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Effects of denosumab treatment in chronic liver disease patients with osteoporosis

World Journal of Gastroenterology 2020年第33期26卷 4960-4971页

作者： Chisato Saeki Mitsuru Saito Tsunekazu Oikawa Masanori Nakano yuichi torisu Masayuki Saruta Akihito Tsubota Division of Gastroenterology and Hepatology Department of Internal MedicineThe Jikei University School of MedicineTokyo 1058461Japan Department of Orthopaedic Surgery The Jikei University School of MedicineTokyo 1058461Japan Core Research Facilities Research Center for Medical ScienceThe Jikei University School of MedicineTokyo 1058461Japan

BACKGROUND Effective treatment of osteoporosis is essential for improving morbidity and health-related quality of life in chronic liver disease(CLD)*** has been shown to increase bone mineral density(BMD)and decrease the risk of osteoporotic fracture in the general ***,there are few reports evaluating the efficacy of denosumab in CLD *** To investigated the effects and safety of denosumab in CLD patients with *** Sixty CLD patients with osteoporosis were subcutaneously administered denosumab once every 6 *** study period for evaluating efficacy and safety was 12 *** from baseline in BMD at the lumbar spine,femoral neck,and total hip were evaluated at 12 mo of denosumab *** turnover and quality were assessed by measuring serum tartrate-resistant acid phosphatase-5b(bone resorption marker),serum total procollagen type I N-terminal propeptide(bone formation maker),and plasma pentosidine(bone quality marker).RESULTS Among the 405 CLD patients,138(34.1%)patients were diagnosed with osteoporosis;among these,78 patients met the exclusion criteria and thus 60 patients were finally included in the present *** median percentage changes from baseline to 12 mo of denosumab treatment in BMD at the lumbar spine,femoral neck,and total hip were+4.44%,+3.71%,and+4.03%,*** significantly improved BMD,regardless of sex,patient age,and presence of liver *** tartrate-resistant acid phosphatase-5b and procollagen type I N-terminal propeptide levels constantly and significantly declined after denosumab treatment(P<0.001).Plasma pentosidine levels were also significantly lower at 12 mo of treatment(P=0.010).No patients experienced fractures and moderate-to-severe adverse events,except for transient *** Denosumab treatment was safe and increased BMD,suppressed bone turnover,and improved bone quality marker levels in CLD patients with osteoporosis,irrespective

关键词： Chronic liver disease Denosumab Osteoporosis Bone mineral density Bone turnover Bone quality

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Mouse models for investigating the underlying mechanisms of nonalcoholic steatohepatitis-derived hepatocellular carcinoma

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World Journal of Gastroenterology 2018年第18期24卷 1989-1994页

作者： Kazuki Takakura Tsunekazu Oikawa Yoichi Tomita Yusuke Mizuno Masanori Nakano Chisato Saeki yuichi torisu Masayuki Saruta Division of Gastroenterology and Hepatology Department of Internal Medicine The Jikei University School of Medicine

As the incidence of hepatocellular carcinoma(HCC) caused by infection with the hepatotropic viruses hepatitis B and hepatitis C decreases, greater attention has become focused on HCC caused by nonalcoholic steatohepatitis(NASH), an advanced form of nonalcoholic fatty liver disease which has shown increasing prevalence in correspondence with the overall increase in metabolic syndrome over the recent decades. Several clinical population studies have shown a positive relationship between NASH and HCC, while also providing initial insights into the underlying mechanisms of HCC development from NASH. Research into the pathological progression of NASH to HCC has advanced by use of several beneficial rodent models. In this review, we summarize the established mouse models for preclinical research of NASH-associated HCC and discuss the underlying hepatic mechanisms of NASH-related tumorigenesis identified to date that could lead to new targets for treatment and prevention.

