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Asian Journal of Pharmaceutical Sciences 2013年第2期8卷 104-109页

作者： Toshimasa Tsukamoto Kohei Hironaka Takuya Fujisawa Daiki Yamaguchi Kohei Tahara yuichi tozuka Hirofumi Takeuchi Laboratory of Pharmaceutical Engineering Gifu Pharmaceutical University1-25-4 Daigaku-nishiGifu 501-1196Japan Laboratory of Formulation Design and Pharmaceutical Technology Osaka University of Pharmaceutical SciencesOsakaJapan

The purpose of this study was to design a submicron-sized liposomal non-steroidal antiinflammatory drug(NSAID)preparation that targets the retina via topical instillation of eye ***(BRF)-loaded liposomes were prepared using the calcium acetate gradient *** sizes and encapsulation efficiencies were optimized by screening several liposome formulations of lipid,drug concentration,and buffer *** entrapment efficiency was greater than 90%using this method,and was low using conventional hydration *** initial BRF loading using the pH gradient method caused aggregation of *** circumvent aggregation,the negatively charged lipid dicetylphosphate was incorporated into liposomes,which formed anion layer preventing *** of BRF from liposomes was sustained for several hours depending on lipid concentration,inner water phase,initial drug amounts,and surface *** modification with chitosan(CS),a mucoadhesive cationic polymer,was achieved using electrostatic interactions of negatively charged *** optimal concentration of CS for evasion of liposome aggregation was 0.15%.

关键词： NSAIDs pH Gradient method Surface modification Chitosan Eye drop

Revisiting ENSO impacts on the Indian Ocean SST based on a combined linear regression method

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Acta Oceanologica Sinica 2021年第5期40卷 47-57页

作者： Lianyi Zhang Yan Du Tomoki tozuka Shoichiro Kido State Key Laboratory of Tropical Oceanography South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China University of Chinese Academy of Sciences Beijing 100049China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China Department of Earth and Planetary Science Graduate School of ScienceThe University of TokyoTokyo 113-0033Japan Application Laboratory(APL) Research Institute for Value-Added-Information Generation(VAiG)Japan Agency for Marine-Earth Science and TechnologyYokohama 236-0001Japan

The El Nino-Southern Oscillation(ENSO)has great impacts on the Indian Ocean sea surface temperature(SST).In fact,two major modes of the Indian Ocean SST namely the Indian Ocean Basin(IOB)and the Indian Ocean Dipole(IOD)modes,exerting strong influences on the Indian Ocean rim countries,are both influenced by the *** on a combined linear regression method,this study quantifies the ENSO impacts on the IOB and the IOD during ENSO concurrent,developing,and decaying *** removing the ENSO impacts,the spring peak of the IOB disappears along with significant decrease in number of events,while the number of events is only slightly reduced and the autumn peak remains for the *** isolating the ENSO impacts during each stage,this study reveals that the leading impacts of ENSO contribute to the IOD development,while the delayed impacts facilitate the IOD phase switch and prompt the IOB ***,the decadal variations of ENSO impacts are various during each stage and over different *** imply that merely removing the concurrent ENSO impacts would not be sufficient to investigate intrinsic climate variability of the Indian Ocean,and the present method may be useful to study climate variabilities independent of ENSO.

关键词： Indian Ocean ENSO sea surface temperature climate modes combined linear regression

Grain boundary functions as a spin valve

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National Science Review 2020年第7期7卷 1148-1149页

作者： yuichi Ikuhara Institute of Engineering Innovation The University of Tokyo Nanostructure Research Laboratory Japan Fine Ceramics Center

In practical applications, most metals and ceramic materials are used in polycrystalline form, composed of numbers of tiny single crystals called grains. The atomic arrangements at the interfaces between these grains, namely the grain boundaries(GBs), are very different from those inside the bulk part. The GB atomic structures are rather complicated and disordered, dependent on the orientations

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Visible light responsive photocatalysts developed by substitution with metal cations aiming at artificial photosynthesis

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Frontiers in Energy 2021年第3期15卷 568-576页

作者： yuichi YAMAGUCHI Akihiko KUDO Department of Applied Chemistry Faculty of ScienceTokyo University of ScienceTokyo 162-8601Japan

To solve resource,energy,and environmental issues,development of sustainable clean energy system is strongly *** recent years,hydrogen has been paid much attention to as a clean *** hydrogen production by water splitting using a photocatalyst as artificial photosynthesis is a promising method to solve these *** utilization of visible light comprised of solar light is essential for practical *** strategies,i.e.,doping,control of valence band,and formation of solid solution are often utilized as the useful methods to develop visible light responsive *** minireview introduces the recent work on visible-light-driven photocatalysts developed by substitution with metal cations of those strategies.

