollution convenient

Extracapsular invasion as a risk factor for disease recurrence in colorectal cancer

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World Journal of Gastroenterology 2011年第15期17卷 2003-2006页

作者： Takaaki Fujii yuichi Tabe Reina Yajima Satoru yamaguchi Soichi Tsutsumi Takayuki Asao Hiroyuki Kuwano Depart ment of General Surgical Science Graduate School of Medicine Gunma University Gunma 371-8511 Japan

AIM: To evaluate the presence of extracapsular invasion (ECI) in positive nodes as a predictor of disease recurrence disease in colorectal cancer. METHODS: Two hundred and twenty-eight consecutive patients who underwent colorectal resection were identified for inclusion in this study, of which 46 had positive lymph nodes. Among 46 cases with stage Ⅲcolorectal cancer, 16 had ECI at positive nodes and 8 had disease recurrence. The clinical and pathological features of these cases were reviewed. RESULTS: In the univariate analysis, the number of positive lymph nodes and depth of tumor invasion were significantly associated with the presence of ECI at positive nodes. Multivariate analysis demonstrated that only ECI was a predictor of recurrence. The recurrence-free interval differed significantly among patients with ECI at positive ***: Our results suggest that ECI at metastatic nodes can identify which cases are at high risk of short-term disease recurrence in colorectal cancer.

关键词：复发间隔大肠癌疾病危险因素入侵 ECI 淋巴结单因素分析

Role of phosphorylated Smad3 signal components in intraductal papillary mucinous neoplasm of pancreas

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Hepatobiliary & Pancreatic Diseases International 2020年第6期19卷 581-589页

作者： yuichi Hori Tsukasa Ikeura Takashi yamaguchi Katsunori Yoshida Koichi Matsuzaki Mitsuaki Ishida Sohei Satoi Kazuichi Okazaki Department of Gastroenterology and Hepatology Kansai Medical University2-5-1 ShinmachiHirakataOsaka 5731191Japan Department of Pathology Kansai Medical University2-5-1 ShinmachiHirakataOsaka 5731191Japan Department of Surgery Kansai Medical University2-5-1 ShinmachiHirakataOsaka 5731191Japan

Background:Malignant intraductal papillary mucinous neoplasm(IPMN)has poor *** carcinogenesis of IPMN is not *** aim of this study was to clarify transitions in phosphorylated Smad3 signaling during IPMN ***:By using immunohistochemistry,we examined the expression of pSmad3C and pSmad3L from 51 IPMN surgical specimens resected at our institution between 2010 and *** also examined the expression of Ki-67,c-Myc and ***:The median immunostaining index of pSmad3C was 79.2%in low-grade dysplasia,74.9%in highgrade dysplasia,and 42.0%in invasive carcinoma(P<0.01),whereas that of pSmad3L was 3.4%,4.3%,and 42.4%,respectively(P<0.01).There was a negative relationship between the expression of pSmad3C and c-Myc(P<0.001,r=-0.615)and a positive relationship between the expression of pSmad3L and c-Myc(P<0.001,r=0.696).Negative relationship between the expression of pSmad3C and Ki-67(P<0.01,r=-0.610)and positive relationship between the expression of pSmad3L and Ki-67(P<0.01,r=0.731)were confirmed.p-JNK-positive cells were frequently observed among pSmad3L-positive cancer *** median of pSmad3L/pSmad3C ratio in the non-recurrence group and the recurrence group were 0.58(range,0.05–0.93),3.83(range,0.85–5.96),respectively(P=0.02).The median immunostaining index of c-Myc in the non-recurrence group and the recurrence group were 2.91(range,0–36.9)and 82.1(range,46.2–97.1),respectively(P=0.02).The median immunostaining index of Ki-67 in the non-recurrence group and the recurrence group were 12.9(range 5.7–30.8)and 90.9(range 52.9–98.5),respectively(P=0.02).Conclusions:pSmad3L was upregulated in malignant ***3L/pSmad3C ratio may be a useful prognostic factor in IPMN.

关键词： Intraductal papillary mucinous neoplasms of the pancreas Immunohistochemistry Phosphorylated Smad Carcinogenesis Prognosis

Preparation of bromfenac-loaded liposomes modified with chitosan for ophthalmic drug delivery and evaluation of physicochemical properties and drug release profile

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Asian Journal of Pharmaceutical Sciences 2013年第2期8卷 104-109页

作者： Toshimasa Tsukamoto Kohei Hironaka Takuya Fujisawa Daiki yamaguchi Kohei Tahara yuichi Tozuka Hirofumi Takeuchi Laboratory of Pharmaceutical Engineering Gifu Pharmaceutical University1-25-4 Daigaku-nishiGifu 501-1196Japan Laboratory of Formulation Design and Pharmaceutical Technology Osaka University of Pharmaceutical SciencesOsakaJapan

The purpose of this study was to design a submicron-sized liposomal non-steroidal antiinflammatory drug(NSAID)preparation that targets the retina via topical instillation of eye ***(BRF)-loaded liposomes were prepared using the calcium acetate gradient *** sizes and encapsulation efficiencies were optimized by screening several liposome formulations of lipid,drug concentration,and buffer *** entrapment efficiency was greater than 90%using this method,and was low using conventional hydration *** initial BRF loading using the pH gradient method caused aggregation of *** circumvent aggregation,the negatively charged lipid dicetylphosphate was incorporated into liposomes,which formed anion layer preventing *** of BRF from liposomes was sustained for several hours depending on lipid concentration,inner water phase,initial drug amounts,and surface *** modification with chitosan(CS),a mucoadhesive cationic polymer,was achieved using electrostatic interactions of negatively charged *** optimal concentration of CS for evasion of liposome aggregation was 0.15%.