关键词： Hepatocellular carcinoma Nonalcoholic steatohepatitis Nonalcoholic fatty liver disease

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Clinical usefulness of ursodeoxycholic acid for Japanese patients with autoimmune hepatitis

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World Journal of Hepatology 2017年第1期9卷 57-63页

作者： yuichi torisu Masanori Nakano Keiko Takano Ryo Nakagawa Chisato Saeki Atsushi Hokari Tomohisa Ishikawa Masayuki Saruta Mikio Zeniya Division of Gastroenterology and Hepatology Department of Internal Medicine the Jikei University School of Medicine Department of Internal Medicine Fuji City General Hospital Department of Internal Medicine Sanno Medical Center

AIM To evaluate the therapeutic effects of ursodeoxycholic acid(UDCA) on autoimmune hepatitis(AIH).METHODS A total 136 patients who were diagnosed with AIH were included in our study. All of the patients underwent a liver biopsy, and had at least a probable diagnosis on the basis of either the revised scoring system or the simplified scores. Initial treatment included UDCA monotherapy(Group U, n = 48) and prednisolone(PSL) monotherapy(Group P, n = 88). Group U was further classified into two subgroups according to the effect of UDCA: Patients who had achieved remission induction with UDCA monotherapy and showed no sign of relapse(Subgroup U1, n = 34) and patients who additionally received PSL during follow-up(Subgroup U2, n = 14). We compared the clinical and histological findings between each groups, and investigated factorscontributing to the response to UDCA *** In Group U, 34 patients(71%) achieved and maintained remission over 49(range: 8-90) mo(Subgroup U1) and 14 patients(29%) additionally received PSL(Subgroup U2) during follow-up. Two patients in Subgroup U2 achieved remission induction once but additionally required PSL administration because of relapse(15 and 35 mo after the start of treatment). The remaining 12 patients in Subgroup U2 failed to achieve remission induction during follow-up, and PSL was added during 7(range: 2-18) mo. Compared with Subgroup U2, Subgroup U1 had significantly lower alanine aminotransferase(ALT) levels at onset(124 IU/L vs 262 IU/L, P = 0.023) and a significantly higher proportion of patients with mild inflammation(A1) on histological examination(70.6% vs 35.7%, P = 0.025). When multivariate analysis was performed to identify factors contributing to the response to UDCA monotherapy, only a serum ALT level of 200 IU/L or lower was found to be associated with a significant difference(P = 0.013).CONCLUSION To prevent adverse events related to corticosteroids, UDCA monotherapy for AIH needs to be considered in pat

关键词： Autoimmune hepatitis Japanese patients Adverse events Corticosteroids Ursodeoxycholic acid

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Pancreatic cancer screening in patients with presumed branch-duct intraductal papillary mucinous neoplasms

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World Journal of Clinical Oncology 2019年第2期10卷 67-74页

作者： yuichi torisu Kazuki Takakura Yuji Kinoshita Yoichi Tomita Masanori Nakano Masayuki Saruta Division of Gastroenterology and Hepatology Department of Internal Medicine The Jikei University School of Medicine

Because delayed diagnosis is one of the causes of poor prognosis in pancreatic ductal adenocarcinoma(PDAC), early detection is a key for overall improvement of prognosis. Towards this end, periodic screening is recommended for individuals considered high-risk for PDAC. Advances in diagnostic imaging modalities have increased the frequency of incidental findings of pancreatic cysts,including the intraductal papillary mucinous neoplasm(IPMN)-a major risk factor of PDAC, having 1% annual prevalence of concomitance with *** retainment of patients with IPMN and regular follow-up by routine imaging examination will likely improve early detection and better prognosis of PDAC. Unfortunately, current guidelines only address management of PDAC derived from IPMN and overlook PDAC concomitant with IPMN. Screening of patients with IPMN, by endoscopic ultrasonography(currently the most reliable modality for detecting small PDAC), may facilitate early detection of both IPMNderived and-concomitant PDAC. Prospective studies to evaluate the usefulness of endoscopic ultrasonography in screening of IPMN-concomitant PDAC will also help in determining the optimal surveillance strategy for more widespread applications.