关键词： visible light responsive photocatalyst water splitting artificial photosynthesis:metal ion substitution

Rate of hexabromocyclododecane decomposition and production of brominated polycyclic aromatic hydrocarbons during combustion in a pilot-scale incinerator

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Journal of Environmental Sciences 2017年第11期29卷 91-96页

作者： yuichi Miyake Masahiro Tokumura Qi Wang Takashi Amagai yuichi Horii University of Shizuoka 52-1 Yada Suruga-ku Shizuoka 422-8526 Japan Center for Environmental Science in Saitama 914 Kamitanadare Kazo Saitama 34F-0115 Japan

Here, we examined the incineration of extruded polystyrene containing hexabromocyclododecane（HBCD） in a pilot-scale incinerator under various combustion temperatures（800–950℃） and flue gas residence times（2–8 sec）. Rates of HBCD decomposition ranged from 99.996%（800℃, 2 sec） to 99.9999%（950℃, 8 sec）; the decomposition of HBCD, except during the initial stage of combustion（flue gas residence time 〈 2 sec）, followed a pseudo-first-order kinetics model. An Arrhenius plot revealed that the activation energy and frequency factor of the decomposition of HBCD by combustion were 14.2 kJ/mol and 1.69 sec^（-1）,respectively. During combustion, 11 brominated polycyclic aromatic hydrocarbons（BrPAHs）were detected as unintentional by-products. Of the 11 BrPAHs detected, 2-bromoanthracene and 1-bromopyrene were detected at the highest concentrations. The mutagenic and carcinogenic BrPAHs 1,5-dibromoanthracene and 1-bromopyrene were most frequently detected in the flue gases analyzed. The total concentration of BrPAHs exponentially increased（range,87.8–2,040,000 ng/m^3） with increasing flue gas residence time. Results from a qualitative analysis using gas chromatography/high-resolution mass spectrometry suggest that bromofluorene and bromopyrene（or fluoranthene） congeners were also produced during the combustion.

关键词： Brominated polycyclic aromatic hydrocarbons Flame retardant Hexabromocyclododecane(HBCD) Incinerator Persistent organic pollutants(POPs)

Growth promotion of interspecific hybrid embryos between Cucumis anguria and Melon(C. melo) by fruit heating

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Horticultural Plant Journal 2022年第2期8卷 215-220页

作者： yuichi Matsumoto Mako Tsunamoto Center for Education and Research in Agricultural Innovation Faculty of AgricultureSaga UniversitySaga 8470021Japan

Wild species of the genus Cucumis, such as C. anguria, are resistant to various melon(C. melo) diseases such as Fusarium wilt race 1.2 and are anticipated as genetic resources of melon. However, in the interspecific crosses between C. anguria and melon, the abortion of the embryos was observed in the early growth stage and could not be regenerated even when cultured. Therefore, for embryo rescue, it is necessary to promote embryo growth during abortion occurrence. This study investigated the effects of fruit heating on embryo growth in interspecific hybrids of C. anguria and melon. In the heating device, the minimum night temperature around the fruit was maintained above 21.5 °C. The ovule grain area of C. anguria × MR-1 with fruit heating was significantly enlarged compared to that without fruit-heating. It was also significantly enlarged compared with the ovule grain area of C. anguria self-pollination. Although, in C. anguria × MR-1 without fruit-heating, no embryo was observed until 10 days after pollination(DAP), and pre-embryos were observed at 13 DAP. Conversely, in C. anguria × MR-1 with fruit-heating, pre-embryos were even observed at 10 DAP. These results suggest that the possibility of embryo or ovule culture regeneration has increased due to embryo growth promotion.

关键词： Cucumis anguria L. Interspecific cross Melon Night temperature Ovule area

Three-dimensional crystal defect imaging by STEM depth sectioning

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Chinese Physics B 2024年第8期33卷 2-7页

作者： Ryo Ishikawa Naoya Shibata yuichi Ikuhara Institute of Engineering Innovation The University of TokyoBunkyoTokyo 113-8656Japan

One of the major innovations awaiting in electron microscopy is full three-dimensional imaging at atomic *** the success of aberration correction to deep sub-angstrom lateral resolution,spatial resolution in depth is still far from atomic *** scanning transmission electron microscopy(STEM),this poor depth resolution is due to the limitation of the illumination *** overcome this physical limitation,it is essential to implement a next-generation aberration corrector in STEM that can significantly improve the depth *** review discusses the capability of depth sectioning for three-dimensional imaging combined with large-angle illumination ***,the statistical analysis approach remarkably improves the depth resolution,making it possible to achieve three-dimensional atomic resolution imaging at oxide *** will also discuss the future prospects of three-dimensional imaging at atomic resolution by STEM depth sectioning.