关键词： NSAIDs pH Gradient method Surface modification Chitosan Eye drop

The Existence of Symptomatic Localized Lesion(s) and ≤4 Lesions Are Indications for Radiotherapy: Screening Computed Tomography Images of Patients with Metastatic/Recurrent/Inoperable Cancer in a Single Japanese Institution Observational Study

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2016年第1期5卷 110-119页

作者： Shinsaku yamaguchi yuichi Matsuki Shinji Yotsumoto Hiroaki Satou Michiko Watanabe Sachie Yotsumoto Department of Radiology Kitakyushu General Hospital Kitakyushu Japan Department of Forensic Medicine School of Medicine University of Occupational and En-vironmental Health Kitakyushu Japan

Background: To investigate the prevalence of indications for radiotherapy (RT) in patients with metastatic/recurrent/inoperable cancer. We also sought to analyze such patients’ clinical and radiological characteristics for indications of radiotherapy in those patients who had either surveillance or an initial assessment done by computed tomography (CT). Methods: Two diagnostic radiologists and a radiation oncologist evaluated a total of 13,225 consecutive patients from January 2012 to December 2012 at a single Japanese institution. Patients with metastatic/recurrent/ inoperable cancer were selected for further study. After two diagnostic radiologists identified patients with a detectable cancerous lesion, a radiation oncologist subsequently investigated whether there was any indication for RT. The oncologist also evaluated the relationship between patients’ clinical/radiological factors, and patients with or without indications for RT. Results: Two diagnostic radiologists selected 329 patients showing a detectable gross cancerous lesion. In this patient group, a radiation oncologist identified 196 patients with metastatic/recurrent/inoperable cancer, of which 96 patients (49%) showed an indication for RT. According to both univariate and multivariate analyses, ≤4 lesions were significantly associated with patients who showed an indication for RT (P = 0.0002 and P 0.001, respectively). Conclusions: In screening CT images, approximately half of all patients with metastatic/recurrent/inoperable cancer showed an indication for RT. Moreover, ≤4 lesions and/or the existence of a symptomatic, localized lesion were highly suggestive of an indication for RT. These findings would be of considerable interest to radiation oncologists planning appropriate treatments for cancer patients.

关键词： Surveillance CT Radiation Oncologist Indication for Radiotherapy

Evaluation of novel slim biopsy forceps for diagnosis of biliary strictures: Single-institutional study of consecutive 360 cases(with video)

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World Journal of Gastroenterology 2017年第35期23卷 6429-6436页

作者： Kenjiro Yamamoto Takayoshi Tsuchiya Takao Itoi Shujiro Tsuji Reina Tanaka Ryosuke Tonozuka Mitsuyoshi Honjo Shuntaro Mukai Kentaro Kamada Mitsuru Fujita Yasutsugu Asai Yukitoshi Matsunami yuichi Nagakawa Hiroshi yamaguchi Atsushi Sofuni Department of Gastroenterology and Hepatology Tokyo Medical University Third Department of Surgery Tokyo Medical University Department of Pathology Tokyo Medical University

AIM To evaluate the feasibility and reliability of endoscopic transpapillary bile duct biopsy for the diagnosis of biliary *** A total of 360 patients(241 men) who underwent endoscopic retrograde cholangiopancreatography for biliary strictures with biopsy from April 2012 to March 2016 at Tokyo Medical University Hospital were retrospectively reviewed. This study was approved by our Institutional Review Board(No. 3516). Informed consent was obtained from all individual participants included in this study. The biopsy specimens were obtained using a novel slim biopsy forceps(Radial Jaw 4P, Boston Scientific, Boston, MA, United States).RESULTS The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 69.6%, 100%, 100%, 59.1%, and 78.8%, respectively. The sensitivity was 75.6% in bile duct cancer, 64% in pancreatic cancer, 61.1% in gallbladder cancer, and 57.1% in metastasis. In bile duct cancer, a lower sensitivity was observed for perihilar bile duct stricture(68.7%) than for distal bile duct stricture(83.1%). In terms of the stricture lengths of pancreatic cancer, gallbladder cancer, and metastasis, a longer stenosis resulted in a better sensitivity. In particular, there was a significant difference between pancreatic cancer and gallbladder cancer(P < 0.05). One major complication was perforation of the extrahepatic bile duct with bile leakage. CONCLUSION Endoscopic transpapillary biopsy alone using novel slim biopsy forceps is feasible and reliable, but restrictive. Biopsy should be performed in consideration of the stricture level, stricture length, and cancer type.