关键词： Intraductal papillary mucinous neoplasm Pancreatic ductal adenocarcinoma Endoscopic ultrasonography Screening Early diagnosis

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Path tracking control of autonomous agricultural mobile robots

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第10期8卷 1596-1603页

作者： ZHU Zhong-xiang CHEN Jun YOSHIDA Toyofumi torisu Ryo SONG Zheng-he MAO En-rong College of Engineering China Agricultural University Beijing 100083 China College of Mechanical and Electronic Engineering Northwest A＆F University Yangling 712100 China Faculty of Agriculture Iwate University Morioka 0208550 Japan

In a tractor automatic navigation system, path planning plays a significant role in improving operation efficiency. This study aims to create a suboptimal reference course for headland turning of a robot tractor and design a path-tracking controller to guide the robot tractor along the reference course. A time-minimum suboptimal control method was used to generate the reference turning course based on the mechanical parameters of the test tractor. A path-tracking controller consisting of both feedforward and feedback component elements was also proposed. The feedforward component was directly determined by the desired steering angle of the current navigation point on the reference course, whereas the feedback component was derived from the designed optimal controller. Computer simulation and field tests were performed to validate the path-tracking performance. Field test results indicated that the robot tractor followed the reference courses precisely on flat meadow, with average and standard lateral devia- tions being 0.031 m and 0.086 m, respectively. However, the tracking error increased while operating on sloping meadow due to the employed vehicle kinematic model.

关键词： Headland turning Path creation Path-tracking controller Optimal control Robot tractor

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Measurement of prostaglandin metabolites is useful in diagnosis of small bowel ulcerations

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World Journal of Gastroenterology 2019年第14期25卷 1753-1763页

作者： yuichi Matsuno Junji Umeno Motohiro Esaki Yoichiro Hirakawa Yuta Fuyuno Yasuharu Okamoto Atsushi Hirano Shigeyoshi Yasukawa Fumihito Hirai Toshiyuki Matsui Shuhei Hosomi Kenji Watanabe Naoki Hosoe Haruhiko Ogata Tadakazu Hisamatsu Shunichi Yanai Shuji Kochi Koichi Kurahara Tsuneyoshi Yao Takehiro torisu Takanari Kitazono Takayuki Matsumoto Department of Medicine and Clinical Science Graduate School of Medical Sciences Kyushu University Department of Endoscopic Diagnostics and Therapeutic Saga University Hospital Department of Epidemiology and Public Health Graduate School of Medical Sciences Kyushu University Department of Gastroenterology Fukuoka University Chikushi Hospital Department of Gastroenterology Osaka City University Graduate School of Medicine Department of Intestinal Inflammation Research Hyogo College of Medicine Center for Diagnostic and Therapeutic Endoscopy School of Medicine Keio University the Third Department of Internal Medicine Kyorin University School of Medicine Division of Gastroenterology Department of Internal Medicine Iwate Medical University Division of Gastroenterology Matsuyama Red Cross Hospital Department of Gastroenterology Sada Hospital

BACKGROUND We recently reported on a hereditary enteropathy associated with a gene encoding a prostaglandin transporter and referred to as chronic enteropathy associated with SLCO2 A1 gene(CEAS). Crohn's disease(CD) is a major differential diagnosis of CEAS, because these diseases share some clinical features. Therefore, there is a need to develop a convenient screening test to distinguish CEAS from *** To examine whether prostaglandin E major urinary metabolites(PGE-MUM) can serve as a biomarker to distinguish CEAS from *** This was a transactional study of 20 patients with CEAS and 98 patients with *** was diagnosed by the confirmation of homozygous or compound heterozygous mutation of SLCO2 A1. We measured the concentration of PGEMUM in spot urine by radioimmunoassay, and the concentration was compared between the two groups of patients. We also determined the optimal cut-off value of PGE-MUM to distinguish CEAS from CD by receiver operating characteristic(ROC) curve *** Twenty Japanese patients with CEAS and 98 patients with CD were ***-MUM concentration in patients with CEAS was significantly higher than that in patients with CD(median 102.7 vs 27.9 μg/g × Cre, P < 0.0001). One log unit increase in PGE-MUM contributed to 7.3 increase in the likelihood for the diagnosis of CEAS [95% confidence interval(CI) 3.2-16.7]. A logistic regression analysis revealed that the association was significant even after adjusting confounding factors(adjusted odds ratio 29.6, 95%CI 4.7-185.7). ROC curve analysis revealed the optimal PGE-MUM cut-off value for the distinction of CEAS from CD to be 48.9 μg/g × Cre with 95.0% sensitivity and 79.6% *** PGE-MUM measurement is a convenient, non-invasive and useful test for the distinction of CEAS from CD.