关键词： atomic-resolution STEM STEM depth sectioning depth resolution dopants surface topography

Analytical study of performance evaluation for seismic retrofitting of reinforced concrete building using 3D dynamic nonlinear finite element analysis

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Earthquake Engineering and Engineering Vibration 2011年第2期10卷 291-302页

作者： yuichi Sato Shinichi Kajihara Yoshio Kaneko Department of Architecture and Architectural Engineering Kyoto University Technology Center Taisei Corporation

This paper presents three-dimensional finite element （FE） analyses of an all-frame model of a three-story reinforced concrete （RC） building damaged in the 1999 Taiwan Chi-Chi Earthquake. Non-structural brick walls of the building acted as a seismic resistant element although their contributions were neglected in the design. Hence, the entire structure of a typical frame was modeled and static and dynamic nonlinear analyses were conducted to evaluate the contributions of the brick walls. However, the results of the analyses were considerably overestimated due to coarse mesh discretizations, which were unavoidable due to limited computer resources. This study corrects the overestimations by modifying （1） the tensile strengths and （2） shear stiffness reduction factors of concrete and brick. The results indicate that brick walls improve frame strength although shear failures are caused in columns shortened by spandrel walls. Then, the effectiveness of three types of seismic retrofits is evaluated. The maximum drift of the first floor is reduced by 89.3%, 94.8%, and 27.5% by Steel-confined, FuI1-RC, and Full-brick models, respectively. Finally, feasibility analyses of models with soils were conducted. The analyses indicated that the soils elongate the natural period of building models although no significant differences were observed.

关键词： reinforced concrete 1999 Taiwan Chi-Chi earthquake nonlinear finite element analysis seismic retrofit brick wall

QUADRANT ANALYSIS OF BUBBLE INDUCED VELOCITY FLUCTUATIONS IN A TRANSITIONAL BOUNDARY LAYER

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Journal of Hydrodynamics 2009年第1期21卷 93-99页

作者： HUANG Jian MURAI yuichi YAMAMOTO Fujio Graduate School of Engineering Fiber Amenity Engineering Course University of Fukui Bunkyo 3-9-1 Fukui 910-8507 Japan Division of Energy and Environment System School of Engineering Hokkaido University Sapporo Japan Graduate School of Engineering University of Fukui Bunkyo 3-9-1 Fukui 910-8507 Japan

Our previous study showed that the frictional drag decreases with increasing void fraction at Re〉1300, while it increases at Re 〈 1000. Decomposition of the Reynolds shear stress also implied that bubbles induce isotropy of turbulence. In order to confirm our previous analysis and to further investigate flow fields in the vicinity of bubbles, we analyze velocity fluctuations on the quadrant space in the streamwise and transverse directions （u′-v′ plane）. Here, we focus on two specific Reynolds numbers （at Re≈900 and ≈1410, which are close to the laminar-to-turbulent transition regime） and discuss bubble effects on sweep （u′〉 0, v′〈 0 ） and ejection （u′〈 0, v′〉 0） events as a function of the Reynolds number. We also illustrate velocity fluctuations in the vicinity of an individual bubble and a swarm of bubbles on the u′- v′ coordinates. The results show that a bubble swarm suppresses the velocity fluctuations at Re≈1410.

关键词： bubbly channel flow Particle Tracking Velocimetry (PTV) quadrant analysis velocity fluctuation boundary layer,laminar-to-turbulent transition

TESTING k-EDGE-CONNECTIVITY OF DIGRAPHS

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Journal of Systems Science & Complexity 2010年第1期23卷 91-101页

作者： yuichi YOSHIDA.HiroI TO School of Informatics Kyoto University

This paper presents an algorithm that tests whether a given degree-bounded digraph is k-edge-connected or E-far from k-edge-connectivity. This is the first testing algorithm for k-edge- connectivity of digraphs whose running time is independent of the number of vertices and edges. A digraph of n vertices with degree bound d is ε-far from k-edge-connectivity if at least εdn edges have to be added or deleted to make the digraph k-edge-connected, preserving the degree bound. Given a constant error parameter ε and a degree bound d, our algorithm always accepts all k-edge-connected digraphs and reiects all digraphs that is ε-far from k-edge-connectivity with orobabilitv at least 2/*** runs in O（d（εd^-c）^k logεd^-1O）（c〉1 is a constant）time when input digraphs are restricted to be （k-1）-edge connected and runs in O（d（εd^-ck）^klogεd^-kO）（c〉1 is a constant）time for general digraphs.

关键词： Digraph graph k-edge-connectivity property testing.