关键词： Endoscopic transpapillary biopsy Biopsy forceps Biliary stricture Bile duct cancer Endoscopic retrograde cholangiography

Tubulopapillary adenoma of the gallbladder accompanied by bile duct tumor thrombus

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World Journal of Gastroenterology 2014年第26期20卷 8736-8739页

作者： Kentaroh Yamamoto Fumio Yamamoto Atsuhiro Maeda Hirotsune Igimi Mami Yamamoto Ryosuke yamaguchi yuichi Yamashita Department of Surgery Yamamoto Memorial Hospital Department of Internal Medicine Maeda Hospital Department of Gastroenterological Surgery Fukuoka University School of Medicine

Intraductal papillary mucinous neoplasm of the bile duct(IPNB)is recognized as a precancerous lesion;however,both its pathogenesis and progression remain *** present here a case of IPNB arising from the gallbladder accompanied by bile duct tumor thrombus in a 79-year-old *** resected specimen revealed a tubulopapillary adenoma with no malignant *** case suggests that even in the absence of malignant cells,these tumors can behave as malignant tumors requiring aggressive *** if no malignant cells are present,intraepithelial neoplasms occurring in the ampullopancreatobiliary tract can behave as malignant tumors.

关键词： Intraductal papillary mucinous neoplasm of the bil

Hayabusa2’s superior solar conjunction mission operations: Planning and post-operation results

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Astrodynamics 2020年第4期4卷 265-288页

作者： Stefania Soldini Hiroshi Takeuchi Sho Taniguchi Shota Kikuchi Yuto Takei Go Ono Masaya Nakano Takafumi Ohnishi Takanao Saiki yuichi Tsuda Fuyuto Terui Naoko OgawaYuya MimasuTadateru Takahashi Atsushi Fujii Satoru NakazawaKent Yoshikawa Yusuke Oki Chikako Hirose Hirotaka Sawada Tomohiro yamaguchi Makoto Yoshikawa Department of Mechanical Materials and Aerospace EngineeringUniversity of LiverpoolLiverpool L693BXUK Institute of Space and Astronautical Science Japan Aerospace Exploration AgencySagamihara 252-5210Japan Fujitsu Limited Tokyo 105-7123Japan Mitsubishi Electric Corporation Tokyo 100-8310Japan

In late 2018,the asteroid Ryugu was in the Sun's shadow during the superior solar conjunction *** the Sun-Earth-Ryugu angle decreased to below 3°,the Hayabusa2 spacecraft experienced 21 days of planned blackout in the Earth-probe communication *** was the first time a spacecraft had experienced solar conjunction while hovering around a minor *** the safety of the spacecraft,a low energy transfer trajectory named Ayu was designed in the Hill reference frame to increase its altitude from 20 to 110 *** trajectory was planned with the newly developed optNEAR tool and validated with real time *** article shows the results of the conjunction operation,from planning to fight data.

关键词： superior solar conjunction Hayabusa2 Ryugu hovering satellite mission operations

Dual-Energy X-Ray Computed Tomography Scanner Using Two Different Energy-Selection Electronics and a Lutetium-Oxyorthosilicate Photomultiplier Detector

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2017年第3期6卷 266-279页

作者： Osahiko Hagiwara Eiichi Sato Yasuyuki Oda Satoshi yamaguchi yuichi Sato Hiroshi Matsukiyo Toshiyuki Enomoto Manabu Watanabe Shinya Kusachi Department of Surgery Toho University Ohashi Medical Center Tokyo Japan Department of Physics Iwate Medical University Yahaba Japan Department of Radiology School of Medicine Iwate Medical University Morioka Japan Central Radiation Department Iwate Medical University Hospital Morioka Japan

To obtain two kinds of tomograms at two different X-ray energy ranges simultaneously, we have constructed a dual-energy X-ray photon counter with a lutetium-oxyorthosilicate photomultiplier detector system, three comparators, two microcomputers, and two frequency-voltage converters. X-ray photons are detected using the detector system, and the event pulses are input to three comparators simultaneously to determine threshold energies. At a tube voltage of 100 kV, the three threshold energies are 16, 35 and 52 keV, and two energy ranges are 16 - 35 and 52 - 100 keV. X-ray photons in the two ranges are counted using microcomputers, and the logical pulses from the two microcomputers are input to two frequency-voltage converters. In dual-energy computed tomography (CT), the tube voltage and current were 100 kV and 0.29 mA, respectively. Two tomograms were obtained simultaneously at two energy ranges. The energy ranges for gadolinium-L-edge and K-edge CT were 16 - 35 and 52 - 100 keV, respectively. The maximum count rate of dual-energy CT was 105 kilocounts per second with energies ranging from 16 to 100 keV, and the exposure time for tomography was 19.6 min.

关键词： X-Ray Photon Counting LSO-PMT Detector Dual-Energy Counter Energy-Dispersive CT Gd-L-Edge CT Gd-K-Edge CT