关键词： Chronic enteropathy associated with SLCO2A1 gene Prostaglandin E major urinary metabolites Chronic nonspecific multiple ulcers of the small intestine Crohn's disease Small intestine

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Autonomous Guidance of Tractor along Arbitrary Rectilinear Path on Sloped Terrain

Autonomous Guidance of Tractor along Arbitrary Rectilinear P...

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国际农业工程大会

作者： Ryo torisu Enrong Mao Professor Faculty of Agriculture Iwate University Japan Professor College of Engineering China Agricultural University China

＜正＞ Considerable grasslands of Japan are in hilly areas where farm machines must perform various tasks. Therefore, autonomous vehicles for slope-land farming should be considered. This paper presented an automatic vehicle guidance system to navigate the vehicle along arbitrary rectilinear path on sloped terrain. A previous neural network vehicle model was reconstructed to qualify in representing the characteristics of the vehicle motion on slope-land

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拖拉机在牧草地上自动引导行走的控制

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农业机械学报 2005年第7期36卷 104-107页

作者：陈军鸟巢谅朱忠祥西北农林科技大学机械与电子工程学院日本岩手大学农学部

利用车辆运动学模型,应用最优控制理论,对拖拉机自动引导行走方法进行了研究。利用前馈控制方法生成了车辆自动行走的轨道;通过对车辆运动状态方程的线性化,设计了车辆沿生成的轨道引导行走的负反馈控制器。最后利用该方法在牧草地上进... 详细信息

利用车辆运动学模型,应用最优控制理论,对拖拉机自动引导行走方法进行了研究。利用前馈控制方法生成了车辆自动行走的轨道;通过对车辆运动状态方程的线性化,设计了车辆沿生成的轨道引导行走的负反馈控制器。最后利用该方法在牧草地上进行了实车实验,结果表明:拖拉机在倾斜度小于3°的地面上直线行走时的横向标准偏差小于0.08m。

关键词：拖拉机自动行走控制

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基于PD控制的拖拉机半挂车机组自动直线倒车系统

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农业机械学报 2006年第7期37卷 98-100,73页

作者：朱忠祥陈军鸟巢谅中国农业大学工学院西北农林科技大学机械与电子工程学院日本岩手大学农学部

利用PD控制设计了拖拉机半挂车机组的自动直线倒车控制系统。建立了表达拖拉机半挂车机组行驶特性的运动学模型。对非线性的拖拉机半挂车机组控制系统进行了线性化处理。应用计算机仿真找出适当的比例系数和微分系数,然后进行田间试验... 详细信息

利用PD控制设计了拖拉机半挂车机组的自动直线倒车控制系统。建立了表达拖拉机半挂车机组行驶特性的运动学模型。对非线性的拖拉机半挂车机组控制系统进行了线性化处理。应用计算机仿真找出适当的比例系数和微分系数,然后进行田间试验。试验结果表明所设计的PD控制器不但稳定,而且成功地实现了拖拉机半挂车机组的自动直线倒车。

关键词：拖拉机半挂车机组倒车控制系统仿真

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基于神经网络的农用车辆自动跟踪控制

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农业机械学报 2007年第5期38卷 131-133,121页

作者：陈军朱忠祥鸟巢谅武田纯一西北农林科技大学机械与电子工程学院日本岩手大学农学部

跟踪控制器是农用车辆自动行驶控制的重要组成部分。将神经网络控制技术应用于车辆的自动行驶控制中,使得控制器具有良好的自学习功能,提高了控制器的环境适应能力和现场处理能力。在牧草地上的实车实验结果表明:车辆沿直线路径自动行驶... 详细信息

跟踪控制器是农用车辆自动行驶控制的重要组成部分。将神经网络控制技术应用于车辆的自动行驶控制中,使得控制器具有良好的自学习功能,提高了控制器的环境适应能力和现场处理能力。在牧草地上的实车实验结果表明:车辆沿直线路径自动行驶时,95%的偏差绝对值小于5cm。

关键词：车辆跟踪控制神经网络

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